Structure and function of the platelet integrin αIIbβ3
Joel S. Bennett
Joel S. Bennett
Published December 1, 2005
Citation Information: J Clin Invest. 2005;115(12):3363-3369. https://doi.org/10.1172/JCI26989.
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Review Series

Structure and function of the platelet integrin αIIbβ3

Abstract

The platelet integrin αIIbβ3 is required for platelet aggregation. Like other integrins, αIIbβ3 resides on cell surfaces in an equilibrium between inactive and active conformations. Recent experiments suggest that the shift between these conformations involves a global reorganization of the αIIbβ3 molecule and disruption of constraints imposed by the heteromeric association of the αIIb and β3 transmembrane and cytoplasmic domains. The biochemical, biophysical, and ultrastructural results that support this conclusion are discussed in this Review.

Authors

Joel S. Bennett

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Figure 4

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Model of the structure of the β3 TM and cytoplasmic domains. Helices are...
Model of the structure of the β3 TM and cytoplasmic domains. Helices are shown as cylinders. Three different orientations of the β3 TM domain in the plasma membrane are shown. The membrane-proximal region of the cytoplasmic domain is shaded. Arrows indicate possible interactions between helices. Adapted with permission from Biochemistry (68).