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Ralph Theo Schermuly, … , Werner Seeger, Friedrich Grimminger
Published October 3, 2005
Citation Information: J Clin Invest. 2005;115(10):2811-2821. https://doi.org/10.1172/JCI24838.
Citation Information: J Clin Invest. 2005;115(10):2811-2821. https://doi.org/10.1172/JCI24838.
Abstract
Progression of pulmonary hypertension is associated with increased proliferation and migration of pulmonary vascular smooth muscle cells. PDGF is a potent mitogen and involved in this process. We now report that the PDGF receptor antagonist STI571 (imatinib) reversed advanced pulmonary vascular disease in 2 animal models of pulmonary hypertension. In rats with monocrotaline-induced pulmonary hypertension, therapy with daily administration of STI571 was started 28 days after induction of the disease. A 2-week treatment resulted in 100% survival, compared with only 50% in sham-treated rats. The changes in RV pressure, measured continuously by telemetry, and right heart hypertrophy were reversed to near-normal levels. STI571 prevented phosphorylation of the PDGF receptor and suppressed activation of downstream signaling pathways. Similar results were obtained in chronically hypoxic mice, which were treated with STI571 after full establishment of pulmonary hypertension. Moreover, expression of the PDGF receptor was found to be significantly increased in lung tissue from pulmonary arterial hypertension patients compared with healthy donor lung tissue. We conclude that STI571 reverses vascular remodeling and cor pulmonale in severe experimental pulmonary hypertension regardless of the initiating stimulus. This regimen offers a unique novel approach for antiremodeling therapy in progressed pulmonary hypertension.
Authors
Ralph Theo Schermuly, Eva Dony, Hossein Ardeschir Ghofrani, Soni Pullamsetti, Rajkumar Savai, Markus Roth, Akylbek Sydykov, Ying Ju Lai, Norbert Weissmann, Werner Seeger, Friedrich Grimminger
Total citations by year
Citation information
Citations to this article (389)
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American journal of respiratory and critical care medicine | 2020 |
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Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice
B Neupane, A Sydykov, K Pradhan, C Vroom, C Herden, S Karnati, HA Ghofrani, S Avdeev, S Ergün, RT Schermuly, D Kosanovic |
Respiratory Research | 2020 |
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Cancer and pulmonary hypertension: Learning lessons and real-life interplay
SS Pullamsetti, S Nayakanti, P Chelladurai, A Mamazhakypov, S Mansouri, R Savai, W Seeger |
Global Cardiology Science and Practice | 2020 |
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Relationship between compliance and pulmonary vascular resistance in pulmonary arterial hypertension
S Guigui, SI Zaidi, JJ Lee, T Elajami, CG Mihos, E Escolar |
Journal of Thoracic Disease | 2020 |
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PDGF mediates pulmonary arterial smooth muscle cell proliferation and migration by regulating NFATc2
FY Zhao, SL Xu, CF Zhang, J Liu, Y Zhang, J Yang, |
Molecular medicine reports | 2020 |
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Cell Death in the Lung: The Apoptosis–Necroptosis Axis
M Sauler, IS Bazan, PJ Lee |
Annual Review of Physiology | 2019 |
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A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension
ND Arnold, JA Pickworth, LE West, S Dawson, JA Carvalho, H Casbolt, AT Braithwaite, J Iremonger, L Renshall, V Germaschewski, M McCourt, P Bland-Ward, H Kowash, AG Hameed, AM Rothman, MG Frid, AA Thompson, HR Evans, M Southwood, NW Morrell, DC Crossman, MK Whyte, KR Stenmark, CM Newman, DG Kiely, SE Francis, A Lawrie |
Nature Communications | 2019 |
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Smooth Muscle Phenotype in Idiopathic Pulmonary Hypertension: Hyper-Proliferative but not Cancerous
F Perros, P Sentenac, D Boulate, G Manaud, T Kotsimbos, F Lecerf, L Lamrani, E Fadel, O Mercier, A Londono-Vallejo, M Humbert, S Eddahibi |
International journal of molecular sciences | 2019 |
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Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again
KW Prins, T Thenappan, EK Weir, R Kalra, M Pritzker, SL Archer |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2019 |
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Loss of secretin results in systemic and pulmonary hypertension with cardiopulmonary pathologies in mice
AM Zaw, R Sekar, SO Mak, HK Law, BK Chow |
Scientific Reports | 2019 |
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The Search for Disease-Modifying Therapies in Pulmonary Hypertension
CS Woodcock, SY Chan |
Journal of cardiovascular pharmacology and therapeutics | 2019 |
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Mitochondrial Dysfunction: Metabolic Drivers of Pulmonary Hypertension
HB Suliman, E Nozik-Grayck |
Antioxidants & Redox Signaling | 2019 |
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Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure
E Spiekerkoetter, EA Goncharova, C Guignabert, K Stenmark, G Kwapiszewska, M Rabinovitch, N Voelkel, HJ Bogaard, B Graham, SS Pullamsetti, WM Kuebler |
Pulmonary circulation | 2019 |
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Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension
AJ Sweatt, HK Hedlin, V Balasubramanian, A Hsi, LK Blum, WH Robinson, F Haddad, PM Hickey, RA Condliffe, A Lawrie, MR Nicolls, M Rabinovitch, P Khatri, RT Zamanian |
Circulation research | 2019 |
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Circulating Apoptotic Signals During Acute and Chronic Exposure to High Altitude in Kyrgyz Population
D Kosanovic, SM Platzek, A Petrovic, A Sydykov, A Maripov, A Mamazhakypov, M Sartmyrzaeva, KM Uulu, M Cholponbaeva, A Toktosunova, N Omurzakova, M Duishobaev, C Vroom, O Pak, N Weissmann, HA Ghofrani, A Sarybaev, RT Schermuly |
Frontiers in physiology | 2019 |
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Clinical trial design and new therapies for pulmonary arterial hypertension
O Sitbon, M Gomberg-Maitland, J Granton, MI Lewis, SC Mathai, M Rainisio, NL Stockbridge, MR Wilkins, RT Zamanian, LJ Rubin |
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology | 2019 |
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Pulmonary Hypertension and Obesity: Focus on Adiponectin
F Perrotta, E Nigro, M Mollica, A Costigliola, V DAgnano, A Daniele, A Bianco, G Guerra |
International journal of molecular sciences | 2019 |
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Drug repositioning in pulmonary arterial hypertension: challenges and opportunities
D Grinnan, C Trankle, A Andruska, B Bloom, E Spiekerkoetter |
Pulmonary circulation | 2019 |
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From Molecular Mechanisms to Clinical Management of Antineoplastic Drug-Induced Cardiovascular Toxicity: A Translational Overview
CG Tocchetti, C Cadeddu, DD Lisi, S Femminò, R Madonna, D Mele, I Monte, G Novo, C Penna, A Pepe, P Spallarossa, G Varricchi, C Zito, P Pagliaro, G Mercuro |
Antioxidants & Redox Signaling | 2019 |
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Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
A Weiss, MC Neubauer, D Yerabolu, B Kojonazarov, BC Schlueter, L Neubert, D Jonigk, N Baal, C Ruppert, P Dorfmuller, SS Pullamsetti, N Weissmann, HA Ghofrani, F Grimminger, W Seeger, RT Schermuly |
Nature Communications | 2019 |
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Caffeic Acid Phenethyl Ester Rescues Pulmonary Arterial Hypertension through the Inhibition of AKT/ERK-Dependent PDGF/HIF-1α In Vitro and In Vivo
CC Cheng, PL Chi, MC Shen, CW Shu, SR Wann, CP Liu, CJ Tseng, WC Huang |
International journal of molecular sciences | 2019 |
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CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension
Y Luo, X Teng, L Zhang, J Chen, Z Liu, X Chen, S Zhao, S Yang, J Feng, X Yan |
Nature Communications | 2019 |
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Pulmonary hypertension with dasatinib and other tyrosine kinase inhibitors
A El-Dabh, D Acharya |
Pulmonary circulation | 2019 |
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Tyrosine kinase inhibitors relax pulmonary arteries in human and murine precision-cut lung slices
AD Rieg, NA Bünting, C Cranen, S Suleiman, JW Spillner, H Schnöring, T Schröder, S von Stillfried, T Braunschweig, PW Manley, G Schälte, R Rossaint, S Uhlig, C Martin |
Respiratory Research | 2019 |
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PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension
L Kovacs, Y Cao, W Han, L Meadows, A Kovacs-Kasa, D Kondrikov, AD Verin, SA Barman, Z Dong, Y Huo, Y Su |
American journal of respiratory and critical care medicine | 2019 |
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Pulmonary hypertension in metastatic breast cancer: a case of pulmonary tumour thrombotic microangiopathy
LK Tran, LM Gross, P Hagley, R Minkin |
BMJ case reports | 2019 |
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Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase
Anna Klinke, Eva Berghausen, Kai Friedrichs, Simon Molz, Denise Lau, Lisa Remane, Matthias Berlin, Charlotte Kaltwasser, Matti Adam, Dennis Mehrkens, Martin Mollenhauer, Kashish Manchanda, Thorben Ravekes, Gustavo Heresi, Metin Aytekin, Raed Dweik, Jan Hennigs, Lukas Kubala, Erik Michaelsson, Stephan Rosenkranz, Tanja Rudolph, Stanley L. Hazen, Hans Klose, Ralph Schermuly, Volker Rudolph, Stephan Baldus |
JCI Insight | 2018 |
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PDGF-BB regulates the pulmonary vascular tone: impact of prostaglandins, calcium, MAPK- and PI3K/AKT/mTOR signalling and actin polymerisation in pulmonary veins of guinea pigs
AD Rieg, S Suleiman, C Anker, E Verjans, R Rossaint, S Uhlig, C Martin |
