Ig V region restrictions in human chronic lymphocytic leukemia suggest some cases have a common origin
Grant R. Kolar, J. Donald Capra
Grant R. Kolar, J. Donald Capra
Published April 1, 2004
Citation Information: J Clin Invest. 2004;113(7):952-954. https://doi.org/10.1172/JCI21412.
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Commentary

Ig V region restrictions in human chronic lymphocytic leukemia suggest some cases have a common origin

Abstract

The factors that contribute to the development of B cell chronic lymphocytic leukemia (B-CLL) are unknown, and the groups of individuals at the greatest risk for developing this common leukemia are not well defined. Molecular features are important for classifying cases of B-CLL, and it is now apparent that similarities among Ig rearrangements between patients may give important clues to the origin of this disease.

Authors

Grant R. Kolar, J. Donald Capra

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Figure 1

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Antigen may play a role in the progression of class-switched B-CLL in a ...
Antigen may play a role in the progression of class-switched B-CLL in a number of ways: (A) a foreign agent is recognized by an unmutated B cell and aids in the transformation of the cell once it is internalized, or (B) an unmutated IgG memory cell may serve as a starting point prior to transformation. Alternatively (C or D) B-CLL cells with a particular rearrangement may recognize an autoantigen or foreign antigen and in response expand and undergo class-switch recombination. Freq, frequency; Ag, antigen; CSR, class switch recombination.