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Kyoko Katakura, … , Lars Eckmann, Eyal Raz
Published March 1, 2005
Citation Information: J Clin Invest. 2005;115(3):695-702. https://doi.org/10.1172/JCI22996.
Citation Information: J Clin Invest. 2005;115(3):695-702. https://doi.org/10.1172/JCI22996.
Abstract
Experimental colitis is mediated by inflammatory or dysregulated immune responses to microbial factors of the gastrointestinal tract. In this study we observed that administration of Toll-like receptor 9 (TLR9) agonists suppressed the severity of experimental colitis in RAG1–/– but not in SCID mice. This differential responsiveness between phenotypically similar but genetically distinct animals was related to a partial blockade in TLR9 signaling and defective production of type I IFN (i.e., IFN-α/β) in SCID mice upon TLR9 stimulation. The addition of neutralization antibodies against type I IFN abolished the antiinflammatory effects induced by TLR9 agonists, whereas the administration of recombinant IFN-β mimicked the antiinflammatory effects induced by TLR9 agonists in this model. Furthermore, mice deficient in the IFN-α/β receptor exhibited more severe colitis than wild-type mice did upon induction of experimental colitis. These results indicate that TLR9-triggered type I IFN has antiinflammatory functions in colitis. They also underscore the important protective role of type I IFN in intestinal homeostasis and suggest that strategies to modulate innate immunity may be of therapeutic value for the treatment of intestinal inflammatory conditions.
Authors
Kyoko Katakura, Jongdae Lee, Daniel Rachmilewitz, Gloria Li, Lars Eckmann, Eyal Raz
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Citations to this article (224)
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|
Strategies for targeting cytokines in inflammatory bowel disease.
Neurath MF |
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|
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Paudel D, Nair DV, Tian S, Hao F, Goand UK, Joseph G, Prodes E, Chai Z, Robert CE, Chassaing B, Patterson AD, Singh V |
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|
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Maler MD, Zwick S, Kallfass C, Engelhard P, Shi H, Hellig L, Zhengyang P, Hardt A, Zissel G, Ruzsics Z, Jahnen-Dechent W, Martin SF, Nielsen PJ, Stolz D, Lopatecka J, Bastyans S, Beutler B, Schamel WW, Fejer G, Freudenberg MA |
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|
Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation
Casado-Bedmar M, Roy M, Berthet L, Hugot JP, Yang C, Manceau H, Peoc\u2019h K, Chassaing B, Merlin D, Viennois E |
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|
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NOD2-mediated dual negative regulation of inflammatory responses triggered by TLRs in the gastrointestinal tract.
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|
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|
Ninjurin1 deficiency differentially mitigates colorectal cancer induced by azoxymethane and dextran sulfate sodium in male and female mice
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|
The protein kinase R modifies gut physiology to limit colitis
Yim HC, Chakrabarti A, Kessler S, Morimoto H, Wang D, Sooraj D, Ahmed AU, de la Motte C, Silverman RH, Williams BR, Sadler AJ |
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|
Diet prevents the expansion of segmented filamentous bacteria and ileo-colonic inflammation in a model of Crohn's disease.
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|
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Cell-penetrating TLR inhibitor peptide alleviates ulcerative colitis by the functional modulation of macrophages
Thapa B, Pak S, Chung D, Shin HK, Lee SH, Lee K |
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|
Effect of Clostridium butyricum on High-Fat Diet-Induced Intestinal Inflammation and Production of Short-Chain Fatty Acids.
Choi Y, Choi SI, Kim N, Nam RH, Jang JY, Na HY, Shin CM, Lee DH, Min H, Kim YR, Seok YJ |
Digestive Diseases and Sciences | 2023 |
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Temporary consumption of western diet trains the immune system to reduce future gut inflammation
Wu D, Wang X, Yang X, Gu L, McGeachy MJ, Liu X |
iScience | 2023 |
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Inflammatory Bowel Disease: Emerging Therapies and Future Treatment Strategies
Bretto E, Ribaldone DG, Caviglia GP, Saracco GM, Bugianesi E, Frara S |
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Regulation of type I IFN responses by deubiquitinating enzyme A in inflammatory bowel diseases
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Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice
Vasquez Ayala A, Hsu CY, Oles RE, Matsuo K, Loomis LR, Buzun E, Carrillo Terrazas M, Gerner RR, Lu HH, Kim S, Zhang Z, Park JH, Rivaud P, Thomson M, Lu LF, Min B, Chu H |
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Tao R, Zong G, Pan Y, Li H, Cheng P, Deng R, Chen W, Wang A, Xia S, Tang W, Lu Y, Wei Z |
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The HIF-prolyl hydroxylases have distinct and non-redundant roles in colitis-associated cancer
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|
