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Norman E. Sharpless, Ronald A. DePinho
Published January 15, 2004
Citation Information: J Clin Invest. 2004;113(2):160-168. https://doi.org/10.1172/JCI20761.
Citation Information: J Clin Invest. 2004;113(2):160-168. https://doi.org/10.1172/JCI20761.
Abstract
Mammalian aging occurs in part because of a decline in the restorative capacity of tissue stem cells. These self-renewing cells are rendered malignant by a small number of oncogenic mutations, and overlapping tumor suppressor mechanisms (e.g., p16INK4a-Rb, ARF-p53, and the telomere) have evolved to ward against this possibility. These beneficial antitumor pathways, however, appear also to limit the stem cell life span, thereby contributing to aging.
Authors
Norman E. Sharpless, Ronald A. DePinho
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Citation information
Citations to this article (385)
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Journal of Biosciences | 2013 |
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New Advances on Disease Biomarkers and Molecular Targets in Biomedicine
NP Lee, CY Cheng, JM Luk |
2013 | |
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Systems Biology of Tumor Dormancy
H Enderling, N Almog, L Hlatky |
2012 | |
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Systems Biology of Tumor Dormancy
H Enderling, N Almog, L Hlatky |
2012 | |
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Systems Biology of Tumor Dormancy
H Enderling, N Almog, L Hlatky |
2012 | |
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Systems Biology of Tumor Dormancy
H Enderling, N Almog, L Hlatky |
2012 | |
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Systems Biology of Tumor Dormancy
H Enderling, N Almog, L Hlatky |
2012 | |
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Systems Biology of Tumor Dormancy
H Enderling, N Almog, L Hlatky |
2012 | |
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Systems Biology of Tumor Dormancy
H Enderling, N Almog, L Hlatky |
2012 | |
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Systems Biology of Tumor Dormancy
H Enderling, N Almog, L Hlatky |
2012 | |
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Systems Biology of Tumor Dormancy
H Enderling, N Almog, L Hlatky |
2012 | |
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Cell Senescence
L Galluzzi, I Vitale, O Kepp, G Kroemer |
2012 | |
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Cell Senescence
L Galluzzi, I Vitale, O Kepp, G Kroemer |
2012 | |
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Cell Senescence
L Galluzzi, I Vitale, O Kepp, G Kroemer |
2012 | |
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Cell Senescence
L Galluzzi, I Vitale, O Kepp, G Kroemer |
2012 | |
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Oxidative Stress, Mitochondrial Dysfunction, and Aging
H Cui, Y Kong, H Zhang |
Journal of Signal Transduction | 2012 |
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Axis of ageing: telomeres, p53 and mitochondria
E Sahin, RA DePinho |
Nature Reviews Molecular Cell Biology | 2012 |
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c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression
HY Kua, H Liu, WF Leong, L Li, D Jia, G Ma, Y Hu, X Wang, JF Chau, YG Chen, Y Mishina, S Boast, J Yeh, L Xia, GQ Chen, L He, SP Goff, B Li |
Nature Cell Biology | 2012 |
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Physiology of the Gastrointestinal Tract, Two Volume Set
PR Kiela, JF Collins, FK Ghishan |
Physiology of the Gastrointestinal Tract, Two Volume Set | 2012 |
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Geminin is required for mitotic proliferation of spermatogonia
KA Barry, KM Schultz, CJ Payne, TJ McGarry |
Developmental Biology | 2012 |
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Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: Implication to age-associated bone diseases and defects
MJ Kim, CW Kim, YS Choi, MH Kim, CJ Park, Y Suh |
Mechanisms of Ageing and Development | 2012 |
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Oxidative Stress and Disease: Oxidative Stress, Immunity, and Aging
P Singh, M Campbell |
Oxidative Stress and Disease | 2012 |
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Telomere biology towards cardiac stem cell therapy in patients with heart failure
H Oh |
Okayama Igakkai Zasshi (Journal of Okayama Medical Association) | 2012 |
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Age-by-disease biological interactions: implications for late-life depression
BC McKinney, H Oh, E Sibille |
Frontiers in Genetics | 2012 |
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Smurf2 regulates the senescence response and suppresses tumorigenesis in mice
C Ramkumar, Y Kong, H Cui, S Hao, SN Jones, RM Gerstein, H Zhang |
Cancer research | 2012 |
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A role for c-Abl in cell senescence and spontaneous immortalization
M Zhang, L Li, Z Wang, H Liu, J Hou, M Zhang, A Hao, Y Liu, G He, Y Shi, L He, X Wang, Y Wan, B Li |
AGE | 2012 |
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MicroRNA-152 and -181a participate in human dermal fibroblasts senescence acting on cell adhesion and remodeling of the extra-cellular matrix
M Mancini, G Saintigny, C Mahé, M Annicchiarico-Petruzzelli, G Melino, E Candi |
Aging | 2012 |
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Identification and Characterization of Side Population Cells from Adult Human Dental Pulp after Ischemic Culture
J Wang, X Wei, J Ling, Y Huang, Q Gong, Y Huo |
Journal of Endodontics | 2012 |
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Effects of valproic acid on the expression of trophic factors in human bone marrow mesenchymal stromal cells
GW Cho, BY Kang, KS Kim, SH Kim |
Neuroscience Letters | 2012 |
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Melanocyte stem cells: Biology and current aspects
M Gola, R Czajkowski, A Bajek, A Dura, T Drewa |
Medical science monitor : international medical journal of experimental and clinical research | 2012 |
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Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques
C Patterson, MS Willis |
2012 | |
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Telomere Territory and Cancer
P Mehdipour |
2012 | |