Respiratory Research | 2018 |
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Sex differences in pulmonary arterial hypertension: role of infection and autoimmunity in the pathogenesis of disease
KA Batton, CO Austin, KA Bruno, CD Burger, BP Shapiro, DL Fairweather |
Biology of sex differences | 2018 |
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Aryl Hydrocarbon Receptor Nuclear Translocator in Vascular Smooth Muscle Cells Is Required for Optimal Peripheral Perfusion Recovery
AH Borton, BL Benson, LE Neilson, A Saunders, MA Alaiti, AY Huang, MK Jain, A Proweller, DL RamirezBergeron |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2018 |
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Recent advances in pulmonary arterial hypertension
MR Wilkins, J Aman, L Harbaum, A Ulrich, J Wharton, CJ Rhodes |
F1000Research | 2018 |
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Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension: Mechanisms responsible for persistent pulmonary hypertension
CJ Hu, H Zhang, A Laux, SS Pullamsetti, KR Stenmark |
The Journal of Physiology | 2018 |
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Mitochondrial dysfunction and pulmonary hypertension: cause, effect, or both
JD Marshall, I Bazan, Y Zhang, WH Fares, PJ Lee |
American journal of physiology. Lung cellular and molecular physiology | 2018 |
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Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats
Y Cheng, M Yu, J Xu, M He, H Wang, H Kong, W Xie |
BMC Pulmonary Medicine | 2018 |
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Antineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective
G Varricchi, P Ameri, C Cadeddu, A Ghigo, R Madonna, G Marone, V Mercurio, I Monte, G Novo, P Parrella, F Pirozzi, A Pecoraro, P Spallarossa, C Zito, G Mercuro, P Pagliaro, CG Tocchetti |
Frontiers in physiology | 2018 |
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Polymorphonuclear Leukocytes in Pulmonary Hypertension and Fibrosis: Not Always What They Appear to Be
N Durmus, G Grunig |
American journal of respiratory cell and molecular biology | 2018 |
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Reversal of the Warburg effect with DCA in PDGF‑treated human PASMC is potentiated by pyruvate dehydrogenase kinase‑1 inhibition mediated through blocking Akt/GSK‑3β signalling
B Li, Y Zhu, Q Sun, C Yu, L Chen, Y Tian, J Yan |
International journal of molecular medicine | 2018 |
|
Cerivastatin Nanoliposome as a Potential Disease Modifying Approach for the Treatment of Pulmonary Arterial Hypertension
Y Lee, SB Pai, RV Bellamkonda, DH Thompson, J Singh |
The Journal of pharmacology and experimental therapeutics | 2018 |
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Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications
KH Chen, A Dasgupta, J Lin, F Potus, S Bonnet, J Iremonger, J Fu, J Mewburn, D Wu, K Dunham-Snary, AL Theilmann, ZC Jing, C Hindmarch, ML Ormiston, A Lawrie, SL Archer |
Circulation | 2018 |
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Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension
T Kudryashova, Y Shen, A Pena, E Cronin, E Okorie, D Goncharov, E Goncharova |
International journal of molecular sciences | 2018 |
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Imatinib for right heart failure in COPD
P Douschan, G Kovacs, V Foris, M Kuehnelt-Leddihn, H Olschewski |
Pulmonary circulation | 2018 |
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Resolution of sickle cell disease–associated inflammation and tissue damage with 17 R -resolvin D1
A Matte, A Recchiuti, E Federti, B Koehl, T Mintz, WE Nemer, PL Tharaux, V Brousse, I Andolfo, A Lamolinara, O Weinberg, A Siciliano, PC Norris, IR Riley, A Iolascon, CN Serhan, C Brugnara, LD Franceschi |
Blood | 2018 |
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The cancer theory of pulmonary arterial hypertension
O Boucherat, G Vitry, I Trinh, R Paulin, S Provencher, S Bonnet |
Pulmonary circulation | 2017 |
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Pathobiology of pulmonary arterial hypertension: understanding the roads less travelled
AR Hemnes, M Humbert |
European Respiratory Review | 2017 |
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Imatinib Alters Agonists-mediated Cytoskeletal Biomechanics in Lung Endothelium
X Wang, R Bleher, L Wang, JG Garcia, SM Dudek, GS Shekhawat, VP Dravid |
Scientific Reports | 2017 |
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Serotonin Signaling Through the 5-HT 1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial HypertensionHighlights
KY Hood, KM Mair, AP Harvey, AC Montezano, RM Touyz, MR MacLean |
Arteriosclerosis, thrombosis, and vascular biology | 2017 |
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T ranslational A dvances in the F ield of P ulmonary H ypertension .From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs
SS Pullamsetti, R Savai, W Seeger, EA Goncharova |
American journal of respiratory and critical care medicine | 2017 |
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Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide–Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model
H Christou, H Hudalla, Z Michael, EJ Filatava, J Li, M Zhu, JS Possomato-Vieira, C Dias-Junior, S Kourembanas, RA Khalil |
The Journal of pharmacology and experimental therapeutics | 2017 |
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Imatinib relaxes the pulmonary venous bed of guinea pigs
NA Maihöfer, S Suleiman, D Dreymüller, PW Manley, R Rossaint, S Uhlig, C Martin, AD Rieg |
Respiratory Research | 2017 |
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Steps forward in the treatment of pulmonary arterial hypertension: latest developments and clinical opportunities
JB Badlam, TM Bull |
Therapeutic Advances in Chronic Disease | 2017 |
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Cardiovascular Complications of Targeted Therapies for Chronic Myeloid Leukemia
R Damrongwatanasuk, MG Fradley |
Current Treatment Options in Cardiovascular Medicine | 2017 |
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Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension
J Grimminger, M Richter, K Tello, N Sommer, H Gall, HA Ghofrani |
Canadian respiratory journal : journal of the Canadian Thoracic Society | 2017 |
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Enhanced inflammatory cell profiles in schistosomiasis-induced pulmonary vascular remodeling
Z Ali, D Kosanovic, E Kolosionek, RT Schermuly, BB Graham, A Mathie, G Butrous |
Pulmonary circulation | 2017 |
|
Pulmonary Hypertension and Cancer: Etiology, Diagnosis, and Management
FA Ballout, AS Manshad, TM Okwuosa |
Current Treatment Options in Cardiovascular Medicine | 2017 |
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Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis
A Xiong, Y Liu |
Frontiers in pharmacology | 2017 |
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Imatinib attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors activation in isoproterenol induced model
LX Wang, X Yang, Y Yue, T Fan, J Hou, GX Chen, MY Liang, ZK Wu, RG Katare |
PloS one | 2017 |
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Nanoparticle-Mediated Drug Delivery System for Pulmonary Arterial Hypertension
K Nakamura, H Matsubara, S Akagi, T Sarashina, K Ejiri, N Kawakita, M Yoshida, T Miyoshi, A Watanabe, N Nishii, H Ito |
Journal of Clinical Medicine | 2017 |
|
Identifying “super responders” in pulmonary arterial hypertension
SJ Halliday, AR Hemnes |
Pulmonary circulation | 2017 |
|
Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway
YJ Lai, HH Hsu, GJ Chang, SH Lin, WJ Chen, CC Huang, JH Pang |
Scientific Reports | 2017 |
|
Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 41-8543 ameliorates experimental pulmonary hypertension
M Amirjanians, B Egemnazarov, A Sydykov, B Kojonazarov, R Brandes, H Luitel, K Pradhan, JP Stasch, G Redlich, N Weissmann, F Grimminger, W Seeger, H Ghofrani, R Schermuly |
Oncotarget | 2017 |
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BMP4 inhibits PDGF-induced proliferation and collagen synthesis via PKA-mediated inhibition of calpain-2 in pulmonary artery smooth muscle cells
P Cai, L Kovacs, S Dong, G Wu, Y Su |
American journal of physiology. Lung cellular and molecular physiology | 2017 |
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Pulmonary hypertensive vasculopathy in parenchymal lung diseases and/or hypoxia: Number 1 in the Series “Pathology for the clinician” Edited by Peter Dorfmüller and Alberto Cavazza
MR Ghigna, WJ Mooi, K Grünberg |
European Respiratory Review | 2017 |
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Cardiovascular care of patients with chronic myeloid leukemia (CML) on tyrosine kinase inhibitor (TKI) therapy
MC Barber, MJ Mauro, J Moslehi |
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program | 2017 |
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Drug-Induced Pulmonary Hypertension: The First 50 Years
VA de Jesus Perez |
Advances in Pulmonary Hypertension | 2017 |
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MicroRNA-140-5p and SMURF1 Regulate Pulmonary Arterial Hypertension
Alexander Rothman, Nadine Arnold, Josephine Pickworth, James Iremonger, Loredana Ciuclan, Robert Matthew Henry Allen, Sabine Guth-Gundel, Mark Southwood, Nicholas Morrell, Matthew Thomas, Sheila Francis, David Rowlands, Allan Lawrie |
Journal of Clinical Investigation | 2016 |
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Dasatinib Induces Lung Vascular Toxicity And Predisposes To Pulmonary Hypertension
Christophe Guignabert, Carole Phan, Andrei seferian, Alice Huertas, Ly Tu, Raphael Thuillet, Caroline Sattler, Morane Le Hiress, Yuichi Tamura, Etienne-Marie Jutant, Marie-Camille Chaumais, Stephane Bouchet, Benjamin Manéglier, Mathieu Molimard, Philippe Rousselot, Olivier Sitbon, Gerald Simonneau, David Montani, Marc Humbert |