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|
The intestinal clock drives the microbiome to maintain gastrointestinal homeostasis
Heddes M, Altaha B, Niu Y, Reitmeier S, Kleigrewe K, Haller D, Kiessling S |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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J Li, S Yu, X Pan, M Zhang, Z Lv, LL Pan, J Sun |
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|
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|
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|
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Zhou Y, Duan L, Zeng Y, Niu L, Pu Y, Jacobs JP, Chang C, Wang J, Khalique A, Pan K, Fang J, Jing B, Zeng D, Ni X |
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|
Epithelial Toll-like receptors and their role in gut homeostasis and disease
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|
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E Viennois, A Bretin, PE Dubé, AC Maue, CJ Dauriat, N Barnich, AT Gewirtz, B Chassaing |
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|
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|
Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations
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|
Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis
J Wu, Z Wei, P Cheng, C Qian, F Xu, Y Yang, A Wang, W Chen, Z Sun, Y Lu |
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|
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HY Won, JY Lee, D Ryu, HT Kim, SY Chang |
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|
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P Scarozza, H Schmitt, G Monteleone, MF Neurath, R Atreya |
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|
Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases
HQ Tran, RE Ley, AT Gewirtz, B Chassaing |
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|
Complex Bacterial Consortia Reprogram the Colitogenic Activity of Enterococcus faecalis in a Gnotobiotic Mouse Model of Chronic, Immune-Mediated Colitis
I Lengfelder, IG Sava, JJ Hansen, K Kleigrewe, J Herzog, K Neuhaus, T Hofmann, RB Sartor, D Haller |
Frontiers in immunology | 2019 |
|
IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses
RA Gottschalk, MG Dorrington, B Dutta, KS Krauss, AJ Martins, S Uderhardt, W Chan, JS Tsang, P Torabi-Parizi, ID Fraser, RN Germain |
eLife | 2019 |
|
Host-derived fecal microRNAs can indicate gut microbiota healthiness and ability to induce inflammation
E Viennois, B Chassaing, A Tahsin, A Pujada, L Wang, AT Gewirtz, D Merlin |
Theranostics | 2019 |
|
Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine
M Kumar, M Garand, SA Khodor |
Journal of Translational Medicine | 2019 |
|
Type I interferons and endoplasmic reticulum stress in health and disease
Sprooten J, Garg AD |
International review of cell and molecular biology | 2019 |
|
Neuroimmune Communication in Health and Disease
C Reardon, K Murray, AE Lomax |
Physiological reviews | 2018 |
|
The cholinergic anti-inflammatory pathway revisited
K Murray, C Reardon |
Neurogastroenterology and Motility | 2018 |
|
Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment
M Kasembeli, U Bharadwaj, P Robinson, D Tweardy |
International journal of molecular sciences | 2018 |
|
Plasmacytoid Dendritic Cells Are Largely Dispensable for the Pathogenesis of Experimental Inflammatory Bowel Disease
CM Sawai, L Serpas, AG Neto, G Jang, A Rashidfarrokhi, R Kolbeck, MA Sanjuan, B Reizis, V Sisirak |
Frontiers in immunology | 2018 |
|
Enteric Virome Sensing—Its Role in Intestinal Homeostasis and Immunity
R Metzger, A Krug, K Eisenächer |
Viruses | 2018 |
|
Increased Pancreatic Protease Activity in Response to Antibiotics Impairs Gut Barrier and Triggers Colitis
H Yoon, M Schaubeck, I Lagkouvardos, A Blesl, S Heinzlmeir, H Hahne, T Clavel, S Panda, C Ludwig, B Kuster, C Manichanh, P Kump, D Haller, G Hörmannsperger |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2018 |
|
Mice harboring pathobiont-free microbiota do not develop intestinal inflammation that normally results from an innate immune deficiency
B Chassaing, AT Gewirtz, M Chamaillard |
PloS one | 2018 |
|
MIS416 Enhances Therapeutic Functions of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Experimental Colitis by Modulating Systemic Immune Milieu
BC Lee, N Shin, JY Lee, I Kang, JJ Kim, SE Lee, SW Choi, GA Webster, KS Kang |
Frontiers in immunology | 2018 |
|
Toll-like Receptors and Inflammatory Bowel Disease
Y Lu, X Li, S Liu, Y Zhang, D Zhang |
Frontiers in immunology | 2018 |
|
Regulatory T-Cells Mediate IFN-α-Induced Resistance against Antigen-Induced Arthritis
SC Narendra, JP Chalise, S Biggs, U Kalinke, M Magnusson |
Frontiers in immunology | 2018 |
|
Distinct Effects of Type I and III Interferons on Enteric Viruses
H Ingle, S Peterson, M Baldridge |
Viruses | 2018 |
|
Microbial Changes and Host Response in F344 Rat Colon Depending on Sex and Age Following a High-Fat Diet
SM Lee, N Kim, H Yoon, RH Nam, DH Lee |
Frontiers in microbiology | 2018 |
|
Mononuclear phagocyte system in hepatitis C virus infection
Y Yang, ZK Tu, XK Liu, P Zhang |
World journal of gastroenterology : WJG | 2018 |
|
Nucleic Acid Induced Interferon and Inflammasome Responses in Regulating Host Defense to Gastrointestinal Viruses.
