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Citations to this article

TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
Koichi Obata, … , Makoto Tominaga, Koichi Noguchi
Koichi Obata, … , Makoto Tominaga, Koichi Noguchi
Published September 1, 2005
Citation Information: J Clin Invest. 2005;115(9):2393-2401. https://doi.org/10.1172/JCI25437.
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Research Article Neuroscience Article has an altmetric score of 12

TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury

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Abstract

Cold hyperalgesia is a well-documented symptom of inflammatory and neuropathic pain; however, the underlying mechanisms of this enhanced sensitivity to cold are poorly understood. A subset of transient receptor potential (TRP) channels mediates thermosensation and is expressed in sensory tissues, such as nociceptors and skin. Here we report that the pharmacological blockade of TRPA1 in primary sensory neurons reversed cold hyperalgesia caused by inflammation and nerve injury. Inflammation and nerve injury increased TRPA1, but not TRPM8, expression in tyrosine kinase A–expressing dorsal root ganglion (DRG) neurons. Intrathecal administration of anti–nerve growth factor (anti-NGF), p38 MAPK inhibitor, or TRPA1 antisense oligodeoxynucleotide decreased the induction of TRPA1 and suppressed inflammation- and nerve injury–induced cold hyperalgesia. Conversely, intrathecal injection of NGF, but not glial cell line–derived neurotrophic factor, increased TRPA1 in DRG neurons through the p38 MAPK pathway. Together, these results demonstrate that an NGF-induced TRPA1 increase in sensory neurons via p38 activation is necessary for cold hyperalgesia. Thus, blocking TRPA1 in sensory neurons might provide a fruitful strategy for treating cold hyperalgesia caused by inflammation and nerve damage.

Authors

Koichi Obata, Hirokazu Katsura, Toshiyuki Mizushima, Hiroki Yamanaka, Kimiko Kobayashi, Yi Dai, Tetsuo Fukuoka, Atsushi Tokunaga, Makoto Tominaga, Koichi Noguchi

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SV Rodriguez, IC Aguilar, LC Villa, FS de Tejada
Spinal Cord Series and Cases 2017
Thermo-Sensitive TRP Channels: Novel Targets for Treating Chemotherapy-Induced Peripheral Pain
M Nazıroğlu, N Braidy
Frontiers in physiology 2017
Peripheral and spinal TRPA1 channels contribute to formalin-induced long-lasting mechanical hypersensitivity
VA Martínez-Rojas, G García, R Noriega-Navarro, CG Guzman-Priego, JE Torres-Lopez, V Granados-Soto, J Murbartián
Journal of pain research 2017
Role of the Excitability Brake Potassium Current I KD in Cold Allodynia Induced by Chronic Peripheral Nerve Injury
A González, G Ugarte, C Restrepo, G Herrera, R Piña, JA Gómez-Sánchez, M Pertusa, P Orio, R Madrid
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017
TRP channels: potential drug target for neuropathic pain
L Marwaha, Y Bansal, R Singh, P Saroj, R Bhandari, A Kuhad
Inflammopharmacology 2016
Differential Activation of TRP Channels in the Adult Rat Spinal Substantia Gelatinosa by Stereoisomers of Plant-Derived Chemicals
E Kumamoto, T Fujita
Pharmaceuticals (Basel, Switzerland) 2016
Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice
Á Horváth, V Tékus, M Boros, G Pozsgai, B Botz, É Borbély, J Szolcsányi, E Pintér, Z Helyes
Arthritis Research & Therapy 2016
Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies
A Mickle, A Shepherd, D Mohapatra
Pharmaceuticals (Basel, Switzerland) 2016
Blocking TRPA1 in Respiratory Disorders: Does It Hold a Promise?
