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Progress on new vaccine strategies for the immunotherapy and prevention of cancer
Jay A. Berzofsky, … , John E. Janik, John C. Morris
Jay A. Berzofsky, … , John E. Janik, John C. Morris
Published June 1, 2004
Citation Information: J Clin Invest. 2004;113(11):1515-1525. https://doi.org/10.1172/JCI21926.
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Review

Progress on new vaccine strategies for the immunotherapy and prevention of cancer

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Abstract

In recent years, great strides in understanding and regulating the immune system have led to new hope for harnessing its exquisite specificity to destroy cancer cells without affecting normal tissues. This review examines the fundamental immunologic advances and the novel vaccine strategies arising from these advances, as well as the early clinical trials studying new approaches to treat or prevent cancer.

Authors

Jay A. Berzofsky, Masaki Terabe, SangKon Oh, Igor M. Belyakov, Jeffrey D. Ahlers, John E. Janik, John C. Morris

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Figure 2

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Approaches to antitumor vaccination. (A) Irradiated tumor cells transduc...
Approaches to antitumor vaccination. (A) Irradiated tumor cells transduced with a viral gene transfer vector encoding a cytokine such as GM-CSF attract APCs (DCs) that acquire, process, and present tumor-associated antigens (TAAs) encoded by the vector in the context of MHC. (B) DCs can be directly loaded by incubation with tumor protein lysates or peptides with sequences based on expressed tumor antigens, or by viral gene transfer vectors expressing TAAs. (C) TAAs can be locally supplied to DCs by the direct injection of peptides, viral gene expression vectors, or naked DNA expression plasmids. DCs migrate to secondary lymphoid tissues where they present the antigen epitopes to T cells to generate an antitumor cytolytic T cell response.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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