Dubois H, van Loo G, Wullaert A |
International review of cell and molecular biology | 2018 |
|
Type I and III Interferon in the Gut: Tight Balance between Host Protection and Immunopathology
J Pott, S Stockinger |
Frontiers in immunology | 2017 |
|
The Protective Role of Type I Interferons in the Gastrointestinal Tract
KP Kotredes, B Thomas, AM Gamero |
Frontiers in immunology | 2017 |
|
Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans
E Viennois, Y Zhao, MK Han, B Xiao, M Zhang, M Prasad, L Wang, D Merlin |
Scientific Reports | 2017 |
|
Molecular Pathogenesis and Signal Transduction by Helicobacter pylori
N Tegtmeyer, S Backert |
Molecular Pathogenesis and Signal Transduction by Helicobacter pylori | 2017 |
|
Therapeutic effect of imiquimod on dextran sulfate sodium-induced ulcerative colitis in mice
L Chen, Z Zhou, Y Yang, N Chen, H Xiang, MT Khayyal |
PloS one | 2017 |
|
High frequency of intestinal T H 17 cells correlates with microbiota alterations and disease activity in multiple sclerosis
I Cosorich, G Dalla-Costa, C Sorini, R Ferrarese, MJ Messina, J Dolpady, E Radice, A Mariani, PA Testoni, F Canducci, G Comi, V Martinelli, M Falcone |
Science Advances | 2017 |
|
Supplementation of Low- and High-fat Diets with Fermentable Fiber Exacerbates Severity of DSS-induced Acute Colitis:
JP Miles, J Zou, MV Kumar, M Pellizzon, E Ulman, M Ricci, AT Gewirtz, B Chassaing |
Inflammatory Bowel Diseases | 2017 |
|
Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β
Q Zhu, TD Kanneganti |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
|
Co-supplementation of isomalto-oligosaccharides potentiates metabolic health benefits of polyphenol-rich cranberry extract in high fat diet-fed mice via enhanced gut butyrate production
DP Singh, S Singh, V Bijalwan, V Kumar, P Khare, RK Baboota, P Singh, RK Boparai, J Singh, KK Kondepudi, K Chopra, M Bishnoi |
European Journal of Nutrition | 2017 |
|
Transcriptomic Landscape of Treatment—Naïve Ulcerative Colitis
H Taman, CG Fenton, IV Hensel, E Anderssen, J Florholmen, RH Paulssen |
Journal of Crohn's & colitis | 2017 |
|
The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation
MC Canesso, L Lemos, TC Neves, FM Marim, TB Castro, ÉS Veloso, CP Queiroz, J Ahn, HC Santiago, FS Martins, J Alves-Silva, E Ferreira, DC Cara, AT Vieira, GN Barber, SC Oliveira, AM Faria |
Mucosal Immunology | 2017 |
|
Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases
Z Zhou, M Ding, L Huang, G Gilkeson, R Lang, W Jiang |
Clinical Immunology | 2016 |
|
Mining gut microbiome oligopeptides by functional metaproteome display
J Zantow, S Just, I Lagkouvardos, S Kisling, S Dübel, P Lepage, T Clavel, M Hust |
Scientific Reports | 2016 |
|
Clinical Effects of a Topically Applied Toll-like Receptor 9 Agonist in Active Moderate-to-Severe Ulcerative Colitis
R Atreya, S Bloom, F Scaldaferri, V Gerardi, C Admyre, Å Karlsson, T Knittel, J Kowalski, M Lukas, R Löfberg, S Nancey, R Petryka, G Rydzewska, R Schnabel, U Seidler, MF Neurath, C Hawkey |
Journal of Crohn's & colitis | 2016 |
|
Inhibition of Interleukin-10 Signaling Induces Microbiota-dependent Chronic Colitis in Apolipoprotein E Deficient Mice:
V Singh, M Kumar, BS Yeoh, X Xiao, P Saha, MJ Kennett, M Vijay-Kumar |
Inflammatory Bowel Diseases | 2016 |
|
Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease
K Kamdar, S Khakpour, J Chen, V Leone, J Brulc, T Mangatu, DA Antonopoulos, EB Chang, SA Kahn, BS Kirschner, G Young, RW DePaolo |
Cell Host & Microbe | 2016 |
|
Imiquimod-induced CCR9 Ameliorates murine TNBS Colitis
R Suzuki, K Katakura, T Fujiwara, N Gunji, H Watanabe, H Ohira |
FUKUSHIMA JOURNAL OF MEDICAL SCIENCE | 2016 |
|
Decreased Frequency of Intestinal Regulatory CD5+ B Cells in Colonic Inflammation
Y Mishima, S Ishihara, A Oka, N Fukuba, N Oshima, H Sonoyama, N Yamashita, Y Tada, R Kusunoki, I Moriyama, T Yuki, K Kawashima, Y Kinoshita, E Mizoguchi |
PloS one | 2016 |
|
Citrobacter rodentium NleB Protein Inhibits Tumor Necrosis Factor (TNF) Receptor-associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production
X Gao, TH Pham, LA Feuerbacher, K Chen, MP Hays, G Singh, C Rueter, R Hurtado-Guerrero, PR Hardwidge |
The Journal of biological chemistry | 2016 |
|
Type I Interferons Control Proliferation and Function of the Intestinal Epithelium
YV Katlinskaya, KV Katlinski, A Lasri, N Li, DP Beiting, AC Durham, T Yang, E Pikarsky, CJ Lengner, FB Johnson, Y Ben-Neriah, SY Fuchs |
Molecular and cellular biology | 2016 |
|
Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces
C Nakahashi-Oda, KG Udayanga, Y Nakamura, Y Nakazawa, N Totsuka, H Miki, S Iino, S Tahara-Hanaoka, S Honda, K Shibuya, A Shibuya |
Nature Immunology | 2016 |
|
Hydrogen peroxide scavenger, catalase, alleviates ion transport dysfunction in murine colitis
KE Barrett, DF McCole |
Clinical and Experimental Pharmacology and Physiology | 2016 |
|
Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation
K Arimura, H Takagi, T Uto, T Fukaya, T Nakamura, N Choijookhuu, Y Hishikawa, Y Yamashita, K Sato |
Mucosal Immunology | 2016 |
|
Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis
K Flück, G Breves, J Fandrey, S Winning |
Mucosal Immunology | 2015 |
|
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
B Chassaing, O Koren, JK Goodrich, AC Poole, S Srinivasan, RE Ley, AT Gewirtz |
Nature | 2015 |
|
The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense
S Hu, L Peng, YT Kwak, EM Tekippe, C Pasare, JS Malter, LV Hooper, MH Zaki |
Cell Reports | 2015 |
|
Salmonella Typhimurium Co-Opts the Host Type I IFN System To Restrict Macrophage Innate Immune Transcriptional Responses Selectively