Journal of Clinical Investigation | 2016 |
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Smooth Muscle Enriched Long Noncoding RNA ( SMILR ) Regulates Cell ProliferationCLINICAL PERSPECTIVE
MD Ballantyne, K Pinel, R Dakin, AT Vesey, L Diver, R Mackenzie, R Garcia, P Welsh, N Sattar, G Hamilton, N Joshi, MR Dweck, JM Miano, MW McBride, DE Newby, RA McDonald, AH Baker |
Circulation | 2016 |
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Calpain-2 activates Akt via TGF-β 1 -mTORC2 pathway in pulmonary artery smooth muscle cells
P Abeyrathna, L Kovacs, W Han, Y Su |
American journal of physiology. Cell physiology | 2016 |
|
The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities
NS Saad, K Floyd, AA Ahmed, PJ Mohler, PM Janssen, MT Elnakish, V Lionetti |
PloS one | 2016 |
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Pioglitazone alleviates cardiac and vascular remodelling and improves survival in monocrotaline induced pulmonary arterial hypertension
A Behringer, M Trappiel, EM Berghausen, H Freyhaus, E Wellnhofer, M Odenthal, F Blaschke, F Er, N Gassanov, S Rosenkranz, S Baldus, K Kappert, E Caglayan |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2016 |
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Medical therapies for pulmonary arterial hypertension
T Pulido, N Zayas, MA de Mendieta, K Plascencia, J Escobar |
Heart Failure Reviews | 2016 |
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Acute cor pulmonale due to pulmonary tumor thrombotic microangiopathy in two patients with breast cancer
SY Moon, KH Lee, JS Lee, HS Yang, HG Lee, YH Cho, SY Yoon |
The Korean Journal of Internal Medicine | 2016 |
|
Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension
O Rafikova, R Rafikov, A Kangath, N Qu, S Aggarwal, S Sharma, J Desai, T Fields, B Ludewig, JX Yuan, D Jonigk, SM Black |
Free radical biology & medicine | 2016 |
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Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension
L Kovacs, W Han, R Rafikov, Z Bagi, S Offermanns, TC Saido, SM Black, Y Su |
American journal of respiratory cell and molecular biology | 2016 |
|
Right Ventricular Pressure Overload and Pathophysiology of Growing Porcine Biomodel
J Kobr, Z Slavik, H Uemura, I Saeed, A Furck, K Pizingerová, J Fremuth, Z Tonar |
Pediatric Cardiology | 2016 |
|
PDGF-dependent β-catenin activation is associated with abnormal pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension
J Takahashi, M Orcholski, K Yuan, VJ Perez, N Mantei |
FEBS Letters | 2016 |
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PDGF induces SphK1 expression via Egr-1 to promote pulmonary artery smooth muscle cell proliferation
JR Sysol, V Natarajan, RF Machado |
American journal of physiology. Cell physiology | 2016 |
|
Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series)
KS Awad, JD West, VJ Perez, M MacLean |
Pulmonary circulation | 2016 |
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Expression Profiling Elucidates a Molecular Gene Signature for Pulmonary Hypertension in Sarcoidosis
S Singla, T Zhou, K Javaid, T Abbasi, N Casanova, W Zhang, SF Ma, MS Wade, I Noth, NJ Sweiss, JG Garcia, RF Machado |
Pulmonary circulation | 2016 |
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MiR-328 targeting PIM-1 inhibits proliferation and migration of pulmonary arterial smooth muscle cells in PDGFBB signaling pathway
Z Qian, L Zhang, J Chen, Y Li, K Kang, J Qu, Z Wang, Y Zhai, L Li, D Gou |
Oncotarget | 2016 |
|
Vascular Cells in Blood Vessel Wall Development and Disease.
Mazurek R, Dave JM, Chandran RR, Misra A, Sheikh AQ, Greif DM |
Advances in pharmacology (San Diego, Calif.) | 2016 |
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BMPR-II Deficiency Promotes Pulmonary Hypertension via Increased Inflammatory Cytokine Production
E Soon, A Crosby, M Southwood, P Yang, T Tajsic, M Toshner, S Appleby, CM Shanahan, KD Bloch, J Pepke-Zaba, P Upton, NW Morrell |
American journal of respiratory and critical care medicine | 2015 |
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Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells
LC Price, D Shao, C Meng, F Perros, BE Garfield, J Zhu, D Montani, P Dorfmuller, M Humbert, IM Adcock, SJ Wort |
Respiratory Research | 2015 |
|
Propylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-Secretase
YJ Lai, GJ Chang, YH Yeh, JH Pang, CC Huang, WJ Chen, Y Su |
PloS one | 2015 |
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Cardio-Oncology: How New Targeted Cancer Therapies and Precision Medicine Can Inform Cardiovascular Discovery
AM Bellinger, CL Arteaga, T Force, BD Humphreys, GD Demetri, BJ Druker, JJ Moslehi |
Circulation | 2015 |
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Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury
AN Rizzo, S Sammani, AE Esquinca, JR Jacobson, JG Garcia, E Letsiou, SM Dudek |
American journal of physiology. Lung cellular and molecular physiology | 2015 |
|
Mitochondrial dynamics in pulmonary arterial hypertension
J Ryan, A Dasgupta, J Huston, KH Chen, SL Archer |
Journal of Molecular Medicine | 2015 |
|
Medikamentöse Therapie der pulmonalen Hypertonie: Was ist neu?
MJ Richter, H Gall, K Tello, N Sommer, W Seeger, F Grimminger, HA Ghofrani |
Der Internist | 2015 |
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Hyperplastic Growth of Pulmonary Artery Smooth Muscle Cells from Subjects with Pulmonary Arterial Hypertension Is Activated through JNK and p38 MAPK
JL Wilson, J Yu, L Taylor, P Polgar, M Kuwana |
PloS one | 2015 |
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Epoprostenol sodium for treatment of pulmonary arterial hypertension
K Nakamura, Y Saito, S Akagi, T Sarashina, K Ejiri, A Miura, A Ogawa, H Matsubara, H Ito |
Vascular Health and Risk Management | 2015 |
|
Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension
E Spiekerkoetter, YK Sung, D Sudheendra, M Bill, MA Aldred, MC van de Veerdonk, AV Noordegraaf, J Long-Boyle, R Dash, PC Yang, A Lawrie, AJ Swift, M Rabinovitch, RT Zamanian |
American journal of respiratory and critical care medicine | 2015 |
|
Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension
S Zhou, MT Li, YY Jia, JJ Liu, Q Wang, Z Tian, YT Liu, HZ Chen, DP Liu, XF Zeng |
BioMed Research International | 2015 |
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Renal sympathetic denervation prevents the development of pulmonary arterial hypertension and cardiac dysfunction in dogs
W Hu, SB Yu, L Chen, RQ Guo, QY Zhao |
The Kaohsiung Journal of Medical Sciences | 2015 |
|
The limits of oral therapy in pulmonary arterial hypertension management
ZC Jing, QQ Liu |
Therapeutics and Clinical Risk Management | 2015 |
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Tyrosine Kinase Inhibitor-Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia
JJ Moslehi, M Deininger |
Journal of Clinical Oncology | 2015 |
|
Genetic Ablation of PDGF-Dependent Signaling Pathways Abolishes Vascular Remodeling and Experimental Pulmonary Hypertension
H Freyhaus, EM Berghausen, W Janssen, M Leuchs, M Zierden, K Murmann, A Klinke, M Vantler, E Caglayan, T Kramer, S Baldus, RT Schermuly, MD Tallquist, S Rosenkranz |
Arteriosclerosis, thrombosis, and vascular biology | 2015 |
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Nestin-expressing vascular wall cells drive development of pulmonary hypertension
F Saboor, AN Reckmann, CU Tomczyk, DM Peters, N Weissmann, A Kaschtanow, RT Schermuly, TV Michurina, G Enikolopov, D Müller, A Mietens, R Middendorff |
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology | 2015 |
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A novel vascular homing Peptide strategy to selectively enhance pulmonary drug efficacy in pulmonary arterial hypertension
M Toba, A Alzoubi, K O'Neill, K Abe, T Urakami, M Komatsu, D Alvarez, TA Järvinen, D Mann, E Ruoslahti, IF McMurtry, M Oka |
The American Journal of Pathology | 2014 |
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Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension
R Savai, HM Al-Tamari, D Sedding, B Kojonazarov, C Muecke, R Teske, MR Capecchi, N Weissmann, F Grimminger, W Seeger, RT Schermuly, SS Pullamsetti |
Nature Medicine | 2014 |
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Pulmonary hypertension and metabolic syndrome: Possible connection, PPARγ and Caveolin-1
R Mathew |
World journal of cardiology | 2014 |
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A translational preclinical model of interstitial pulmonary fibrosis and pulmonary hypertension: mechanistic pathways driving disease pathophysiology
ER Jarman, VS Khambata, LY Ye, K Cheung, M Thomas, N Duggan, G Jarai |
Physiological Reports | 2014 |
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Role for Telomerase in Pulmonary Hypertension
N Mouraret, A Houssaini, S Abid, R Quarck, E Marcos, A Parpaleix, G Gary-Bobo, JL Dubois-Rande, G Derumeaux, J Boczkowski, M Delcroix, MA Blasco, L Lipskaia, V Amsellem, S Adnot |
Circulation | 2014 |
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PK10453, a nonselective platelet-derived growth factor receptor inhibitor, prevents the progression of pulmonary arterial hypertension
V Medarametla, S Festin, C Sugarragchaa, A Eng, A Naqwi, T Wiedmann, LS Zisman |
Pulmonary circulation | 2014 |
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Drug discovery in pulmonary arterial hypertension: attacking the enigmatic root of a deadly weed
RJ White, KL Lannan, RP Phipps |
Drug Discovery Today | 2014 |
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Imatinib for the treatment of pulmonary arterial hypertension and pulmonary capillary hemangiomatosis
D Nayyar, K Muthiah, G Kumarasinghe, R Hettiarachchi, D Celermajer, E Kotlyar, A Keogh |
Pulmonary circulation | 2014 |
|
Editorial: Could reverse remodeling be a novel treatment goal of pulmonary hypertension?
