JCI - Citations to PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

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PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

Rohit N. Kulkarni, … , Marc Montminy, C. Ronald Kahn

Rohit N. Kulkarni, … , Marc Montminy, C. Ronald Kahn

Published September 15, 2004
Citation Information: J Clin Invest. 2004;114(6):828-836. https://doi.org/10.1172/JCI21845.

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Revealing the biological features of the axolotl pancreas as a new research model Ma H, Peng G, Hu Y, Lu B, Zheng Y, Wu Y, Feng W, Shi Y, Pan X, Song L, Stützer I, Liu Y, Fei J	Frontiers in Cell and Developmental Biology	2025
Rare, Tightly-Bound, Multi-Cellular Clusters in the Pancreatic Ducts of Adult Mice Function Like Progenitor Cells and Survive and Proliferate After Acinar Cell Injury Tremblay JR, Ortiz JA, Quijano JC, Zook HN, Erdem N, LeBon JM, Li W, Jou K, Tsark W, Mann JR, Kozlowski MT, Tirrell DA, Esni F, Engle DD, Riggs AD, Ku HT	STEM CELLS	2024
TRPM7 kinase is required for insulin production and compensatory islet responses during obesity Noushafarin Khajavi, Andreas Beck, Klea Ricku, Philipp Beyerle, Katharina Jacob, Sabrina Syamsul, Anouar Belkacemi, Houssein Salah, Tanja Popp, Aaron Novikoff, Andreas Breit, Vladimir Chubanov, Timo Müller, Susanna Zierler, Thomas Gudermann	JCI Insight	2023
β−Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives Wess J, Oteng AB, Rivera-Gonzalez O, Gurevich EV, Gurevich VV	Pharmacological reviews	2023
FoxO1 as a tissue-specific therapeutic target for type 2 diabetes Teaney NA, Cyr NE	Frontiers in Endocrinology	2023
Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus H Kaneto, T Kimura, M Shimoda, A Obata, J Sanada, Y Fushimi, T Matsuoka, K Kaku	Biomedicines	2022
PDX-1: A Promising Therapeutic Target to Reverse Diabetes. Zhang Y, Fang X, Wei J, Miao R, Wu H, Ma K, Tian J	Biomolecules	2022
Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice GA Bronczek, GM Soares, JF de Barros, JF Vettorazzi, MA Kurauti, E Marconato-Júnior, L Zangerolamo, C Marmentini, AC Boschero, JM Costa-Júnior	Scientific Reports	2021
Adipose Tissue Macrophages Modulate Obesity-Associated β Cell Adaptations through Secreted miRNA-Containing Extracellular Vesicles H Gao, Z Luo, Z Jin, Y Ji, W Ying	Cells	2021
Excessive Intake of High-Fructose Corn Syrup Drinks Induces Impaired Glucose Tolerance H Hattori, Y Hanai, Y Oshima, H Kataoka, N Eto	Biomedicines	2021
β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity LF Barella, M Rossi, SP Pydi, J Meister, S Jain, Y Cui, O Gavrilova, G Fulgenzi, L Tessarollo, J Wess	Nature Communications	2021
Menin‐regulated Pbk controls high fat diet‐induced compensatory beta cell proliferation J Ma, B Xing, Y Cao, X He, KE Bennett, C Tong, C An, T Hojnacki, Z Feng, S Deng, S Ling, G Xie, Y Wu, Y Ren, M Yu, BW Katona, H Li, A Naji, X Hua	EMBO Molecular Medicine	2021
Pancreatic and duodenal homeobox-1 (PDX1) contributes to β-cell mass expansion and proliferation induced by Akt/PKB pathway MA Jara, JP Werneck-De-Castro, C Lubaczeuski, JD Johnson, E Bernal-Mizrachi	Islets	2020
MicroRNA-17-92 Regulates Beta-Cell Restoration After Streptozotocin Treatment S Wan, J Zhang, X Chen, J Lang, L Li, F Chen, L Tian, Y Meng, X Yu	Frontiers in Endocrinology	2020
Elevated β-cell stress levels promote severe diabetes development in mice with MODY4 BM Trojanowski, HH Salem, H Neubauer, E Simon, M Wagner, R Dorajoo, BO Boehm, L Labriola, T Wirth, B Baumann	Journal of Endocrinology	2020
