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Transcriptional regulation of epithelial-mesenchymal transition
Yingqi Teng, … , Michael Zeisberg, Raghu Kalluri
Yingqi Teng, … , Michael Zeisberg, Raghu Kalluri
Published February 1, 2007
Citation Information: J Clin Invest. 2007;117(2):304-306. https://doi.org/10.1172/JCI31200.
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Commentary

Transcriptional regulation of epithelial-mesenchymal transition

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Abstract

It has become increasingly obvious that the notion of a terminally differentiated cell is likely a simplified concept. Epithelial-mesenchymal transition (EMT), during which epithelial cells assume a mesenchymal phenotype, is a key event occurring during normal development and pathological processes. Multiple extracellular stimuli and transcriptional regulators can trigger EMT, but how such distinct signaling pathways orchestrate the complex cellular events that facilitate EMT is not well understood. In this issue of the JCI, Venkov et al. report on their examination of fibroblasts resulting from EMT and describe a novel protein-DNA complex that is essential for transcription of fibroblast-specific protein 1 (FSP1) and sufficient to induce early EMT events (see the related article beginning on page 482). Collectively, their results suggest that this complex is an important regulator of the EMT transcriptome.

Authors

Yingqi Teng, Michael Zeisberg, Raghu Kalluri

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Figure 1

The CBF-A/KAP-1/FTS-1 complex is a master regulator of EMT.

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The CBF-A/KAP-1/FTS-1 complex is a master regulator of EMT.
In an epithe...
In an epithelial cell undergoing EMT, the CBF-A and KAP-1 proteins recognize and bind to the FTS-1 sites in the genomic DNA. The CBF-A/KAP-1/FTS-1 complex controls the expression of a wide spectrum of EMT-responsive genes, possibly via the FTS-1 sites also present in their promoters. Arrows with + or – symbols indicate whether the abundance of a given protein is increased or decreased, respectively, via the action of the CBF-A/KAP-1/FTS-1 complex. ZO-1, zona occludens 1.

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