K Yamauchi-Takihara |
Journal of Cardiology Cases | 2014 |
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Upregulated copper transporters in hypoxia-induced pulmonary hypertension
AM Zimnicka, H Tang, Q Guo, FK Kuhr, MJ Oh, J Wan, J Chen, KA Smith, DR Fraidenburg, MS Choudhury, I Levitan, RF Machado, JH Kaplan, JX Yuan |
PloS one | 2014 |
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Inhalation of the BK(Ca)-opener NS1619 attenuates right ventricular pressure and improves oxygenation in the rat monocrotaline model of pulmonary hypertension
M Revermann, S Neofitidou, T Kirschning, M Schloss, RP Brandes, C Hofstetter |
PloS one | 2014 |
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Protective Effects of 10-nitro-oleic Acid in a Hypoxia-Induced Murine Model of Pulmonary Hypertension
A Klinke, A Möller, M Pekarova, T Ravekes, K Friedrichs, M Berlin, KM Scheu, L Kubala, H Kolarova, G Ambrozova, RT Schermuly, SR Woodcock, BA Freeman, S Rosenkranz, S Baldus, V Rudolph, TK Rudolph |
American journal of respiratory cell and molecular biology | 2014 |
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NPY/Y 1 receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension: NPY/NPY1R axis in pulmonary hypertension
S Crnkovic, B Egemnazarov, P Jain, U Seay, N Gattinger, LM Marsh, Z Bálint, G Kovacs, B Ghanim, W Klepetko, RT Schermuly, N Weissmann, A Olschewski, G Kwapiszewska |
British Journal of Pharmacology | 2014 |
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Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Pulmonary arterial hypertension associated with connective tissue diseases
A Boueiz, PM Hassoun |
Annals of thoracic medicine | 2014 |
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Clinical significance of assessment of thrombospondin and placenta growth factor levels in patients with sickle cell anemia: two centers egyptian studies
AA Hagag, G Elmashad, AE El-Lateef |
Mediterranean journal of hematology and infectious diseases | 2014 |
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Pulmonary arterial hypertension in adults: novel drugs and catheter ablation techniques show promise? Systematic review on pharmacotherapy and interventional strategies
S Rosanio, F Pelliccia, C Gaudio, C Greco, AM Keylani, DC D'Agostino |
BioMed Research International | 2014 |
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Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension
H Tang, J Chen, DR Fraidenburg, S Song, JR Sysol, AR Drennan, S Offermanns, RD Ye, MG Bonini, RD Minshall, JG Garcia, RF Machado, A Makino, JX Yuan |
American journal of physiology. Lung cellular and molecular physiology | 2014 |
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Interleukin 13– and interleukin 17A–induced pulmonary hypertension phenotype due to inhalation of antigen and fine particles from air pollution
SH Park, WC Chen, N Esmaeil, B Lucas, LM Marsh, J Reibman, G Grunig |
Pulmonary circulation | 2014 |
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Targeting Receptor Tyrosine Kinases and Their Downstream Signaling with Cell-Penetrating Peptides in Human Pulmonary Artery Smooth Muscle and Endothelial Cells
J Yu, C Rupasinghe, JL Wilson, L Taylor, N Rahimi, D Mierke, P Polgar |
Chemical Biology & Drug Design | 2014 |
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Correlation between nuclear factor κB activity and pulmonary artery pressure in a rat high pulmonary blood flow model
J Yang, XX Yu, A Abulaiti, JC Fei |
Experimental and therapeutic medicine | 2014 |
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Optimal management of pulmonary arterial hypertension: prognostic indicators to determine treatment course
L Fuso, F Baldi, E Arrighi, S Valente |
Therapeutics and Clinical Risk Management | 2014 |
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Aberrant Chloride Intracellular Channel 4 Expression Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension
B Wojciak-Stothard, VB Abdul-Salam, KH Lao, H Tsang, DC Irwin, C Lisk, Z Loomis, KR Stenmark, JC Edwards, SH Yuspa, LS Howard, RJ Edwards, CJ Rhodes, JS Gibbs, J Wharton, L Zhao, MR Wilkins |
Circulation | 2014 |
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AAV Delivery of Tumor Necrosis Factor- Short Hairpin RNA Attenuates Cold-Induced Pulmonary Hypertension and Pulmonary Arterial Remodeling
P Crosswhite, K Chen, Z Sun |
Hypertension | 2014 |
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Platelet TLR4: A Critical Link in Pulmonary Arterial Hypertension
Z Sun |
Circulation research | 2014 |
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Current Clinical Management of Pulmonary Arterial Hypertension
RT Zamanian, KT Kudelko, YK Sung, VJ Perez, J Liu, E Spiekerkoetter |
Circulation research | 2014 |
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Control of vascular smooth muscle function by Src-family kinases and reactive oxygen species in health and disease: Src and ROS in vascular smooth muscle
CE MacKay, GA Knock |
The Journal of Physiology | 2014 |
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Pulmonary Arterial Hypertension and Insulin Resistance
DB Bradley |
Journal of molecular and genetic medicine : an international journal of biomedical research | 2014 |
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Molecular Mechanisms of Pulmonary Arterial Remodeling
P Crosswhite, Z Sun |
Molecular Medicine | 2014 |
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Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction
T Novoyatleva, Y Schymura, W Janssen, F Strobl, JM Swiercz, C Patra, G Posern, A Wietelmann, TS Zheng, RT Schermuly, FB Engel |
Basic Research in Cardiology | 2013 |
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Anticipated classes of new medications and molecular targets for pulmonary arterial hypertension
NW Morrell, SL Archer, A Defelice, S Evans, M Fiszman, T Martin, M Saulnier, M Rabinovitch, R Schermuly, D Stewart, H Truebel, G Walker, KR Stenmark |
Pulmonary circulation | 2013 |
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A comprehensive review: the evolution of animal models in pulmonary hypertension research; are we there yet?
