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Usage Information

HIV and CXCR4 in a kiss of autophagic death
Beth Levine, Donald L. Sodora
Beth Levine, Donald L. Sodora
Published August 1, 2006
Citation Information: J Clin Invest. 2006;116(8):2078-2080. https://doi.org/10.1172/JCI29447.
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Commentary

HIV and CXCR4 in a kiss of autophagic death

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Abstract

AIDS is characterized by CD4+ T lymphocyte depletion, yet the mechanisms underlying this central aspect of HIV pathogenesis are still poorly understood. In this issue of the JCI, Espert et al. identify a mechanism by which the HIV envelope glycoprotein can induce death in uninfected CD4+ T cells (see the related article beginning on page 2161). The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degradation pathway of autophagy, which is necessary for both apoptotic and nonapoptotic cell death.

Authors

Beth Levine, Donald L. Sodora

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Usage data is cumulative from May 2024 through May 2025.

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Figure 55 1
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