Treatment with anti-CD3 antibody (anti-CD3) causes transient diarrhea. In this issue of the JCI, Clayburgh et al. show that, in jejunum of mice injected with anti-CD3 or with TNF, fluid accumulation and changes in epithelial phenotype develop, the latter including an increase in the passive permeability to proteins, smaller solutes, and water and the endocytosis of the brush border Na+/H+ exchanger, thereby inhibiting Na+ absorption (a second cytokine, LIGHT, has the former effect, but not the latter) (see the related article beginning on page 2682). These phenotypic changes, by themselves, do not, however, explain increased fluid secretion. Since active anion secretion is not stimulated (in fact it is inhibited), a non–epithelial cell–mediated driving force must be present — most likely an increase in interstitial pressure due to an effect of TNF on capillary permeability, smooth muscle contractility, or both.
Michael Field
Title and authors | Publication | Year |
---|---|---|
HIV pathogenesis: the host
AA Lackner, MM Lederman, B Rodriguez |
Cold Spring Harbor Perspectives in Medicine | 2012 |
Good fences make good neighbors: Gastrointestinal mucosal structure
HL Turner, JR Turner |
Gut microbes | 2010 |
CCAAT/Enhancer Binding Protein β Is a Major Mediator of Inflammation and Viral Replication in the Gastrointestinal Tract of Simian Immunodeficiency Virus-Infected Rhesus Macaques
M Mohan, PP Aye, JT Borda, X Alvarez, AA Lackner |
The American Journal of Pathology | 2008 |
Response to Field
Jerrold R. Turner, Daniel R. Clayburgh, Mark W. Musch, Michael Leitges, Yang-Xin Fu |
Journal of Clinical Investigation | 2006 |