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Usage Information

A new cardiac MASTer switch for the renin-angiotensin system
Thu H. Le, Thomas M. Coffman
Thu H. Le, Thomas M. Coffman
Published April 3, 2006
Citation Information: J Clin Invest. 2006;116(4):866-869. https://doi.org/10.1172/JCI28312.
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Commentary

A new cardiac MASTer switch for the renin-angiotensin system

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Abstract

The aspartyl protease renin was first isolated from the kidney by Tigerstedt more than a century ago. In the kidney, renin secretion is tightly linked to sodium intake and renal perfusion pressure, reflecting the important role of the renin-angiotensin system (RAS) in controlling body fluid volume and blood pressure. The study by Mackins et al. in this issue of the JCI describes a novel source of renin: the mast cell (see the related article beginning on page 1063). This discovery suggests a distinct pathway for activation of the RAS that may have a particular impact on the pathogenesis of chronic tissue injury as well as more acute pathology such as arrhythmias in the heart.

Authors

Thu H. Le, Thomas M. Coffman

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Usage data is cumulative from May 2024 through May 2025.

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Figure 72 1
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