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Molecular Pathology of Neoplastic Gastrointestinal Diseases
AR Sepulveda, JP Lynch |
2012 | |
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Nutrition, Diet and Cancer
S Shankar, RK Srivastava |
2012 | |
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Lineage-specific restraint of pituitary gonadotroph cell adenoma growth
V Chesnokova, S Zonis, C Zhou, A Ben-Shlomo, K Wawrowsky, Y Toledano, Y Tong, K Kovacs, B Scheithauer, S Melmed |
PloS one | 2011 |
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Pathogenesis of pituitary tumors
S Melmed |
Nature Reviews Endocrinology | 2011 |
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From tissue turnover to the cell of origin for pancreatic cancer
B Kong, CW Michalski, M Erkan, H Friess, J Kleeff |
Nature Reviews Gastroenterology & Hepatology | 2011 |
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Regulation of senescence in cancer and aging
Y Kong, H Cui, C Ramkumar, H Zhang |
Journal of Aging Research | 2011 |
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Metabolic Syndrome
M Wang |
Metabolic Syndrome | 2011 |
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Encyclopedia of Life Sciences
B Dahlbäck |
Encyclopedia of Life Sciences | 2011 |
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Progress in Molecular Biology and Translational Science
JF Wilkins, F Úbeda |
Modifications of Nuclear DNA and its Regulatory Proteins | 2011 |
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NUMB-ing down cancer by more than just a NOTCH
S Pece, S Confalonieri, PR Romano, PP di Fiore |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2011 |
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Human cancer classification: a systems biology- based model integrating morphology, cancer stem cells, proteomics, and genomics
HA Idikio |
Journal of Cancer | 2011 |
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Advances in Cancer Research
M Lemaire, S Deleu, ED Bruyne, EV Valckenborgh, E Menu, K Vanderkerken |
Advances in Cancer Research Volume 110 | 2011 |
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Antidepressants Stimulate Hippocampal Neurogenesis by Inhibiting p21 Expression in the Subgranular Zone of the Hipppocampus
RN Pechnick, S Zonis, K Wawrowsky, R Cosgayon, C Farrokhi, L Lacayo, V Chesnokova |
PloS one | 2011 |
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NK-Like T Cells and Plasma Cytokines, but Not Anti-Viral Serology, Define Immune Fingerprints of Resilience and Mild Disability in Exceptional Aging
AN Vallejo, DL Hamel, RG Mueller, DG Ives, JJ Michel, RM Boudreau, AB Newman |
PloS one | 2011 |
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Heart Failure: A Companion to Braunwald's Heart Disease
A Diwan, GW Dorn |
Heart Failure: A Companion to Braunwald's Heart Disease | 2011 |
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Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells
AA Goldberg, A Beach, GF Davies, TA Harkness, A Leblanc, VI Titorenko |
Oncotarget | 2011 |
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Aging-Associated Changes in Hematopoiesis and Leukemogenesis: What's the Connection?
CJ Henry, A Marusyk, J DeGregori |
Aging | 2011 |
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Computational analysis of expression of human embryonic stem cell-associated signatures in tumors
X Wang |
BMC Research Notes | 2011 |
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The PKB/FOXO switch in aging and cancer
DE Kloet, BM Burgering |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 |
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Telomere length in peripheral blood and breast cancer risk in a prospective case-cohort analysis: results from the Sister Study
S Kim, DP Sandler, G Carswell, LA de Roo, CG Parks, R Cawthon, CR Weinberg, JA Taylor |
Cancer Causes & Control | 2011 |
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p53 regulation by ubiquitin
CL Brooks, W Gu |
FEBS Letters | 2011 |
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The impact of acetylation and deacetylation on the p53 pathway
CL Brooks, W Gu |
Protein & Cell | 2011 |
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Importance of serum source for the in vitro replicative senescence of human bone marrow derived mesenchymal stem cells
S Duggal, JE Brinchmann |
Journal of Cellular Physiology | 2011 |
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Telomerase-Mediated Apoptosis of Chicken Lymphoblastoid Tumor Cell Line by Lanthanum Chloride
Z Zhang, J Wang, J Li, S Xu |
Biological Trace Element Research | 2011 |
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How Cancer Shapes Evolution and How Evolution Shapes Cancer
M Casás-Selves, J DeGregori |
Evolution | 2011 |
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A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis
W Jia, S Wang, JW Horner, N Wang, H Wang, EJ Gunther, RA DePinho, J Zhu |
The FASEB Journal | 2011 |
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Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence
J Cho, H Shen, H Yu, H Li, T Cheng, SB Lee, BC Lee |
Blood | 2010 |
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Pituitary Senescence: The Evolving Role of Pttg
V Chesnokova, S Melmed |
Molecular and Cellular Endocrinology | 2010 |
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Tissue-specific dysregulation of DNA methylation in aging
RF Thompson, G Atzmon, C Gheorghe, HQ Liang, C Lowes, JM Greally, N Barzilai |
Aging Cell | 2010 |
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p21WAF1/CIP1 gene transcriptional activation exerts cell growth inhibition and enhances chemosensitivity to cisplatin in lung carcinoma cell
J Wei, J Zhao, M Long, Y Han, X Wang, F Lin, J Ren, T He, H Zhang |
BMC Cancer | 2010 |
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ARF-induced downregulation of Mip130/LIN-9 protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf
J Song, R Sandoval, MA Pilkinton, X Tian, P Raychaudhuri, OR Colamonici |
Oncogene | 2010 |
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Selective Isolation of Young Cells from Human Corneal Endothelium by the Sphere-Forming Assay
T Mimura, S Yamagami, S Yokoo, T Usui, S Amano |
Tissue Engineering Part C: Methods | 2010 |