DJ Perkins, R Rajaiah, SM Tennant, G Ramachandran, EE Higginson, TN Dyson, SN Vogel |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
|
The role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasis
MR Spalinger, M Scharl |
United European gastroenterology journal | 2015 |
|
Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence
M Schaubeck, T Clavel, J Calasan, I Lagkouvardos, SB Haange, N Jehmlich, M Basic, A Dupont, M Hornef, M Bergen, A Bleich, D Haller |
Gut | 2015 |
|
A gp130–Src–YAP module links inflammation to epithelial regeneration
K Taniguchi, LW Wu, SI Grivennikov, PR de Jong, I Lian, FX Yu, K Wang, SB Ho, BS Boland, JT Chang, WJ Sandborn, G Hardiman, E Raz, Y Maehara, A Yoshimura, J Zucman-Rossi, KL Guan, M Karin |
Nature | 2015 |
|
Involvement of DNA-PKcs in the Type I IFN Response to CpG-ODNs in Conventional Dendritic Cells in TLR9-Dependent or -Independent Manners
C Ma, NP Spies, T Gong, CX Jones, WM Chu, L Gabriele |
PloS one | 2015 |
|
Surface-Associated Lipoproteins Link Enterococcus faecalis Virulence to Colitogenic Activity in IL-10-Deficient Mice Independent of Their Expression Levels
S Ocvirk, IG Sava, I Lengfelder, I Lagkouvardos, N Steck, JH Roh, S Tchaptchet, Y Bao, JJ Hansen, J Huebner, IM Carroll, BE Murray, RB Sartor, D Haller, RH Valdivia |
PLoS pathogens | 2015 |
|
Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid
F Semple, H MacPherson, S Webb, F Kilanowski, L Lettice, SL McGlasson, AP Wheeler, V Chen, GL Millhauser, L Melrose, DJ Davidson, JR Dorin, G Sirugo |
PLoS genetics | 2015 |
|
Adequate Dextran Sodium Sulfate-induced Colitis Model in Mice and Effective Outcome Measurement Method
YH Park, N Kim, YK Shim, YJ Choi, RH Nam, YJ Choi, MH Ham, JH Suh, SM Lee, CM Lee, H Yoon, HS Lee, DH Lee |
Journal of Cancer Prevention | 2015 |
|
Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation
JB Fan, S Miyauchi-Ishida, K Arimoto, D Liu, M Yan, CW Liu, B Győrffy, DE Zhang |
Proceedings of the National Academy of Sciences | 2015 |
|
MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis
Runtsch MC, Hu R, Alexander M, Wallace J, Kagele D, Petersen C, Valentine JF, Welker NC, Bronner MP, Chen X, Smith DP, Ajami NJ, Petrosino JF, Round JL, O'Connell RM |
Oncotarget | 2015 |
|
Osteopontin expression by CD103- dendritic cells drives intestinal inflammation
E Kourepini, M Aggelakopoulou, T Alissafi, N Paschalidis, DC Simoes, V Panoutsakopoulou |
Proceedings of the National Academy of Sciences | 2014 |
|
Inflammasome activation has an important role in the development of spontaneous colitis
J Zhang, S Fu, S Sun, Z Li, B Guo |
Mucosal Immunology | 2014 |
|
Multiple roles of toll-like receptor 4 in colorectal cancer
D Yesudhas, V Gosu, MA Anwar, S Choi |
Frontiers in immunology | 2014 |
|
Cytokines in inflammatory bowel disease
MF Neurath |
Nature Reviews Immunology | 2014 |
|
Preconditioning with Intravenous Colitic Cell-Free DNA Prevents DSS-Colitis by Altering TLR9-Associated Gene Expression Profile
G Műzes, F Sipos, I Fűri, M Constantinovits, S Spisák, B Wichmann, G Valcz, Z Tulassay, B Molnár |
Digestive Diseases and Sciences | 2014 |
|
Plasmacytoid Dendritic Cells Mediate Anti-inflammatory Responses to a Gut Commensal Molecule via Both Innate and Adaptive Mechanisms
S Dasgupta, D Erturk-Hasdemir, J Ochoa-Reparaz, HC Reinecker, DL Kasper |
Cell Host & Microbe | 2014 |
|
The role of type I interferons in intestinal infection, homeostasis, and inflammation
H Cho, BL Kelsall |
Immunological Reviews | 2014 |
|
Type I Interferons in Bacterial Infections: Taming of Myeloid Cells and Possible Implications for Autoimmunity
EM Eshleman, LL Lenz |
Frontiers in immunology | 2014 |
|
Fetal exposure to maternal inflammation does not affect postnatal development of genetically-driven ileitis and colitis
J Hemmerling, K Heller, G Hörmannsperger, M Bazanella, T Clavel, G Kollias, D Haller |
PloS one | 2014 |
|
Intravenous Administration of a Single-Dose Free-Circulating DNA of Colitic Origin Improves Severe Murine DSS-Colitis
F Sipos, G Műzes, I Fűri, S Spisák, B Wichmann, TM Germann, M Constantinovits, T Krenács, Z Tulassay, B Molnár |
Pathology & Oncology Research | 2014 |
|
C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation
N Waldschmitt, E Berger, E Rath, RB Sartor, B Weigmann, M Heikenwalder, M Gerhard, KP Janssen, D Haller |
Mucosal Immunology | 2014 |
|
Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer
E Viennois, B Xiao, S Ayyadurai, L Wang, PG Wang, Q Zhang, Y Chen, D Merlin |
Laboratory Investigation | 2014 |
|
Ontogeny of Intestinal Epithelial Innate Immune Responses
MW Hornef, M Fulde |
Frontiers in immunology | 2014 |
|
Trp53 deficiency protects against acute intestinal inflammation
ME Spehlmann, CF Manthey, SM Dann, E Hanson, SS Sandhu, LY Liu, FK Abdelmalak, MA Diamanti, K Retzlaff, J Scheller, S Rose-John, FR Greten, JY Wang, L Eckmann |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
|
SUSTAINED TL1A (TNFSF15) EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS
L Zheng, X Zhang, J Chen, R Ichikawa, K Wallace, C Pothoulakis, HW Koon, SR Targan, DQ Shih |
European Journal of Microbiology and Immunology | 2013 |
|
New targets for mucosal healing and therapy in inflammatory bowel diseases
MF Neurath |
Mucosal Immunology | 2013 |
|
Role of the gut microbiota in immunity and inflammatory disease
N Kamada, SU Seo, GY Chen, G Núñez |
Nature Reviews Immunology | 2013 |
|
IDO1 Metabolites Activate β-catenin Signaling to Promote Cancer Cell Proliferation and Colon Tumorigenesis in Mice
AI Thaker, MS Rao, KS Bishnupuri, TA Kerr, L Foster, JM Marinshaw, RD Newberry, WF Stenson, MA Ciorba |
Gastroenterology | 2013 |
|
Pro-Inflammatory Signaling by IL-10 and IL-22: Bad Habit Stirred Up by Interferons?