I Mukhopadhyay, A Kulkarni, N Khairatkar-Joshi
Pharmaceuticals (Basel, Switzerland) 2016
Agonist-induced sensitisation of the irritant receptor ion channel TRPA1: Agonist-induced sensitisation of TRPA1
JE Meents, MJ Fischer, PA McNaughton
The Journal of Physiology 2016
TRPA1 channels: molecular sentinels of cellular stress and tissue damage: TRPA1 channels and cellular stress
F Viana
The Journal of Physiology 2016
Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner
ES Fernandes, FA Russell, KM Alawi, C Sand, L Liang, R Salamon, JV Bodkin, AA Aubdool, M Arno, C Gentry, SJ Smillie, S Bevan, JE Keeble, M Malcangio, SD Brain
Arthritis Research & Therapy 2016
Loss of Transient Receptor Potential Ankyrin 1 Channel Deregulates Emotion, Learning and Memory, Cognition, and Social Behavior in Mice
KI Lee, HC Lin, HT Lee, FC Tsai, TS Lee
Molecular Neurobiology 2016
The preventive effect of resiniferatoxin on the development of cold hypersensitivity induced by spinal nerve ligation: involvement of TRPM8
WU Koh, SS Choi, JH Kim, HJ Yoon, HS Ahn, SK Lee, JG Leem, JG Song, JW Shin
BMC neuroscience 2016
Impacts of anti-nerve growth factor antibody on pain-related behaviors and expressions of opioid receptor in spinal dorsal horn and dorsal root ganglia of rats with cancer-induced bone pain
P Yao, Y Ding, Z Wang, J Ma, T Hong, Y Zhu, H Li, S Pan
Molecular Pain 2016
Mechanosensory and ATP Release Deficits following Keratin14-Cre-Mediated TRPA1 Deletion Despite Absence of TRPA1 in Murine Keratinocytes
KJ Zappia, SR Garrison, O Palygin, AD Weyer, ME Barabas, MW Lawlor, A Staruschenko, CL Stucky, S Beggs
PloS one 2016
Ovariectomy-Induced Mitochondrial Oxidative Stress, Apoptosis, and Calcium Ion Influx Through TRPA1, TRPM2, and TRPV1 Are Prevented by 17β-Estradiol, Tamoxifen, and Raloxifene in the Hippocampus and Dorsal Root Ganglion of Rats
Y Yazğan, M Nazıroğlu
Molecular Neurobiology 2016
Modulation of the Activities of Neuronal Ion Channels by Fatty Acid-Derived Pro-Resolvents
G Choi, SW Hwang
Frontiers in physiology 2016
Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats
SG Lehto, AD Weyer, BD Youngblood, M Zhang, R Yin, W Wang, Y Teffera, M Cooke, CL Stucky, L Schenkel, S Geuns-Meyer, BD Moyer, KD Wild, NR Gavva
Molecular Pain 2016
TRPA1 in the spinal dorsal horn is involved in post-inflammatory visceral hypersensitivity: in vivo study using TNBS-treated rat model
Q Li, C Guo, MA Chowdhury, T Dai, W Han
Journal of pain research 2016
Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner
G Bidaux, A Borowiec, D Gordienko, B Beck, GG Shapovalov, L Lemonnier, M Flourakis, M Vandenberghe, C Slomianny, E Dewailly, P Delcourt, E Desruelles, A Ritaine, R Polakowska, J Lesage, M Chami, R Skryma, N Prevarskaya
Proceedings of the National Academy of Sciences 2015
TRPA1 as a drug target—promise and challenges
J Chen, DH Hackos
Naunyn-Schmiedeberg's Archives of Pharmacology 2015
Streptozotocin Stimulates the Ion Channel TRPA1 Directly: INVOLVEMENT OF PEROXYNITRITE
DA Andersson, MR Filipović, C Gentry, M Eberhardt, N Vastani, A Leffler, P Reeh, S Bevan
The Journal of biological chemistry 2015
TRPs and pain
Y Dai
Seminars in Immunopathology 2015
TRPA1 mediates amplified sympathetic responsiveness to activation of metabolically sensitive muscle afferents in rats with femoral artery occlusion
J Xing, J Lu, J Li
Frontiers in physiology 2015
Species-specific temperature sensitivity of TRPA1
WJ Laursen, EO Anderson, LJ Hoffstaetter, SN Bagriantsev, EO Gracheva
Temperature 2015
Peripherally increased artemin is a key regulator of TRPA1/V1 expression in primary afferent neurons