G Maarman, S Lecour, G Butrous, F Thienemann, K Sliwa |
Pulmonary circulation | 2013 |
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Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension
A Houssaini, S Abid, N Mouraret, F Wan, D Rideau, M Saker, E Marcos, CM Tissot, JL Dubois-Randé, V Amsellem, S Adnot |
American journal of respiratory cell and molecular biology | 2013 |
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The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats
M Izikki, O Mercier, F Lecerf, LL Guin, E Hoang, P Dorfmüller, F Perros, M Humbert, G Simonneau, P Dartevelle, E Fadel, S Eddahibi |
PloS one | 2013 |
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Activation of Lung p53 by Nutlin-3a Prevents and Reverses Experimental Pulmonary Hypertension
N Mouraret, E Marcos, S Abid, G Gary-Bobo, M Saker, A Houssaini, JL Dubois-Rande, L Boyer, J Boczkowski, G Derumeaux, V Amsellem, S Adnot |
Circulation | 2013 |
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Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension
R Malhotra, S Paskin-Flerlage, RT Zamanian, P Zimmerman, JW Schmidt, DY Deng, M Southwood, R Spencer, CS Lai, W Parker, RN Channick, NW Morrell, CG Elliott, PB Yu |
Pulmonary circulation | 2013 |
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Pulmonary arterial hypertension
D Montani, S Günther, P Dorfmüller, F Perros, B Girerd, G Garcia, X Jaïs, L Savale, E Artaud-Macari, LC Price, M Humbert, G Simonneau, O Sitbon |
Orphanet Journal of Rare Diseases | 2013 |
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Pulmonary vascular remodeling and right heart failure in pulmonary hypertension: future role of positron emission tomography in decoding the enigma
HJ Harms, MC van de Veerdonk, AA Lammertsma, A Noordegraaf, H Bogaard |
Translational Respiratory Medicine | 2013 |
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Endothelial Indoleamine 2,3-Dioxygenase Protects against Development of Pulmonary Hypertension
Y Xiao, H Christou, L Liu, G Visner, SA Mitsialis, S Kourembanas, H Liu |
American journal of respiratory and critical care medicine | 2013 |
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PGC1α-mediated Mitofusin-2 Deficiency in Female Rats and Humans with Pulmonary Arterial Hypertension
JJ Ryan, G Marsboom, YH Fang, PT Toth, E Morrow, N Luo, L Piao, Z Hong, K Ericson, HJ Zhang, M Han, CR Haney, CT Chen, WW Sharp, SL Archer |
American journal of respiratory and critical care medicine | 2013 |
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Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension
RM Tuder, SL Archer, P Dorfmüller, SC Erzurum, C Guignabert, E Michelakis, M Rabinovitch, R Schermuly, KR Stenmark, NW Morrell |
Journal of the American College of Cardiology | 2013 |
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Rapid-onset pulmonary arterial hypertension in a patient with acute lymphoblastic leukemia treated with dasatinib
JC Kim, SH Shin, HG Yi, SH Kim, SI Woo, DH Kim, KS Park, J Kwan |
Herz | 2013 |
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Cardiovascular Safety of Tyrosine Kinase Inhibitors: With a Special Focus on Cardiac Repolarisation (QT Interval)
RR Shah, J Morganroth, DR Shah |
Drug Safety | 2013 |
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Mineralocorticoid Receptors in Vascular Disease: Connecting Molecular Pathways to Clinical Implications
AP McGraw, A McCurley, IR Preston, IZ Jaffe |
Current Atherosclerosis Reports | 2013 |
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ACE2 Activation Confers Endothelial Protection and Attenuates Neointimal Lesions in Prevention of Severe Pulmonary Arterial Hypertension in Rats
G Li, Y Liu, Y Zhu, A Liu, Y Xu, X Li, Z Li, J Su, L Sun |
Lung | 2013 |
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Targeting the PDGF Signaling Pathway in the Treatment of Non-Malignant Diseases
CH Heldin |
Journal of Neuroimmune Pharmacology | 2013 |
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Analysis of Erectile Responses to Imatinib in the Rat
EA Pankey, GF Lasker, S Gur, WJ Hellstrom, PJ Kadowitz |
Urology | 2013 |
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Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia
S Fleck, G Bautista, SM Keating, TH Lee, RL Keller, AJ Moon-Grady, K Gonzales, PJ Norris, MP Busch, CJ Kim, R Romero, H Lee, D Miniati, TC MacKenzie |
Pediatric Research | 2013 |
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Novel therapeutic approaches to preserve the right ventricle
S Farha, EL Lundgrin, SC Erzurum |
Current Heart Failure Reports | 2013 |
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Signal transduction in the development of pulmonary arterial hypertension
S Malenfant, AS Neyron, R Paulin, F Potus, J Meloche, S Provencher, S Bonnet |
Pulmonary circulation | 2013 |
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A cell permeable peptide targeting the intracellular loop 2 of endothelin B receptor reduces pulmonary hypertension in a hypoxic rat model
DS Green, C Rupasinghe, R Warburton, JL Wilson, CO Sallum, L Taylor, A Yatawara, D Mierke, P Polgar, N Hill |
PloS one | 2013 |
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Weaning from intravenous prostanoids and normalization of hemodynamics by long-term imatinib therapy in severe idiopathic pulmonary arterial hypertension
R Speich, U Treder, G Domenighetti, LC Huber, S Ulrich |
International Journal of Clinical Pharmacy | 2013 |
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Thrombin has biphasic effects on the nitric oxide-cGMP pathway in endothelial cells and contributes to experimental pulmonary hypertension
KF Nickel, V Laux, R Heumann, G Degenfeld |
PloS one | 2013 |
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Expression of regulatory platelet microRNAs in patients with sickle cell disease
S Jain, MG Kapetanaki, N Raghavachari, K Woodhouse, G Yu, S Barge, C Coronnello, PV Benos, GJ Kato, N Kaminski, MT Gladwin |
PloS one | 2013 |
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Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension
IR Preston, KD Sagliani, RR Warburton, NS Hill, BL Fanburg, IZ Jaffe |
American journal of physiology. Lung cellular and molecular physiology | 2013 |
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Modification of hemodynamic and immune responses to exposure with a weak antigen by the expression of a hypomorphic BMPR2 gene
SH Park, WC Chen, C Hoffman, LM Marsh, J West, G Grunig |
PloS one | 2013 |
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Beneficial effects of a novel agonist of the adenosine A2A receptor on monocrotaline-induced pulmonary hypertension in rats
AK Alencar, SL Pereira, TL Montagnoli, RC Maia, AE Kümmerle, SS Landgraf, C Caruso-Neves, EB Ferraz, R Tesch, JH Nascimento, CM de Sant'Anna, CA Fraga, EJ Barreiro, RT Sudo, G Zapata-Sudo |
British Journal of Pharmacology | 2013 |
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mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects
EA Goncharova |
The FASEB Journal | 2013 |
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Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2
J Wan, A Yamamura, AM Zimnicka, G Voiriot, KA Smith, H Tang, RJ Ayon, MS Choudhury, EA Ko, J Wang, C Wang, A Makino, JX Yuan |
American journal of physiology. Lung cellular and molecular physiology | 2013 |
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The Role of Collagen Synthesis in Ventricular and Vascular Adaptation to Hypoxic Pulmonary Hypertension
D Schreier, T Hacker, G Song, N Chesler |
Journal of Biomechanical Engineering | 2013 |
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Imatinib attenuates monocrotaline pulmonary hypertension and has potent vasodilator activity in pulmonary and systemic vascular beds in the rat
EA Pankey, S Thammasiboon, GF Lasker, S Baber, JA Lasky, PJ Kadowitz |
American journal of physiology. Heart and circulatory physiology | 2013 |
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Selective Inactivation of PTEN in Smooth Muscle Cells Synergizes With Hypoxia to Induce Severe Pulmonary Hypertension
H Horita, SB Furgeson, A Ostriker, KA Olszewski, T Sullivan, LR Villegas, M Levine, JE Parr, CD Cool, RA Nemenoff, MC WeiserEvans |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2013 |
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Inhibition of Phosphodiesterase-1 Attenuates Cold-Induced Pulmonary Hypertension
P Crosswhite, Z Sun |
Hypertension | 2013 |
|
Pathogenesis of pulmonary arterial hypertension: lessons from cancer
Guignabert C, Tu L, Le Hiress M, Ricard N, Sattler C, Seferian A, Huertas A, Humbert M, Montani D |
European Respiratory Review | 2013 |
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New horizons in pulmonary arterial hypertension therapies
Galiè N, Ghofrani AH |
European Respiratory Review | 2013 |
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Molecular pathogenesis of pulmonary arterial hypertension
Marlene Rabinovitch |
Journal of Clinical Investigation | 2012 |
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Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension
AG Hameed, ND Arnold, J Chamberlain, JA Pickworth, C Paiva, S Dawson, S Cross, L Long, L Zhao, NW Morrell, DC Crossman, CM Newman, DG Kiely, SE Francis, A Lawrie |
Journal of Experimental Medicine | 2012 |
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Immune and inflammatory mechanisms in pulmonary arterial hypertension
