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Citations to this article

Ghrelin action in the brain controls adipocyte metabolism
Claudia Theander-Carrillo, … , Matthias H. Tschöp, Françoise Rohner-Jeanrenaud
Claudia Theander-Carrillo, … , Matthias H. Tschöp, Françoise Rohner-Jeanrenaud
Published July 3, 2006
Citation Information: J Clin Invest. 2006;116(7):1983-1993. https://doi.org/10.1172/JCI25811.
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Ghrelin action in the brain controls adipocyte metabolism

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Abstract

Many homeostatic processes, including appetite and food intake, are controlled by neuroendocrine circuits involving the CNS. The CNS also directly regulates adipocyte metabolism, as we have shown here by examining central action of the orexigenic hormone ghrelin. Chronic central ghrelin infusion resulted in increases in the glucose utilization rate of white and brown adipose tissue without affecting skeletal muscle. In white adipocytes, mRNA expression of various fat storage–promoting enzymes such as lipoprotein lipase, acetyl-CoA carboxylase α, fatty acid synthase, and stearoyl-CoA desaturase–1 was markedly increased, while that of the rate-limiting step in fat oxidation, carnitine palmitoyl transferase–1α, was decreased. In brown adipocytes, central ghrelin infusion resulted in lowered expression of the thermogenesis-related mitochondrial uncoupling proteins 1 and 3. These ghrelin effects were dose dependent, occurred independently from ghrelin-induced hyperphagia, and seemed to be mediated by the sympathetic nervous system. Additionally, the expression of some fat storage enzymes was decreased in ghrelin-deficient mice, which led us to conclude that central ghrelin is of physiological relevance in the control of cell metabolism in adipose tissue. These results unravel the existence of what we believe to be a new CNS-based neuroendocrine circuit regulating metabolic homeostasis of adipose tissue.

Authors

Claudia Theander-Carrillo, Petra Wiedmer, Philippe Cettour-Rose, Ruben Nogueiras, Diego Perez-Tilve, Paul Pfluger, Tamara R. Castaneda, Patrick Muzzin, Annette Schürmann, Ildiko Szanto, Matthias H. Tschöp, Françoise Rohner-Jeanrenaud