Y Ikeda-Miyagawa, K Kobayashi, H Yamanaka, M Okubo, S Wang, Y Dai, H Yagi, M Hirose, K Noguchi
Molecular Pain 2015
Wu-Tou Decoction Inhibits Chronic Inflammatory Pain in Mice: Participation of TRPV1 and TRPA1 Ion Channels
C Wang, C Liu, H Wan, D Wang, D Sun, T Xu, Y Yang, Y Qu, Y Xu, X Jing, J Liu, S Chen, Z Liu, N Lin
BioMed Research International 2015
In vivo patch-clamp analysis of the antinociceptive actions of TRPA1 activation in the spinal dorsal horn
M Yamanaka, W Taniguchi, N Nishio, H Hashizume, H Yamada, M Yoshida, T Nakatsuka
Molecular Pain 2015
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction
HL Shi
World journal of gastroenterology : WJG 2015
Expression of vesicular glutamate transporters in transient receptor potential melastatin 8 (TRPM8)-positive dental afferents in the mouse
YS Kim, TH Kim, DD McKemy, YC Bae
Neuroscience 2015
KCNQ channels in nociceptive cold-sensing trigeminal ganglion neurons as therapeutic targets for treating orofacial cold hyperalgesia
AA Abd-Elsayed, R Ikeda, Z Jia, J Ling, X Zuo, M Li, JG Gu
Molecular Pain 2015
ThermoTRPs and Pain
RJ Laing, A Dhaka
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2015
The role of TRPA1 in muscle pain and mechanical hypersensitivity under inflammatory conditions in rats
J Asgar, Y Zhang, JL Saloman, S Wang, MK Chung, JY Ro
Neuroscience 2015
Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to acute cold hypersensitivity after oxaliplatin administration
K Yamamoto, N Chiba, T Chiba, T Kambe, K Abe, K Kawakami, I Utsunomiya, K Taguchi
Molecular Pain 2015
Role of TRP channels in the induction of heat shock proteins (Hsps) by heating skin
WL Hsu, T Yoshioka
Biophysics 2015
The Analgesic and Antineuroinflammatory Effect of Baicalein in Cancer-Induced Bone Pain
S Hu, Y Chen, ZF Wang, QL Mao-Ying, WL Mi, JW Jiang, GC Wu, YQ Wang
Evidence-Based Complementary and Alternative Medicine 2015
Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity
CL Li, KC Li, D Wu, Y Chen, H Luo, JR Zhao, SS Wang, MM Sun, YJ Lu, YQ Zhong, XY Hu, R Hou, BB Zhou, L Bao, HS Xiao, X Zhang
Cell Research 2015
Comprehensive thermal preference phenotyping in mice using a novel automated circular gradient assay
F Touska, Z Winter, A Mueller, V Vlachova, J Larsen, K Zimmermann
Temperature 2015
Thermotaxis, circadian rhythms, and TRP channels in Drosophila
A Bellemer
Temperature 2015
A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
DS Brenner, JP Golden, SK Vogt, RW Gereau
Journal of visualized experiments : JoVE 2015
CX3CR1 monocytes orchestrate the development of vincristine-induced pain
Elizabeth Old, Suchita Nadkarni, John Grist, Clive Gentry, Stuart Bevan, Ki-Wook Kim, Adrian Mogg, Mauro Perretti, Marzia Malcangio
Journal of Clinical Investigation 2014
Transient Receptor Potential Channels as Targets for Phytochemicals
LS Premkumar
ACS Chemical Neuroscience 2014
Annexin A2 Regulates TRPA1-Dependent Nociception
L Avenali, P Narayanan, T Rouwette, I Cervellini, M Sereda, D Gomez-Varela, M Schmidt
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective
RH Straub
Journal of Molecular Medicine 2014
TRP Channels Involved in Spontaneous L-Glutamate Release Enhancement in the Adult Rat Spinal Substantia Gelatinosa
E Kumamoto, T Fujita, CY Jiang
Cells 2014
A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain
J Gui, B Liu, G Cao, AM Lipchik, M Perez, Z Dekan, M Mobli, NL Daly, PF Alewood, LL Parker, GF King, Y Zhou, SE Jordt, MN Nitabach
Current Biology 2014
Are Sensory TRP Channels Biological Alarms for Lipid Peroxidation?