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Bone Marrow-Derived Stromal Cells from Amyotrophic Lateral Sclerosis Patients Have Diminished Stem Cell Capacity
GW Cho, MY Noh, HY Kim, SH Koh, KS Kim, SH Kim |
Stem Cells and Development | 2010 |
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Ageing, telomeres, senescence, and liver injury
M Hoare, T Das, G Alexander |
Journal of Hepatology | 2010 |
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Robbins and Cotran Pathologic Basis of Disease
A Maitra |
Robbins and Cotran Pathologic Basis of Disease | 2010 |
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Aging well - the role of minimally invasive aesthetic dermatological procedures in women over 65
U Wollina, CR Payne |
Journal of Cosmetic Dermatology | 2010 |
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The Stem Cell Hypothesis of Aging
A Meiliana, A Wijaya |
The Indonesian Biomedical Journal | 2010 |
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Distinct and Temporal Roles of Nucleosomal Remodeling and Histone Deacetylation in the Repression of the hTERT Gene
S Wang, C Hu, J Zhu, Y Zheng |
Molecular biology of the cell | 2010 |
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Pre-Invasive Disease: Pathogenesis and Clinical Management
RC Fitzgerald |
2010 | |
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Polyploidization and Cancer
RY Poon |
2010 | |
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Potential and pitfalls of stem cell therapy in old age
D Piccin, CM Morshead |
Disease models & mechanisms | 2010 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Telomere Diseases
RT Calado, NS Young |
The New England journal of medicine | 2009 |
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Tumor suppressor mechanisms in immune aging
Y Liu, NE Sharpless |
Current Opinion in Immunology | 2009 |
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Poor maternal nutrition followed by accelerated postnatal growth leads to telomere shortening and increased markers of cell senescence in rat islets
JL Tarry-Adkins, JH Chen, NS Smith, RH Jones, H Cherif, SE Ozanne |
The FASEB Journal | 2009 |
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Sulforaphane Increases Cyclin-Dependent Kinase Inhibitor, p21 Protein in Human Oral Carcinoma Cells and Nude Mouse Animal Model to Induce G2/M Cell Cycle Arrest
JH Kim, KH Kwon, JY Jung, HS Han, JH Shim, S Oh, KH Choi, ES Choi, JA Shin, DH Leem, Y Soh, NP Cho, SD Cho |
Journal of Clinical Biochemistry and Nutrition | 2009 |
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Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia
JB Koorstra, SM Hong, C Shi, AK Meeker, JK Ryu, GJ Offerhaus, MG Goggins, RH Hruban, A Maitra |
Modern Pathology | 2009 |
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Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis
K Okudela, T Yazawa, T Woo, M Sakaeda, J Ishii, H Mitsui, H Shimoyamada, H Sato, M Tajiri, N Ogawa, M Masuda, T Takahashi, H Sugimura, H Kitamura |
The American Journal of Pathology | 2009 |
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Telomere length, oxidative damage, antioxidants and breast cancer risk
J Shen, MD Gammon, MB Terry, Q Wang, P Bradshaw, SL Teitelbaum, AI Neugut, RM Santella |
International Journal of Cancer | 2009 |
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A common biological mechanism in cancer and Alzheimer's disease?
MI Behrens, C Lendon, CM Roe |
Current Alzheimer research | 2009 |
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Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy
M Waskar, GN Landis, J Shen, C Curtis, K Tozer, D Abdueva, D Skvortsov, S Tavaré, J Tower |
Aging | 2009 |
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A structural basis for cellular senescence
A Aranda-Anzaldo |
Aging | 2009 |
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How the study of Helicobacter infection can contribute to the understanding of carcinoma development
C Stoicov, H Li, J Cerny, JM Houghton |
Clinical Microbiology and Infection | 2009 |
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p53 and telomerase control rat myocardial tissue response to hypoxia and ageing
A Cataldi, S Zara, M Rapino, M Zingariello, V Giacomo, A Antonucci |
European Journal of Histochemistry : EJH | 2009 |
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Using Mice to Examine p53 Functions in Cancer, Aging, and Longevity
LA Donehower |
Cold Spring Harbor perspectives in biology | 2009 |
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Role of nuclear glutathione as a key regulator of cell proliferation
FV Pallardó, J Markovic, JL García, J Viña |
Molecular Aspects of Medicine | 2009 |
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Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells: HDAC inhibitors regulate stemness of MSCs
S Lee, JR Park, MS Seo, KH Roh, SB Park, JW Hwang, B Sun, K Seo, YS Lee, SK Kang, JW Jung, KS Kang |
Cell Proliferation | 2009 |
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Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: Implications for glioma histogenesis and biology
W Rhee, S Ray, H Yokoo, ME Hoane, CC Lee, AM Mikheev, PJ Horner, RC Rostomily |
Glia | 2009 |
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Aging in the lympho-hematopoietic stem cell compartment
H Geiger, KL Rudolph |
Trends in Immunology | 2009 |
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Vitamin D and aging
P Tuohimaa |
The Journal of Steroid Biochemistry and Molecular Biology | 2009 |
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Handbook on Immunosenescence
T Fulop, C Franceschi, K Hirokawa, G Pawelec |
2009 | |
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Sublethal Doses of an Anti-erbB2 Antibody Leads to Death by Apoptosis in Cardiomyocytes Sensitized by Low Prosenescent Doses of Epirubicin: The Protective Role of Dexrazoxane
P Spallarossa, P Altieri, P Pronzato, C Aloi, G Ghigliotti, A Barsotti, C Brunelli |
The Journal of pharmacology and experimental therapeutics | 2009 |
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Stem Cells in Marine Organisms
B Rinkevich, V Matranga |
2009 | |
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Mesenchymal Stem Cells for the Heart
J Wang, X Xie |
2009 | |
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Cancer Genome and Tumor Microenvironment