H Mühl |
Frontiers in immunology | 2013 |
|
Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cell-mediated colitis
A Kole, JP He, A Rivollier, DD Silveira, K Kitamura, KJ Maloy, BL Kelsall |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
|
Type I interferon protects against pneumococcal invasive disease by inhibiting bacterial transmigration across the lung
KS LeMessurier, H Häcker, L Chi, E Tuomanen, V Redecke |
PLoS pathogens | 2013 |
|
Interferon alpha inhibits antigen-specific production of proinflammatory cytokines and enhances antigen-specific transforming growth factor beta production in antigen-induced arthritis
J Chalise, S Narendra, B Paudyal, M Magnusson |
Arthritis Research & Therapy | 2013 |
|
The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity
Y Wang, I Shaked, SM Stanford, W Zhou, JM Curtsinger, Z Mikulski, ZR Shaheen, G Cheng, K Sawatzke, AM Campbell, JL Auger, H Bilgic, FM Shoyama, DO Schmeling, HH Balfour, K Hasegawa, AC Chan, JA Corbett, BA Binstadt, MF Mescher, K Ley, N Bottini, EJ Peterson |
Immunity | 2013 |
|
Indoleamine 2,3 dioxygenase in intestinal disease
MA Ciorba |
Current Opinion in Gastroenterology | 2013 |
|
Protection against colitis by CD100-dependent modulation of intraepithelial γδ T lymphocyte function
TF Meehan, DA Witherden, CH Kim, K Sendaydiego, I Ye, O Garijo, HK Komori, A Kumanogoh, H Kikutani, L Eckmann, WL Havran |
Mucosal Immunology | 2013 |
|
High fat diet accelerates pathogenesis of murine Crohn's disease-like ileitis independently of obesity
L Gruber, S Kisling, P Lichti, FP Martin, S May, M Klingenspor, M Lichtenegger, M Rychlik, D Haller |
PloS one | 2013 |
|
Plasmacytoid dendritic cells are crucial in Bifidobacterium adolescentis-mediated inhibition of Yersinia enterocolitica infection
A Wittmann, IB Autenrieth, JS Frick |
PloS one | 2013 |
|
Generation of mouse small intestinal epithelial cell lines that allow the analysis of specific innate immune functions
J Schwerk, M Köster, H Hauser, M Rohde, M Fulde, MW Hornef, T May |
PloS one | 2013 |
|
Involvement of DNA-PKcs in the IL-6 and IL-12 response to CpG-ODN is mediated by its interaction with TRAF6 in dendritic cells
C Ma, M Muranyi, CH Chu, J Zhang, WM Chu |
PloS one | 2013 |
|
PTPN22 in Autoimmunity: Different Cell and Different Way
LB Ivashkiv |
Immunity | 2013 |
|
Microbial Activation of Gut Dendritic Cells and the Control of Mucosal Immunity
JL Owen, M Mohamadzadeh |
Journal of Interferon & Cytokine Research | 2013 |
|
Properties of myenteric neurones and mucosal functions in the distal colon of diet-induced obese mice
F Reichardt, C Baudry, L Gruber, G Mazzuoli, R Moriez, C Scherling, P Kollmann, H Daniel, S Kisling, D Haller, M Neunlist, M Schemann |
The Journal of Physiology | 2013 |
|
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock
E Aksoy, S Taboubi, D Torres, S Delbauve, A Hachani, MA Whitehead, WP Pearce, I Berenjeno-Martin, G Nock, A Filloux, R Beyaert, V Flamand, B Vanhaesebroeck |
Nature Immunology | 2012 |
|
Immunomodulatory functions of type I interferons
JM González-Navajas, J Lee, M David, E Raz |
Nature Reviews Immunology | 2012 |
|
TLR9 is important for protection against intestinal damage and for intestinal repair
WA Rose, K Sakamoto, CA Leifer |
Scientific Reports | 2012 |
|
Fecal Lipocalin 2, a Sensitive and Broadly Dynamic Non-Invasive Biomarker for Intestinal Inflammation
B Chassaing, G Srinivasan, MA Delgado, AN Young, AT Gewirtz, M Vijay-Kumar |
PloS one | 2012 |
|
Type I Interferons Maintain Foxp3 Expression and T-Regulatory Cell Functions Under Inflammatory Conditions in Mice
SE Lee, X Li, JC Kim, J Lee, JM González–Navajas, SH Hong, IK Park, JH Rhee, E Raz |
Gastroenterology | 2012 |
|
Toll-like receptor 9 (TLR9) polymorphism associated with symptomatic malaria: a cohort study
AH Omar, M Yasunami, A Yamazaki, H Shibata, MF Ofori, BD Akanmori, MN Shuaibu, M Kikuchi, K Hirayama |
Malaria Journal | 2012 |
|
Murine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits
AM McKnite, ME Perez-Munoz, L Lu, EG Williams, S Brewer, PA Andreux, JW Bastiaansen, X Wang, SD Kachman, J Auwerx, RW Williams, AK Benson, DA Peterson, DC Ciobanu |
PloS one | 2012 |
|
Novel Players in Inflammatory Bowel Disease Pathogenesis