SI Choi, S Yoo, J Lim, S Hwang
International journal of molecular sciences 2014
Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1
C Fusi, S Materazzi, S Benemei, E Coppi, G Trevisan, IM Marone, D Minocci, FD Logu, T Tuccinardi, MR di Tommaso, T Susini, G Moneti, G Pieraccini, P Geppetti, R Nassini
2014
Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity
B Lee, H Cho, J Jung, YD Yang, DJ Yang, U Oh
Molecular Pain 2014
Sensory TRP Channel Interactions with Endogenous Lipids and Their Biological Outcomes
S Yoo, J Lim, S Hwang
Molecules (Basel, Switzerland) 2014
Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression
P Malsch, M Andratsch, C Vogl, AS Link, C Alzheimer, SM Brierley, PA Hughes, M Kress
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Chemical Structure and Morphology of Dorsal Root Ganglion Neurons from Naive and Inflamed Mice
ME Barabas, EC Mattson, E Aboualizadeh, CJ Hirschmugl, CL Stucky
The Journal of biological chemistry 2014
Gallic acid functions as a TRPA1 antagonist with relevant antinociceptive and antiedematogenic effects in mice
G Trevisan, MF Rossato, R Tonello, C Hoffmeister, JZ Klafke, F Rosa, KV Pinheiro, FV Pinheiro, AA Boligon, ML Athayde, J Ferreira
Naunyn-Schmiedeberg's Archives of Pharmacology 2014
Temporal mismatch between pain behaviour, skin Nerve Growth Factor and intra-epidermal nerve fibre density in trigeminal neuropathic pain
LJ Evans, AR Loescher, FM Boissonade, SA Whawell, PP Robinson, D Andrew
BMC neuroscience 2014
Cold hypersensitivity increases with age in mice with sickle cell disease
KJ Zappia, SR Garrison, CA Hillery, CL Stucky
PAIN 2014
Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics: Nociception-related TRP channels in PSN
J Sousa-Valente, AP Andreou, L Urban, I Nagy
British Journal of Pharmacology 2014
Contribution of Transient Receptor Potential Ankyrin 1 to Chronic Pain in Aged Mice With Complete Freund's Adjuvant-Induced Arthritis: TRPA1 and Chronic Pain in Murine Arthritis
SR Garrison, CL Stucky
Arthritis & Rheumatology 2014
Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: A comparison with topical menthol
R Patel, L Gonçalves, M Leveridge, SR Mack, A Hendrick, NL Brice, AH Dickenson
PAIN 2014
Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury
L Aloe, P Bianchi, AD Bellis, M Soligo, ML Rocco
NEURAL REGEN RES 2014
Transient receptor potential ankyrin 1 in spinal cord dorsal horn is involved in neuropathic pain in nerve root constriction rats
T Miyakawa, Y Terashima, T Takebayashi, K Tanimoto, T Iwase, I Ogon, T Kobayashi, N Tohse, T Yamashita
Molecular Pain 2014
TRPA1 is essential for the vascular response to environmental cold exposure
AA Aubdool, R Graepel, X Kodji, KM Alawi, JV Bodkin, S Srivastava, C Gentry, R Heads, AD Grant, ES Fernandes, S Bevan, SD Brain
Nature Communications 2014
Perineural pretreatment of bee venom attenuated the development of allodynia in the spinal nerve ligation injured neuropathic pain model; an experimental study
W Koh, S Choi, J Lee, S Lee, S Lee, Y Lee, J Leem, J Song, J Shin
BMC complementary and alternative medicine 2014
Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain
J Luo, ET Walters, SM Carlton, H Hu
Current neuropharmacology 2013
Species differences and molecular determinant of TRPA1 cold sensitivity
J Chen, D Kang, J Xu, M Lake, JO Hogan, C Sun, K Walter, B Yao, D Kim
Nature Communications 2013
Pre-clinical studies in cough research: Role of Transient Receptor Potential (TRP) channels
MS Grace, E Dubuis, MA Birrell, MG Belvisi
Pulmonary Pharmacology & Therapeutics 2013
Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity
M Takaishi, K Uchida, F Fujita, M Tominaga
The Journal of Physiological Sciences 2013
TRPV1, but not TRPA1, in primary sensory neurons contributes to cutaneous incision-mediated hypersensitivity
ME Barabas, CL Stucky
Molecular Pain 2013
Systemic morphine treatment induces changes in firing patterns and responses of nociceptive afferent fibers in mouse glabrous skin
D Hogan, AL Baker, JA Morón, SM Carlton
PAIN 2013
Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity
Y Zhou, Y Suzuki, K Uchida, M Tominaga
Nature Communications 2013
Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat
MR Due, J Park, L Zheng, M Walls, YM Allette, FA White, R Shi
Journal of Neurochemistry 2013
Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain
EK Lippoldt, RR Elmes, DD McCoy, WM Knowlton, DD McKemy
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Plant derived aporphinic alkaloid S-(+)-dicentrine induces antinociceptive effect in both acute and chronic inflammatory pain models: evidence for a role of TRPA1 channels