Danzhi Jiangtang Capsule Mediates NIT-1 Insulinoma Cell Proliferation and Apoptosis by GLP-1/Akt Signaling Pathway YJ Wu, YB Wu, ZH Fang, MQ Chen, YF Wang, CY Wu, MA Lv	Evidence-Based Complementary and Alternative Medicine	2019
The epigenetics of diabetes, obesity, overweight and cardiovascular disease HO Smail	AIMS Genetics	2019
How, When, and Where Do Human β-Cells Regenerate? G Basile, RN Kulkarni, NG Morgan	Current Diabetes Reports	2019
m6A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes DF Jesus, Z Zhang, S Kahraman, NK Brown, M Chen, J Hu, MK Gupta, C He, RN Kulkarni		2019
Intracellular lipid metabolism impairs β-cell compensation during diet-induced obesity Risheng Ye, Ruth Gordillo, Mengle Shao, Toshiharu Onodera, Zhe Chen, Shiuhwei Chen, Xiaoli Lin, Jeffrey A. SoRelle, Xiaohong Li, Miao Tang, mark keller, Regina Kuliawat, Alan D. Attie, Rana Gupta, William L. Holland, Bruce Beutler, Joachim Herz, Philipp E. Scherer	Journal of Clinical Investigation	2018
A PDX1-ATF transcriptional complex governs β cell survival during stress CA Juliana, J Yang, CE Cannon, AL Good, MW Haemmerle, DA Stoffers	Molecular Metabolism	2018
Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high-fat diet MD Seferovic, CA Beamish, RE Mosser, SE Townsend, K Pappan, V Poitout, KM Aagaard, M Gannon	American journal of physiology. Endocrinology and metabolism	2018
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Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning JM Spaeth, M Gupte, M Perelis, YP Yang, H Cyphert, S Guo, JH Liu, M Guo, J Bass, MA Magnuson, C Wright, R Stein	Diabetes	2017
Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor M Sakaguchi, S Fujisaka, W Cai, JN Winnay, M Konishi, BT O'Neill, M Li, R García-Martín, H Takahashi, J Hu, RN Kulkarni, CR Kahn	Cell Metabolism	2017
Impaired Insulin Signaling is Associated with Hepatic Mitochondrial Dysfunction in IR+/−-IRS-1+/− Double Heterozygous (IR-IRS1dh) Mice A Franko, A Kunze, M Böse, JC Kleist-Retzow, M Paulsson, U Hartmann, R Wiesner	International journal of molecular sciences	2017
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The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion Y Nakatsu, K Mori, Y Matsunaga, T Yamamotoya, K Ueda, Y Inoue, K Mitsuzaki-Miyoshi, H Sakoda, M Fujishiro, S Yamaguchi, A Kushiyama, H Ono, H Ishihara, T Asano	The Journal of biological chemistry	2017
Genetic Disruption of Adenosine Kinase in Mouse Pancreatic β-Cells Protects Against High-Fat Diet–Induced Glucose Intolerance G Navarro, Y Abdolazimi, Z Zhao, H Xu, S Lee, NA Armstrong, JP Annes	Diabetes	2017
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Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication S Dhawan, E Dirice, RN Kulkarni, A Bhushan	Diabetes	2016
Exendin-4 enhances expression of Neurod1 and Glut2 in insulin-producing cells derived from mouse embryonic stem cells Q Zhao, Y Yang, J Hu, Z Shan, Y Wu, L Lei	Archives of Medical Science : AMS	2016
Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function KD Henley, DE Stanescu, PA Kropp, CV Wright, KJ Won, DA Stoffers, M Gannon	Cell Reports	2016
Pancreatic Islet Responses to Metabolic Trauma: SJ Burke, MD Karlstad, JJ Collier	Shock	2016
Adipose- and muscle-derived Wnts trigger pancreatic β-cell adaptation to systemic insulin resistance K Kozinski, M Jazurek, P Dobrzyn, J Janikiewicz, K Kolczynska, A Gajda, A Dobrzyn	Scientific Reports	2016
Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation IA Valdez, E Dirice, MK Gupta, J Shirakawa, AK Teo, RN Kulkarni	Cell Reports	2016
Expression of pancreatic and duodenal homeobox1 (PDX1) protein in the interior and exterior regions of the intestine, revealed by development and analysis of Pdx1 knockout mice H Hashimoto, T Kamisako, T Kagawa, S Haraguchi, M Yagoto, R Takahashi, K Kawai, H Suemizu	Laboratory animal research	2015
Role of Pancreatic Transcription Factors in Maintenance of Mature β-Cell Function H Kaneto, T Matsuoka	International journal of molecular sciences	2015
WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability BP Boerner, NM George, SU Mir, NE Sarvetnick	Endocrine Journal	2015
Differences in insulin biosynthesis pathway between small and large islets do not correspond to insulin secretion HH Huang, L Stehno-Bittel	Islets	2015
Vitamin A Deficiency Causes Hyperglycemia and Loss of Pancreatic β-Cell Mass SE Trasino, YD Benoit, LJ Gudas	The Journal of biological chemistry	2014
Mangiferin Facilitates Islet Regeneration and β-Cell Proliferation through Upregulation of Cell Cycle and β-Cell Regeneration Regulators HL Wang, CY Li, B Zhang, YD Liu, BM Lu, Z Shi, N An, LK Zhao, JJ Zhang, JK Bao, Y Wang	International journal of molecular sciences	2014
Sox17 Regulates Insulin Secretion in the Normal and Pathologic Mouse β Cell D Jonatan, JR Spence, AM Method, M Kofron, K Sinagoga, L Haataja, P Arvan, GH Deutsch, JM Wells, Y Ikeda	PloS one	2014
Pancreatic and Duodenal Homeobox Protein 1 (Pdx-1) Maintains Endoplasmic Reticulum Calcium Levels through Transcriptional Regulation of Sarco-endoplasmic Reticulum Calcium ATPase 2b (SERCA2b) in the Islet Cell JS Johnson, T Kono, X Tong, WR Yamamoto, A Zarain-Herzberg, MJ Merrins, LS Satin, P Gilon, C Evans-Molina	The Journal of biological chemistry	2014
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Peroxisome proliferator-activated receptor γ (PPARγ) and its target genes are downstream effectors of FoxO1 protein in islet β-cells: mechanism of β-cell compensation and failure D Gupta, AA Leahy, N Monga, M Peshavaria, TL Jetton, JL Leahy	The Journal of biological chemistry	2013
Beta cell dysfunction and insulin resistance ME Cerf	Frontiers in Endocrinology	2013
The role of FOXO1 in β-cell failure and type 2 diabetes mellitus T Kitamura	Nature Reviews Endocrinology	2013
The transcriptional co-regulator HCF-1 is required for INS-1 β-cell glucose-stimulated insulin secretion TN Iwata, TJ Cowley, M Sloma, Y Ji, H Kim, L Qi, SS Lee	PloS one	2013
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Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes V Nesca, C Guay, C Jacovetti, V Menoud, ML Peyot, DR Laybutt, M Prentki, R Regazzi	Diabetologia	2013
Neonatal exendin-4 reduces growth, fat deposition and glucose tolerance during treatment in the intrauterine growth-restricted lamb KL Gatford, SA Sulaiman, SN Mohammad, MJ de Blasio, ML Harland, RA Simmons, JA Owens	PloS one	2013
Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development SM Green-Mitchell, SA Tersey, BK Cole, K Ma, NS Kuhn, TD Cunningham, NA Maybee, SK Chakrabarti, M McDuffie, DA Taylor-Fishwick, RG Mirmira, JL Nadler, MA Morris	PloS one	2013
PDX1 in Ducts Is Not Required for Postnatal Formation of -Cells but Is Necessary for Their Subsequent Maturation L Guo, A Inada, C Aguayo-Mazzucato, J Hollister-Lock, Y Fujitani, GC Weir, CV Wright, A Sharma, S Bonner-Weir	Diabetes	2013