SF Murphy, JH Kwon, DL Boone |
Current Gastroenterology Reports | 2012 |
|
The interferon signature and STAT1 expression in rheumatoid arthritis synovial fluid macrophages are induced by tumor necrosis factor α and counter-regulated by the synovial fluid microenvironment
RA Gordon, G Grigoriev, A Lee, GD Kalliolias, LB Ivashkiv |
Arthritis & Rheumatism | 2012 |
|
Chemoproteomic Profiling Identifies Changes in DNA-PK as Markers of Early Dengue Virus Infection
ML Vetter, MA Rodgers, MP Patricelli, PL Yang |
ACS chemical biology | 2012 |
|
Methyl deficient diet aggravates experimental colitis in rats
M Chen, L Peyrin-Biroulet, A George, F Coste, A Bressenot, C Bossenmeyer-Pourie, JM Alberto, B Xia, B Namour, JL Guéant |
Journal of Cellular and Molecular Medicine | 2011 |
|
Constitutive TL1A (TNFSF15) Expression on Lymphoid or Myeloid Cells Leads to Mild Intestinal Inflammation and Fibrosis
DQ Shih, R Barrett, X Zhang, N Yeager, HW Koon, P Phaosawasdi, Y Song, B Ko, MH Wong, KS Michelsen, G Martins, C Pothoulakis, SR Targan, MM Heimesaat |
PloS one | 2011 |
|
Mucosal Macrophages in Intestinal Homeostasis and Inflammation
AM Mowat, CC Bain |
Journal of Innate Immunity | 2011 |
|
Localized delivery of interferon-β by Lactobacillus exacerbates experimental colitis
AP McFarland, R Savan, S Wagage, A Addison, K Ramakrishnan, M Karwan, T Duong, HA Young |
PloS one | 2011 |
|
Wound healing of intestinal epithelial cells
M Iizuka, S Konno |
World journal of gastroenterology : WJG | 2011 |
|
Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis
XD Li, YH Chiu, AS Ismail, CL Behrendt, M Wight-Carter, LV Hooper, ZJ Chen |
Proceedings of the National Academy of Sciences | 2011 |
|
Immunomodulatory mechanisms of lactobacilli
JM Wells |
Microbial cell factories | 2011 |
|
Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation
C Reardon, M Lechmann, A Brüstle, MG Gareau, N Shuman, D Philpott, SF Ziegler, TW Mak |
Immunity | 2011 |
|
Regulation of Cysteinyl Leukotriene Receptor 2 Expression—A Potential Anti-Tumor Mechanism
C Magnusson, AM Bengtsson, M Liu, J Liu, Y Ceder, R Ehrnström, A Sjölander |
PloS one | 2011 |
|
The TLR7 ligand Imiquimod induces type I IFN and antimicrobial peptides to ameliorate DSS-induced acute colitis
SK Sainathan, KS Bishnupuri, K Aden, Q Luo, CW Houchen, S Anant, BK Dieckgraefe |
Inflammatory Bowel Diseases | 2011 |
|
Cell-intrinsic role for IFN-α-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response
HS Li, A Gelbard, GJ Martinez, E Esashi, H Zhang, H Nguyen-Jackson, YJ Liu, WW Overwijk, SS Watowich |
Blood | 2011 |
|
Helicobacter pylori DNA decreases pro-inflammatory cytokine production by dendritic cells and attenuates dextran sodium sulphate-induced colitis
J Luther, SY Owyang, T Takeuchi, TS Cole, M Zhang, M Liu, J Erb-Downward, JH Rubenstein, CC Chen, AV Pierzchala, JA Paul, JY Kao |
Gut | 2011 |
|
Aberrant plasmacytoid dendritic cell distribution and function in patients with Crohn's disease and ulcerative colitis: pDC in Crohn's disease and ulcerative colitis
DC Baumgart, D Metzke, O Guckelberger, A Pascher, C Grötzinger, I Przesdzing, Y Dörffel, J Schmitz, S Thomas |
Clinical & Experimental Immunology | 2011 |
|
TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis
Jose M Gonzalez-Navajas, Sean Fine, Jason Law, Sandip Datta, Kim Phung Nguyen, Mandy Yu, Maripat Corr, kyoko katakura, Lars Eckmann, Jongdae Lee, Eyal Raz |
Journal of Clinical Investigation | 2010 |
|
Nucleotide-binding Oligomerization Domain 1 Contributes to Host Defense against Helicobacter pylori via Induction of Type I IFN and Activation of the IFN-stimulated Gene Factor 3 Signaling Pathway
Tomohiro Watanabe, Naoki Asano, Stefan Fichtner-Feigl, Peter Gorelick, Yoshihisa Tsuji, Yuko Matsumoto, Tsutomu Chiba, Ivan J Fuss, Atsushi Kitani, Warren Strober |
Journal of Clinical Investigation | 2010 |
|
Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production
JM González-Navajas, J Law, KP Nguyen, M Bhargava, MP Corr, N Varki, L Eckmann, HM Hoffman, J Lee, E Raz |
Journal of Experimental Medicine | 2010 |
|
Toll-like receptors in inflammatory bowel diseases: A decade later
E Cario |
Inflammatory Bowel Diseases | 2010 |
|