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Total
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Frontiers in neuroscience 2013
Pmch-deficiency in rats is associated with normal adipocyte differentiation and lower sympathetic adipose drive
JD Mul, E O'Duibhir, YB Shrestha, A Koppen, P Vargoviç, PW Toonen, E Zarebidaki, R Kvetnansky, E Kalkhoven, E Cuppen, TJ Bartness
PloS one 2013
Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors
KM Heppner, CL Piechowski, A Muller, N Ottaway, S Sisley, DL Smiley, KM Habegger, PT Pfluger, R DiMarchi, H Biebermann, MH Tschop, DA Sandoval, D Perez-Tilve
Diabetes 2013
Central Melanin-Concentrating Hormone Influences Liver and Adipose Metabolism Via Specific Hypothalamic Nuclei and Efferent Autonomic/JNK1 Pathways
M Imbernon, D Beiroa, MJ Vázquez, DA Morgan, C Veyrat–Durebex, B Porteiro, A Díaz–Arteaga, A Senra, S Busquets, DA Velásquez, O Al–Massadi, L Varela, M Gándara, FJ López–Soriano, R Gallego, LM Seoane, JM Argiles, M López, RJ Davis, G Sabio, F Rohner–Jeanrenaud, K Rahmouni, C Dieguez, R Nogueiras
Gastroenterology 2012
Molecules affecting hypothalamic control of core body temperature in response to calorie intake
T Bartfai, B Conti
Frontiers in Genetics 2012
Ghrelin – A Pleiotropic Hormone Secreted from Endocrine X/A-Like Cells of the Stomach
A Stengel, Y Taché
Frontiers in neuroscience 2012
Sensing of Fatty Acids for Octanoylation of Ghrelin Involves a Gustatory G-Protein
S Janssen, J Laermans, H Iwakura, J Tack, I Depoortere
PloS one 2012
Yin and Yang - the Gastric X/A-like Cell as Possible Dual Regulator of Food Intake
A Stengel, Y Taché
Journal of Neurogastroenterology and Motility 2012
Estradiol signaling in the regulation of reproduction and energy balance
K Sinchak, EJ Wagner
Frontiers in Neuroendocrinology 2012
Gastric Peptides and their Regulation of Hunger and Satiety
A Stengel, Y Taché
Current Gastroenterology Reports 2012
Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin
L Martins, D Fernández-Mallo, MG Novelle, MJ Vázquez, M Tena-Sempere, R Nogueiras, M López, C Diéguez
PloS one 2012
Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells
I Sakata, WM Park, AK Walker, PK Piper, JC Chuang, S Osborne-Lawrence, JM Zigman
American journal of physiology. Endocrinology and metabolism 2012
Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase
PB de Morentin, AJ Whittle, J Ferno, R Nogueiras, C Dieguez, A Vidal-Puig, M Lopez
Diabetes 2012
Acylation Type Determines Ghrelin's Effects on Energy Homeostasis in Rodents
KM Heppner, N Chaudhary, TD Müller, H Kirchner, KM Habegger, N Ottaway, DL Smiley, R DiMarchi, SM Hofmann, SC Woods, B Sivertsen, B Holst, PT Pfluger, D Perez-Tilve, MH Tschöp
Endocrinology 2012
Role of Ghrelin in the Pathophysiology of Eating Disorders: Implications for Pharmacotherapy
SC Cano, M Merkestein, KP Skibicka, SL Dickson, RA Adan
CNS Drugs 2012
The role of ghrelin-octanoyl-acyl-transferase in thermoregulation.
Heppner KM, Müller TD, Kirchner H, Perez-Tilve D, Pfluger PT, Tschöp MH, Hofmann SM
Journal of Endocrinological Investigation 2012
The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism
P Wiedmer, N Chaudhary, M Rath, CX Yi, G Ananthakrishnan, R Nogueiras, EK Wirth, H Kirchner, U Schweizer, W Jonas, C Veyrat-Durebex, F Rohner-Jeanrenaud, A Schurmann, HG Joost, MH Tschöp, D Perez-Tilve
Physiology & Behavior 2011
Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance
PB de Morentin, CR González, AK Saha, L Martins, C Diéguez, A Vidal-Puig, M Tena-Sempere, M López
Reviews in Endocrine and Metabolic Disorders 2011
Ablations of Ghrelin and Ghrelin Receptor Exhibit Differential Metabolic Phenotypes and Thermogenic Capacity during Aging
X Ma, L Lin, G Qin, X Lu, M Fiorotto, VD Dixit, Y Sun, K Stadler
PloS one 2011
Obestatin as a regulator of adipocyte metabolism and adipogenesis
U Gurriarán-Rodríguez, O Al-Massadi, A Roca-Rivada, AB Crujeiras, R Gallego, M Pardo, LM Seoane, Y Pazos, FF Casanueva, JP Camiña
Journal of Cellular and Molecular Medicine 2011
Ghrelin-induced adiposity is independent of orexigenic effects
D Perez-Tilve, K Heppner, H Kirchner, SH Lockie, SC Woods, DL Smiley, M Tschöp, P Pfluger
The FASEB Journal 2011
Ghrelin Enhances Olfactory Sensitivity and Exploratory Sniffing in Rodents and Humans
