Although matrix metalloproteinases (MMPs) are expressed in abundance in arterial aneurysms, their contribution to arterial wall degeneration, dilation, and rupture has not been determined. We investigated MMP function in a rat model of aneurysm associated with arterial dilation, elastin loss, medial invasion by mononuclear inflammatory cells, and MMP upregulation. Rupture was correlated with increased gelatinase B (MMP-9) and activated gelatinase A (MMP-2). Syngeneic rat smooth muscle cells retrovirally transfected with tissue inhibitor of matrix metalloproteinases (TIMP)-1 cDNA (LTSN) or with the vector alone as a control (LXSN) were seeded onto the luminal surface of the vessels. The seeding of LTSN cells resulted in TIMP-1 local overexpression. The seeding with LTSN cells, but not LXSN cells, decreased MMP-9, activated MMP-2 and 28-kD caseinase and elastase activity, preserved elastin in the media, and prevented aneurysmal degeneration and rupture. We conclude that MMP overexpression is responsible for aneurysmal degeneration and rupture in this rat model and that local pharmacological blockade might be a reasonable strategy for controlling the formation of aneurysms in humans.
E Allaire, R Forough, M Clowes, B Starcher, A W Clowes
Title and authors | Publication | Year |
---|---|---|
Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections.
Ganizada BH, J A Veltrop R, Akbulut AC, Koenen RR, Accord R, Lorusso R, Maessen JG, Reesink K, Bidar E, Schurgers LJ |
Basic Research in Cardiology | 2024 |
Pharmacological Inhibition of MMP-12 Exerts Protective Effects on Angiotensin II-Induced Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice
Di Gregoli K, Atkinson G, Williams H, George SJ, Johnson JL |
International journal of molecular sciences | 2024 |
Advances and challenges in regenerative therapies for abdominal aortic aneurysm
Chao CL, Applewhite B, Reddy NK, Matiuto N, Dang C, Jiang B |
Frontiers in Cardiovascular Medicine | 2024 |
A Novel Strategy for the Treatment of Aneurysms: Inhibition of MMP-9 Activity through the Delivery of TIMP-1 Encoding Synthetic mRNA into Arteries
Golombek S, Doll I, Kaufmann L, Lescan M, Schlensak C, Avci-Adali M |
International journal of molecular sciences | 2024 |
Greater TIMP-1 protein levels and neointimal formation represent sex-dependent cellular events limiting aortic vessel expansion in female rats.
Al-Katat A, Boudreau L, Gagnon E, Assous I, Villeneuve L, Leblanc CA, Bergeron A, Sirois M, El-Hamamsy I, Calderone A |
IUBMB life | 2024 |
Vitamin D and Bone Metabolism in Adult Patients with Neurofibromatosis Type 1.
Modica R, Altieri B, D'Aniello F, Benevento E, Cannavale G, Minotta R, Liccardi A, Colao A, Faggiano A |
Metabolites | 2023 |
The contribution of matrix metalloproteinases and their inhibitors to the development, progression, and rupture of abdominal aortic aneurysms
Atkinson G, Bianco R, Di Gregoli K, Johnson JL |
Frontiers in Cardiovascular Medicine | 2023 |
Pathogenic mechanisms and therapeutic implications of extracellular matrix remodelling in cerebral vasospasm
Hu Z, Deng X, Zhou S, Zhou C, Shen M, Gao X, Huang Y |
Fluids and barriers of the CNS | 2023 |
The ascending aorta of male hypertensive bicuspid aortic valve patients preferentially associated with a cellular aneurysmal phenotype
A Bergeron, V Hertig, L Villeneuve, V Chauvette, I ElHamamsy, A Calderone |
Physiological Reports | 2022 |
Patient-derived microphysiological model identifies the therapeutic potential of metformin for thoracic aortic aneurysm
Ma W, Zhang J, Liu S, Yan S, Xu K, Zhang YS, Abudupataer M, Ming Y, Zhu S, Xiang B, Zhou X, Luo S, Huang H, Tang Y, Zhang S, Xie Z, Chen N, Sun X, Li J, Lai H, Wang C, Zhu K, Zhang W |
EBioMedicine | 2022 |
Theories and Molecular Basis of Vascular Aging: A Review of the Literature from VascAgeNet Group on Pathophysiological Mechanisms of Vascular Aging
Gkaliagkousi E, Lazaridis A, Dogan S, Fraenkel E, Tuna BG, Mozos I, Vukicevic M, Yalcin O, Gopcevic K |
International journal of molecular sciences | 2022 |
Aortic Wall Inflammation in the Pathogenesis, Diagnosis and Treatment of Aortic Aneurysms.
Skotsimara G, Antonopoulos A, Oikonomou E, Papastamos C, Siasos G, Tousoulis D |
Inflammation | 2022 |
Importance of NLRP3 Inflammasome in Abdominal Aortic Aneurysms
J Shi, J Guo, Z Li, B Xu, M Miyata |
Journal of Atherosclerosis and Thrombosis | 2021 |
Neutrophils as Regulators and Biomarkers of Cardiovascular Inflammation in the Context of Abdominal Aortic Aneurysms
J Klopf, C Brostjan, C Neumayer, W Eilenberg |
Biomedicines | 2021 |
Progress in Heritable Soft Connective Tissue Diseases
J Halper |
2021 | |
Progress in Heritable Soft Connective Tissue Diseases
J Halper |
2021 | |
Progress in Heritable Soft Connective Tissue Diseases
J Halper |
2021 | |
Progress in Heritable Soft Connective Tissue Diseases
J Halper |
2021 | |
Progress in Heritable Soft Connective Tissue Diseases
J Halper |
2021 | |
Progress in Heritable Soft Connective Tissue Diseases
J Halper |
2021 | |
Progress in Heritable Soft Connective Tissue Diseases
J Halper |
2021 | |
Progress in Heritable Soft Connective Tissue Diseases
J Halper |
2021 | |
Progress in Heritable Soft Connective Tissue Diseases
J Halper |
2021 | |
Progress in Heritable Soft Connective Tissue Diseases
J Halper |
2021 | |
The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections
Rombouts KB, van Merrienboer TA, Ket JC, Bogunovic N, van der Velden J, Yeung KK |