HE Chami, PM Hassoun |
Progress in Cardiovascular Diseases | 2012 |
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A process-based review of mouse models of pulmonary hypertension
M Das, J Fessel, H Tang, J West |
Pulmonary circulation | 2012 |
|
Targeting Energetic Metabolism
RM Tuder, LA Davis, BB Graham |
American journal of respiratory and critical care medicine | 2012 |
|
STAT3 signaling in pulmonary arterial hypertension
R Paulin, J Meloche, S Bonnet |
JAK-STAT | 2012 |
|
Scleroderma therapy: clinical overview of current trends and future perspective
AA Topal, RS Dhurat |
Rheumatology International | 2012 |
|
Pulmonary hypertension-"state of the art" management in 2012
A Saxena |
Indian Heart Journal | 2012 |
|
Morphometric analysis of intralobular, interlobular and pleural lymphatics in normal human lung
F Sozio, A Rossi, E Weber, DJ Abraham, AG Nicholson, AU Wells, EA Renzoni, P Sestini |
Journal of Anatomy | 2012 |
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Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension
H Christou, OM Reslan, V Mam, AF Tanbe, SH Vitali, M Touma, E Arons, SA Mitsialis, S Kourembanas, RA Khalil |
American journal of physiology. Lung cellular and molecular physiology | 2012 |
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Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension
G Marsboom, C Wietholt, CR Haney, PT Toth, JJ Ryan, E Morrow, T Thenappan, P Bache-Wiig, L Piao, J Paul, CT Chen, SL Archer |
American journal of respiratory and critical care medicine | 2012 |
|
Oxidant signaling for interleukin-13 gene expression in lung smooth muscle cells
G Bansal, CM Wong, L Liu, YJ Suzuki |
Free radical biology & medicine | 2012 |
|
Today’s and tomorrow’s imaging and circulating biomarkers for pulmonary arterial hypertension
M Barrier, J Meloche, MH Jacob, A Courboulin, S Provencher, S Bonnet |
Cellular and Molecular Life Sciences | 2012 |
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The Soluble Guanylate Cyclase Stimulator Riociguat Ameliorates Pulmonary Hypertension Induced by Hypoxia and SU5416 in Rats
M Lang, B Kojonazarov, X Tian, A Kalymbetov, N Weissmann, F Grimminger, A Kretschmer, JP Stasch, W Seeger, HA Ghofrani, RT Schermuly |
PloS one | 2012 |
|
TRP channels: sensors and transducers of gasotransmitter signals
N Takahashi, D Kozai, Y Mori |
Frontiers in physiology | 2012 |
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Early Treatment with Fumagillin, an Inhibitor of Methionine Aminopeptidase-2, Prevents Pulmonary Hypertension in Monocrotaline-Injured Rats
DJ Kass, E Rattigan, R Kahloon, K Loh, L Yu, A Savir, M Markowski, A Saqi, R Rajkumar, F Ahmad, HC Champion |
PloS one | 2012 |
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Cigarette Smoke Extract Stimulates Rat Pulmonary Artery Smooth Muscle Cell Proliferation via PKC-PDGFB Signaling
A Xing, Y Du, X Hu, J Xu, H Zhang, Y Li, X Nie |
Journal of Biomedicine and Biotechnology | 2012 |
|
Quercetin attenuates the progression of monocrotaline-induced pulmonary hypertension in rats
H Gao, C Chen, S Huang, B Li |
Journal of Biomedical Research | 2012 |
|
Pulmonary Arterial Hypertension in Connective Tissue Diseases
SC Mathai, PM Hassoun |
Heart Failure Clinics | 2012 |
|
A Critical Role for p130 Cas in the Progression of Pulmonary Hypertension in Humans and Rodents
L Tu, FS de Man, B Girerd, A Huertas, MC Chaumais, F Lecerf, C François, F Perros, P Dorfmüller, E Fadel, D Montani, S Eddahibi, M Humbert, C Guignabert |
American journal of respiratory and critical care medicine | 2012 |
|
Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling
E Panzhinskiy, WM Zawada, KR Stenmark, M Das |
Cardiovascular Research | 2012 |
|
Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation
Q Yang, Z Lu, R Ramchandran, LD Longo, JU Raj |
American journal of physiology. Lung cellular and molecular physiology | 2012 |
|
Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates
EM Novelli, GJ Kato, MV Ragni, Y Zhang, ME Hildesheim, M Nouraie, S Barge, MP Meyer, AC Hassett, VR Gordeuk, MT Gladwin, JS Isenberg |
American Journal of Hematology | 2012 |
|
Platelet-Derived Growth Factor Maintains Stored Calcium Through a Nonclustering Orai1 Mechanism But Evokes Clustering If the Endoplasmic Reticulum Is Stressed by Store Depletion
L McKeown, NK Moss, P Turner, J Li, N Heath, D Burke, D O'Regan, MS Gilthorpe, KE Porter, DJ Beech |
Circulation research | 2012 |
|
The potential for resident lung mesenchymal stem cells to promote functional tissue regeneration: understanding microenvironmental cues.
Foronjy RF, Majka SM |
Cells | 2012 |
|
Pathways in pulmonary arterial hypertension: the future is here
Sitbon O, Morrell N |
European Respiratory Review | 2012 |
|
Inhibition of ABCC4 (MRP4) prevents and reverses pulmonary hypertension in mice
Yannis Hara, Yassine Sassi, Christelle Guibert, Natacha Gambaryan, Peter Dorfmuller, Saadia Eddahibi, Anne-Marie Lompre, Marc Humbert, Jean-Sébastien Hulot |
Journal of Clinical Investigation | 2011 |
|
Calpain is a Novel Target in Pulmonary Vascular Remodeling of Pulmonary Hypertension
Wanli Ma, Weihong Han, Peter Greer, Rubin Tuder, Haroldo Toque, Kevin Wang, R. William Caldwell, Yunchao Su |
Journal of Clinical Investigation | 2011 |
|
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
|
Mechanisms of disease: pulmonary arterial hypertension
RT Schermuly, HA Ghofrani, MR Wilkins, F Grimminger |
Nature Reviews Cardiology | 2011 |
|
Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats
BK Dahal, D Kosanovic, C Kaulen, T Cornitescu, R Savai, J Hoffmann, I Reiss, HA Ghofrani, N Weissmann, WM Kuebler, W Seeger, F Grimminger, RT Schermuly |
Respiratory Research | 2011 |
|
New perspectives for the treatment of pulmonary hypertension
RS Baliga, RJ MacAllister, AJ Hobbs |
British Journal of Pharmacology | 2011 |
|
Treatment of pulmonary arterial hypertension with targeted therapies
DS O'Callaghan, L Savale, D Montani, X Jaïs, O Sitbon, G Simonneau, M Humbert |
Nature Reviews Cardiology | 2011 |
|
Pharmacogenomics in pulmonary arterial hypertension: Toward a mechanistic, target-based approach to therapy
SI Said, SA Hamidi |
Pulmonary circulation | 2011 |
|
Platelet-derived growth factor receptor-β and epidermal growth factor receptor in pulmonary vasculature of systemic sclerosis-associated pulmonary arterial hypertension versus idiopathic pulmonary arterial hypertension and pulmonary veno-occlusive disease: a case-control study
MJ Overbeek, A Boonstra, AE Voskuyl, MC Vonk, A Vonk-Noordegraaf, MP van Berkel, WJ Mooi, BA Dijkmans, LS Hondema, EF Smit, K Grünberg |
Arthritis Research & Therapy | 2011 |
|
Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes
T Force, KL Kolaja |
Nature Reviews Drug Discovery | 2011 |
|
Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β
BK Dahal, R Heuchel, SS Pullamsetti, J Wilhelm, HA Ghofrani, N Weissmann, W Seeger, F Grimminger, RT Schermuly |
Pulmonary circulation | 2011 |
|
Cell-Specific Dual Role of Caveolin-1 in Pulmonary Hypertension
R Mathew |
Pulmonary Medicine | 2011 |
|
Glycogen synthase kinase 3beta contributes to proliferation of arterial smooth muscle cells in pulmonary hypertension
P Sklepkiewicz, RT Schermuly, X Tian, HA Ghofrani, N Weissmann, D Sedding, T Kashour, W Seeger, F Grimminger, SS Pullamsetti |
PloS one | 2011 |
|
Krüppel-like Factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension
A Courboulin, VL Tremblay, M Barrier, J Meloche, MH Jacob, M Chapolard, M Bisserier, R Paulin, C Lambert, S Provencher, S Bonnet |
Respiratory Research | 2011 |
|
Signal Transducers and Activators of Transcription-3/Pim1 Axis Plays a Critical Role in the Pathogenesis of Human Pulmonary Arterial Hypertension
R Paulin, A Courboulin, J Meloche, V Mainguy, ED de la Roque, N Saksouk, J Côté, S Provencher, MA Sussman, S Bonnet |
Circulation | 2011 |
|
The Role of Inflammation and Autoimmunity in the Pathophysiology of Pulmonary Arterial Hypertension
N Kherbeck, MC Tamby, G Bussone, H Dib, F Perros, M Humbert, L Mouthon |
Clinical Reviews in Allergy & Immunology | 2011 |
|
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension
D Kosanovic, B Kojonazarov, H Luitel, BK Dahal, A Sydykov, T Cornitescu, W Janssen, RP Brandes, N Davie, HA Ghofrani, N Weissmann, F Grimminger, W Seeger, RT Schermuly |
Respiratory Research | 2011 |
|
Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling
X Tian, C Vroom, HA Ghofrani, N Weissmann, E Bieniek, F Grimminger, W Seeger, RT Schermuly, SS Pullamsetti |
PloS one | 2011 |
|
Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-capillary pulmonary hypertension?
JK Hennigs, G Keller, HJ Baumann, F Honecker, S Kluge, C Bokemeyer, TH Brümmendorf, H Klose |
BMC Pulmonary Medicine | 2011 |
|
From oncoproteins/tumor suppressors to microRNAs, the newest therapeutic targets for pulmonary arterial hypertension
R Paulin, A Courboulin, M Barrier, S Bonnet |
Journal of Molecular Medicine | 2011 |
|
Treatment for pulmonary hypertension including lung transplantation
KF Kusano |
General Thoracic and Cardiovascular Surgery | 2011 |
|
Human immunodeficiency virus transgenic rats exhibit pulmonary hypertension
AK Lund, J Lucero, L Herbert, Y Liu, JS Naik |
AJP Lung Cellular and Molecular Physiology | 2011 |
|
Vascular involvement in systemic sclerosis (scleroderma)
D Pattanaik, M Brown, AE Postlethwaite |
Journal of inflammation research | 2011 |
|
Obesity and pulmonary arterial hypertension: Is adiponectin the molecular link between these conditions?