J Tong, E Mannea, P Aimé, PT Pfluger, CX Yi, TR Castaneda, HW Davis, X Ren, S Pixley, S Benoit, K Julliard, SC Woods, TL Horvath, MM Sleeman, D D'Alessio, S Obici, R Frank, MH Tschöp
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
1 Peripheral ghrelin stimulates feeding behavior and positive energy balance in a sciurid hibernator
JE Healy, JL Bateman, CE Ostrom, GL Florant
Hormones and Behavior 2011
Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues
L Lin, PK Saha, X Ma, IO Henshaw, L Shao, BH Chang, ED Buras, Q Tong, L Chan, OP McGuinness, Y Sun
Aging Cell 2011
Ghrelin-induced hypothermia: a physiological basis but no clinical risk
P Wiedmer, F Strasser, TL Horvath, D Blum, R Dimarchi, T Lutz, A Schürmann, HG Joost, MH Tschöp, J Tong
Physiology & Behavior 2011
The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin
DA Velasquez, G Martinez, A Romero, MJ Vazquez, KD Boit, IG Dopeso-Reyes, M Lopez, A Vidal, R Nogueiras, C Dieguez
Diabetes 2011
Integrating GHS into the Ghrelin System
JD Veldhuis, CY Bowers
International Journal of Peptides 2010
Ghrelin: New Molecular Pathways Modulating Appetite and Adiposity
R Nogueiras, LM Williams, C Dieguez
Obesity facts 2010
Uncoupling protein-2 decreases the lipogenic actions of ghrelin
ZB Andrews, DM Erion, R Beiler, CS Choi, GI Shulman, TL Horvath
Endocrinology 2010
Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis
SD Jordan, AC Könner, JC Brüning
Cellular and Molecular Life Sciences 2010
Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice
PJ Delhanty, Y Sun, JA Visser, A Kerkwijk, M Huisman, WF van Ijcken, S Swagemakers, RG Smith, AP Themmen, AJ der Lely
PloS one 2010
Neuronal regulation of homeostasis by nutrient sensing
TK Lam
Nature Medicine 2010
Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia
TD Müller, D Perez-Tilve, J Tong, PT Pfluger, MH Tschöp
Journal of Cachexia, Sarcopenia and Muscle 2010
Ghrelin in chronic kidney disease
WW Cheung, RH Mak
International Journal of Peptides 2010
Effect of Ghrelin on Glucose-Insulin Homeostasis: Therapeutic Implications
S Sangiao-Alvarellos, F Cordido
International Journal of Peptides 2010
Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender
R Lage, MJ Vázquez, L Varela, AK Saha, A Vidal-Puig, R Nogueiras, C Diéguez, M López
The FASEB Journal 2010
Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: Role as regulators of food intake and body weight
A Stengel, M Goebel, L Wang, Y Taché
Peptides 2010
The metabolic response to the activation of the β- adrenergic receptor by salbutamol is amplified by acylated ghrelin
DH St-Pierre, A Benso, E Gramaglia, F Prodam, B Lucatello, V Ramella-Gigliardi, I Olivetti, M Tomelini, F Broglio
Journal of Endocrinological Investigation 2010
Ghrelin Induces Abdominal Obesity Via GHS-R-Dependent Lipid Retention
JS Davies, P Kotokorpi, SR Eccles, SK Barnes, PF Tokarczuk, SK Allen, HS Whitworth, IA Guschina, BA Evans, A Mode, JM Zigman, T Wells
Molecular Endocrinology 2009
Endocrine disrupters as obesogens
F Grün, B Blumberg
Molecular and Cellular Endocrinology 2009
Energy Homoeostasis: The Roles of Adipose Tissue-Derived Hormones, Peptide YY and Ghrelin
J Hall, R Roberts, N Vora
Obesity facts 2009
G Protein-Coupled Receptor 39 Deficiency Is Associated with Pancreatic Islet Dysfunction
B Holst, KL Egerod, C Jin, PS Petersen, MV Østergaard, J Hald, AM Sprinkel, J Størling, T Mandrup-Poulsen, JJ Holst, P Thams, C Ørskov, N Wierup, F Sundler, OD Madsen, TW Schwartz
Endocrinology 2009
Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
R Nogueiras, D Pérez-Tilve, C Veyrat-Durebex, DA Morgan, L Varela, WG Haynes, JT Patterson, E Disse, PT Pfluger, M López, SC Woods, R DiMarchi, C Diéguez, K Rahmouni, F Rohner-Jeanrenaud, MH Tschöp
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Effect of reducing hypothalamic ghrelin receptor gene expression on energy balance
YB Shrestha, K Wickwire, S Giraudo
Peptides 2009
Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion
S Sangiao-Alvarellos, MJ Vázquez, L Varela, R Nogueiras, AK Saha, F Cordido, M López, C Diéguez
Endocrinology 2009
Ghrelin and peptide YY in postpartum lactating and nonlactating women
DE Larson-Meyer, E Ravussin, L Heilbronn, L DeJonge
The American journal of clinical nutrition 2009
Restricted feeding-induced sleep, activity, and body temperature changes in normal and preproghrelin-deficient mice
