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Citations to this article

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Elizabeta Nemeth, … , Bente K. Pedersen, Tomas Ganz
Elizabeta Nemeth, … , Bente K. Pedersen, Tomas Ganz
Published May 1, 2004
Citation Information: J Clin Invest. 2004;113(9):1271-1276. https://doi.org/10.1172/JCI20945.
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Article Hematology Article has an altmetric score of 26

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

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Abstract

Hypoferremia is a common response to systemic infections or generalized inflammatory disorders. In mouse models, the development of hypoferremia during inflammation requires hepcidin, an iron regulatory peptide hormone produced in the liver, but the inflammatory signals that regulate hepcidin are largely unknown. Our studies in human liver cell cultures, mice, and human volunteers indicate that IL-6 is the necessary and sufficient cytokine for the induction of hepcidin during inflammation and that the IL-6–hepcidin axis is responsible for the hypoferremia of inflammation.

Authors

Elizabeta Nemeth, Seth Rivera, Victoria Gabayan, Charlotte Keller, Sarah Taudorf, Bente K. Pedersen, Tomas Ganz

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Total
Citations: 19 45 69 68 74 68 52 63 62 40 60 60 48 44 41 43 41 29 23 16 11 2 978
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ISSN: 0021-9738 (print), 1558-8238 (online)

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