DP Montrucchio, MM Córdova, AR Santos
PloS one 2013
TRP channels and analgesia
LS Premkumar, M Abooj
Life Sciences 2012
Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release
N Hatano, Y Itoh, H Suzuki, Y Muraki, H Hayashi, K Onozaki, IC Wood, DJ Beech, K Muraki
The Journal of biological chemistry 2012
The thermo-TRP ion channel family: properties and therapeutic implications
L Vay, C Gu, PA McNaughton
British Journal of Pharmacology 2012
Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells
DS Cao, L Zhong, TH Hsieh, M Abooj, M Bishnoi, L Hughes, LS Premkumar
PloS one 2012
1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1
M Takaishi, F Fujita, K Uchida, S Yamamoto, MS Shimizu, CH Uotsu, M Shimizu, M Tominaga
Molecular Pain 2012
The perception and endogenous modulation of pain
MH Ossipov
Scientifica 2012
Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9
T Berta, T Liu, YC Liu, ZZ Xu, RR Ji
Molecular Pain 2012
TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation
RC Lennertz, EA Kossyreva, AK Smith, CL Stucky
PloS one 2012
Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice
YC Liu, T Berta, T Liu, PH Tan, RR Ji
Molecular Pain 2012
A Novel Behavioral Assay for Measuring Cold Sensation in Mice
DS Brenner, JP Golden, RW 4th
PloS one 2012
The molecular and cellular basis of cold sensation
DD McKemy
ACS Chemical Neuroscience 2012
TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons
ME Barabas, EA Kossyreva, CL Stucky
PloS one 2012
Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies
MJ Eberhardt, MR Filipovic, A Leffler, J la Roche, K Kistner, MJ Fischer, T Fleming, K Zimmermann, I Ivanovic-Burmazovic, PP Nawroth, A Bierhaus, PW Reeh, SK Sauer
The Journal of biological chemistry 2012
Differential expression and functionality of TRPA1 protein genetic variants in conditions of thermal stimulation
D May, J Baastrup, MR Nientit, A Binder, M Schünke, R Baron, I Cascorbi
The Journal of biological chemistry 2012
Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice
K Okubo, M Matsumura, Y Kawaishi, Y Aoki, M Matsunami, Y Okawa, F Sekiguchi, A Kawabata
British Journal of Pharmacology 2012
Properties and Therapeutic Potential of Transient Receptor Potential Channels with Putative Roles in Adversity: Focus on TRPC5, TRPM2 and TRPA1
LH Jiang, N Gamper, DJ Beech
Current drug targets 2011
Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception
M Raisinghani, L Zhong, JA Jeffry, M Bishnoi, RM Pabbidi, F Pimentel, DS Cao, MS Evans, LS Premkumar
AJP Cell Physiology 2011
TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation
PE Kunkler, CJ Ballard, GS Oxford, JH Hurley
PAIN 2011
Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain
D Sukhtankar, A Okun, A Chandramouli, MA Nelson, TW Vanderah, AE Cress, F Porreca, T King
Molecular Pain 2011
Involvement of peripheral ionotropic glutamate receptors in orofacial thermal hyperalgesia in rats
K Honda, N Noma, M Shinoda, M Miyamoto, A Katagiri, D Kita, MG Liu, BJ Sessle, M Yasuda, K Iwata
Molecular Pain 2011
Role of the transient receptor potential vanilloid 1 in inflammation and sepsis
I Devesa, R Planells-Cases, G Fernández-Ballester, JM González-Ros, A Ferrer-Montiel, A Fernández-Carvajal
Journal of inflammation research 2011
NEW PERSPECTIVES ON THE ENDOTHELIN AXIS IN PAIN
TP Barr, S Kam, A Khodorova, JP Montmayeur, GR Strichartz
Pharmacological research : the official journal of the Italian Pharmacological Society 2011
Protein kinase C modulation of thermo-sensitive transient receptor potential channels: Implications for pain signaling
S Mandadi, PJ Armati, BD Roufogalis
Journal of Natural Science, Biology, and Medicine 2011
Chronic alteration in phosphatidylinositol 4,5-bisphosphate levels regulates capsaicin and mustard oil responses
MJ Patil, S Belugin, AN Akopian
Journal of Neuroscience Research 2011
Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons
M Patil, A Patwardhan, MM Salas, KM Hargreaves, AN Akopian
Neuropharmacology 2011
TRPV1 and TRPA1 Function and Modulation are Target Tissue-Dependent
S Malin, D Molliver, JA Christianson, ES Schwartz, P Cornuet, KM Albers, BM Davis
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
New strategies to develop novel pain therapies: addressing thermoreceptors from different points of view
A Fernández-Carvajal, G Fernández-Ballester, I Devesa, JM González-Ros, A Ferrer-Montiel
Pharmaceuticals (Basel, Switzerland) 2011
The dynamic TRPA1 channel: a suitable pharmacological pain target?