A Thomas-Tikhonenko |
2009 | |
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Stem Cell Biology in Health and Disease
T Dittmar, KS Zanker |
2009 | |
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Cell-based Therapeutic Approaches for Parkinson's Disease: Progress and Perspectives
SV Anisimov |
Reviews in the Neurosciences | 2009 |
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PML-IV functions as a negative regulator of telomerase by interacting with TERT
W Oh, J Ghim, EW Lee, MR Yang, ET Kim, JH Ahn, J Song |
Journal of cell science | 2009 |
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Mitotic Aberrations in Shwachman-Diamond Syndrome
Karyn M. Austin, Mohan L. Gupta, Jr., Scott Coats, Asmin Tulpule, Gustavo Mostoslavsky, Richard C. Mulligan, George Daley, David Pellman, and Akiko Shimamura |
Journal of Clinical Investigation | 2008 |
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Profiling the proteome dynamics during the cell cycle of human hepatoma cells
SY Hsieh, FH Zhuang, YT Wu, JK Chen, YL Lee |
PROTEOMICS | 2008 |
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p21(Cip1) restrains pituitary tumor growth
V Chesnokova, S Zonis, K Kovacs, A Ben-Shlomo, K Wawrowsky, S Bannykh, S Melmed |
Proceedings of the National Academy of Sciences | 2008 |
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Aging and disease as modifiers of efficacy of cell therapy
S Dimmeler, A Leri |
Circulation research | 2008 |
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Replicative stress, stem cells and aging
Y Ruzankina, A Asare, EJ Brown |
Mechanisms of Ageing and Development | 2008 |
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CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control
JN Min, RA Whaley, NE Sharpless, P Lockyer, AL Portbury, C Patterson |
Molecular and cellular biology | 2008 |
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Hereditary breast cancer: new genetic developments, new therapeutic avenues
PM Campeau, WD Foulkes, MD Tischkowitz |
Human Genetics | 2008 |
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Telomeres, stem cells, and hematology
PM Lansdorp |
Blood | 2008 |
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p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus
RN Pechnick, S Zonis, K Wawrowsky, J Pourmorady, V Chesnokova |
Proceedings of the National Academy of Sciences | 2008 |
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Cancer stem cells, endothelial progenitors, and mesenchymal stem cells: "seed and soil" theory revisited
EH Lin, Y Jiang, Y Deng, R Lapsiwala, T Lin, CA Blau |
Gastrointestinal cancer research : GCR | 2008 |
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Emerging drugs for acromegaly
P Chanson |
Expert Opinion on Emerging Drugs | 2008 |
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Prostatic preneoplasia and beyond
AM Joshua, A Evans, TV der Kwast, M Zielenska, AK Meeker, A Chinnaiyan, JA Squire |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2008 |
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Oxidative stress causes telomere damage in Fanconi anaemia cells – a possible predisposition for malignant transformation
O Uziel, H Reshef, A Ravid, I Fabian, D Halperin, R Ram, M Bakhanashvili, J Nordenberg, M Lahav |
British Journal of Haematology | 2008 |
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NUMB controls p53 tumour suppressor activity
IN Colaluca, D Tosoni, P Nuciforo, F Senic-Matuglia, V Galimberti, G Viale, S Pece, PP di Fiore |
Nature | 2008 |
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Growth, Differentiation, and Biochemical Signatures of Rhesus Monkey Mesenchymal Stem Cells
BS Kim, CC Lee, JE Christensen, TR Huser, JW Chan, AF Tarantal |
Stem Cells and Development | 2008 |
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Dual roles of telomere dysfunction in initiation and suppression of tumorigenesis
W Cosme-Blanco, S Chang |
Experimental Cell Research | 2008 |
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Aging stem cells, latexin, and longevity
Y Liang, GV Zant |
Experimental Cell Research | 2008 |
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Aging mechanism as the “down side” of adaptation: A network approach
MT Borup, A Trusina, AM Andersson |
Journal of Theoretical Biology | 2008 |
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Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells
K Futami, Y Ishikawa, M Goto, Y Furuichi, M Sugimoto |
Cancer Science | 2008 |
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Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer
W Böcker, Z Yin, I Drosse, F Haasters, O Rossmann, M Wierer, C Popov, M Locher, W Mutschler, D Docheva, M Schieker |
Journal of Cellular and Molecular Medicine | 2008 |
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Differential hTERT mRNA processing between young and older glioma patients
A Shervington, R Patel |
FEBS Letters | 2008 |
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Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae
CH Liao, YM Hsiao, CH Lin, CS Yeh, JC Wang, CH Ni, CP Hsu, JL Ko |
Food and Chemical Toxicology | 2008 |
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LNCaP prostate cancer cells are insensitive to zinc-induced senescence
PF Wong, S AbuBakar |
Journal of Trace Elements in Medicine and Biology | 2008 |
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Telomeres and Aging
G Aubert, PM Lansdorp |
Physiological reviews | 2008 |
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Immortalization of Neural Precursors When Telomerase Is Overexpressed in Embryonal Carcinomas and Stem Cells
AE Schwob, LJ Nguyen, KF Meiri, M Bronner-Fraser |
Molecular biology of the cell | 2008 |
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Angiotensin II–Mediated Oxidative DNA Damage Accelerates Cellular Senescence in Cultured Human Vascular Smooth Muscle Cells via Telomere-Dependent and Independent Pathways
KE Herbert, Y Mistry, R Hastings, T Poolman, L Niklason, B Williams |
Circulation research | 2008 |
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The Surgery of Childhood Tumors
R Carachi, JL Grosfeld, AF Azmy |
2008 | |
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How does suppression of IGF-1 signaling by DNA damage affect aging and longevity?
