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Salt handling and hypertension
Kevin M. O’Shaughnessy, Fiona E. Karet
Kevin M. O’Shaughnessy, Fiona E. Karet
Published April 15, 2004
Citation Information: J Clin Invest. 2004;113(8):1075-1081. https://doi.org/10.1172/JCI21560.
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Science in Medicine

Salt handling and hypertension

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Abstract

The kidney plays a central role in our ability to maintain appropriate sodium balance, which is critical to determination of blood pressure. In this review we outline current knowledge of renal salt handling at the molecular level, and, given that Westernized societies consume more salt than is required for normal physiology, we examine evidence that the lowering of salt intake can combat hypertension.

Authors

Kevin M. O’Shaughnessy, Fiona E. Karet

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Figure 2

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BP changes in chimpanzees fed a salt-supplemented diet. Twenty-two chimp...
BP changes in chimpanzees fed a salt-supplemented diet. Twenty-two chimpanzees were fed infant formula either alone (n = 12) or with added salt (n = 10) as follows: 5 g/d for 19 weeks, 10 g/d for 3 weeks, and 15 g/d for 67 weeks. A 20-week period without added dietary salt concluded the experiment. The BP changes were significantly increased over base line (*P < 0.05, **P < 0.01, ***P < 0.001) and significantly different between groups (+P < 0.05; +++P < 0.001). Reproduced with permission from Nature Medicine (48).

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