R Summer, K Walsh, BD Medoff |
Pulmonary circulation | 2011 |
|
Mesenchymal Stromal Cells Expressing Heme Oxygenase-1 Reverse Pulmonary Hypertension
OD Liang, SA Mitsialis, MS Chang, E Vergadi, C Lee, M Aslam, A Fernandez-Gonzalez, X Liu, R Baveja, S Kourembanas |
Stem Cells | 2011 |
|
Is peroxisome proliferator-activated receptor gamma (PPARγ) a therapeutic target for the treatment of pulmonary hypertension?
DE Green, RL Sutliff, CM Hart |
Pulmonary circulation | 2011 |
|
Lung transplantation for pulmonary hypertension
MP George, HC Champion, JM Pilewski |
Pulmonary circulation | 2011 |
|
Tyrosine Kinase Inhibitors Are Potent Acute Pulmonary Vasodilators in Rats
K Abe, M Toba, A Alzoubi, K Koubsky, M Ito, H Ota, S Gairhe, WT Gerthoffer, KA Fagan, IF McMurtry, M Oka |
American journal of respiratory cell and molecular biology | 2011 |
|
Disruption of platelet-derived growth factor-dependent phosphatidylinositol 3-kinase and phospholipase Cγ 1 activity abolishes vascular smooth muscle cell proliferation and migration and attenuates neointima formation in vivo
E Caglayan, M Vantler, O Leppänen, F Gerhardt, L Mustafov, HT Freyhaus, K Kappert, M Odenthal, WH Zimmermann, MD Tallquist, S Rosenkranz |
Journal of the American College of Cardiology | 2011 |
|
PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells
A Ogawa, AL Firth, KA Smith, MV Maliakal, JX Yuan |
American journal of physiology. Cell physiology | 2011 |
|
Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner
A Lawrie, AG Hameed, J Chamberlain, N Arnold, A Kennerley, K Hopkinson, J Pickworth, DG Kiely, DC Crossman, SE Francis |
The American Journal of Pathology | 2011 |
|
Looking to the future: a new decade of pulmonary arterial hypertension therapy
McLaughlin VV |
European Respiratory Review | 2011 |
|
The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
Michele Hickey, Theresa Richardson, Tao Wang, Matias Mosqueira, Evguenia Arguiri, Hongwei Yu, Qian-Chun Yu, Charalambos Solomides, Edward Morrisey, Tejvir Khurana, Melpo Christofidou-Solomidou, M. Celeste Simon |
Journal of Clinical Investigation | 2010 |
|
Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension
L Tu, L Dewachter, B Gore, E Fadel, P Dartevelle, G Simonneau, M Humbert, S Eddahibi, C Guignabert |
American journal of respiratory cell and molecular biology | 2010 |
|
Genomics of pulmonary arterial hypertension: implications for therapy
MW Geraci, TM Bull, RM Tuder |
Heart Failure Clinics | 2010 |
|
Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells
W Ren, SW Watts, BL Fanburg |
AJP Lung Cellular and Molecular Physiology | 2010 |
|
Targeting non-malignant disorders with tyrosine kinase inhibitors
F Grimminger, RT Schermuly, HA Ghofrani |
Nature Reviews Drug Discovery | 2010 |
|
Tyrosine kinases in inflammatory dermatologic disease
RT Paniagua, DF Fiorentino, L Chung, WH Robinson |
Journal of the American Academy of Dermatology | 2010 |
|
The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis
Y Asano, AM Bujor, M Trojanowska |
Journal of Dermatological Science | 2010 |
|
Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies
SL Archer, EK Weir, MR Wilkins |
Circulation | 2010 |
|
Effects of HIV Protease Inhibitors on Progression of Monocrotaline- and Hypoxia-Induced Pulmonary Hypertension in Rats
G Gary-Bobo, A Houssaini, V Amsellem, D Rideau, P Pacaud, A Perrin, J Brégeon, E Marcos, JL Dubois-Randé, O Sitbon, L Savale, S Adnot |
Circulation | 2010 |
|
Sex Hormones and Vascular Protection in Pulmonary Arterial Hypertension
HA Christou, RA Khalil |
Journal of Cardiovascular Pharmacology | 2010 |
|
Reversible or Irreversible Remodeling in Pulmonary Arterial Hypertension
S Sakao, K Tatsumi, NF Voelkel |
American journal of respiratory cell and molecular biology | 2010 |
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Interleukin-6 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension
Y Furuya, T Satoh, M Kuwana |
International Journal of Rheumatology | 2010 |
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Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension
P Crosswhite, Z Sun |
Journal of Hypertension | 2010 |
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Novel approaches to treat experimental pulmonary arterial hypertension: a review
S Umar, P Steendijk, DL Ypey, DE Atsma, EE van der Wall, MJ Schalij, A der Laarse |
Journal of biomedicine & biotechnology | 2010 |
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Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis
S Nikolova, A Guenther, R Savai, N Weissmann, HA Ghofrani, M Konigshoff, O Eickelberg, W Klepetko, R Voswinckel, W Seeger, F Grimminger, RT Schermuly, SS Pullamsetti |
Respiratory Research | 2010 |
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Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy
HA Ghofrani, NW Morrell, MM Hoeper, H Olschewski, AJ Peacock, RJ Barst, S Shapiro, H Golpon, M Toshner, F Grimminger, S Pascoe |
American journal of respiratory and critical care medicine | 2010 |
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Schistosomiasis-Induced Experimental Pulmonary Hypertension
BB Graham, MM Mentink-Kane, H El-Haddad, S Purnell, L Zhang, A Zaiman, EF Redente, DW Riches, PM Hassoun, A Bandeira, HC Champion, G Butrous, TA Wynn, RM Tuder |
The American Journal of Pathology | 2010 |
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Right Ventricular Failure: A Novel Era of Targeted Therapy
D Banerjee, F Haddad, RT Zamanian, J Nagendran |
Current Heart Failure Reports | 2010 |
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A Central Role for CD68(+) Macrophages in Hepatopulmonary Syndrome
T Thenappan, A Goel, G Marsboom, YH Fang, PT Toth, HJ Zhang, H Kajimoto, Z Hong, J Paul, C Wietholt, J Pogoriler, L Piao, J Rehman, SL Archer |
American journal of respiratory and critical care medicine | 2010 |
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Gene Delivery of Cytochrome P450 Epoxygenase Ameliorates Monocrotaline-Induced Pulmonary Artery Hypertension in Rats
C Zheng, L Wang, R Li, B Ma, L Tu, X Xu, RT Dackor, DC Zeldin, DW Wang |
American journal of respiratory cell and molecular biology | 2010 |
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Lung Involvement in Systemic Sclerosis
PM Hassoun |
Presse medicale (Paris, France : 1983) | 2010 |
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Measuring right ventricular function in the normal and hypertensive mouse hearts using admittance-derived pressure-volume loops
DM Tabima, TA Hacker, NC Chesler |
American journal of physiology. Heart and circulatory physiology | 2010 |
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Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension
D Urboniene, I Haber, YH Fang, T Thenappan, SL Archer |
AJP Lung Cellular and Molecular Physiology | 2010 |
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Combination of Sildenafil and Simvastatin Ameliorates Monocrotaline-induced Pulmonary Hypertension in Rats
T Kuang, J Wang, B Pang, X Huang, ED Burg, JX Yuan, C Wang |
Pulmonary Pharmacology & Therapeutics | 2010 |
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Modulation of Gi Proteins in Hypertension: Role of Angiotensin II and Oxidative Stress
MB Anand-Srivastava |
Current cardiology reviews | 2010 |
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PPARgamma as a potential therapeutic target in pulmonary hypertension
RL Sutliff, BY Kang, CM Hart |
Therapeutic advances in respiratory disease | 2010 |
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Role for dysregulated endothelium-derived FGF2 signaling in progression of pulmonary hypertension
Mohamed Izikki, Christophe Guignabert, Elie Fadel, Marc Humbert, Ly Tu, Patricia Zadigue, Philippe Dartevelle, Gerald Simonneau, Serge Adnot, Bernard Maitre, Bernadette Raffestin, Saadia Eddahibi |
Journal of Clinical Investigation | 2009 |
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Wnt signaling regulates smooth muscle precursor development in the lung via a tenascin-C/platelet derived growth factor receptor pathway
Ethan David Cohen, Kaori Ihida-Stansbury, Min Min Lu, Reynold A. Panettieri, Peter L. Jones, and Edward E. Morrisey |
Journal of Clinical Investigation | 2009 |
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Synergy between proteasome inhibitors and imatinib mesylate in chronic myeloid leukemia
Z Hu, XF Pan, FQ Wu, LY Ma, DP Liu, Y Liu, TT Feng, FY Meng, XL Liu, QL Jiang, XQ Chen, JL Liu, P Liu, Z Chen, SJ Chen, GB Zhou |
PloS one | 2009 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Future Perspectives for the Treatment of Pulmonary Arterial Hypertension
HA Ghofrani, RJ Barst, RL Benza, HC Champion, KA Fagan, F Grimminger, M Humbert, G Simonneau, DJ Stewart, C Ventura, LJ Rubin |
Journal of the American College of Cardiology | 2009 |
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Recent Advances in the Treatment of Systemic Sclerosis
VK Bournia, PG Vlachoyiannopoulos, C Selmi, HM Moutsopoulos, ME Gershwin |
Clinical Reviews in Allergy & Immunology | 2009 |
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Transforming growth factor beta as a therapeutic target in systemic sclerosis
J Varga, B Pasche |
Nature reviews. Rheumatology | 2009 |
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Molecular framework for response to imatinib mesylate in systemic sclerosis
L Chung, DF Fiorentino, MJ Benbarak, AS Adler, MM Mariano, RT Paniagua, A Milano, MK Connolly, BD Ratiner, RL Wiskocil, ML Whitfield, HY Chang, WH Robinson |
Arthritis & Rheumatism | 2009 |
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Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype
BN Davis, AC Hilyard, PH Nguyen, G Lagna, A Hata |
The Journal of biological chemistry | 2009 |
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Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization
C Guignabert, CM Alvira, TP Alastalo, H Sawada, G Hansmann, M Zhao, L Wang, N El-Bizri, M Rabinovitch |
American journal of physiology. Lung cellular and molecular physiology | 2009 |
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Therapies for scleroderma-related pulmonary arterial hypertension
PM Hassoun |
Expert Review of Respiratory Medicine | 2009 |
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Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model
RE Nisbet, JM Bland, DJ Kleinhenz, PO Mitchell, ER Walp, RL Sutliff, CM Hart |
American journal of respiratory cell and molecular biology | 2009 |
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Angiogenic and inflammatory markers of cardiopulmonary changes in children and adolescents with sickle cell disease
X Niu, M Nouraie, A Campbell, S Rana, CP Minniti, C Sable, D Darbari, N Dham, NS Reading, JT Prchal, GJ Kato, MT Gladwin, OL Castro, VR Gordeuk |
PloS one | 2009 |
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Can we improve outcome of congenital diaphragmatic hernia?