G Hinkal, LA Donehower |
Mechanisms of Ageing and Development | 2008 |
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Expression of an IFN-Inducible Cellular Senescence Gene, IFI16 , Is Up-Regulated by p53
LL Song, F Alimirah, R Panchanathan, H Xin, D Choubey |
Molecular cancer research : MCR | 2008 |
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Function of JunB in Transient Amplifying Cell Senescence and Progression of Human Prostate Cancer
N Konishi, K Shimada, M Nakamura, E Ishida, I Ota, N Tanaka, K Fujimoto |
Clinical cancer research | 2008 |
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Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth
V Chesnokova, S Zonis, T Rubinek, R Yu, A Ben-Shlomo, K Kovacs, K Wawrowsky, S Melmed |
Cancer research | 2007 |
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Bone Marrow-Derived Progenitors
K Kauser, AM Zeiher |
2007 | |
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Lack of Hypoxia-Inducible Factor-1 Impairs Midbrain Neural Precursor Cells Involving Vascular Endothelial Growth Factor Signaling
J Milosevic, M Maisel, F Wegner, J Leuchtenberger, RH Wenger, M Gerlach, A Storch, J Schwarz |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2007 |
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Transcriptional Control of Vascular Smooth Muscle Cell Proliferation by Peroxisome Proliferator-Activated Receptor-gamma: Therapeutic Implications for Cardiovascular Diseases
F Gizard, D Bruemmer |
PPAR Research | 2007 |
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How stem cells age and why this makes us grow old
NE Sharpless, RA DePinho |
Nature Reviews Molecular Cell Biology | 2007 |
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Cellular signaling in normal and cancerous stem cells
E Grinstein, P Wernet |
Cellular Signalling | 2007 |
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Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability
J Li, DP Sejas, S Burma, DJ Chen, Q Pang |
Carcinogenesis | 2007 |
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Therapeutic cloning: promises and issues
C Kfoury |
McGill journal of medicine : MJM : an international forum for the advancement of medical sciences by students | 2007 |
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Stem cell ageing: does it happen and can we intervene?
I Bellantuono, WN Keith |
Expert Reviews in Molecular Medicine | 2007 |
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Aging, Graying and Loss of Melanocyte Stem Cells
KY Sarin, SE Artandi |
Stem Cell Reviews | 2007 |
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p53 in health and disease
KH Vousden, DP Lane |
Nature Reviews Molecular Cell Biology | 2007 |
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Differential role of epigenetic modulators in malignant and normal stem cells: a novel tool in preclinical in vitro toxicology and clinical therapy
S Snykers, M Vinken, V Rogiers, T Vanhaecke |
Archives of Toxicology | 2007 |
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Telomere length in peripheral blood cells of germlineTP53 mutation carriers is shorter than that of normal individuals of corresponding age
M Trkova, K Prochazkova, V Krutilkova, D Sumerauer, Z Sedlacek |
Cancer | 2007 |
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Cell Turnover and Adult Tissue Homeostasis: From Humans to Planarians
J Pellettieri, AS Alvarado |
Annual Review of Genetics | 2007 |
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Determination of telomerase activity in stem cells and non-stem cells of breast cancer
Z Li, Y He, J Zhang, J Zhang, T Huang |
Frontiers of Medicine in China | 2007 |
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Common mechanisms for the regulation of B cell differentiation and transformation by the transcriptional repressor protein BCL-6
S Kusam, A Dent |
Immunologic Research | 2007 |
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Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss
Y Ruzankina, C Pinzon-Guzman, A Asare, T Ong, L Pontano, G Cotsarelis, VP Zediak, M Velez, A Bhandoola, EJ Brown |
Cell Stem Cell | 2007 |
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High-throughput microRNAome analysis in human germ cell tumours
AJ Gillis, HJ Stoop, R Hersmus, JW Oosterhuis, Y Sun, C Chen, S Guenther, J Sherlock, I Veltman, J Baeten, PJ der Spek, P Alarcon, LH Looijenga |
The Journal of Pathology | 2007 |
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Targeting ALT: The role of alternative lengthening of telomeres in pathogenesis and prevention of cancer
FM Bollmann |
Cancer Treatment Reviews | 2007 |
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Immune remodeling: lessons from repertoire alterations during chronological aging and in immune-mediated disease
AN Vallejo |
Trends in Molecular Medicine | 2007 |
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Stem Cells and the Rate of Living
J Krishnamurthy, NE Sharpless |
Cell Stem Cell | 2007 |
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Histone methylation controls telomerase-independent telomere lengthening in cells undergoing dedifferentiation
G Grafi, H Ben-Meir, Y Avivi, M Moshe, Y Dahan, A Zemach |
Developmental Biology | 2007 |
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Encyclopedia of Gerontology
DM Baird |
Encyclopedia of Gerontology | 2007 |
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Science of Cancer and Aging
I Irminger-Finger |
Journal of Clinical Oncology | 2007 |
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Transcriptional Silencing of a Novel hTERT Reporter Locus during In Vitro Differentiation of Mouse Embryonic Stem Cells
S Wang, C Hu, J Zhu, J Cleveland |
Molecular biology of the cell | 2007 |
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The zinc finger transcription factor ZFHX1A is linked to cell proliferation by Rb–E2F1
Y Liu, ME Costantino, D Montoya-Durango, Y Higashi, DS Darling, DC Dean |
Biochemical Journal | 2007 |
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Cancer: A matter of life cycle?
