Complements of the house
Eric A. Schon
Eric A. Schon
Published September 15, 2004
Citation Information: J Clin Invest. 2004;114(6):760-762. https://doi.org/10.1172/JCI22942.
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Commentary

Complements of the house

Abstract

Finding mutations in nuclear genes responsible for disorders in the mitochondrial oxidative phosphorylation system has been a tedious matter. A “Venn diagram” approach — not unlike a classic complementation experiment — reported in this issue will now make the search easier.

Authors

Eric A. Schon

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Figure 2

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Venn diagram approach used by Kirby et al. (6). Smiling and frowning fac...
Venn diagram approach used by Kirby et al. (6). Smiling and frowning faces indicate elevated complex I activity (indicating rescue of the phenotype) and reduced complex I activity, respectively. The diagrams show only some of the possible combinations of outcomes.