Prostate cancer is the second most common malignancy in men. The prostate gland (A) is located just below the male bladder and can undergo a period of growth beginning in middle age. Malignant tumors of glandular origin (B) are usually adenocarcinomas. Early detection is possible through annual digital rectal examinations and routine PSA testing. Glinksy et al. (4) use gene expression profiling to identify and test prognostic indicators for prostate cancer. The authors developed several genetic “signatures” able to discriminate recurrent versus nonrecurrent disease. Image copyright of Mayo Foundation for Medical Education and Research. All rights reserved. Used with permission from www.MayoClinic.com.