Garrison SR, Stucky CL
Current pharmaceutical biotechnology 2011
Nociceptors: the sensors of the pain pathway
Adrienne Dubin, Ardem Patapoutian
Journal of Clinical Investigation 2010
Targeting TRPV1 as an alternative approach to narcotic analgesics to treat chronic pain conditions
LS Premkumar
The AAPS Journal 2010
Transient receptor potential channels in pain and inflammation: therapeutic opportunities
MA Schumacher
Pain practice : the official journal of World Institute of Pain 2010
The General Anesthetic Propofol Excites Nociceptors by Activating TRPV1 and TRPA1 Rather than GABAA Receptors*
MJ Fischer, A Leffler, F Niedermirtl, K Kistner, M Eberhardt, PW Reeh, C Nau
The Journal of biological chemistry 2010
TRPA1 contributes to cold hypersensitivity
D Camino, S Murphy, M Heiry, LB Barrett, TJ Earley, CA Cook, MJ Petrus, M Zhao, M D'Amours, N Deering, GJ Brenner, M Costigan, NJ Hayward, JA Chong, CM Fanger, CJ Woolf, A Patapoutian, MM Moran
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
TRPV1 regulates activation and modulation of TRPA1 by Ca2+
MJ Patil, NA Jeske, AN Akopian
Neuroscience 2010
TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats
S McGaraughty, KL Chu, RJ Perner, S Didomenico, ME Kort, PR Kym
Molecular Pain 2010
p38 mediates mechanical allodynia in a mouse model of type 2 diabetes
HT Cheng, JR Dauch, SS Oh, JM Hayes, Y Hong, EL Feldman
Molecular Pain 2010
Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons
SH Kim, Y Lee, B Akitake, OM Woodward, WB Guggino, C Montell
Proceedings of the National Academy of Sciences 2010
Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel
A Staruschenko, NA Jeske, AN Akopian
The Journal of biological chemistry 2010
Transient receptor potential channel A1 and noxious cold responses in rat cutaneous nociceptors
JP Dunham, JL Leith, BM Lumb, LF Donaldson
Neuroscience 2010
Understanding inflammatory pain: ion channels contributing to acute and chronic nociception
JE Linley, K Rose, L Ooi, N Gamper
Pflügers Archiv - European Journal of Physiology 2010
Transient Receptor Potential Vanilloid-1 (TRPV1) and Ankyrin-1 (TRPA1) Participate in Visceral Hyperalgesia in Chronic Water Avoidance Stress Rat Model
YB Yu, J Yang, XL Zuo, LJ Gao, P Wang, YQ Li
Neurochemical Research 2010
TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord
D Uta, H Furue, AE Pickering, MH Rashid, H Mizuguchi-Takase, T Katafuchi, K Imoto, M Yoshimura
European Journal of Neuroscience 2010
Transient Receptor Potential Vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in mice
LE Ta, AJ Bieber, SM Carlton, CL Loprinzi, PA Low, AJ Windebank
Molecular Pain 2010
Synergistic Role of TRPV1 and TRPA1 in Pancreatic Pain and Inflammation
ES Schwartz, JA Christianson, X Chen, JH La, BM Davis, KM Albers, GF Gebhart
Gastroenterology 2010
Bradykinin and Nerve Growth Factor Play Pivotal Roles in Muscular Mechanical Hyperalgesia after Exercise (Delayed-Onset Muscle Soreness)
S Murase, E Terazawa, F Queme, H Ota, T Matsuda, K Hirate, Y Kozaki, K Katanosaka, T Taguchi, H Urai, K Mizumura
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli
SM Brierley, PA Hughes, AJ Page, KY Kwan, CM Martin, TA O'Donnell, NJ Cooper, AM Harrington, B Adam, T Liebregts, G Holtmann, DP Corey, GY Rychkov, LA Blackshaw
Gastroenterology 2009
Transient receptor potential channels: targeting pain at the source
A Patapoutian, S Tate, CJ Woolf
Nature reviews. Drug discovery 2009
Coapplication of Lidocaine and the Permanently Charged Sodium Channel Blocker QX-314 Produces a Long-lasting Nociceptive Blockade in Rodents:
AM Binshtok, P Gerner, SB Oh, M Puopolo, S Suzuki, DP Roberson, T Herbert, CF Wang, D Kim, G Chung, AA Mitani, GK Wang, BP Bean, CJ Woolf