L Hout, I Sluiter, S Gischler, AD Klein, R Rottier, H Ijsselstijn, I Reiss, D Tibboel |
Pediatric Surgery International | 2009 |
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Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis
RD Kenagy, N Fukai, SK Min, F Jalikis, TR Kohler, AW Clowes |
Journal of Vascular Surgery | 2009 |
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Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury
J Cortijo, A Iranzo, X Milara, M Mata, M Cerdá-Nicolás, A Ruiz-Saurí, H Tenor, A Hatzelmann, EJ Morcillo |
British Journal of Pharmacology | 2009 |
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Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells
C Wang, JF Li, L Zhao, J Liu, J Wan, YX Wang, J Wang, C Wang |
Respiratory Research | 2009 |
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Impaired Vasoconstriction and Nitric Oxide-Mediated Relaxation in Pulmonary Arteries of Hypoxia- and Monocrotaline-Induced Pulmonary Hypertensive Rats
V Mam, AF Tanbe, SH Vitali, E Arons, HA Christou, RA Khalil |
The Journal of pharmacology and experimental therapeutics | 2009 |
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Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats
A Csiszar, N Labinskyy, S Olson, JT Pinto, S Gupte, JM Wu, F Hu, P Ballabh, A Podlutsky, G Losonczy, R de Cabo, R Mathew, MS Wolin, Z Ungvari |
Hypertension | 2009 |
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Significant improvement of right ventricular function by imatinib mesylate in scleroderma-associated pulmonary arterial hypertension
H ten Freyhaus, D Dumitrescu, H Bovenschulte, E Erdmann, S Rosenkranz |
Clinical Research in Cardiology | 2009 |
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A Novel Antiproliferative BMP-2−PPARgamma−ApoE−Axis In Smooth Muscle Cells And Its Role In Pulmonary Hypertension
Georg Hansmann, Vinicio A. de Jesus Perez, Tero-Pekka Alastalo, Cristina M. Alvira, Christophe Guignabert, Janine M. Bekkers, Stefan Schellong, Takashi Urashima, Lingli Wang, Nicholas W. Morrell, Marlene Rabinovitch* |
Journal of Clinical Investigation | 2008 |
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Molecular pathogenesis of pulmonary arterial hypertension
Marlene Rabinovitch |
Journal of Clinical Investigation | 2008 |
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Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response
B Keserü, E Barbosa-Sicard, R Popp, B Fisslthaler, A Dietrich, T Gudermann, BD Hammock, JR Falck, N Weissmann, R Busse, I Fleming |
The FASEB Journal | 2008 |
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Role of platelet-derived growth factors in physiology and medicine
J Andrae, R Gallini, C Betsholtz |
Genes & development | 2008 |
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Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension
AL Zaiman, M Podowski, S Medicherla, K Gordy, F Xu, L Zhen, LA Shimoda, E Neptune, L Higgins, A Murphy, S Chakravarty, A Protter, PB Sehgal, HC Champion, RM Tuder |
American journal of respiratory and critical care medicine | 2008 |
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The cancer paradigm of severe pulmonary arterial hypertension
PR Rai, CD Cool, JA King, T Stevens, N Burns, RA Winn, M Kasper, NF Voelkel |
American journal of respiratory and critical care medicine | 2008 |
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Induction of vascular atrophy as a novel approach to treating restenosis. A review
SK Min, RD Kenagy, AW Clowes |
Journal of Vascular Surgery | 2008 |
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Prednisolone inhibits PDGF-induced nuclear translocation of NF-kappaB in human pulmonary artery smooth muscle cells
A Ogawa, AL Firth, W Yao, LJ Rubin, JX Yuan |
American journal of physiology. Lung cellular and molecular physiology | 2008 |
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The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice
RE Nisbet, AS Graves, DJ Kleinhenz, HL Rupnow, AL Reed, TH Fan, PO Mitchell, RL Sutliff, CM Hart |
American journal of respiratory cell and molecular biology | 2008 |
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Human herpesvirus-8 infection of primary pulmonary microvascular endothelial cells
TM Bull, CA Meadows, CD Coldren, M Moore, SM Sotto-Santiago, SP Nana-Sinkam, TB Campbell, MW Geraci |
American journal of respiratory cell and molecular biology | 2008 |
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Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension
L Moreno-Vinasco, M Gomberg-Maitland, ML Maitland, AA Desai, PA Singleton, S Sammani, L Sam, Y Liu, AN Husain, RM Lang, MJ Ratain, YA Lussier, JG Garcia |
Physiological genomics | 2008 |
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Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury
R Dumitrascu, S Koebrich, E Dony, N Weissmann, R Savai, SS Pullamsetti, HA Ghofrani, A Samidurai, H Traupe, W Seeger, F Grimminger, RT Schermuly |
BMC Pulmonary Medicine | 2008 |
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Pulmonary hypertension associated with COPD
Elwing J, Panos RJ |
International journal of chronic obstructive pulmonary disease | 2008 |
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Lungengefäßerkrankungen
Ghofrani A, Grimminger F, Mayer K, Olschewski H, Schranz D, Seeger W, Walmrath HD |
2008 | |
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The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted
S Bonnet, G Rochefort, G Sutendra, SL Archer, A Haromy, L Webster, K Hashimoto, SN Bonnet, ED Michelakis |
Proceedings of the National Academy of Sciences | 2007 |
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Pathology of pulmonary hypertension
RM Tuder, JC Marecki, A Richter, I Fijalkowska, S Flores |
Clinics in Chest Medicine | 2007 |
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Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice
R Paddenberg, P Stieger, AL Lilien, P Faulhammer, A Goldenberg, HH Tillmanns, W Kummer, RC Braun-Dullaeus |
Respiratory Research | 2007 |
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A refined radio-telemetry technique to monitor right ventricle or pulmonary artery pressures in rats: a useful tool in pulmonary hypertension research
ML Handoko, I Schalij, K Kramer, A Sebkhi, PE Postmus, WJ van der Laarse, WJ Paulus, A Vonk-Noordegraaf |
Pflügers Archiv : European journal of physiology | 2007 |
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Autoimmunity in systemic sclerosis: Current concepts
F Boin, A Rosen |
Current Rheumatology Reports | 2007 |
|
Wachstumsfaktoren
N Hunzelmann, S Eming, S Rosenkranz |
Zeitschrift für Rheumatologie | 2007 |
|
Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange
N Weissmann, A Dietrich, B Fuchs, H Kalwa, M Ay, R Dumitrascu, A Olschewski, U Storch, MM Schnitzler, HA Ghofrani, RT Schermuly, O Pinkenburg, W Seeger, F Grimminger, T Gudermann |
Proceedings of the National Academy of Sciences | 2006 |
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Effects of olmesartan, an AT1 receptor antagonist, on hypoxia-induced activation of ERK1/2 and pro-inflammatory signals in the mouse lung
Y Tanabe, Y Morikawa, T Kato, S Kanai, T Watakabe, A Nishijima, H Iwata, K Isobe, M Ishizaki, K Nakayama |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2006 |
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Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells
EJ Growcott, KG Spink, X Ren, S Afzal, KH Banner, J Wharton |
Respiratory Research | 2006 |
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Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells
CV Garat, D Fankell, PF Erickson, JE Reusch, NN Bauer, IF McMurtry, DJ Klemm |
Molecular and cellular biology | 2006 |
|
Long term imatinib treatment in pulmonary arterial hypertension
R Souza, O Sitbon, F Parent, G Simonneau, M Humbert |
Thorax | 2006 |
|
PDGF signaling in pulmonary arterial hypertension
RJ Barst |
Journal of Clinical Investigation | 2005 |
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