European Journal of Clinical Investigation | 2021 |
Sonication-Assisted Method for Decellularization of Human Umbilical Artery for Small-Caliber Vascular Tissue Engineering
CH Lin, K Hsia, CK Su, CC Chen, CC Yeh, H Ma, JH Lu |
Polymers | 2021 |
Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture
SM Krishna, SK Morton, J Li, J Golledge |
International journal of molecular sciences | 2020 |
Myeloid-Derived TSP1 (Thrombospondin-1) Contributes to Abdominal Aortic Aneurysm Through Suppressing Tissue Inhibitor of Metalloproteinases-1
H Yang, T Zhou, CM Sorenson, N Sheibani, B Liu |
Arteriosclerosis, thrombosis, and vascular biology | 2020 |
The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases
GA Cabral-Pacheco, I Garza-Veloz, CC la Rosa, JM Ramirez-Acuña, BA Perez-Romero, JF Guerrero-Rodriguez, N Martinez-Avila, ML Martinez-Fierro |
International journal of molecular sciences | 2020 |
Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age
DR Machin, Y Auduong, VR Gogulamudi, Y Liu, T Islam, LA Lesniewski, AJ Donato |
Aging | 2020 |
Small Diameter Xenogeneic Extracellular Matrix Scaffolds for Vascular Applications
ML Higuita, LG Griffiths |
Tissue Engineering Part B: Reviews | 2020 |
Selected conditions associated with an increased incidence of incisional hernia: A review of molecular biology
MJ Reilly, NK Larsen, S Agrawal, FG Thankam, DK Agrawal, RJ Fitzgibbons |
The American Journal of Surgery | 2020 |
Matrix Metalloproteinase in Abdominal Aortic Aneurysm and Aortic Dissection
EM Maguire, SW Pearce, R Xiao, AY Oo, Q Xiao |
Pharmaceuticals (Basel, Switzerland) | 2019 |
Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm
S Jana, M Hu, M Shen, Z Kassiri |
Experimental & molecular medicine | 2019 |
Pharmacologic Management of Aneurysms
JH Lindeman, JS Matsumura |
Circulation research | 2019 |
The genetic basis of Turner syndrome aortopathy
H Corbitt, J Gutierrez, M Silberbach, CL Maslen |
American journal of medical genetics. Part C, Seminars in medical genetics | 2019 |
Deletion of BMAL1 (Brain and Muscle ARNT-Like Protein-1) in Smooth Muscle Cells Protects Mice From Abdominal Aortic Aneurysms
J Lutshumba, S Liu, Y Zhong, T Hou, A Daugherty, H Lu, Z Guo, MC Gong |
Arteriosclerosis, thrombosis, and vascular biology | 2018 |
TIMP3 and TIMP1 are risk genes for bicuspid aortic valve and aortopathy in Turner syndrome
H Corbitt, SA Morris, CH Gravholt, KH Mortensen, R Tippner-Hedges, M Silberbach, CL Maslen, BE Morrow |
PLoS genetics | 2018 |
Exploring antibody-dependent adaptive immunity against aortic extracellular matrix components in experimental aortic aneurysms
R Coscas, S Dupont, S Mussot, L Louedec, H Etienne, M Morvan, G Chiocchia, Z Massy, MP Jacob, JB Michel |
Journal of Vascular Surgery | 2018 |
Ruptured Abdominal Aortic Aneurysm
N Fujimura, RL Dalman |
Ruptured Abdominal Aortic Aneurysm | 2017 |
Multi-modality molecular imaging of aortic aneurysms
BJ Malm, MM Sadeghi |
Journal of Nuclear Cardiology | 2017 |
Abdominal aortic aneurysm-associated microRNA-516a-5p regulates expressions of methylenetetrahydrofolate reductase, matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-1 in human abdominal aortic vascular smooth muscle cells
CY Chan, BL Cheuk, SW Cheng |
Annals of Vascular Surgery | 2017 |
Gingival fibroblasts protect against experimental abdominal aortic aneurysm development and rupture through tissue inhibitor of metalloproteinase-1 production
A Giraud, L Zeboudj, M Vandestienne, J Joffre, B Esposito, S Potteaux, J Vilar, D Cabuzu, J Kluwe, S Seguier, A Tedgui, Z Mallat, A Lafont, H Ait-Oufella |
Cardiovascular Research | 2017 |
Animal Models in the Research of Abdominal Aortic Aneurysms Development
N Patelis, D Moris, D Schizas, C Damaskos, D Perrea, C Bakoyiannis, T Liakakos, S Georgopoulos |
Physiological research / Academia Scientiarum Bohemoslovaca | 2017 |
Animal Models Used to Explore Abdominal Aortic Aneurysms: A Systematic Review
JL Poulsen, J Stubbe, JS Lindholt |
European Journal of Vascular and Endovascular Surgery | 2016 |
MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and ElastinNovelty and Significance
KD Gregoli, NN Anuar, R Bianco, SJ White, AC Newby, SJ George, JL Johnson |
Circulation research | 2016 |
Ruptured abdominal aortic aneurysm—epidemiology, predisposing factors, and biology
T Schmitz-Rixen, M Keese, M Hakimi, A Peters, D Böckler, K Nelson, RT Grundmann |
Langenbeck's Archives of Surgery | 2016 |
Rat aorta as a pharmacological tool for in vitro and in vivo studies
M Rameshrad, H Babaei, Y Azarmi, DF Fouladi |
Life Sciences | 2016 |
The pathophysiologic basis of abdominal aortic aneurysm progression: a critical appraisal
JH Lindeman |
Expert Review of Cardiovascular Therapy | 2015 |
Attenuation of atherosclerotic lesions in diabetic apolipoprotein E-deficient mice using gene silencing of macrophage migration inhibitory factor
H Sun, XJ Zhang, L Zhao, X Zhen, SY Huang, SS Wang, H He, ZM Liu, NN Xu, FL Yang, ZH Qu, ZY Ma, C Zhang, Y Zhang, Q Hu |
Journal of Cellular and Molecular Medicine | 2015 |
Bone Marrow from Blotchy Mice Is Dispensable to Regulate Blood Copper and Aortic Pathologies but Required for Inflammatory Mediator Production in LDLR-Deficient Mice during Chronic Angiotensin II Infusion
D Harris, Y Liang, C Chen, S Li, O Patel, Z Qin |
Annals of Vascular Surgery | 2015 |