STAT2 contributes to promotion of colorectal and skin carcinogenesis
AM Gamero, MR Young, R Mentor-Marcel, G Bobe, AJ Scarzello, J Wise, NH Colburn |
Cancer prevention research (Philadelphia, Pa.) | 2010 |
|
Activation of Toll-like receptor 9 attenuates unilateral ureteral obstruction-induced renal fibrosis
B Xin, X Wang, W Jin, H Yan, B Cui, X Zhang, F Hua, H Yang, Z Hu |
Acta Pharmacologica Sinica | 2010 |
|
Commensal Escherichia coli Reduces Epithelial Apoptosis through IFN-αA–Mediated Induction of Guanylate Binding Protein-1 in Human and Murine Models of Developing Intestine
J Mirpuri, JC Brazil, AJ Berardinelli, TR Nasr, K Cooper, M Schnoor, PW Lin, CA Parkos, NA Louis |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
|
Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis
MA Ciorba, EE Bettonville, KG McDonald, R Metz, GC Prendergast, RD Newberry, WF Stenson |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
|
Microbe–dendritic cell dialogue controls regulatory T-cell fate
JR Grainger, JA Hall, N Bouladoux, G Oldenhove, Y Belkaid |
Immunological Reviews | 2010 |
|
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18
R Salcedo, A Worschech, M Cardone, Y Jones, Z Gyulai, RM Dai, E Wang, W Ma, D Haines, C O'hUigin, FM Marincola, G Trinchieri |
Journal of Experimental Medicine | 2010 |
|
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
MT Abreu |
Nature Reviews Immunology | 2010 |
|
Innate immune mechanisms of colitis and colitis-associated colorectal cancer
M Saleh, G Trinchieri |
Nature Reviews Immunology | 2010 |
|
Overview of the biology of type I interferons
GD Kalliolias, LB Ivashkiv |
Arthritis Research & Therapy | 2010 |
|
Inflammatory bowel diseases: when natural friends turn into enemies-the importance of CpG motifs of bacterial DNA in intestinal homeostasis and chronic intestinal inflammation
F Obermeier, C Hofmann, W Falk |
International Journal of Inflammation | 2010 |
|
Toll-like receptor 9 gene mutations and polymorphisms in Japanese ulcerative colitis patients
K Fuse, K Katakura, N Sakamoto, H Ohira |
World journal of gastroenterology : WJG | 2010 |
|
The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis
MJ van Vliet, HJ Harmsen, ES de Bont, WJ Tissing |
PLoS pathogens | 2010 |
|
Probiotics: From Bench to Market: Probiotics: From Bench to Market
M Klein, ME Sanders, T Duong, HA Young |
Annals of the New York Academy of Sciences | 2010 |
|
Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis
SC Gribar, CP Sodhi, WM Richardson, RJ Anand, GK Gittes, MF Branca, A Jakub, X Shi, S Shah, JA Ozolek, DJ Hackam |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
|
A role for CD47 in the development of experimental colitis mediated by SIRPalpha+CD103- dendritic cells
G Fortin, M Raymond, VQ Van, M Rubio, P Gautier, M Sarfati, D Franchimont |
Journal of Experimental Medicine | 2009 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
|
Latent cytomegalovirus infection exacerbates experimental colitis
C Onyeagocha, MS Hossain, A Kumar, RM Jones, J Roback, AT Gewirtz |
The American Journal of Pathology | 2009 |
|
Current concepts regarding the pathogenesis of necrotizing enterocolitis
M Petrosyan, YS Guner, M Williams, A Grishin, HR Ford |
Pediatric Surgery International | 2009 |
|
The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis
EC Lavelle, C Murphy, LA O’Neill, EM Creagh |
Mucosal Immunology | 2009 |
|
Microbes in gastrointestinal health and disease
AS Neish |
Gastroenterology | 2009 |
|
Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA
CD Sadik, M Bachmann, J Pfeilschifter, H Mühl |
Nucleic Acids Research | 2009 |
|
Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: impact on chronic inflammation
G Hoermannsperger, G Hörmannsperger, T Clavel, M Hoffmann, C Reiff, D Kelly, G Loh, M Blaut, G Hölzlwimmer, M Laschinger, D Haller |
PloS one | 2009 |
|
TLR8-mediated activation of human monocytes inhibits TL1A expression
M Saruta, KS Michelsen, LS Thomas, QT Yu, CJ Landers, SR Targan |
European Journal of Immunology | 2009 |
|
Probiotics and immunity
AT Borchers, C Selmi, FJ Meyers, CL Keen, ME Gershwin |
Journal of Gastroenterology | 2009 |
|
Mechanism of cytokine modulation of epithelial tight junction barrier.