J Erenpreisa, MS Cragg |
Cell Biology International | 2007 |
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The PAX3-FKHR Fusion Gene of Rhabdomyosarcoma Cooperates with Loss of p16 INK4A to Promote Bypass of Cellular Senescence
CM Linardic, S Naini, JE Herndon, C Kesserwan, SJ Qualman, CM Counter |
Cancer research | 2007 |
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WRN at telomeres: implications for aging and cancer
AS Multani, S Chang |
Journal of cell science | 2007 |
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Determination of telomerase activity in stem cells and non-stem cells of breast cancer.
Li Z, He Y, Zhang J, Zhang J, Huang T |
Frontiers of Medicine in China | 2007 |
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Common mechanisms for the regulation of B cell differentiation and transformation by the transcriptional repressor protein BCL-6.
Kusam S, Dent A |
Immunologic research | 2007 |
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Aging, graying and loss of melanocyte stem cells.
Sarin KY, Artandi SE |
Stem Cell Reviews | 2007 |
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Human short-term repopulating cells have enhanced telomerase reverse transcriptase expression
M Järås, A Edqvist, J Rebetz, LG Salford, B Widegren, X Fan |
Blood | 2006 |
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Inactivation of p16 INK4a (inhibitor of cyclin-dependent kinase 4A) Immortalizes Primary Human Keratinocytes By Maintaining Cells in the Stem Cell Compartment
R Maurelli, G Zambruno, L Guerra, C Abbruzzese, G Dimri, M Gellini, S Bondanza, E Dellambra |
The FASEB Journal | 2006 |
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Increased hematopoietic stem cell mobilization in aged mice
Z Xing, MA Ryan, D Daria, KJ Nattamai, GV Zant, L Wang, Y Zheng, H Geiger |
Blood | 2006 |
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Stem cells, senescence, neosis and self-renewal in cancer
R Rajaraman, DL Guernsey, MM Rajaraman, SR Rajaraman |
Cancer Cell International | 2006 |
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Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
VC Gray-Schopfer, SC Cheong, H Chong, J Chow, T Moss, ZA Abdel-Malek, R Marais, D Wynford-Thomas, DC Bennett |
British Journal of Cancer | 2006 |
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The biogenesis and regulation of telomerase holoenzymes
K Collins |
Nature reviews. Molecular cell biology | 2006 |
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A hierarchy of proliferative cells exists in mouse lens epithelium: implications for lens maintenance
M Zhou, J Leiberman, J Xu, RM Lavker |
Investigative ophthalmology & visual science | 2006 |
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Increased p53 activity does not accelerate telomere-driven ageing
I García-Cao, M García-Cao, A Tomás-Loba, J Martín-Caballero, JM Flores, P Klatt, MA Blasco, M Serrano |
EMBO reports | 2006 |
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Mechanism of telomerase activation by v-Rel and its contribution to transformation
R Hrdlicková, J Nehyba, AS Liss, HR Bose |
Journal of virology | 2006 |
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Induction of the tumor-suppressor p16(INK4a) within regenerative epithelial crypts in ulcerative colitis
EE Furth, KS Gustafson, CY Dai, SL Gibson, P Menard-Katcher, T Chen, J Koh, GH Enders |
Neoplasia (New York, N.Y.) | 2006 |
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Tetraploidy/aneuploidy and stem cells in cancer promotion: The role of chromosome passenger proteins
HG Nguyen, K Ravid |
Journal of Cellular Physiology | 2006 |
|
Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging
H Zhang |
Journal of Cellular Physiology | 2006 |
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Does autologous transplantation directly increase the risk of secondary leukemia in lymphoma patients?
CR Hake, TA Graubert, TS Fenske |
Bone Marrow Transplantation | 2006 |
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The epigenetic progenitor origin of human cancer
AP Feinberg, R Ohlsson, S Henikoff |
Nature Reviews Genetics | 2006 |
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Glioma: What is the role of c-Myc, hsp90 and telomerase?