Comparative study of abdominal and thoracic aortic aneurysms: their pathogenesis and a gingival fibroblasts-based ex vivo treatment
H Cherifi, B Gogly, LS Loison-Robert, L Couty, FC Ferré, A Nassif, A Lafont, BP Fournier |
SpringerPlus | 2015 |
Vascular smooth muscle cell differentiation to an osteogenic phenotype involves matrix metalloproteinase-2 modulation by homocysteine
T Liu, J Lin, T Ju, L Chu, L Zhang |
Molecular and Cellular Biochemistry | 2015 |
Temporal regulation of venous extracellular matrix components during arteriovenous fistula maturation
MR Hall, K Yamamoto, CD Protack, M Tsuneki, G Kuwahara, R Assi, KE Brownson, H Bai, JA Madri, A Dardik |
The Journal of Vascular Access | 2014 |
The ω-3 Polyunsaturated Fatty Acid, Eicosapentaenoic Acid, Attenuates Abdominal Aortic Aneurysm Development via Suppression of Tissue Remodeling
JH Wang, K Eguchi, S Matsumoto, K Fujiu, I Komuro, R Nagai, I Manabe, E Aikawa |
PloS one | 2014 |
Cardiac Regeneration and Repair
JT Favreau, HC Ott, GR Gaudette |
Cardiac Regeneration and Repair | 2014 |
The Role of the Macrophage in the Development of Aortic Dissection
A Usman, MG Massad |
Cardiology | 2014 |
Biomarkers for AAA: Encouraging steps but clinical relevance still to be delivered
NM Htun, K Peter |
PROTEOMICS – CLINICAL APPLICATIONS | 2014 |
Diagnosis and treatment of thoracic aortic aneurysm
J Moon, YS Hong |
Journal of Korean Medical Association | 2014 |
Biochemomechanics of Intraluminal Thrombus in Abdominal Aortic Aneurysms
JS Wilson, L Virag, PD Achille, I Karšaj, JD Humphrey |
Journal of Biomechanical Engineering | 2013 |
Vascular Medicine: A Companion to Braunwald's Heart Disease
P Libby |
Vascular Medicine: A Companion to Braunwald's Heart Disease | 2013 |
Bone Marrow Mesenchymal Stem Cells Stabilize Already-formed Aortic Aneurysms More Efficiently than Vascular Smooth Muscle Cells in a Rat Model
F Schneider, F Saucy, R Blic, J Dai, F Mohand, H Rouard, JB Ricco, JP Becquemin, M Gervais, E Allaire |
European Journal of Vascular and Endovascular Surgery | 2013 |
Effects of the use of assisted reproduction and high-caloric diet consumption on body weight and cardiovascular health of juvenile mouse offspring
AL Schenewerk, FI Ramirez, C Foote, T Ji, LA Martinez-Lemus, RM Rivera |
Reproduction | 2013 |
CYP2J2 overexpression increases EETs and protects against angiotensin II-induced abdominal aortic aneurysm in mice
Z Cai, G Zhao, J Yan, W Liu, W Feng, B Ma, L Yang, J Wang, L Tu, DW Wang |
Journal of lipid research | 2013 |
CYP2J2 overexpression increases EETs and protects against angiotensin II-induced abdominal aortic aneurysm in mice[S]
Z Cai, G Zhao, J Yan, W Liu, W Feng, B Ma, L Yang, J Wang, L Tu, DW Wang |
Journal of lipid research | 2013 |
Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II
R Basu, D Fan, V Kandalam, J Lee, SK Das, X Wang, TA Baldwin, GY Oudit, Z Kassiri |
The Journal of biological chemistry | 2012 |
Elastin in large artery stiffness and hypertension
JE Wagenseil, RP Mecham |
Journal of Cardiovascular Translational Research | 2012 |
Treatment With Simvastatin Inhibits the Formation of Abdominal Aortic Aneurysms in Rabbits
ST Mastoraki, IK Toumpoulis, CE Anagnostopoulos, D Tiniakos, A Papalois, TP Chamogeorgakis, DC Angouras, CK Rokkas |
Annals of Vascular Surgery | 2012 |
Fucoidan interferes with Porphyromonas gingivalis-induced aneurysm enlargement by decreasing neutrophil activation
JM Alsac, S Delbosc, M Rouer, C Journé, L Louedec, O Meilhac, JB Michel |
Journal of Vascular Surgery | 2012 |
Loss of Timp3 Gene Leads to Abdominal Aortic Aneurysm Formation in Response to Angiotensin II
R Basu, D Fan, V Kandalam, J Lee, SK Das, X Wang, TA Baldwin, GY Oudit, Z Kassiri |
The Journal of biological chemistry | 2012 |
Animal Models of Cardiovascular Diseases
C Zaragoza, C Gomez-Guerrero, JL Martin-Ventura, L Blanco-Colio, B Lavin, B Mallavia, C Tarin, S Mas, A Ortiz, J Egido |
Journal of Biomedicine and Biotechnology | 2011 |
Combining two potential causes of metalloproteinase secretion causes abdominal aortic aneurysms in rats: a new experimental model
KM Mata, PS Prudente, FS Rocha, CM Prado, EM Floriano, J Elias, E Rizzi, RF Gerlach, MA Rossi, SG Ramos |
International Journal of Experimental Pathology | 2011 |
Long Term Stabilization of Expanding Aortic Aneurysms by a Short Course of Cyclosporine A through Transforming Growth Factor-Beta Induction
J Dai, S Michineau, G Franck, P Desgranges, JP Becquemin, M Gervais, E Allaire |
PloS one | 2011 |
Advances in Clinical Chemistry
M Mahler |
Advances in Clinical Chemistry Volume 54 | 2011 |
Downregulation of Remodelling Enzymatic Activity Induced by an Angiotensin-converting Enzyme Inhibitor (Perindopril) Reduces the Degeneration of Experimental Abdominal Aortic Aneurysms in a Rat Model
JM Alsac, C Journe, L Louedec, J Dai, P Julia, JN Fabiani, JB Michel |
European Journal of Vascular and Endovascular Surgery | 2011 |
Invited Commentary
AS Kumar, BA Prasad |
The Annals of Thoracic Surgery | 2011 |
Mesenchymal stem cells attenuate angiotensin II-induced aortic aneurysm growth in apolipoprotein E-deficient mice
R Hashizume, A Yamawaki-Ogata, Y Ueda, WR Wagner, Y Narita |
Journal of Vascular Surgery | 2011 |
Bioengineering of a Semiautologous Arterial Vessels with Reconstructed Media and Intima, Longtime Tested In Vivo
TA Sagban, E Schiegel, K Grabitz, W Sandmann, KM Balzer |
Advanced Engineering Materials | 2011 |
Simulation of abdominal aortic aneurysm growth with updating hemodynamic loads using a realistic geometry
