We used a spheroid model of colon carcinoma to analyze integrin dynamics as a function of the epithelial-mesenchymal transition (EMT), a process that provides a paradigm for understanding how carcinoma cells acquire a more aggressive phenotype. This EMT involves transcriptional activation of the β6 integrin subunit and a consequent induction of αvβ6 expression. This integrin enhances the tumorigenic properties of colon carcinoma, including activation of autocrine TGF-β and migration on interstitial fibronectin. Importantly, this study validates the clinical relevance of the EMT. Kaplan-Meier analysis of β6 expression in 488 colorectal carcinomas revealed a striking reduction in median survival time of patients with high β6 expression. Elevated receptor expression did not simply reflect increasing tumor stage, since log-rank analysis showed a more significant impact on the survival of patients with early-stage, as opposed to late-stage, disease. Cox regression analysis confirmed that this integrin is an independent variable for these tumors. These findings define the αvβ6 integrin as an important risk factor for early-stage disease and a novel therapeutic candidate for colorectal cancer.
Richard C. Bates, David I. Bellovin, Courtney Brown, Elizabeth Maynard, Bingyan Wu, Hisaaki Kawakatsu, Dean Sheppard, Peter Oettgen, Arthur M. Mercurio
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Blockade of αvβ6 and αvβ8 integrins with a chromogranin A-derived peptide inhibits TGFβ activation in tumors and suppresses tumor growth
Gasparri AM, Pocaterra A, Colombo B, Taiè G, Gnasso C, Gori A, Pozzi F, Smith A, Magni F, Ugolini A, Doglio M, Bonini MC, Mondino A, Corti A, Curnis F |
Journal of Experimental & Clinical Cancer Research : CR | 2025 |
The Combination of Oncolytic Virus and Antibody Blockade of TGF-β Enhances the Efficacy of αvβ6-Targeting CAR T Cells Against Pancreatic Cancer in an Immunocompetent Model
Zhao Z, Cutmore LC, Baleeiro RB, Hartlebury JJ, Brown N, Chard-Dunmall L, Lemoine N, Wang Y, Marshall JF |
Cancers | 2025 |
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Maltseva D, Nersisyan A, Tonevitsky A |
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The association and clinicopathological significance of Integrin alphavbeta6 and Rac1 expression in gastric carcinoma
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Frontiers in Oncology | 2024 |
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Si G, Chen X, Li Y, Yuan X |
Heliyon | 2024 |
Near-infrared imaging of head and neck squamous cell carcinoma using indocyanine green that targets the αvβ6 peptide.
Yuan Y, Fan T, Wang J, Yuan Y, Tao X |
Journal of Biomedical Optics | 2024 |
N6-methyladenosine modification and post-translational modification of epithelial–mesenchymal transition in colorectal cancer
Wang Y, Chen Y, Zhao M |
Discover. Oncology | 2024 |
Integrin αvβ6 mediates the immune escape through regulation of PD-L1 and serves as a novel marker for immunotherapy of colon carcinoma
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American journal of cancer research | 2024 |
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Johansen AM, Forsythe SD, McGrath CT, Barker G, Jimenez H, Paluri RK, Pasche BC |
Clinical cancer research : an official journal of the American Association for Cancer Research | 2024 |
(68)Ga-Trivehexin PET/CT: a promising novel tracer for primary hyperparathyroidism.
Kuyumcu S, Denizmen D, Has-Simsek D, Poyanli A, Uzum AK, Buyukkaya F, Isik EG, Onder S, Aksakal N, Ozkan ZG, Sanli Y |
European journal of nuclear medicine and molecular imaging | 2024 |
Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC.
Che X, Tian X, Wang Z, Zhu S, Ye S, Wang Y, Chen Y, Huang Y, Anwaier A, Yao P, Chen Y, Wu K, Liu Y, Xu W, Zhang H, Ye D |
Cancer cell international | 2024 |
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Science Advances | 2024 |
A stapled chromogranin A-derived peptide homes in on tumors that express αvβ6 or αvβ8 integrins
Monieri M, Rainone P, Sacchi A, Gori A, Gasparri AM, Coliva A, Citro A, Ferrara B, Policardi M, Valtorta S, Pocaterra A, Alfano M, Sheppard D, Piemonti L, Moresco RM, Corti A, Curnis F |
International journal of biological sciences | 2023 |
Colorectal polyps: Targets for fluorescence-guided endoscopy to detect high-grade dysplasia and T1 colorectal cancer.
Dekkers N, Zonoobi E, Dang H, Warmerdam MI, Crobach S, Langers AMJ, van der Kraan J, Hilling DE, Peeters KCMJ, Holman FA, Vahrmeijer AL, Sier CFM, Hardwick JCH, Boonstra JJ |
United European gastroenterology journal | 2023 |
An Overview of In Vitro Assays of 64Cu-, 68Ga-, 125I-, and 99mTc-Labelled Radiopharmaceuticals Using Radiometric Counters in the Era of Radiotheranostics
Benfante V, Stefano A, Ali M, Laudicella R, Arancio W, Cucchiara A, Caruso F, Cammarata FP, Coronnello C, Russo G, Miele M, Vieni A, Tuttolomondo A, Yezzi A, Comelli A |
Diagnostics | 2023 |
An immune, stroma, and epithelial-mesenchymal transition-related signature for predicting recurrence and chemotherapy benefit in stage II-III colorectal cancer.