Imaging Beta Cell Regeneration and Interactions with Islet Vasculature in Transparent Adult Zebrafish LG Moss, TV Caplan, JB Moss	Zebrafish	2013
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Fetal PGC-1α overexpression programs adult pancreatic β-cell dysfunction B Valtat, JP Riveline, P Zhang, A Singh-Estivalet, M Armanet, N Venteclef, A Besseiche, DP Kelly, F Tronche, P Ferré, JF Gautier, B Bréant, B Blondeau	Diabetes	2012
A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation E Tarabra, S Pelengaris, M Khan	International Journal of Endocrinology	2012
Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication JP Annes, JH Ryu, K Lam, PJ Carolan, K Utz, J Hollister-Lock, AC Arvanites, LL Rubin, G Weir, DA Melton	Proceedings of the National Academy of Sciences	2012
Pdx1 Is Post-Translationally Modified In vivo and Serine 61 Is the Principal Site of Phosphorylation T Frogne, KB Sylvestersen, S Kubicek, ML Nielsen, J Hecksher-Sørensen, M Federici	PloS one	2012
Differential regulation of embryonic and adult β cell replication U Gunasekaran, CW Hudgens, BT Wright, MF Maulis, M Gannon	Cell cycle (Georgetown, Tex.)	2012
Development of novel cell lines of diabetic dysfunction model fit for cell-based screening tests of medicinal materials M Saito, A Hayakawa, N Inagaki, H Matsuoka	Cytotechnology	2012
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PDX1-engineered embryonic stem cell-derived insulin producing cells regulate hyperglycemia in diabetic mice SP Raikwar, N Zavazava	Transplantation Research	2012
Hepatocyte-specific Ptpn6 deletion protects from obesity-linked hepatic insulin resistance E Xu, A Charbonneau, Y Rolland, K Bellmann, L Pao, KA Siminovitch, BG Neel, N Beauchemin, A Marette	Diabetes	2012
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Endoplasmic Reticulum Oxidoreductin-1-Like β (ERO1lβ) Regulates Susceptibility to Endoplasmic Reticulum Stress and Is Induced by Insulin Flux in β-Cells C Khoo, J Yang, G Rajpal, Y Wang, J Liu, P Arvan, DA Stoffers	Endocrinology	2011
Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus F Folli, T Okada, C Perego, J Gunton, CW Liew, M Akiyama, A D'Amico, SL Rosa, C Placidi, R Lupi, P Marchetti, G Sesti, M Hellerstein, L Perego, RN Kulkarni	PloS one	2011
Control of Pancreatic β Cell Regeneration by Glucose Metabolism S Porat, N Weinberg-Corem, S Tornovsky-Babaey, R Schyr-Ben-Haroush, A Hija, M Stolovich-Rain, D Dadon, Z Granot, V Ben-Hur, P White, CA Girard, R Karni, KH Kaestner, FM Ashcroft, MA Magnuson, A Saada, J Grimsby, B Glaser, Y Dor	Cell Metabolism	2011
Effects of diabetes mellitus on the rat liver during the postmenopausal period D Unal, S Aksak, Z Halici, O Sengul, B Polat, B Unal, M Halici	Journal Of Molecular Histology	2011
Early-Life Origins of Type 2 Diabetes: Fetal Programming of the Beta-Cell Mass B Portha, A Chavey, J Movassat	Experimental Diabetes Research	2011
Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat SE Pinney, LJ Santos, Y Han, DA Stoffers, RA Simmons	Diabetologia	2011
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Pdx1 regulation of pancreatic beta cell survival and function is modulated by the ubiquitin ligase adaptor Pcif1 Kathryn Claiborn, Mira Sachdeva, Corey Cannon, David Groff, Jeffrey Singer, Doris Stoffers	Journal of Clinical Investigation	2010
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Glucose and aging control the quiescence period that follows pancreatic beta cell replication SJ Salpeter, AM Klein, D Huangfu, J Grimsby, Y Dor	Development (Cambridge, England)	2010