A Sheidaei, SC Hunley, S Zeinali-Davarani, LG Raguin, S Baek |
Medical engineering & physics | 2011 |
A finite element model of stress-mediated vascular adaptation: application to abdominal aortic aneurysms
S Zeinali-Davarani, A Sheidaei, S Baek |
Computer Methods in Biomechanics and Biomedical Engineering | 2011 |
Imbalance between tissue inhibitor of metalloproteinase 1 and matrix metalloproteinase 9 after cardiopulmonary resuscitation
J Li, J Zhong, H Liu, Q Zeng, X Meng, D Liu, G Su, Y Zhang |
The American Journal of Emergency Medicine | 2011 |
Tumor Necrosis Factor-Alpha and Receptor Activator of Nuclear Factor-κB Ligand Augment Human Macrophage Foam-Cell Destruction of Extracellular Matrix Through Protease-Mediated Processes
H Skjøt-Arkil, N Barascuk, L Larsen, M Dziegiel, K Henriksen, MA Karsdal |
ASSAY and Drug Development Technologies | 2011 |
Animal models of abdominal aortic aneurysm and their role in furthering management of human disease
A Trollope, JV Moxon, CS Moran, J Golledge |
Cardiovascular Pathology | 2011 |
Long Term Stabilization of Expanding Aortic Aneurysms by a Short Course of Cyclosporine A through Transforming Growth Factor-Beta Induction
J Dai, S Michineau, G Franck, P Desgranges, JP Becquemin, M Gervais, E Allaire, Q Xu |
PloS one | 2011 |
Biomechanics and Mechanobiology of Aneurysms
T McGloughlin |
2011 | |
Chirurgie der abdominalen und thorakalen Aorta
RI Rückert, W Hepp, B Luther |
2011 | |
Nitroglycerin Alters Matrix Remodeling Proteins in THP-1 Human Macrophages and Plasma Metalloproteinase Activity in Rats
AS Krishnatry, SM Fung, DA Brazeau, D Soda, HL Fung |
Nitric Oxide | 2010 |
Macrophage-Mediated Proteolytic Remodeling of the Extracellular Matrix in Atherosclerosis Results in Neoepitopes: A Potential New Class of Biochemical Markers
H Skjøt-Arkil, N Barascuk, T Register, MA Karsdal |
ASSAY and Drug Development Technologies | 2010 |
Aortic Length Changes During Abdominal Aortic Aneurysm Formation, Expansion and Stabilisation in a Rat Model
S Michineau, J Dai, M Gervais, M Zidi, AW Clowes, JP Becquemin, JB Michel, E Allaire |
European Journal of Vascular and Endovascular Surgery | 2010 |
Traité de médecine vasculaire
I Brochériou |
Traité de médecine vasculaire. | 2010 |
Correlation between the SYNTAX Score and serum matrix metalloproteinase-3 levels in patients with chronic coronary heart disease
M Gřiva, R Náplava, M Špendlíková, J Jarkovský, O Hlinomaz, Č Číhalík |
Cor et Vasa | 2010 |
Pleiotropic roles of S100A12 in coronary atherosclerotic plaque formation and rupture
J Goyette, WX Yan, E Yamen, YM Chung, SY Lim, K Hsu, F Rahimi, ND Girolamo, C Song, W Jessup, M Kockx, YV Bobryshev, SB Freedman, CL Geczy |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II
J Deguchi, H Huang, P Libby, E Aikawa, P Whittaker, J Sylvan, RT Lee, M Aikawa |
Laboratory Investigation | 2009 |
Immune Cells and Molecular Mediators in the Pathogenesis of the Abdominal Aortic Aneurysm
KD Rizas, N Ippagunta, MD Tilson |
Cardiology in Review | 2009 |
Matrix metalloproteinases and cardiovascular diseases
A Papazafiropoulou, N Tentolouris |
Hippokratia | 2009 |
Aspirin Inhibits MMP-2 and MMP-9 Expression and Activity Through PPARα/γ and TIMP-1-Mediated Mechanisms in Cultured Mouse Celiac Macrophages
Y Yiqin, X Meilin, X Jie, Z Keping |
Inflammation | 2009 |
New Insight in Aetiopathogenesis of Aortic Diseases
E Allaire, F Schneider, F Saucy, J Dai, F Cochennec, S Michineau, M Zidi, JP Becquemin, M Kirsch, M Gervais |
European Journal of Vascular and Endovascular Surgery | 2009 |
Development and Application of an Experimental Abdominal Aortic Aneurysm Model
PE Baker, KV Ramnarine |
Ultrasound | 2009 |
Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model
J Dai, L Louedec, M Philippe, JB Michel, X Houard |
Journal of Vascular Surgery | 2009 |
Gingival fibroblast inhibits MMP-7: Evaluation in an ex vivo aorta model
B Gogly, B Fournier, L Couty, A Naveau, C Brasselet, E Durand, B Coulomb, A Lafont |
Journal of Molecular and Cellular Cardiology | 2009 |
Pathophysiology of Pelvic Organ Prolapse
RA Word, S Pathi, JI Schaffer |
Obstetrics and Gynecology Clinics of North America | 2009 |
El inhibidor tisular de la metaloproteinasa-1 es un marcador temprano de disfunción endotelial en un modelo murino de lesión oxidativa venosa
R Moore, A Hawley, R Sigler, D Farris, S Wrobleski, E Ramacciotti, D Myers |
Anales de Cirugía Vascular | 2009 |
Physiopathologie des anévrismes idiopathiques de l’aorte thoracique ascendante
NC Radu, M Gervais, E Allaire, DY Loisance, ME Kirsch |
La Presse Médicale | 2009 |
L'inhibiteur tissulaire de la métalloprotéinase-1 est un marqueur précoce de dysfonction aiguë endothéliale dans un modèle de lésion veineuse oxydative chez le rongeur
R Moore, A Hawley, R Sigler, D Farris, S Wrobleski, E Ramacciotti, D Myers |
Annales de Chirurgie Vasculaire | 2009 |
Tissue Inhibitor of Metalloproteinase-1 is an Early Marker of Acute Endothelial Dysfunction in a Rodent Model of Venous Oxidative Injury
R Moore, A Hawley, R Sigler, D Farris, S Wrobleski, E Ramacciotti, D Myers |
Annals of Vascular Surgery | 2009 |
Advances in Understanding Aortic Diseases
T Kazui, S Takamoto |
2009 | |
Digging in the “Soil” of the Aorta to Understand the Growth of Abdominal Aortic Aneurysms
JA Curci |
Vascular | 2009 |
Thoracic Aortic Dissection: Are Matrix Metalloproteinases Involved?