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Cancer Medicine | 2023 |
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Brockmueller A, Sajeev A, Koklesova L, Samuel SM, Kubatka P, Büsselberg D, Kunnumakkara AB, Shakibaei M |
Cancer metastasis reviews | 2023 |
Nidogen-1/NID1 Function and Regulation during Progression and Metastasis of Colorectal Cancer
Rokavec M, Jaeckel S, Hermeking H |
Cancers | 2023 |
Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells
S Krishn, V Garcia, N Naranjo, F Quaglia, C Shields, M Harris, A Kossenkov, Q Liu, E Corey, D Altieri, L Languino |
Cancer biology & therapy | 2022 |
Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer
P Busenhart, A Montalban-Arques, E Katkeviciute, Y Morsy, C Passen, L Hering, K Atrott, S Lang, J Garzon, E Naschberger, A Hartmann, G Rogler, M Stürzl, M Spalinger, M Scharl |
Journal for ImmunoTherapy of Cancer | 2022 |
A comparison of 64Cu-labeled bi-terminally PEGylated A20FMDV2 peptides targeting integrin ανβ6
Huynh TT, Sreekumar S, Mpoy C, Rogers BE |
Oncotarget | 2022 |
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2022 | |
RNA N6-methyladenosine modification in regulating cancer stem cells and tumor immune microenvironment and its implication for cancer therapy.
Kumari S, Kumar S, Muthuswamy S |
Journal of Cancer Research and Clinical Oncology | 2022 |
Synthesis and Systematic Study on the Effect of Different PEG Units on Stability of PEGylated, Integrin-αvβ6-Specific A20FMDV2 Analogues in Rat Serum and Human Plasma.
Hung KY, Kowalczyk R, Desai A, Brimble MA, Marshall JF, Harris PWR |
Molecules (Basel, Switzerland) | 2022 |
ALDH1A3-Linc00284 Axis Mediates the Invasion of Colorectal Cancer by Targeting TGFβ Signaling via Sponging miR-361-5p.
Ke C, Shen M, Wang P, Chen Z, Lin S, Dong F |
International Journal of Genomics | 2022 |
Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment.
Brzozowska E, Deshmukh S |
International journal of molecular sciences | 2022 |
Pathogenesis of Fistulating Crohn’s Disease: A Review
McGregor CG, Tandon R, Simmons A |
Cellular and Molecular Gastroenterology and Hepatology | 2022 |
Neuropilin-1 and Integrins as Receptors for Chromogranin A-Derived Peptides.
Corti A, Anderluzzi G, Curnis F |
Pharmaceutics | 2022 |
Overcoming TGFβ-mediated immune evasion in cancer
DV Tauriello, E Sancho, E Batlle |
Nature Reviews Cancer | 2021 |
Extracellular matrix and its therapeutic potential for cancer treatment
J Huang, L Zhang, D Wan, L Zhou, S Zheng, S Lin, Y Qiao |
Signal Transduction and Targeted Therapy | 2021 |
Epithelial to Mesenchymal Transition: A Challenging Playground for Translational Research. Current Models and Focus on TWIST1 Relevance and Gastrointestinal Cancers
L Greco, F Rubbino, A Morelli, F Gaiani, F Grizzi, GL deAngelis, A Malesci, L Laghi |
International journal of molecular sciences | 2021 |
Integrins regulate stemness in solid tumor: an emerging therapeutic target
J Xiong, L Yan, C Zou, K Wang, M Chen, B Xu, Z Zhou, D Zhang |
Journal of Hematology & Oncology | 2021 |
Extracellular Vesicles: An Emerging Mechanism Governing the Secretion and Biological Roles of Tenascin-C
L Albacete-Albacete, M Sánchez-Álvarez, MA del Pozo |
Frontiers in immunology | 2021 |
CEA, EpCAM, αvβ6 and uPAR Expression in Rectal Cancer Patients with a Pathological Complete Response after Neoadjuvant Therapy
D Linders, M Deken, M van der Valk, W Tummers, S Bhairosingh, D Schaap, G van Lijnschoten, E Zonoobi, P Kuppen, C van de Velde, A Vahrmeijer, AF Sarasqueta, C Sier, D Hilling |
Diagnostics | 2021 |
Emerging therapeutic opportunities for integrin inhibitors
RJ Slack, SJ Macdonald, JA Roper, RG Jenkins, RJ Hatley |
Nature Reviews Drug Discovery | 2021 |
SPECT/CT Imaging, Biodistribution and Radiation Dosimetry of a 177Lu-DOTA-Integrin αvβ6 Cystine Knot Peptide in a Pancreatic Cancer Xenograft Model
S Sachindra, T Hellberg, S Exner, S Prasad, N Beindorff, S Rogalla, R Kimura, SS Gambhir, B Wiedenmann, C Grötzinger |
Frontiers in Oncology | 2021 |
Optimized serum stability and specificity of an αvβ6 integrin-binding peptide for tumor targeting
II Cardle, MC Jensen, SH Pun, DL Sellers |
The Journal of biological chemistry | 2021 |
Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression
M Kemper, A Schiecke, H Maar, S Nikulin, A Poloznikov, V Galatenko, M Tachezy, F Gebauer, T Lange, K Riecken, A Tonevitsky, A Aigner, J Izbicki, U Schumacher, D Wicklein |
Journal of Experimental & Clinical Cancer Research | 2021 |
Pilot-phase PET/CT study targeting integrin αvβ6 in pancreatic cancer patients using the cystine-knot peptide–based 18F-FP-R01-MG-F2
R Nakamoto, V Ferri, H Duan, N Hatami, M Goel, J Rosenberg, R Kimura, M Wardak, T Haywood, R Kellow, B Shen, W Park, A Iagaru, SS Gambhir |
European Journal of Nuclear Medicine and Molecular Imaging | 2021 |
Hyperglycemia Promotes Liver Metastasis of Colorectal Cancer via Upregulation of Integrin αvβ6
B Wang, S Wang, W Wang, E Liu, S Guo, C Zhao, J Niu, Z Zhang |
Medical science monitor : international medical journal of experimental and clinical research | 2021 |
Silencing of ITGB6 inhibits the progression of cervical carcinoma via regulating JAK/STAT3 signaling pathway
X Zheng, Y Zhu, X Wang, Y Hou, Y Fang |
Annals of translational medicine | 2021 |
Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions
D Banerjee, RK Tiwari |
2021 | |
Roles of Integrins in Gastrointestinal Cancer Metastasis
S Hou, J Wang, W Li, X Hao, Q Hang |
Frontiers in Molecular Biosciences | 2021 |
It’s Time to Shift the Paradigm: Translation and Clinical Application of Non-αvβ3 Integrin Targeting Radiopharmaceuticals
S Kossatz, AJ Beer, J Notni |
Cancers | 2021 |
The Extracellular Matrix in Soft Tissue Sarcomas: Pathobiology and Cellular Signalling
Pankova V, Thway K, Jones RL, Huang PH |
Frontiers in Cell and Developmental Biology | 2021 |
ITGB6 may promote proliferation and invasion in pancreatic cancer
Zhong C, Li ZX, Yang LJ, Wu G, Xiang B, Wang YL, Zhou Q |
Archives of Medical Science : AMS | 2021 |
The ITGB6 gene: its role in experimental and clinical biology
A Meecham, JF Marshall |
2020 | |
Identification of integrin β6 gene promoter and analysis of its transcription regulation in colon cancer cells
W Niu, QY Bo, J Niu, ZC Niu, C Peng, XQ Zou, ZY Zhang |
World journal of gastrointestinal oncology | 2020 |
The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis
SR Krishn, I Salem, F Quaglia, NM Naranjo, E Agarwal, Q Liu, S Sarker, J Kopenhaver, PA McCue, PH Weinreb, SM Violette, DC Altieri, LR Languino |
Journal of Extracellular Vesicles | 2020 |
Interactions Between Tumor Biology and Targeted Nanoplatforms for Imaging Applications
M Azizi, H DianatMoghadam, R Salehi, M Farshbaf, D Iyengar, S Sau, AK Iyer, H Valizadeh, M Mehrmohammadi, MR Hamblin |
Advanced Functional Materials | 2020 |
A disintegrin and metalloproteinase 8 induced epithelial‐mesenchymal transition to promote the invasion of colon cancer cells via TGF‐β/Smad2/3 signalling pathway
Q Jin, X Jin, T Liu, X Lu, G Wang, N He |
Journal of Cellular and Molecular Medicine | 2020 |
Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective
MS Ong, S Deng, CE Halim, W Cai, TZ Tan, RY Huang, G Sethi, SC Hooi, AP Kumar, CT Yap |
Cancers | 2020 |
Preclinical evaluation of [18F]FB-A20FMDV2 as a selective marker for measuring αVβ6 integrin occupancy using positron emission tomography in rodent lung
M Onega, CA Parker, C Coello, G Rizzo, N Keat, J Ramada-Magalhaes, S Moz, SP Tang, C Plisson, L Wells, S Ashworth, RJ Slack, G Vitulli, FJ Wilson, R Gunn, PT Lukey, J Passchier |
European Journal of Nuclear Medicine and Molecular Imaging | 2020 |
Integrin ανβ6 Protein Expression and Prognosis in Solid Tumors: A Meta-Analysis
A Desnoyers, C González, P Pérez-Segura, A Pandiella, E Amir, A Ocaña |
Molecular diagnosis & therapy | 2020 |
Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus
KM Moore, A Desai, B de Luxán Delgado, SM Trabulo, C Reader, NF Brown, ER Murray, A Brentnall, P Howard, L Masterson, F Zammarchi, JA Hartley, PH van Berkel, JF Marshall |
Theranostics | 2020 |
Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Cell Invasion through Integrin β 6 Upregulation in Colorectal Cancer
Q Sun, Y Shang, F Sun, X Dong, J Niu, F Li |
Oxidative medicine and cellular longevity | 2020 |
CAR T-Cells Targeting the Integrin αvβ6 and Co-Expressing the Chemokine Receptor CXCR2 Demonstrate Enhanced Homing and Efficacy against Several Solid Malignancies
LM Whilding, L Halim, B Draper, AC Parente-Pereira, T Zabinski, DM Davies, J Maher |
Cancers | 2019 |
High Mannose Binding Lectin (PFL) from Pseudomonas fluorescens Down-Regulates Cancer-Associated Integrins and Immune Checkpoint Ligand B7-H4