Mechanisms of non-apoptotic programmed cell death in diabetes and heart failure GW Dorn	Cell cycle (Georgetown, Tex.)	2010
Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents S Georgia, C Hinault, D Kawamori, J Hu, J Meyer, M Kanji, A Bhushan, RN Kulkarni	Diabetes	2010
Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency K Fujimoto, Y Chen, KS Polonsky, GW 2nd	Proceedings of the National Academy of Sciences	2010
Attacking the source: anti-PDX-1 responses in type 1 diabetes Y Luzardo, CE Mathews	Laboratory Investigation	2010
Obesity and hyperinsulinemia in a family with pancreatic agenesis and MODY caused by the IPF1 mutation Pro63fsX60 SS Fajans, GI Bell, VP Paz, JE Below, NJ Cox, C Martin, IH Thomas, M Chen	Translational research : the journal of laboratory and clinical medicine	2010
Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass G Fontés, B Zarrouki, DK Hagman, MG Latour, M Semache, V Roskens, PC Moore, M Prentki, CJ Rhodes, TL Jetton, V Poitout	Diabetologia	2010
Differential Effects of Prenatal and Postnatal Nutritional Environment on β-Cell Mass Development and Turnover in Male and Female Rats AV Matveyenko, I Singh, BC Shin, S Georgia, SU Devaskar	Endocrinology	2010
Vagal control of pancreatic β-cell proliferation J Lausier, WC Diaz, V Roskens, K LaRock, K Herzer, CG Fong, MG Latour, M Peshavaria, TL Jetton	American journal of physiology. Endocrinology and metabolism	2010
The Effect of Tribbles-Related Protein 3 on ER Stress-Suppressed Insulin Gene Expression in INS-1 Cells YY Jang, NK Kim, MK Kim, HY Lee, SJ Kim, HS Kim, HY Seo, IK Lee, KG Park	Korean Diabetes Journal	2010
Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion MM Sachdeva, DA Stoffers	Molecular Endocrinology	2009
Slow and steady is the key to β-cell replication K Brennand, D Melton	Journal of Cellular and Molecular Medicine	2009
Growth factor control of pancreatic islet regeneration and function A Assmann, C Hinault, RN Kulkarni	Pediatric Diabetes	2009
Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases RK Humphrey, SM Yu, LE Flores, US Jhala	The Journal of biological chemistry	2009
Pdx1 and other factors that regulate pancreatic β-cell survival K Fujimoto, KS Polonsky	Diabetes, Obesity and Metabolism	2009
Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress MM Sachdeva, KC Claiborn, C Khoo, J Yang, DN Groff, RG Mirmira, DA Stoffers	Proceedings of the National Academy of Sciences	2009
Bmi-1 regulates the Ink4a/Arf locus to control pancreatic β-cell proliferation S Dhawan, SI Tschen, A Bhushan	Genes & development	2009
Developmental Origins of Type 2 Diabetes: Progressive Epigenetic Modifications Silence Pdx1 Jun H. Park, Doris A. Stoffers, Robert D. Nicholls, Rebecca A. Simmons	Journal of Clinical Investigation	2008
Insulin Stimulates Primary β-Cell Proliferation via Raf-1 Kinase JL Beith, EU Alejandro, JD Johnson	Endocrinology	2008
Pleiotropic Roles of PDX-1 in the Pancreas H Kaneto, T Miyatsuka, D Kawamori, TA Matsuoka	The review of diabetic studies : RDS	2008
In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter D Gupta, TL Jetton, RM Mortensen, SZ Duan, M Peshavaria, JL Leahy	The Journal of biological chemistry	2008
On the origin of the beta cell JM Oliver-Krasinski, DA Stoffers	Genes & development	2008
Skp2-mediated p27 degradation plays an essential role in the growth and adaptive expansion of pancreatic beta cells Lingwen Zhong, Senta Georgia, Shuen-ing Tschen, Keiko Nakayama, Keiichi Nakayama and Anil Bhushan	Journal of Clinical Investigation	2007