X Zhang, YH Shen, SA LeMaire |
Vascular | 2009 |
Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice
X Ma, M Tittiger, RH Knutsen, A Kovacs, L Schaller, RP Mecham, KP Ponder |
Molecular Genetics and Metabolism | 2008 |
Plasma Matrix Metalloproteinase Levels Do Not Predict Tissue Levels in Abdominal Aortic Aneurysms Suitable for Elective Repair
WR Wilson, EC Choke, J Dawson, IM Loftus, MM Thompson |
Vascular | 2008 |
SM22α-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis
N El-Bizri, C Guignabert, L Wang, A Cheng, K Stankunas, CP Chang, Y Mishina, M Rabinovitch |
Development (Cambridge, England) | 2008 |
The Aorta: Structure, Function, Dysfunction and Diseases
C Liapis, J Kakisis |
The Aorta: Structure, Function, Dysfunction and Diseases | 2008 |
Aortic Aneurysms in a Rat Model: In Vivo MR Imaging of Endovascular Cell Therapy 1
JF Deux, J Dai, C Rivière, F Gazeau, P Méric, B Gillet, J Roger, JN Pons, D Letourneur, FP Boudghène, E Allaire |
Radiology | 2008 |
Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease
JD Raffetto, RA Khalil |
Biochemical Pharmacology | 2007 |
Turning back the clock: regression of abdominal aortic aneurysms via pharmacotherapy
H Aoki, K Yoshimura, M Matsuzaki |
Journal of Molecular Medicine | 2007 |
Elastolytic Matrix Metalloproteinases and Coronary Outcome in Children with Kawasaki Disease
AC Lau, H Rosenberg, TT Duong, BW Mccrindle, RS Yeung |
Pediatric Research | 2007 |
Gingival Fibroblasts Inhibit MMP-1 and MMP-3 Activities in an Ex-Vivo Artery Model
A Naveau, N Reinald, B Fournier, E Durand, A Lafont, B Coulomb, B Gogly |
Connective Tissue Research | 2007 |
The influence of hemodynamic forces on biomarkers in the walls of elastase-induced aneurysms in rabbits
R Kadirvel, YH Ding, D Dai, H Zakaria, AM Robertson, MA Danielson, DA Lewis, HJ Cloft, DF Kallmes |
Neuroradiology | 2007 |
Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) Polymorphisms in a Caucasian Population with Abdominal Aortic Aneurysm
I Hinterseher, D Krex, E Kuhlisch, KG Schmidt, C Pilarsky, W Schneiders, HD Saeger, H Bergert |
World Journal of Surgery | 2007 |
Matrix metalloproteinases in peripheral vascular disease
MJ Hobeika, RW Thompson, BE Muhs, PC Brooks, PJ Gagne |
Journal of Vascular Surgery | 2007 |
Can Local Secretion of Prostaglandin E2, Thromboxane B2, and Interleukin-6 Play a Role in Ruptured Abdominal Aortic Aneurysm?
BL Cheuk, SW Cheng |
World Journal of Surgery | 2007 |
Challenges and opportunities in abdominal aortic aneurysm research
M Wassef, GR Upchurch, H Kuivaniemi, RW Thompson, MD Tilson |
Journal of Vascular Surgery | 2007 |
Urinary levels of matrix metalloproteinase 9 and 2 and tissue inhibitor of matrix metalloproteinase in patients with coronary artery disease
PJ Fitzsimmons, R Forough, ME Lawrence, DS Gantt, MH Rajab, H Kim, B Weylie, AM Spiekerman, GJ Dehmer |
Atherosclerosis | 2007 |
Gefäßchirurgie
HJ Safi, AL Estrera, A Azizzadeh, CC Miller |
Gefäßchirurgie | 2007 |
Proteinase Systems and Thoracic Aortic Aneurysm Progression
JR Barbour, FG Spinale, JS Ikonomidis |
Journal of Surgical Research | 2007 |
Efferent vagal nerve stimulation induces tissue inhibitor of metalloproteinase-1 in myocardial ischemia-reperfusion injury in rabbit
K Uemura, M Li, T Tsutsumi, T Yamazaki, T Kawada, A Kamiya, M Inagaki, K Sunagawa, M Sugimachi |
American journal of physiology. Heart and circulatory physiology | 2007 |
Essentials of Restenosis
HJ Duckers, EG Nabel, PW Serruys |
2007 | |
Effects of tissue inhibitor of metalloproteinase 2 deficiency on aneurysm formation
W Xiong, R Knispel, J Mactaggart, BT Baxter |
Journal of Vascular Surgery | 2006 |
Pharmacological targets in the treatment of abdominal aortic aneurysms
MP Bergoeing, RW Thompson, JA Curci |
Expert Opinion on Therapeutic Targets | 2006 |
Apolipoprotein E Knockout Mice Over-Expressing Human Tissue Inhibitor of Metalloproteinase 1 Are Protected against Aneurysm Formation but Not against Atherosclerotic Plaque Development
C Cuaz-Pérolin, I Jguirim, G Larigauderie, A Jlassi, C Furman, M Moreau, MJ Chapman, JC Fruchart, MN Slimane, H Mezdour, M Rouis |
Journal of Vascular Research | 2006 |
Increased serum cathepsin S in patients with atherosclerosis and diabetes
J Liu, L Ma, J Yang, A Ren, Z Sun, G Yan, J Sun, H Fu, W Xu, C Hu, GP Shi |
Atherosclerosis | 2006 |
Oral Administration of Diferuloylmethane (Curcumin) Suppresses Proinflammatory Cytokines and Destructive Connective Tissue Remodeling in Experimental Abdominal Aortic Aneurysms
F Parodi, D Mao, T Ennis, M Pagano, R Thompson |
Annals of Vascular Surgery | 2006 |
Targeting matrix metalloproteases to improve cutaneous wound healing
M Xue, NT Le, CJ Jackson |
Expert Opinion on Therapeutic Targets | 2006 |
Matrix metalloproteinases 2 and 9 in human atherosclerotic and non-atherosclerotic cerebral aneurysms
J Caird, C Napoli, C Taggart, M Farrell, D Bouchier-Hayes |
European Journal of Neurology | 2006 |
Percutaneous transplantation of genetically-modified autologous fibroblasts in the rabbit femoral artery: a novel approach for cardiovascular gene therapy
M Mazighi, D Tchétché, Y Gouëffic, AS Juan, L Louedec, D Hénin, JB Michel, MP Jacob, LJ Feldman |
Journal of Vascular Surgery | 2006 |
Matrix Metalloproteinase 2 Polymorphisms in a Caucasian Population with Abdominal Aortic Aneurysm
I Hinterseher, H Bergert, E Kuhlisch, A Bloomenthal, C Pilarsky, D Ockert, S Schellong, HD Saeger, D Krex |
Journal of Surgical Research | 2006 |
Vascular Medicine
ES Klings, J Loscalzo |
Vascular Medicine | 2006 |