Y Sato, K Matsubara, T Kubo, H Sunayama, Y Hatori, K Morimoto, T Seyama |
Cancers | 2019 |
Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer
YK Man, J Foster, E Carapuça, JA Davies, AL Parker, J Sosabowski, G Halldén |
Scientific Reports | 2019 |
Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis
RH Kimura, L Wang, B Shen, L Huo, W Tummers, FV Filipp, HH Guo, T Haywood, L Abou-Elkacem, L Baratto, F Habte, R Devulapally, TH Witney, Y Cheng, S Tikole, S Chakraborti, J Nix, CA Bonagura, N Hatami, JJ Mooney, T Desai, S Turner, RS Gaster, A Otte, BC Visser, GA Poultsides, J Norton, W Park, M Stolowitz, K Lau, E Yang, A Natarajan, O Ilovich, S Srinivas, A Srinivasan, R Paulmurugan, J Willmann, FT Chin, Z Cheng, A Iagaru, F Li, SS Gambhir |
Nature Communications | 2019 |
Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment
Brown, Marshall |
Cancers | 2019 |
PET/CT Imaging of NSCLC with a αvβ6 Integrin-Targeting Peptide
P Flechsig, T Lindner, A Loktev, S Roesch, W Mier, M Sauter, M Meister, C Herold-Mende, U Haberkorn, A Altmann |
Molecular Imaging and Biology | 2019 |
Research progress on the relationship between lung cancer drug-resistance and microRNAs
X Ma, AL Liang, YJ Liu |
Journal of Cancer | 2019 |
Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis
MB Padua, P Bhat-Nakshatri, M Anjanappa, MS Prasad, Y Hao, X Rao, S Liu, J Wan, Y Liu, K McElyea, M Jacobsen, G Sandusky, S Althouse, S Perkins, H Nakshatri |
Breast Cancer Research | 2018 |
CTBP1 and metabolic syndrome induce an mRNA and miRNA expression profile critical for breast cancer progression and metastasis
PL Farré, GD Scalise, RB Duca, GN Dalton, C Massillo, J Porretti, K Graña, K Gardner, PD Luca, AD Siervi |
Oncotarget | 2018 |
Designer Oncolytic Adenovirus: Coming of Age
A Baker, C Aguirre-Hernández, G Halldén, A Parker |
Cancers | 2018 |
Korean Red Ginseng extract reduces hypoxia-induced epithelial-mesenchymal transition by repressing NF-κB and ERK1/2 pathways in colon cancer
EJ Kim, KA Kwon, YE Lee, JH Kim, SH Kim, JH Kim |
Journal of Ginseng Research | 2018 |
Transforming growth factor‑β1 and lysophosphatidic acid activate integrin β6 gene promoter in Hep‑3B cells
R Xu, M Xu, Y Fu, X Deng, H Han, X Chen, W He, G Chen |
Oncology Letters | 2018 |
Integrin αvβ6 plays a bi-directional regulation role between colon cancer cells and cancer-associated fibroblasts
C Peng, X Zou, W Xia, H Gao, Z Li, N Liu, Z Xu, C Gao, Z He, W Niu, R Fang, S Biswas, M Agrez, X Zhi, J Niu |
Bioscience Reports | 2018 |
Synchronous primary sigmoid colon cancer and primary thyroid cancer followed by a malignant tumor of the kidney: Case report of multiple primary cancer and review of the literature
C Peng, Z Li, H Gao, X Zou, X Wang, C Zhou, J Niu |
Oncology Letters | 2018 |
Epithelial–mesenchymal transition in Crohn’s disease
H Jiang, J Shen, Z Ran |
Mucosal Immunology | 2017 |
The clinical significance and underlying correlation of pStat-3 and integrin αvβ6 expression in gallbladder cancer
L Enyu, W Na, Z Chuanzong, W Ben, W Xiaojuan, W Yan, L Zequn, H Jianguo, W Jiayong, L Benjia, P Cheng, Z Min, Z Zongli |
Oncotarget | 2017 |
Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells
LM Whilding, AC Parente-Pereira, T Zabinski, DM Davies, RM Petrovic, YV Kao, SA Saxena, A Romain, JA Costa-Guerra, S Violette, H Itamochi, S Ghaem-Maghami, S Vallath, JF Marshall, J Maher |
Molecular Therapy | 2017 |
Epithelial Mesenchymal Transition (EMT) in Metastatic Breast Cancer in Omani Women
R Lakhtakia, A Aljarrah, M Furrukh, SS Ganguly |
Cancer Microenvironment | 2017 |
Exploring the Role of RGD-Recognizing Integrins in Cancer
M Nieberler, U Reuning, F Reichart, J Notni, HJ Wester, M Schwaiger, M Weinmüller, A Räder, K Steiger, H Kessler |
Cancers | 2017 |
Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch: Eps8: switching αvβ6 integrin function in pancreatic cancer
J Tod, CJ Hanley, MR Morgan, M Rucka, T Mellows, MA Lopez, P Kiely, KA Moutasim, SJ Frampton, D Sabnis, DR Fine, C Johnson, JF Marshall, G Scita, V Jenei, GJ Thomas |
The Journal of Pathology | 2017 |
Integrins as Therapeutic Targets: Successes and Cancers
S Raab-Westphal, J Marshall, S Goodman |
Cancers | 2017 |
Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy
NO Hodgins, WT Al-Jamal, JT Wang, R Klippstein, JK Sosabowski, JF Marshall, J Maher, KT Al-Jamal |
Journal of Controlled Release | 2017 |
Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions
K Steiger, AM Schlitter, W Weichert, I Esposito, HJ Wester, J Notni |
Molecular imaging | 2017 |
v 6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor
H Lu, T Wang, J Li, C Fedele, Q Liu, J Zhang, Z Jiang, D Jain, RV Iozzo, SM Violette, PH Weinreb, RJ Davis, D Gioeli, TJ FitzGerald, DC Altieri, LR Languino |
Cancer research | 2016 |
Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression
AL Tatler, A Habgood, J Porte, AE John, A Stavrou, E Hodge, C Kerama-Likoko, SM Violette, PH Weinreb, AJ Knox, G Laurent, H Parfrey, PJ Wolters, W Wallace, S Alberti, A Nordheim, G Jenkins |
The Journal of biological chemistry | 2016 |
Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis
AL Tatler, AT Goodwin, O Gbolahan, G Saini, J Porte, AE John, RL Clifford, SM Violette, PH Weinreb, H Parfrey, PJ Wolters, J Gauldie, M Kolb, G Jenkins, A Mora |
PloS one | 2016 |
The role of integrins in TGFβ activation in the tumour stroma
Z Khan, JF Marshall |
Cell and Tissue Research | 2016 |
Integrin β6 serves as an immunohistochemical marker for lymph node metastasis and promotes cell invasiveness in cholangiocarcinoma
Z Li, S Biswas, B Liang, X Zou, L Shan, Y Li, R Fang, J Niu |
Scientific Reports | 2016 |
High expression of integrin β 6 in association with the Rho-Rac pathway identifies a poor prognostic subgroup within HER2 amplified breast cancers
K Desai, MG Nair, JS Prabhu, A Vinod, A Korlimarla, S Rajarajan, R Aiyappa, RS Kaluve, A Alexander, PS Hari, G Mukherjee, RV Kumar, S Manjunath, M Correa, BS Srinath, S Patil, MS Prasad, KS Gopinath, RN Rao, SM Violette, PH Weinreb, TS Sridhar |
Cancer Medicine | 2016 |
Norcantharidin Suppresses Colon Cancer Cell Epithelial-Mesenchymal Transition by Inhibiting the αvβ6-ERK-Ets1 Signaling Pathway
C Peng, Z Li, Z Niu, W Niu, Z Xu, H Gao, W Niu, JY Wang, Z He, C Gao, P Lin, M Agrez, Z Zhang, J Niu |
Scientific Reports | 2016 |
Tumor specific delivery and therapy mediate by integrin β6-target immunoliposomes for β6-siRNA in colon carcinoma
L Song, Z Fan, N Jun, L Benjia, L Zequn, W Xilong, J Zhongming, H yong, W Xiaohong, C Kai, Y Zhenlin |
Oncotarget | 2016 |
Pseudotyped αvβ6 integrin-targeted adenovirus vectors for ovarian cancer therapies
H Uusi-Kerttula, J Davies, L Coughlan, S Hulin-Curtis, R Jones, L Hanna, JD Chester, AL Parker |
Oncotarget | 2016 |
CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer
C Woischke, C Blaj, EM Schmidt, S Lamprecht, J Engel, H Hermeking, T Kirchner, D Horst |
Oncotarget | 2016 |
Tenascin-C and integrins in cancer
T Yoshida, T Akatsuka, K Imanaka-Yoshida |
Cell adhesion & migration | 2015 |
Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models
Y Li, Y Drabsch, P Pujuguet, J Ren, T Laar, L Zhang, H Dam, P Clément-Lacroix, P Dijke |
Breast Cancer Research | 2015 |
Epithelial and Stromal Cell Urokinase Plasminogen Activator Receptor Expression Differentially Correlates with Survival in Rectal Cancer Stages B and C Patients
SB Ahn, C Chan, OF Dent, A Mohamedali, SY Kwun, C Clarke, J Fletcher, PH Chapuis, EC Nice, MS Baker, AW Lo |
PloS one | 2015 |
Integrin traffic - the update
ND Franceschi, H Hamidi, J Alanko, P Sahgal, J Ivaska |
Journal of cell science | 2015 |
Cloning and Characterization of the Human Integrin β6 Gene Promoter
M Xu, X Chen, H Yin, L Yin, F Liu, Y Fu, J Yao, X Deng, A Wijnen |
PloS one | 2015 |
Integrin β6 can be translationally regulated by eukaryotic initiation factor 4E: Contributing to colonic tumor malignancy
L Enyu, N Zhengchuan, W Jiayong, L Benjia, S Qi, Q Ruixi, P Cheng, AQ Khan, S Wei, N Jun |
Tumor Biology | 2015 |
Dexamethasone inhibits hypoxia-induced epithelial-mesenchymal transition in colon cancer
JH Kim |
World journal of gastroenterology : WJG | 2015 |
Integrin β6 acts as an unfavorable prognostic indicator and promotes cellular malignant behaviors via ERK-ETS1 pathway in pancreatic ductal adenocarcinoma (PDAC)
Z Li, P Lin, C Gao, C Peng, S Liu, H Gao, B Wang, J Wang, J Niu, W Niu |
Tumor Biology | 2015 |
Fibroblast surface-associated FGF-2 promotes contact-dependent colorectal cancer cell migration and invasion through FGFR-SRC signaling and integrin αvβ5-mediated adhesion.