Recovery from diabetes by beta cell regeneration Tomer Nir, Douglas A. Melton, Yuval Dor	Journal of Clinical Investigation	2007
From the Cover: Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance T Okada, CW Liew, J Hu, C Hinault, MD Michael, J Krtzfeldt, C Yin, M Holzenberger, M Stoffel, RN Kulkarni	Proceedings of the National Academy of Sciences	2007
A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis DA Babu, TG Deering, RG Mirmira	Molecular Genetics and Metabolism	2007
All beta cells contribute equally to islet growth and maintenance K Brennand, D Huangfu, D Melton	PLoS Biology	2007
Formation and regeneration of the endocrine pancreas S Dhawan, S Georgia, A Bhushan	Current Opinion in Cell Biology	2007
Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice J Cantley, AI Choudhury, H Asare-Anane, C Selman, S Lingard, H Heffron, P Herrera, SJ Persaud, DJ Withers	Diabetologia	2007
Reversal of Streptozotocin-Induced Diabetes in Mice by Cellular Transduction With Recombinant Pancreatic Transcription Factor Pancreatic Duodenal Homeobox-1: A Novel Protein Transduction Domain-Based Therapy V Koya, S Lu, YP Sun, DL Purich, MA Atkinson, SW Li, LJ Yang	Diabetes	2007
Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha RK Gupta, N Gao, RK Gorski, P White, OT Hardy, K Rafiq, JE Brestelli, G Chen, CJ Stoeckert, KH Kaestner	Genes & development	2007
Extracts of Rehmanniae radix, Ginseng radix and Scutellariae radix improve glucose-stimulated insulin secretion and beta-cell proliferation through IRS2 induction SM Park, SM Hong, SR Sung, JE Lee, DY Kwon	Genes & Nutrition	2007
Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats DY Kwon, JS Jang, SM Hong, JE Lee, SR Sung, HR Park, S Park	European Journal of Nutrition	2007
Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity: Oxidative stress in diabetes P Newsholme, EP Haber, SM Hirabara, EL Rebelato, J Procopio, D Morgan, HC Oliveira-Emilio, AR Carpinelli, R Curi	The Journal of Physiology	2007
Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo KT Nguyen, P Tajmir, CH Lin, N Liadis, XD Zhu, M Eweida, G Tolasa-Karaman, F Cai, R Wang, T Kitamura, DD Belsham, MB Wheeler, A Suzuki, TW Mak, M Woo	Molecular and cellular biology	2006
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome JD Johnson, E Bernal-Mizrachi, EU Alejandro, Z Han, TB Kalynyak, H Li, JL Beith, J Gross, GL Warnock, RR Townsend, MA Permutt, KS Polonsky	Proceedings of the National Academy of Sciences	2006
Increased Pancreatic β-Cell Proliferation Mediated by CREB Binding Protein Gene Activation MA Hussain, DL Porras, MH Rowe, JR West, WJ Song, WE Schreiber, FE Wondisford	Molecular and cellular biology	2006
Diabetes outfoxed by GLP-1? GG Holz, OG Chepurny	Science's STKE : signal transduction knowledge environment	2005
Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes H Kaneto, T Matsuoka, Y Nakatani, D Kawamori, T Miyatsuka, M Matsuhisa, Y Yamasaki	Journal of Molecular Medicine	2005
Involvement of oxidative stress and the JNK pathway in glucose toxicity H Kaneto, Y Nakatani, D Kawamori, T Miyatsuka, T Matsuoka	The review of diabetic studies : RDS	2005
Molecular engineering human hepatocytes into pancreatic beta cells for diabetes therapy I Cozar-Castellano, AF Stewart	Proceedings of the National Academy of Sciences	2005

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