Metaloproteinasas de matriz: su implicación en las enfermedades vasculares periféricas
JC Bohórquez-Sierra |
Angiología | 2006 |
Deficiencies in estrogen-mediated regulation of cerebrovascular homeostasis may contribute to an increased risk of cerebral aneurysm pathogenesis and rupture in menopausal and postmenopausal women
CG Harrod, HH Batjer, BR Bendok |
Medical Hypotheses | 2006 |
Pathobiology of Idiopathic Ascending Aortic Aneurysms
EW Kirsch, NC Radu, E Allaire, DY Loisance |
Asian Cardiovascular and Thoracic Annals | 2006 |
Principles of Molecular Medicine
MS Runge, C Patterson |
2006 | |
Increased Angiogenesis at the Site of Abdominal Aortic Aneurysm Rupture
E Choke, GW Cockerill, J Dawson, RW Wilson, A Jones, IM Loftus, MM Thompson |
Annals of the New York Academy of Sciences | 2006 |
Macrophage migration inhibitory factor induces MMP-9 expression: implications for destabilization of human atherosclerotic plaques
YZ Kong, X Yu, JJ Tang, X Ouyang, XR Huang, G Fingerle-Rowson, M Bacher, LA Scher, R Bucala, HY Lan |
Atherosclerosis | 2005 |
Enhancement of MMP-9 Activity in THP-1 Cells by 7-ketocholesterol and Its Suppression by the HMG-CoA Reductase Inhibitor Fluvastatin
H Ozaki, Y Miyashita, H Watanabe, K Shirai |
Journal of Atherosclerosis and Thrombosis | 2005 |
A Review of Biological Factors Implicated in Abdominal Aortic Aneurysm Rupture
E Choke, G Cockerill, WR Wilson, S Sayed, J Dawson, I Loftus, MM Thompson |
European Journal of Vascular and Endovascular Surgery | 2005 |
Gender Differences in Rat Aortic Smooth Muscle Cell Matrix Metalloproteinase-9
DT Woodrum, JW Ford, G Ailawadi, CG Pearce, I Sinha, MJ Eagleton, PK Henke, JC Stanley, GR Upchurch |
Journal of the American College of Surgeons | 2005 |
Up-Regulation and Coexpression of MIF and Matrix Metalloproteinases in Human Abdominal Aortic Aneurysms
L Verschuren, JH Lindeman, JH van Bockel, H Abdul-Hussien, T Kooistra, R Kleemann |
Antioxidants & Redox Signaling | 2005 |
Cell transplantation preserves matrix homeostasis: A novel paracrine mechanism
PW Fedak, PE Szmitko, RD Weisel, SM Altamentova, N Nili, N Ohno, S Verma, S Fazel, BH Strauss, RK Li |
The Journal of Thoracic and Cardiovascular Surgery | 2005 |
Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase
K Yoshimura, H Aoki, Y Ikeda, K Fujii, N Akiyama, A Furutani, Y Hoshii, N Tanaka, R Ricci, T Ishihara, K Esato, K Hamano, M Matsuzaki |
Nature Medicine | 2005 |
Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-κB
FE Parodi, D Mao, TL Ennis, MA Bartoli, RW Thompson |
Journal of Vascular Surgery | 2005 |
Enhanced abdominal aortic aneurysm in TIMP-1-deficient mice1
MK Eskandari, JD Vijungco, A Flores, J Borensztajn, V Shively, WH Pearce |
Journal of Surgical Research | 2005 |
Endovascular Treatment of Aneurysms: Gene Expression of Neointimal Cells Recruited on the Embolic Agent and Evolution with Recurrence in an Experimental Model
J Raymond, C Ogoudikpe, I Salazkin, A Metcalfe, G Gevry, M Chagnon, O Robledo |
Journal of Vascular and Interventional Radiology | 2005 |
An Overview of Matrix Metalloproteinases in the Pathogenesis and Treatment of Abdominal Aortic Aneurysms
WB Keeling, PA Armstrong, PA Stone, DF Bandyk, ML Shames |
Vascular and endovascular surgery | 2005 |
Dual Role of Matrix Metalloproteinases (Matrixins) in Intimal Thickening and Atherosclerotic Plaque Rupture
AC Newby |
Physiological reviews | 2005 |
Elevated levels of matrix metalloprotein-3 in patients with coronary aneurysm: A case control study
I Tengiz, E Ercan, E Aliyev, C Sekuri, C Duman, I Altuglu |
Current controlled trials in cardiovascular medicine | 2004 |
Vascular Smooth Muscle Cell Endovascular Therapy Stabilizes Already Developed Aneurysms in a Model of Aortic Injury Elicited by Inflammation and Proteolysis:
E Allaire, B Muscatelli-Groux, AM Guinault, C Pages, A Goussard, C Mandet, P Bruneval, D Mllire, JP Becquemin |
Annals of Surgery | 2004 |
Matrix metalloproteinases and atherosclerosis
N Watanabe, U Ikeda |
Current Atherosclerosis Reports | 2004 |
Optimization ofin vitro vascular cell transfection with non-viral vectors forin vivo applications
I Elmadbouh, P Rossignol, O Meilhac, R Vranckx, C Pichon, B Pouzet, P Midoux, JB Michel |
The Journal of Gene Medicine | 2004 |
Role of leukocyte elastase in preventing cellular re-colonization of the mural thrombus
V Fontaine, Z Touat, EM Mtairag, R Vranckx, L Louedec, X Houard, B Andreassian, U Sebbag, T Palombi, MP Jacob, O Meilhac, JB Michel |
The American Journal of Pathology | 2004 |
Matrix metalloproteinases: contribution to pathogenesis, diagnosis, surveillance and treatment of abdominal aortic aneurysms
NP Kadoglou, CD Liapis |
Current Medical Research and Opinion | 2004 |
Application of real-time RT-PCR to quantifying gene expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human abdominal aortic aneurysm
T Higashikata, M Yamagishi, H Sasaki, K Minatoya, H Ogino, H Ishibashi-Ueda, H Hao, N Nagaya, H Tomoike, A Sakamoto |
Atherosclerosis | 2004 |
Matrix metalloproteinase activity in thoracic aortic aneurysms associated with bicuspid and tricuspid aortic valves
J Boyum, EK Fellinger, JD Schmoker, L Trombley, K McPartland, FP Ittleman, AB Howard |
The Journal of Thoracic and Cardiovascular Surgery | 2004 |
Thérapie génique des resténoses et de l'athérosclérose : espoirs et réalités
M Mazighi, D Tchétché, F Hyafil, LJ Feldman |
Pathologie Biologie | 2004 |
Proteases and Their Inhibitors in Cancer Metastasis
JM Foidart, RJ Muschel |
2004 | |