Knuchel S, Anderle P, Werfelli P, Diamantis E, Rüegg C |
Oncotarget | 2015 |
Therapeutic Targeting of Integrin αvβ6 in Breast Cancer
KM Moore, GJ Thomas, SW Duffy, J Warwick, R Gabe, P Chou, IO Ellis, AR Green, S Haider, K Brouilette, A Saha, S Vallath, R Bowen, C Chelala, D Eccles, WJ Tapper, AM Thompson, P Quinlan, L Jordan, C Gillett, A Brentnall, S Violette, PH Weinreb, J Kendrew, ST Barry, IR Hart, JL Jones, JF Marshall |
JNCI Journal of the National Cancer Institute | 2014 |
99m Tc-Labeled Cystine Knot Peptide Targeting Integrin α v β 6 for Tumor SPECT Imaging
X Zhu, J Li, Y Hong, RH Kimura, X Ma, H Liu, C Qin, X Hu, TR Hayes, P Benny, SS Gambhir, Z Cheng |
Molecular Pharmaceutics | 2014 |
Identification and Characterization of a Suite of Tumor Targeting Peptides for Non-Small Cell Lung Cancer
MJ McGuire, BP Gray, S Li, D Cupka, LA Byers, L Wu, S Rezaie, YH Liu, N Pattisapu, J Issac, T Oyama, L Diao, JV Heymach, XJ Xie, JD Minna, KC Brown |
Scientific Reports | 2014 |
Protein expression of eIF4E and integrin αvβ6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction
Z Niu, J Wang, S Muhammad, W Niu, E Liu, C Peng, B Liang, Q Sun, S Obo, Z He, S Liu, X Zou, J Niu |
Cell & Bioscience | 2014 |
Correlations between Integrin ανβ6 Expression and Clinico-Pathological Features in Stage B and Stage C Rectal Cancer
SB Ahn, A Mohamedali, C Chan, J Fletcher, SY Kwun, C Clarke, OF Dent, PH Chapuis, E Nice, MS Baker |
PloS one | 2014 |
Role of H-Ras/ERK signaling in carbon nanotube-induced neoplastic-like transformation of human mesothelial cells
W Lohcharoenkal, L Wang, TA Stueckle, J Park, W Tse, CZ Dinu, Y Rojanasakul |
Frontiers in physiology | 2014 |
Dimerization of a Phage-Display Selected Peptide for Imaging of αvβ6- Integrin: Two Approaches to the Multivalent Effect
AN Singh, MJ McGuire, S Li, G Hao, A Kumar, X Sun, KC Brown |
Theranostics | 2014 |
Pathophysiology of fistula formation in Crohn's disease
M Scharl, G Rogler |
World journal of gastrointestinal pathophysiology | 2014 |
Characterization and Evaluation of 64Cu-Labeled A20FMDV2 Conjugates for Imaging the Integrin αvβ6
LY Hu, N Bauer, LM Knight, Z Li, S Liu, CJ Anderson, PS Conti, JL Sutcliffe |
Molecular Imaging and Biology | 2014 |
Integrin αvβ6 and transcriptional factor Ets-1 act as prognostic indicators in colorectal cancer
C Peng, H Gao, Z Niu, B Wang, Z Tan, W Niu, E Liu, J Wang, J Sun, M Shahbaz, M Agrez, J Niu |
Cell & Bioscience | 2014 |
Targeting of the β6 gene to suppress degradation of ECM via inactivation of the MAPK pathway in breast adenocarcinoma cells
Y Zhang, L Wei, J Yu, G Li, X Zhang, A Wang, Y He, H Li, D Yin |
Oncology reports | 2014 |
Tumor Targeting via Integrin Ligands
UK Marelli, F Rechenmacher, TR Sobahi, C Mas-Moruno, H Kessler |
Frontiers in Oncology | 2013 |
Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis
N Sakai, AM Tager |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 |
The role for dickkopf-homolog-1 in the pathogenesis of Crohn's disease-associated fistulae
SM Frei, C Hemsley, T Pesch, S Lang, A Weber, E Jehle, A Rühl, M Fried, G Rogler, M Scharl |
PloS one | 2013 |
Epithelial-mesenchymal plasticity in carcinoma metastasis
JH Tsai, J Yang |
Genes & development | 2013 |
A liposomal drug platform overrides peptide ligand targeting to a cancer biomarker, irrespective of ligand affinity or density
BP Gray, MJ McGuire, KC Brown |
PloS one | 2013 |
Binding of αvβ1 and αvβ6 integrins to tenascin-C induces epithelial-mesenchymal transition-like change of breast cancer cells
D Katoh, K Nagaharu, N Shimojo, N Hanamura, M Yamashita, Y Kozuka, K Imanaka-Yoshida, T Yoshida |
Oncogenesis | 2013 |
Structural guided scaffold phage display libraries as a source of bio-therapeutics
YK Man, D DiCara, N Chan, S Vessillier, SJ Mather, ML Rowe, MJ Howard, JF Marshall, A Nissim |
PloS one | 2013 |
18F-fluorobenzoate-labeled cystine knot peptides for PET imaging of integrin αvβ6
BJ Hackel, RH Kimura, Z Miao, H Liu, A Sathirachinda, Z Cheng, FT Chin, SS Gambhir |
Journal of Nuclear Medicine | 2013 |
Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma
X Mao, S Miao, H He, S Miao, R Pei, X Yang, C Xiu, K Song, J Zhang, J Sun, S Jia, Q Guan |
Tumor Biology | 2013 |
Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β
A Bianchi-Smiraglia, D Kunnev, M Limoge, A Lee, M Beckerle, A Bakin |
Cell cycle (Georgetown, Tex.) | 2013 |
From Phage Display to Nanoparticle Delivery: Functionalizing Liposomes with Multivalent Peptides Improves Targeting to a Cancer Biomarker
BP Gray, S Li, KC Brown |
Bioconjugate Chemistry | 2013 |
The role of the myofibroblast in tumor stroma remodeling
M Otranto, V Sarrazy, F Bonté, B Hinz, G Gabbiani, A Desmouliere |
Cell adhesion & migration | 2012 |
aV integrins and TGF-β-induced EMT: a circle of regulation
FA Mamuya, MK Duncan |
Journal of Cellular and Molecular Medicine | 2012 |
Integrin α9β1 promotes malignant tumor growth and metastasis by potentiating epithelial-mesenchymal transition
SK Gupta, S Oommen, MC Aubry, BP Williams, NE Vlahakis |
Oncogene | 2012 |
Integrin Trafficking and Tumor Progression
S Shin, L Wolgamott, SO Yoon |
International Journal of Cell Biology | 2012 |
Matched rabbit monoclonal antibodies against αv-series integrins reveal a novel αvβ3-LIBS epitope, and permit routine staining of archival paraffin samples of human tumors
SL Goodman, HJ Grote, C Wilm |
Biology Open | 2012 |
RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis
M Sutherland, A Gordon, SD Shnyder, LH Patterson, HM Sheldrake |
Cancers | 2012 |
Elevated Preoperative Carcinoembryonic Antigen (CEA) and Ki67 Is Predictor of Decreased Survival in IIA Stage Colon Cancer
Y Peng, L Wang, J Gu |
World Journal of Surgery | 2012 |
C2-O-sLeX glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells
CA st Hill, D Baharo-Hassan, M Farooqui |
PloS one | 2011 |
Tenascin C Induces Epithelial-Mesenchymal Transition–Like Change Accompanied by SRC Activation and Focal Adhesion Kinase Phosphorylation in Human Breast Cancer Cells
K Nagaharu, X Zhang, T Yoshida, D Katoh, N Hanamura, Y Kozuka, T Ogawa, T Shiraishi, K Imanaka-Yoshida |
The American Journal of Pathology | 2011 |
Chemically Programmed Antibodies Targeting Multiple Alpha(v) Integrins and Their Effects on Tumor-Related Functions in vitro
RK Goswami, KM Bajjuri, JS Forsyth, S Das, W Hassenpflug, ZZ Huang, RA Lerner, B Felding-Habermann, SC Sinha |
Bioconjugate Chemistry | 2011 |
The role of tumour stroma in colorectal cancer invasion and metastasis
J Conti, G Thomas |
Cancers | 2011 |
Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer
RH Kimura, R Teed, BJ Hackel, MA Pysz, CZ Chuang, A Sathirachinda, JK Willmann, SS Gambhir |
Clinical cancer research | 2011 |
Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells
Y Lei, K Huang, C Gao, QC Lau, H Pan, K Xie, J Li, R Liu, T Zhang, N Xie, HS Nai, H Wu, Q Dong, X Zhao, EC Nice, C Huang, Y Wei |
Molecular & cellular proteomics : MCP | 2011 |
Synthesis and biological evaluation of a peptide–paclitaxel conjugate which targets the integrin αvβ6
S Li, BP Gray, MJ McGuire, KC Brown |
Bioorganic & Medicinal Chemistry | 2011 |
Why integrin as a primary target for imaging and therapy.
Niu G, Chen X |
Theranostics | 2011 |
Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor-β1/Snail Activation Aggravates Invasive Growth of Cholangiocarcinoma
Y Sato, K Harada, K Itatsu, H Ikeda, Y Kakuda, S Shimomura, XS Ren, N Yoneda, M Sasaki, Y Nakanuma |
The American Journal of Pathology | 2010 |
Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing
C Margadant, A Sonnenberg |
EMBO reports | 2010 |
Integrins in cancer: biological implications and therapeutic opportunities
JS Desgrosellier, DA Cheresh |
Nature Reviews Cancer | 2010 |
Tropism-Modification Strategies for Targeted Gene Delivery Using Adenoviral Vectors
L Coughlan, R Alba, AL Parker, AC Bradshaw, IA McNeish, SA Nicklin, AH Baker |
Viruses | 2010 |
Oxidative stress induced mechanisms in the progression of periodontal diseases and cancer: a common approach to redox homeostasis?
M Soory |
Cancers | 2010 |
Integrin signaling and lung cancer.
