The role of CXC chemokines in pulmonary fibrosis
Robert M. Strieter, … , Brigitte N. Gomperts, Michael P. Keane
Robert M. Strieter, … , Brigitte N. Gomperts, Michael P. Keane
Published March 1, 2007
Citation Information: J Clin Invest. 2007;117(3):549-556. https://doi.org/10.1172/JCI30562.
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Review Series

The role of CXC chemokines in pulmonary fibrosis

Abstract

The CXC chemokine family is a pleiotropic family of cytokines that are involved in promoting the trafficking of various leukocytes, in regulating angiogenesis and vascular remodeling, and in promoting the mobilization and trafficking of mesenchymal progenitor cells such as fibrocytes. These functions of CXC chemokines are important in the pathogenesis of pulmonary fibrosis and other fibroproliferative disorders. In this Review, we discuss the biology of CXC chemokine family members, specifically as it relates to their role in regulating vascular remodeling and trafficking of circulating mesenchymal progenitor cells (also known as fibrocytes) in pulmonary fibrosis.

Authors

Robert M. Strieter, Brigitte N. Gomperts, Michael P. Keane

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Figure 1

Histopathology of normal lung tissue (A) and lung tissue from two patients with IPF (B and C).

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Histopathology of normal lung tissue (A) and lung tissue from two patien...
Shown are (A) normal lung tissue (H&E staining); (B) IPF lung tissue with severe end-stage fibrosis and honeycomb changes (trichrome staining); and (C) IPF lung tissue with areas of fibrosis and an area compatible with a fibroblastic focus (FF) (H&E staining). Magnification, ×200.