Deficiency of Cathepsin S Reduces Atherosclerosis In Low-Density Lipoprotein Receptor-Deficient Mice
Galina K. Sukhova, Yaou Zhang, Jie-Hong Pan, Youichiro Wada, Takashi Yamamoto, Makoto Naito, Tatsuhiko Kodama, Sotirios Tsimikas, Joseph L. Witztum, Michael L. Lu, Yasuhiko Sakara, Michael T. Chin, Peter Libby, Guo-Ping Shi |
Journal of Clinical Investigation | 2003 |
Different expression of MMPs/TIMP-1 in human atherosclerotic lesions. Relation to plaque features and vascular bed
J Orbe, L Fernandez, JA Rodrıxguez, G Rábago, M Belzunce, A Monasterio, C Roncal, JA Páramo |
Atherosclerosis | 2003 |
Vascular smooth muscle cells efficiently activate a new proteinase cascade involving plasminogen and fibronectin
X Houard, C Monnot, V Dive, P Corvol, M Pagano |
Journal of Cellular Biochemistry | 2003 |
Mechanism of inhibition of matrix metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cells
J Liu, W Xiong, L Baca-Regen, H Nagase, BT Baxter |
Journal of Vascular Surgery | 2003 |
Metalloproteinases in Development and Progression of Vascular Disease
HR Lijnen |
Pathophysiology of Haemostasis and Thrombosis | 2003 |
The dynamic extracellular matrix: intervention strategies during heart failure and atherosclerosis
S Heeneman, JP Cleutjens, BC Faber, EE Creemers, RJ Suylen, E Lutgens, KB Cleutjens, MJ Daemen |
The Journal of Pathology | 2003 |
Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation
PW Fedak, MP de Sa, S Verma, N Nili, P Kazemian, J Butany, BH Strauss, RD Weisel, TE David |
The Journal of Thoracic and Cardiovascular Surgery | 2003 |
Extracellular matrix remodeling and matrix metalloproteinases in the vascular wall during aging and in pathological conditions
MP Jacob |
Biomedicine & Pharmacotherapy | 2003 |
A murine model of thoracic aortic aneurysms
JS Ikonomidis, WC Gibson, J Gardner, S Sweterlitsch, RP Thompson, R Mukherjee, FG Spinale |
Journal of Surgical Research | 2003 |
Airway smooth muscle—its relationship to the extracellular matrix
JL Black, JK Burgess, PR Johnson |
Respiratory Physiology & Neurobiology | 2003 |
A nonintrinsic regional basis for increased infrarenal aortic MMP-9 expression and activity
G Ailawadi, BS Knipp, G Lu, KJ Roelofs, JW Forda, KK Hannawaa, K Bishop, P Thanaporna, PK Henke, JC Stanley, GR Upchurch |
Journal of Vascular Surgery | 2003 |
Paracrine secretion of transforming growth factor-β1 in aneurysm healing and stabilization with endovascular smooth muscle cell therapy1 1Competition of interest: none
F Losy, J Dai, C Pages, M Ginat, B Muscatelli-Groux, AM Guinault, E Rousselle, G Smedile, D Loisance, JP Becquemin, E Allaire |
Journal of Vascular Surgery | 2003 |
Prospects for the Medical Management of Abdominal Aortic Aneurysms
EF Steinmetz, C Buckley, RW Thompson |
Vascular and endovascular surgery | 2003 |
Increased Medial Degradation With Pseudo-Aneurysm Formation in Apolipoprotein E–Knockout Mice Deficient in Tissue Inhibitor of Metalloproteinases-1
V Lemaître, PD Soloway, J DArmiento |
Circulation | 2003 |
Matrix metalloproteinase 2 and 9 work in concert to produce aortic aneurysms
G. Matthew Longo, Wanfen Xiong, Timothy C. Greiner, Yong Zhao, Nicola Fiotti, B. Timothy Baxter |
Journal of Clinical Investigation | 2002 |
Systemic tissue inhibitor of metalloproteinase-1 gene delivery reduces neointimal hyperplasia in balloon-injured rat carotid artery
C Furman, Z Luo, K Walsh, N Duverger, C Copin, JC Fruchart, M Rouis |
FEBS Letters | 2002 |
Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms
V Fontaine, MP Jacob, X Houard, P Rossignol, D Plissonnier, E Angles-Cano, JB Michel |
The American Journal of Pathology | 2002 |
Mechanisms of abdominal aortic aneurysm formation
A Daugherty, LA Cassis |
Current Atherosclerosis Reports | 2002 |
Matrix metalloproteinases and atherosclerotic plaque instability
IM Loftus, AR Naylor, PR Bell, MM Thompson |
The British journal of surgery | 2002 |
Therapeutic developments in matrix metalloproteinase inhibition
PK Shah, DJ Wilkin, TM Doherty, H Uzui, TB Rajavashisth, K Asotra, D Pei |
Expert Opinion on Therapeutic Patents | 2002 |
Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease
N Lamblin, C Bauters, X Hermant, JM Lablanche, N Helbecque, P Amouyel |
Journal of the American College of Cardiology | 2002 |
Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms
B Annabi, D Shédid, P Ghosn, RL Kenigsberg, RR Desrosiers, MW Bojanowski, E Beaulieu, E Nassif, R Moumdjian, R Béliveau |
Journal of Vascular Surgery | 2002 |
Genes potentially involved in plaque rupture
BC Faber, S Heeneman, MJ Daemen, KB Cleutjens |
Current Opinion in Lipidology | 2002 |
Proteolysis of the Abdominal Aortic Aneurysm Wall and the Association with Rupture
E Petersen, F Wågberg, KA Ängquist |
European Journal of Vascular and Endovascular Surgery | 2002 |
Abdominal Aortic Aneurysms: Basic Mechanisms and Clinical Implications
RW Thompson, PJ Geraghty, JK Lee |
Current Problems in Surgery | 2002 |
The role of matrix metalloproteinases in vascular disease
IM Loftus, MM Thompson |
Vascular medicine (London, England) | 2002 |
Metalloproteinase Inhibition and the Response to Angioplasty and Stenting in Atherosclerotic Primates
GS Cherr, SJ Motew, JA Travis, J Fingerle, L Fisher, M Brandl, JK Williams, RL Geary |
Arteriosclerosis, thrombosis, and vascular biology | 2002 |
Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis: The Good, the Bad, and the Ugly
ZS Galis, JJ Khatri |
Circulation research | 2002 |
Matrix Metalloproteinases: Are They Antiatherogenic but Proaneurysmal?