Caccavari F, Valdembri D, Sandri C, Bussolino F, Serini G |
Cell adhesion & migration | 2010 |
Biomarkers for epithelial-mesenchymal transitions
Michael Zeisberg1 and Eric G. Neilson2 |
Journal of Clinical Investigation | 2009 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Mechanisms of the epithelial-mesenchymal transition by TGF-beta
MK Wendt, TM Allington, WP Schiemann |
Future oncology (London, England) | 2009 |
Revisiting the seed and soil in cancer metastasis
M Mendoza, C Khanna |
The International Journal of Biochemistry & Cell Biology | 2009 |
High-throughput in vivo screening of targeted molecular imaging agents
MK Gagnon, SH Hausner, J Marik, CK Abbey, JF Marshall, JL Sutcliffe |
Proceedings of the National Academy of Sciences | 2009 |
Norcantharidin induces HT-29 colon cancer cell apoptosis through the ��v��6���extracellular signal-related kinase signaling pathway
C Peng, X Liu, E Liu, K Xu, W Niu, R Chen, J Wang, Z Zhang, P Lin, J Wang, M Agrez, J Niu |
Cancer Science | 2009 |
MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells
JS Guthi, SG Yang, G Huang, S Li, C Khemtong, CW Kessinger, M Peyton, JD Minna, KC Brown, J Gao |
Molecular Pharmaceutics | 2009 |
Synthesis and characterization of a high-affinity α v β 6 -specific ligand for in vitro and in vivo applications
S Li, MJ McGuire, M Lin, YH Liu, T Oyama, X Sun, KC Brown |
Molecular cancer therapeutics | 2009 |
Targeted In vivo Imaging of Integrin α v β 6 with an Improved Radiotracer and Its Relevance in a Pancreatic Tumor Model
SH Hausner, CK Abbey, RJ Bold, MK Gagnon, J Marik, JF Marshall, CE Stanecki, JL Sutcliffe |
Cancer research | 2009 |
Defining the role of integrin alphavbeta6 in cancer.
Bandyopadhyay A, Raghavan S |
Current drug targets | 2009 |
Matrix metalloproteinase‐2 expression in stromal tissues is a consistent prognostic factor in stage II colon cancer
Inafuku Y, Furuhata T, Tayama M, Okita K, Nishidate T, Mizuguchi T, Kimura Y, Hirata K |
Cancer Science | 2009 |
Engineering a single-chain Fv antibody to alpha v beta 6 integrin using the specificity-determining loop of a foot-and-mouth disease virus
H Kogelberg, B Tolner, GJ Thomas, DD Cara, S Minogue, B Ramesh, S Sodha, D Marsh, MW Lowdell, T Meyer, RH Begent, I Hart, JF Marshall, K Chester |
Journal of Molecular Biology | 2008 |
PAI-1 and functional blockade of SNAI1 in breast cancer cell migration
E Fabre-Guillevin, M Malo, A Cartier-Michaud, H Peinado, G Moreno-Bueno, B Vallée, DA Lawrence, J Palacios, A Cano, G Barlovatz-Meimon, C Charrière-Bertrand |
Breast Cancer Research | 2008 |
Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front
OD Wever, P Pauwels, BD Craene, M Sabbah, S Emami, G Redeuilh, C Gespach, M Bracke, G Berx |
Histochemistry and Cell Biology | 2008 |
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
U Burk, J Schubert, U Wellner, O Schmalhofer, E Vincan, S Spaderna, T Brabletz |
EMBO reports | 2008 |
Intestinal adenomagenesis involves core molecular signatures of the epithelial–mesenchymal transition
X Chen, RB Halberg, RP Burch, WF Dove |
Journal Of Molecular Histology | 2008 |
Transforming Growth Factor β Controls the Directional Migration of Hepatocyte Cohorts by Modulating Their Adhesion to Fibronectin
F Binamé, P Lassus, U Hibner, CH Heldin |
Molecular biology of the cell | 2008 |
Peptide-Targeted Polyglutamic Acid Doxorubicin Conjugates for the Treatment of α v β 6 -Positive Cancers
H Guan, MJ McGuire, S Li, KC Brown |
Bioconjugate Chemistry | 2008 |
In Vivo Positron Emission Tomography (PET) Imaging with an α v β 6 Specific Peptide Radiolabeled using 18 F-“Click” Chemistry: Evaluation and Comparison with the Corresponding 4-[ 18 F]Fluorobenzoyl- and 2-[ 18 F]Fluoropropionyl-Peptides
SH Hausner, J Marik, MK Gagnon, JL Sutcliffe |
Journal of Medicinal Chemistry | 2008 |
Integrin alphavbeta6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver
Yang G, Xu K, Pan Z, Zhang Z, Mi Y, Wang J, Chen R, Niu J |
Cancer Science | 2008 |
Constitutively Activated Stat3 Induces Tumorigenesis and Enhances Cell Motility of Prostate Epithelial Cells through Integrin β6
J Azare, K Leslie, H Al-Ahmadie, W Gerald, PH Weinreb, SM Violette, J Bromberg |
Molecular and cellular biology | 2007 |
Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia
G Guasch, M Schober, HA Pasolli, EB Conn, L Polak, E Fuchs |
Cancer Cell | 2007 |
Role of αvβ6 Integrin in Acute Biliary Fibrosis
B Wang, BM Dolinski, N Kikuchi, DR Leone, MG Peters, PH Weinreb, SM Violette, DM Bissell |
Hepatology | 2007 |
Signaling networks guiding epithelial–mesenchymal transitions during embryogenesis and cancer progression
Moustakas A, Heldin C |
Cancer Science | 2007 |
P-selectin activates integrin-mediated colon carcinoma cell adhesion to fibronectin
ME Reyes-Reyes, MD George, JD Roberts, SK Akiyama |
Experimental Cell Research | 2006 |