A Shervington, N Cruickshanks, H Wright, R Atkinson-Dell, R Lea, G Roberts, L Shervington |
Molecular and Cellular Biochemistry | 2006 |
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Possible mechanisms of the cancer-preventive activities of green tea
CS Yang, S Sang, JD Lambert, Z Hou, J Ju, G Lu |
Molecular Nutrition & Food Research | 2006 |
|
Human pulp-derived cells immortalized with Simian Virus 40 T-antigen
KM Galler, H Schweikl, B Thonemann, RN D'Souza, G Schmalz |
European Journal of Oral Sciences | 2006 |
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Epigenetic modifications in osteogenic differentiation and transformation
D Thomas, M Kansara |
Journal of Cellular Biochemistry | 2006 |
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How genetic analysis tests theories of animal aging
S Hekimi |
Nature Genetics | 2006 |
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Pediatric Surgery
PS Puligandla, JM Laberge |
Pediatric Surgery | 2006 |
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Telomere length of the skin in association with chronological aging and photoaging
M Sugimoto, R Yamashita, M Ueda |
Journal of Dermatological Science | 2006 |
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p53 Ubiquitination: Mdm2 and Beyond
CL Brooks, W Gu |
Molecular Cell | 2006 |
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Maintaining Genetic Integrity in Aging: A Zero Sum Game
Y Suh, J Vijg |
Antioxidants & Redox Signaling | 2006 |
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Ageing, hormonal behaviour and cyclin D1 in ductal breast carcinomas
NM Malara, A Leotta, A Sidoti, S Lio, R D’Angelo, B Caparello, F Munao, F Pino, A Amato |
The Breast | 2006 |
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Increased cell division contributes to carcinogenesis by both gene mutation and aneuploidy
F Zhang, D Zhao, Q Li |
Medical Hypotheses | 2006 |
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p53, longevity assurance and longevity suppression
LA Donehower |
Drug Discovery Today: Disease Mechanisms | 2006 |
|
Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts
DX Mason |
Carcinogenesis | 2006 |
|
Physiology of the Gastrointestinal Tract
DJ Drucker |
Physiology of the Gastrointestinal Tract | 2006 |
|
Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity
JL Tarry-Adkins, SE Ozanne, A Norden, H Cherif, CN Hales |
American journal of physiology. Renal physiology | 2006 |
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The biological sense of cancer: a hypothesis
RA Ruggiero, OD Bustuoabad |
Theoretical Biology and Medical Modelling | 2006 |
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Polyomaviruses and Human Diseases
N Ahsan |
Advances in experimental medicine and biology | 2006 |
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Polyomaviruses and Human Diseases
N Ahsan |
Advances in experimental medicine and biology | 2006 |
|
Polyomaviruses and Human Diseases
N Ahsan |
Advances in experimental medicine and biology | 2006 |
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Cell Cycle Regulation
P Kaldis |
2006 | |
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The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
M Dumble, L Moore, SM Chambers, H Geiger, GV Zant, MA Goodell, LA Donehower |
Blood | 2006 |
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From Melanocytes to Melanoma
VJ Hearing, SP Leong |
2006 | |
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Glioma: what is the role of c-Myc, hsp90 and telomerase?
Shervington A, Cruickshanks N, Wright H, Atkinson-Dell R, Lea R, Roberts G, Shervington L |
Molecular and Cellular Biochemistry | 2006 |
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Low atmospheric oxygen avoids maturation, senescence and cell death of murine mesencephalic neural precursors
J Milosevic, SC Schwarz, K Krohn, M Poppe, A Storch, J Schwarz |
Journal of Neurochemistry | 2005 |
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Adult stem cells and cancer stem cells: tie in or tear apart?
BB Liu, LX Qin, YK Liu |
Journal of Cancer Research and Clinical Oncology | 2005 |
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p63 deficiency activates a program of cellular senescence and leads to accelerated aging
WM Keyes, Y Wu, H Vogel, X Guo, SW Lowe, AA Mills |
Genes & development | 2005 |
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Virus Specific T-Cell Responses
Appay V |
2005 | |
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A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer
BJ Morris |
Journal of Hypertension | 2005 |
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CD28 extinction in human T cells: altered functions and the program of T-cell senescence
AN Vallejo |
Immunological Reviews | 2005 |
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Telomere structure and shortening in telomerase-deficient Trypanosoma brucei
O Dreesen, B Li, GA Cross |
Nucleic Acids Research | 2005 |
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Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure
K Urbanek, D Torella, F Sheikh, AD Angelis, D Nurzynska, F Silvestri, CA Beltrami, R Bussani, AP Beltrami, F Quaini, R Bolli, A Leri, J Kajstura, P Anversa |
Proceedings of the National Academy of Sciences | 2005 |
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Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element
H Geiger, G Rennebeck, GV Zant |
Proceedings of the National Academy of Sciences | 2005 |
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Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells
H Ota, E Tokunaga, K Chang, M Hikasa, K Iijima, M Eto, K Kozaki, M Akishita, Y Ouchi, M Kaneki |
Oncogene | 2005 |
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Role of Polycomb Group Proteins in Stem Cell Self-Renewal and Cancer
J Gil, D Bernard, G Peters |
DNA and Cell Biology | 2005 |
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p16 Is upregulated in proliferative inflammatory atrophy of the prostate
D Faith, S Han, DK Lee, A Friedl, JL Hicks, AM de Marzo, DF Jarrard |
The Prostate | 2005 |
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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
I Varela, J Cadiñanos, AM Pendás, A Gutiérrez-Fernández, AR Folgueras, LM Sánchez, Z Zhou, FJ Rodríguez, CL Stewart, JA Vega, K Tryggvason, JM Freije, C López-Otín |
Nature | 2005 |