Anesthesiology 2009
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+
DA Andersson, C Gentry, S Moss, S Bevan
Proceedings of the National Academy of Sciences 2009
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs
H Hu, J Tian, Y Zhu, C Wang, R Xiao, JM Herz, JD Wood, MX Zhu
Pflügers Archiv : European journal of physiology 2009
Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia
JY Ro, JS Lee, Y Zhang
PAIN 2009
Roles of transient receptor potential channels in pain
CL Stucky, AE Dubin, NA Jeske, SA Malin, DD McKemy, GM Story
Brain Research Reviews 2009
The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain
O Caspani, S Zurborg, D Labuz, PA Heppenstall
PloS one 2009
Intradermal administration of magnesium sulphate and magnesium chloride produces hypesthesia to mechanical but hyperalgesia to heat stimuli in humans
T Ushida, O Iwatsu, K Shimo, T Tetsunaga, M Ikeuchi, T Ikemoto, YC Arai, K Suetomi, M Nishihara
Journal of Neuroinflammation 2009
TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1
MM Salas, KM Hargreaves, AN Akopian
The European journal of neuroscience 2009
TRPA1 modulates mechanotransduction in cutaneous sensory neurons
KY Kwan, JM Glazer, DP Corey, FL Rice, CL Stucky
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
TRPA1 and cold transduction: an unresolved issue?
O Caspani, PA Heppenstall
The Journal of General Physiology 2009
Zinc activates damage-sensing TRPA1 ion channels
H Hu, M Bandell, MJ Petrus, MX Zhu, A Patapoutian
Nature Chemical Biology 2009
Mechano- and thermosensitivity of regenerating cutaneous afferent nerve fibers
W Jänig, L Grossmann, N Gorodetskaya
Experimental Brain Research 2009
QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells
H Doihara, K Nozawa, R Kojima, E Kawabata-Shoda, T Yokoyama, H Ito
Molecular and Cellular Biochemistry 2009
Converting cold into pain
C Belmonte, JA Brock, F Viana
Experimental Brain Research 2009
Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane
M Schmidt, AE Dubin, MJ Petrus, TJ Earley, A Patapoutian
Neuron 2009
Variable Threshold of Trigeminal Cold-Thermosensitive Neurons Is Determined by a Balance between TRPM8 and Kv1 Potassium Channels
R Madrid, E de la Pena, T Donovan-Rodriguez, C Belmonte, F Viana
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury
K Miyoshi, K Obata, T Kondo, H Okamura, K Noguchi
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate
D Kim, EJ Cavanaugh, D Simkin
American journal of physiology. Cell physiology 2008
HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity
SR Eid, ED Crown, EL Moore, HA Liang, KC Choong, S Dima, DA Henze, SA Kane, MO Urban
Molecular Pain 2008
Inflammation reduces mechanical thresholds in a population of transient receptor potential channel A1-expressing nociceptors in the rat
JP Dunham, S Kelly, LF Donaldson
The European journal of neuroscience 2008
ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1
S Mandadi, BD Roufogalis
Current neuropharmacology 2008
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels
B Xiao, AE Dubin, B Bursulaya, V Viswanath, TJ Jegla, A Patapoutian
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Intact Adelta-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats
G Ji, S Zhou, SM Carlton
Neuroscience 2008
Intracellular signaling in primary sensory neurons and persistent pain
JK Cheng, RR Ji
Neurochemical Research 2008
Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors
NB Ruparel, AM Patwardhan, AN Akopian, KM Hargreaves
PAIN 2008
Irritant-Induced Chronic Cough: Irritant-Induced TRPpathy
SM Brooks
Lung 2008
Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators
Y Karashima, J Prenen, V Meseguer, G Owsianik, T Voets, B Nilius
Pflügers Archiv - European Journal of Physiology 2008
Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs: TRPA1 in vagal afferent nerves innervating the airways
C Nassenstein, K Kwong, T Taylor-Clark, M Kollarik, DM MacGlashan, A Braun, BJ Undem
The Journal of Physiology 2008
Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels
J Chen, XF Zhang, ME Kort, JR Huth, C Sun, LJ Miesbauer, SC Cassar, T Neelands, VE Scott, RB Moreland, RM Reilly, PJ Hajduk, PR Kym, CW Hutchins, CR Faltynek
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Visualizing Cold Spots: TRPM8-Expressing Sensory Neurons and Their Projections
A Dhaka, TJ Earley, J Watson, A Patapoutian
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Cannabinoids Desensitize Capsaicin and Mustard Oil Responses in Sensory Neurons via TRPA1 Activation
AN Akopian, NB Ruparel, A Patwardhan, KM Hargreaves
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition
M Petrus, AM Peier, M Bandell, SW Hwang, T Huynh, N Olney, T Jegla, A Patapoutian
Molecular Pain 2007
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists
L Klionsky, R Tamir, B Gao, W Wang, DC Immke, N Nishimura, NR Gavva
Molecular Pain 2007
Plasticity in intact A delta- and C-fibers contributes to cold hypersensitivity in neuropathic rats
G Ji, S Zhou, MY Kochukov, KN Westlund, SM Carlton
Neuroscience 2007
Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization: TRPV1 modulation of TRPA1 activities
AN Akopian, NB Ruparel, NA Jeske, KM Hargreaves
The Journal of Physiology 2007
TRPM8 Mechanism of Cold Allodynia after Chronic Nerve Injury
H Xing, M Chen, J Ling, W Tan, JG Gu
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Bimodal Action of Menthol on the Transient Receptor Potential Channel TRPA1
Y Karashima, N Damann, J Prenen, K Talavera, A Segal, T Voets, B Nilius
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Requirement of a Soluble Intracellular Factor for Activation of Transient Receptor Potential A1 by Pungent Chemicals: Role of Inorganic Polyphosphates
D Kim, EJ Cavanaugh
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Activation of TRPA1 Channel Facilitates Excitatory Synaptic Transmission in Substantia Gelatinosa Neurons of the Adult Rat Spinal Cord
M Kosugi, T Nakatsuka, T Fujita, Y Kuroda, E Kumamoto
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury
K Obata, H Katsura, J Sakurai, K Kobayashi, H Yamanaka, Y Dai, T Fukuoka, K Noguchi
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
TRPpathies
K Kiselyov, A Soyombo, S Muallem
The Journal of Physiology 2006
Distinct ASIC currents are expressed in rat putative nociceptors and are modulated by nerve injury: ASIC function in rat sensory neurones
O Poirot, T Berta, I Decosterd, S Kellenberger
The Journal of Physiology 2006
Characterization of cold sensitivity and thermal preference using an operant orofacial assay
HL Rossi, CJ Vierck, RM Caudle, JK Neubert
Molecular Pain 2006
Neuropathic Pain: Translational research and impact for patient care
R Maag, R Baron
Current Pain and Headache Reports 2006
Desensitization of cold- and menthol-sensitive rat dorsal root ganglion neurones by inflammatory mediators
RM Linte, C Ciobanu, G Reid, A Babes
Experimental Brain Research 2006
Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury
H Katsura, K Obata, T Mizushima, J Sakurai, K Kobayashi, H Yamanaka, Y Dai, T Fukuoka, M Sakagami, K Noguchi
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
The Emerging Role of TRP Channels in Mechanisms of Temperature and Pain Sensation
Story GM
Current neuropharmacology 2006

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