Stromal cell–derived factor–1 (SDF-1) is a chemokine with unique functions, including a role in the trafficking of primitive blood precursor cells. A better understanding at a molecular level of how the binding of SDF-1 to its cell surface receptor, CXCR4, elicits specific biological responses in these cells has now been achieved through the identification of PKC-ζ activation as a common downstream signal. This finding suggests that treatment of a variety of clinical conditions might benefit from the targeting of PKC-ζ.
Connie J. Eaves
Title and authors | Publication | Year |
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Prostate cancer stem cells.
Lang SH, Frame FM, Collins AT |
The Journal of Pathology | 2009 |
CXCR4 is required for the quiescence of primitive hematopoietic cells
Y Nie, YC Han, YR Zou |
Journal of Experimental Medicine | 2008 |
Hierarchy of molecular-pathway usage in bone marrow homing and its shift by cytokines
H Bonig, GV Priestley, T Papayannopoulou |
Blood | 2006 |