E Szentirmai, L Kapás, Y Sun, RG Smith, JM Krueger
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2009
The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice
E Szentirmai, L Kapás, Y Sun, RG Smith, JM Krueger
Proceedings of the National Academy of Sciences 2009
Direct effects of nutrients, acetylcholine, CCK, and insulin on ghrelin release from the isolated stomachs of rats
YB Shrestha, K Wickwire, SQ Giraudo
Peptides 2009
Evidence from knockout mice that peptide YY and neuropeptide Y enforce murine locomotion, exploration and ingestive behaviour in a circadian cycle- and gender-dependent manner
ME Edelsbrunner, H Herzog, P Holzer
Behavioural Brain Research 2009
Central leptin versus ghrelin: effects on bone marrow adiposity and gene expression
S Ambati, Q Li, S Rayalam, DL Hartzell, MA Della-Fera, MW Hamrick, CA Baile
Endocrine 2009
Evidence from knockout mice for distinct implications of neuropeptide-Y Y2 and Y4 receptors in the circadian control of locomotion, exploration, water and food intake
ME Edelsbrunner, E Painsipp, H Herzog, P Holzer
Neuropeptides 2009
Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults
JA Parnell, RA Reimer
The American journal of clinical nutrition 2009
Nutrition: Can ghrelin improve appetite in uremic wasting?
Carrero JJ, Stenvinkel P
Nature reviews. Nephrology 2009
Inducible gene silencing defines CNS insulin action as a major determinant of peripheral glucose and fat metabolism
Linda Koch1, F. Thomas Wunderlich1, Jost Seibler2, A. Christine Könner1, Brigitte Hampel1, Sigrid Irlenbusch1, Georg Brabant3, C. Ronald Kahn4, Frieder Schwenk2,5, Jens C. Brüning1
Journal of Clinical Investigation 2008
The growth hormone-insulin-like growth factor-I axis in chronic kidney disease
RH Mak, WW Cheung, CT Roberts
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2008
Central nervous system regulation of energy metabolism: ghrelin versus leptin
R Nogueiras, MH Tschöp, JM Zigman
Annals of the New York Academy of Sciences 2008
Role of AMP-activated protein kinase in the control of appetite
B Kola
Journal of Neuroendocrinology 2008
Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover study
F Strasser, TA Lutz, MT Maeder, B Thuerlimann, D Bueche, M Tschöp, K Kaufmann, B Holst, M Brändle, R Moos, R Demmer, T Cerny
British Journal of Cancer 2008
Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats
S Strassburg, SD Anker, TR Castaneda, L Burget, D Perez-Tilve, PT Pfluger, R Nogueiras, H Halem, JZ Dong, MD Culler, R Datta, MH Tschöp
American journal of physiology. Endocrinology and metabolism 2008
Reduced anxiety-like and depression-related behavior in neuropeptide Y Y4 receptor knockout mice
E Painsipp, T Wultsch, ME Edelsbrunner, RO Tasan, N Singewald, H Herzog, P Holzer
Genes, Brain and Behavior 2008
The central nervous melanocortin system directly controls peripheral lipid metabolism
Ruben Nogueiras, Petra Wiedmer, Diego Perez-Tilve, Christelle Veyrat-Durebex, Julia M. Keogh, Gregory M. Sutton, Paul T. Pfluger, Tamara R. Castaneda, Susanne Neschen, Susanna M. Hofmann, Philip N. Howles, Donald A. Morgan, Stephen C. Benoit, Ildiko Szanto, Brigitte Schrott, Annette Schürmann, Hans-Georg Joost, Craig Hammond, David Y. Hui, Stephen C. Woods, Kamal Rahmouni, Andrew A. Butler, I. Sadaf Farooqi, Stephen O’Rahilly, Françoise Rohner-Jeanrenaud & Matthias H. Tschöp
Journal of Clinical Investigation 2007
Intestinal Regulation of Glucose
Daniel J. Drucker
Journal of Clinical Investigation 2007
The hormonal control of food intake
AP Coll, IS Farooqi, S O'Rahilly
Cell 2007
Experimental gastritis in mice enhances anxiety in a gender-related manner
E Painsipp, T Wultsch, A Shahbazian, M Edelsbrunner, MC Kreissl, A Schirbel, E Bock, MA Pabst, CK Thoeringer, HP Huber, P Holzer
Neuroscience 2007
Ghrelin reduces hepatic mitochondrial fatty acid β oxidation
C Rigault, FL Borgne, B Georges, J Demarquoy
Journal of Endocrinological Investigation 2007
Ghrelin Effects on the Circadian System of Mice
PC Yannielli, PC Molyneux, ME Harrington, DA Golombek
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
In search of an effective obesity treatment: a shot in the dark or a shot in the arm?
JM Zigman, JK Elmquist
Proceedings of the National Academy of Sciences 2006

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