Al-Sadi R, Boivin M, Ma T |
2009 | |
|
Muramyl Dipeptide Activation of Nucleotide Binding Oligomerization Domain 2 Protects Mice from Experimental Colitis
Tomohiro Watanabe Naoki Asano Peter J Murray Keiko Ozato Prafullakumar Tailor Ivan J Fuss Atsushi Kitani Warren Strober |
Journal of Clinical Investigation | 2008 |
|
Inflammatory bowel disease, past, present and future: lessons from animal models
A Mizoguchi, E Mizoguchi |
Journal of Gastroenterology | 2008 |
|
Immunopathogenesis of inflammatory bowel disease
DQ Shih, SR Targan |
World journal of gastroenterology : WJG | 2008 |
|
Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury
WP Pulskens, GJ Teske, LM Butter, JJ Roelofs, T der Poll, S Florquin, JC Leemans |
PloS one | 2008 |
|
Toll-like receptors in inflammatory bowel disease-stepping into uncharted territory
A Levin, O Shibolet |
World journal of gastroenterology : WJG | 2008 |
|
Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses
JA Hall, N Bouladoux, CM Sun, EA Wohlfert, RB Blank, Q Zhu, ME Grigg, JA Berzofsky, Y Belkaid |
Immunity | 2008 |
|
Molecular mechanisms of the anti-inflammatory functions of interferons
P Kovarik, I Sauer, B Schaljo |
Immunobiology | 2008 |
|
Therapeutic correction of bacterial dysbiosis discovered by molecular techniques
RB Sartor |
Proceedings of the National Academy of Sciences | 2008 |
|
Opposing functions of IKKbeta during acute and chronic intestinal inflammation
L Eckmann, T Nebelsiek, AA Fingerle, SM Dann, J Mages, R Lang, S Robine, MF Kagnoff, RM Schmid, M Karin, MC Arkan, FR Greten |
Proceedings of the National Academy of Sciences | 2008 |
|
Synergistic benefit in inflammatory arthritis by targeting I kappaB kinase epsilon and interferon beta
M Corr, DL Boyle, L Ronacher, N Flores, GS Firestein |
Annals of the rheumatic diseases | 2008 |
|
Important Role for Toll-Like Receptor 9 in Host Defense against Meningococcal Sepsis
H Sjölinder, TH Mogensen, M Kilian, AB Jonsson, SR Paludan |
Infection and immunity | 2008 |
|
Systemic control of plasmacytoid dendritic cells by CD8+ T cells and commensal microbiota.
Fujiwara D, Wei B, Presley LL, Brewer S, McPherson M, Lewinski MA, Borneman J, Braun J |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
|
Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells
X Zhang, E Deriaud, X Jiao, D Braun, C Leclerc, R Lo-Man |
Journal of Experimental Medicine | 2007 |
|
Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells
K Abe, KP Nguyen, SD Fine, JH Mo, C Shen, S Shenouda, M Corr, S Jung, J Lee, L Eckmann, E Raz |
Proceedings of the National Academy of Sciences | 2007 |
|
Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis
SK Sainathan, EM Hanna, Q Gong, KS Bishnupuri, Q Luo, M Colonna, FV White, E Croze, C Houchen, S Anant, BK Dieckgraefe |
Inflammatory Bowel Diseases | 2007 |
|
Clostridium butyricum TO-A Culture Supernatant Downregulates TLR4 in Human Colonic Epithelial Cells
A Isono, T Katsuno, T Sato, T Nakagawa, Y Kato, N Sato, G Seo, Y Suzuki, Y Saito |
Digestive Diseases and Sciences | 2007 |
|
Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis
JR Thiagarajah, D Zhao, AS Verkman |
Gut | 2007 |
|
Antiinfective applications of toll-like receptor 9 agonists
AM Krieg |
Proceedings of the American Thoracic Society | 2007 |
|
Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk
HJ Wu, H Sawaya, B Binstadt, M Brickelmaier, A Blasius, L Gorelik, U Mahmood, R Weissleder, J Carulli, C Benoist, D Mathis |
Journal of Experimental Medicine | 2007 |
|
Flagellin suppresses epithelial apoptosis and limits disease during enteric infection
M Vijay-Kumar, H Wu, R Jones, G Grant, B Babbin, TP King, D Kelly, AT Gewirtz, AS Neish |
The American Journal of Pathology | 2006 |
|
Twist mediates suppression of inflammation by type I IFNs and Axl
MN Sharif, D Šošić, CV Rothlin, E Kelly, G Lemke, EN Olson, LB Ivashkiv |
Journal of Experimental Medicine | 2006 |
|
GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice
L Santucci, M Agostini, S Bruscoli, A Mencarelli, S Ronchetti, E Ayroldi, A Morelli, M Baldoni, C Riccardi |
Gut | 2006 |
|
Activation of anti-hepatitis C virus responses via Toll-like receptor 7
J Lee, CC Wu, KJ Lee, TH Chuang, K Katakura, YT Liu, M Chan, R Tawatao, M Chung, C Shen, HB Cottam, MM Lai, E Raz, DA Carson |
Proceedings of the National Academy of Sciences | 2006 |
|
Involvement of lymphocytes in dextran sulfate sodium-induced experimental colitis
Kim TW, Seo JN, Suh YH, Park HJ, Kim JH, Kim JY, Oh KI |
World journal of gastroenterology : WJG | 2006 |
|
Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn's disease patients
H Braat, P Stokkers, T Hommes, D Cohn, E Vogels, I Pronk, A Spek, A Kampen, S Deventer, M Peppelenbosch, D Hommes |
Journal of Molecular Medicine | 2005 |
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NOD2 regulation of Toll-like receptor responses and the pathogenesis of Crohn's disease
T Watanabe, A Kitani, W Strober |
Gut | 2005 |
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Illuminating the role of type I IFNs in colitis
S Wirtz, MF Neurath |
Journal of Clinical Investigation | 2005 |
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