MP Bendeck |
Circulation research | 2002 |
Oxidative Stress in Human Abdominal Aortic Aneurysms: A Potential Mediator of Aneurysmal Remodeling
FJ Miller, WJ Sharp, X Fang, LW Oberley, TD Oberley, NL Weintraub |
Arteriosclerosis, thrombosis, and vascular biology | 2002 |
Reduced Atherosclerotic Plaque but Enhanced Aneurysm Formation in Mice With Inactivation of the Tissue Inhibitor of Metalloproteinase-1 ( TIMP-1 ) Gene
J Silence, D Collen, HR Lijnen |
Circulation research | 2002 |
Cellular Peptidases in Immune Functions and Diseases 2
J Langner, S Ansorge |
2002 | |
Phenotypic alteration of vascular smooth muscle cells precedes elastolysis in a mouse model of Marfan syndrome
TE Bunton, NJ Biery, L Myers, B Gayraud, F Ramirez, HC Dietz |
Circulation research | 2001 |
Endoluminal smooth muscle cell seeding limits intimal hyperplasia
D Gomes, L Louedec, D Plissonnier, MC Dauge, D Henin, M Osborne-Pellegrin, JB Michel |
Journal of Vascular Surgery | 2001 |
Genetic Studies on the Role of Proteinases and Growth Factors in Atherosclerosis and Aneurysm Formation
A Luttun, P Carmeliet |
Annals of the New York Academy of Sciences | 2001 |
Surgical Research
J Rozga, AA Demetriou |
Surgical Research | 2001 |
MMP9 production by human monocyte-derived macrophages is decreased on polymerized type I collagen
S Lepidi, RD Kenagy, EW Raines, ES Chiu, A Chait, R Ross, AW Clowes |
Journal of Vascular Surgery | 2001 |
The expression and localization of membrane type-1 matrix metalloproteinase in human abdominal aortic aneurysms
A Nollendorfs, TC Greiner, H Nagase, BT Baxter |
Journal of Vascular Surgery | 2001 |
Extracellular matrix remodeling in the vascular wall
MP Jacob, C Badier-Commander, V Fontaine, Y Benazzoug, L Feldman, JB Michel |
Pathologie Biologie | 2001 |
Elastin–laminin receptor and abdominal aortic aneurysms. New subject to study? A review
M Kunecki, A Nawrocka |
Pathologie Biologie | 2001 |
Compensatory Enlargement and Stenosis Develop in ApoE −/− and ApoE*3-Leiden Transgenic Mice
E Lutgens, ED de Muinck, S Heeneman, MJ Daemen |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
Contrasting Outcomes of Atheroma Evolution: Intimal Accumulation Versus Medial Destruction
JB Michel |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
Persistence of Atherosclerotic Plaque but Reduced Aneurysm Formation in Mice With Stromelysin-1 (MMP-3) Gene Inactivation
J Silence, F Lupu, D Collen, HR Lijnen |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
Differential Expression of Matrix Metalloproteinases After Stent Implantation and Balloon Angioplasty in the Hypercholesterolemic Rabbit
LJ Feldman, M Mazighi, A Scheuble, JF Deux, ED Benedetti, C Badier-Commander, E Brambilla, D Henin, PG Steg, MP Jacob |
Circulation | 2001 |
Polymorphisms in Matrix Metalloproteinase-1, -3, -9, and -12 Genes in Relation to Subarachnoid Hemorrhage
B Zhang, S Dhillon, I Geary, WM Howell, F Iannotti, IN Day, S Ye |
Stroke; a journal of cerebral circulation | 2001 |
The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia, and stroke: Insights from genetic studies
A Luttun, M Dewerchin, D Collen, P Carmeliet |
Current Atherosclerosis Reports | 2000 |
Proteinases in cardiovascular aneurysms and rupture: targets for therapy?
P Carmeliet |
Journal of Clinical Investigation | 2000 |
Angiotensin II, atherosclerosis, and aortic aneurysms
BC Berk, J Haendeler, J Sottile |
Journal of Clinical Investigation | 2000 |
Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms
JA Curci, D Mao, DG Bohner, BT Allen, BG Rubin, JM Reilly, GA Sicard, RW Thompson |
Journal of Vascular Surgery | 2000 |
Cardiovascular gene therapy
S Ylä-Herttuala, JF Martin |
The Lancet | 2000 |
PROSPECTS FOR GENETIC THERAPY OF CARDIOVASCULAR DISEASE
HJ Duckers, EG Nabel |
Medical Clinics of North America | 2000 |
Molecular interactions between the plasminogen/plasmin and matrix metalloproteinase systems
HR Lijnen |
Fibrinolysis and Proteolysis | 2000 |
Prospectives pour une biologie cellulaire chirurgicale
JB Michel |
Annales de Chirurgie | 2000 |
Plasminogen activators, matrix metalloproteinases and their inhibitors in implanted vascular prostheses
H Urayama, S Katada, F Kasashima, Y Tanaka, K Kawasuji, Y Watanabe |
European Journal of Vascular and Endovascular Surgery | 2000 |
Circulating Biochemical Marker Levels of Collagen Metabolism Are Abnormal in Patients with Abdominal Aortic Aneurysm
R Tachieda, H Niinuma, A Ohira, S Endoh, K Hiramori, S Makita, M Nakamura |
Angiology | 2000 |
Metalloproteinase Inhibition Reduces Constrictive Arterial Remodeling After Balloon Angioplasty: A Study in the Atherosclerotic Yucatan Micropig
BJ de Smet, D de Kleijn, R Hanemaaijer, JH Verheijen, L Robertus, YJ van der Helm, C Borst, MJ Post |
Circulation | 2000 |
Cystatin C deficiency in human atherosclerosis and aortic aneurysms
GP Shi, GK Sukhova, A Grubb, A Ducharme, LH Rhode, RT Lee, PM Ridker, P Libby, HA Chapman |
Journal of Clinical Investigation | 1999 |
Who are the proteolytic culprits in vascular disease?
WC Parks |
Journal of Clinical Investigation | 1999 |
Marimastat inhibits elastin degradation and matrix metalloproteinase 2 activity in a model of aneurysm disease
GD Treharne, JR Boyle, S Goodall, IM Loftus, PR Bell, MM Thompson |
The British journal of surgery | 1999 |
Tissue Inhibitor of Matrix Metalloproteinases-1 Impairs Arterial Neointima Formation After Vascular Injury in Mice
HR Lijnen, P Soloway, D Collen |
Circulation research | 1999 |
Abdominal aortic aneurysm
JA van der Vliet, AP Boll |
The Lancet | 1997 |