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Stem Cell Self-Renewal and Cancer Cell Proliferation Are Regulated by Common Networks That Balance the Activation of Proto-oncogenes and Tumor Suppressors
R Pardal, A Molofsky, S He, S Morrison |
Cold Spring Harbor Symposia on Quantitative Biology | 2005 |
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Telomere-independent cellular senescence in human fetal cardiomyocytes
AJ Ball, F Levine |
Aging Cell | 2005 |
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The Tale of the Telomere: Implications for Prevention and Treatment of Skin Cancers
BA Gilchrest, MS Eller |
Journal of Investigative Dermatology Symposium Proceedings | 2005 |
|
Handbook of the Biology of Aging
PM Wise |
Handbook of the Biology of Aging | 2005 |
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Telomere Length on Bladder Washing Samples from Patients with Bladder Cancer Correlates with Tumor Characteristics
J Fernandez-Gomez, SE Barmadah, D Gosalbez, O Rodriguez-Faba, A Jalon, R Gonzalez, TG Miralles, A Calas |
European Urology | 2005 |
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Mesenchymal stem cell aging
C Fehrer, G Lepperdinger |
Experimental Gerontology | 2005 |
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INK4a/ARF: A multifunctional tumor suppressor locus
NE Sharpless |
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2005 |
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Diversity of NKR expression in aging T cells and in T cells of the aged: The new frontier into the exploration of protective immunity in the elderly
S Abedin, JJ Michel, B Lemster, AN Vallejo |
Experimental Gerontology | 2005 |
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Chromosomal instability in mouse metastatic pancreatic cancer—it’s Kras and Tp53 after all
JT Siveke, RM Schmid |
Cancer Cell | 2005 |
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ARF-BP1/Mule Is a Critical Mediator of the ARF Tumor Suppressor
D Chen, N Kon, M Li, W Zhang, J Qin, W Gu |
Cell | 2005 |
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Thermodynamic and electrostatic properties of ternary Oxytricha nova TEBP–DNA complex
M Wojciechowski, F Fogolari, M Baginski |
Journal of Structural Biology | 2005 |
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Telomerase extends a helping hand to progenitor cells
S Natesan |
Trends in Biotechnology | 2005 |
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Analysis of telomeric single-strand overhang length in human endometrial cancers
M Hashimoto, S Kyo, K Masutomi, Y Maida, J Sakaguchi, Y Mizumoto, M Nakamura, WC Hahn, M Inoue |
FEBS Letters | 2005 |
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Replicative senescence in sheep fibroblasts is a p53 dependent process
T Davis, JW Skinner, RG Faragher, CJ Jones, D Kipling |
Experimental Gerontology | 2005 |
|
Molecular events in kidney ageing:
KS Famulski, PF Halloran |
Current Opinion in Nephrology and Hypertension | 2005 |
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DNA Damage Recognition
E Hendrickson, J Huffman, J Tainer |
DNA Damage Recognition | 2005 |
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Molecular Carcinogenesis and the Molecular Biology of Human Cancer
J Tichelaar, G Leikauf |
Molecular Carcinogenesis and the Molecular Biology of Human Cancer | 2005 |
|
Longitudinal Assessment of Hematopoietic Abnormalities After Autologous Hematopoietic Cell Transplantation for Lymphoma
R Bhatia, KV Heijzen, A Palmer, A Komiya, ML Slovak, KL Chang, H Fung, A Krishnan, A Molina, A Nademanee, M O'Donnell, L Popplewell, R Rodriguez, SJ Forman, S Bhatia |
Journal of Clinical Oncology | 2005 |
|
Redox Properties of Tea Polyphenols and Related Biological Activities
S Sang, Z Hou, JD Lambert, CS Yang |
Antioxidants & Redox Signaling | 2005 |
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Asymmetry and the origins of ageing
TB Kirkwood |
Mechanisms of Ageing and Development | 2005 |
|
Analyzing T Cell Responses
D Nagorsen, FM Marincola |
2005 | |
|
Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior
I Flores, ML Cayuela, MA Blasco |
Science | 2005 |
|
Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?
PG Pelicci |
Journal of Clinical Investigation | 2004 |
|
Emerging Technologies: Trendy RNA Tools for Aging Research
CC Deocaris, SC Kaul, K Taira, R Wadhwa |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2004 |
|
The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells
N Martinez, B Drescher, H Riehle, C Cullmann, HP Vornlocher, A Ganser, G Heil, A Nordheim, J Krauter, O Heidenreich |
BMC Cancer | 2004 |
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Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG
LQ Sun, DW Lee, Q Zhang, W Xiao, EH Raabe, A Meeker, D Miao, DL Huso, RJ Arceci |
Genes & development | 2004 |
|
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG
LQ Sun, DW Lee, Q Zhang, W Xiao, EH Raabe, A Meeker, D Miao, DL Huso, RJ Arceci |
Genes & development | 2004 |
|
Telomerase dysfunction and dyskeratosis congenita
AJ Walne, I Dokal |
Cytotechnology | 2004 |
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Midbrain-derived neural stem cells: from basic science to therapeutic approaches
A Storch, M Sabolek, J Milosevic, SC Schwarz, J Schwarz |
Cell and Tissue Research | 2004 |
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Cancer and aging: symposium of the 27th annual meeting of the Japanese society for biomedical gerontology, Tokyo
M Kitagawa, M Utsuyama, M Kurata, K Yamamoto, Y Yuasa, Y Ishikawa, T Arai, K Hirokawa |
Cancer Immunology, Immunotherapy | 2004 |
|
Opinion: Will telomere erosion lead to a loss of T-cell memory?
AN Akbar, PC Beverley, M Salmon |
Nature Reviews Immunology | 2004 |
|
Decrease of Nuclear Reactivity to Growth-regulatory Galectin-1 in Senescent Human Keratinocytes and Detection of Non-uniform Staining Profile Alterations upon Prolonged Culture for Galectin-1 and -3
M Chovanec, K Smetana, B Dvorankova, Z Plzakova, S Andre, HJ Gabius |
Anatomia, Histologia, Embryologia: Journal of Veterinary Medicine Series C | 2004 |
|
Flow cytometric detection of accelerated telomere shortening in myelodysplastic syndromes: correlations with aetiological and clinical-biological findings*
GM Rigolin, MD Porta, AM Bugli, B Castagnari, E Mauro, LZ Bragotti, M Ciccone, A Cuneo, G Castoldi |
European Journal of Haematology | 2004 |
|
Signaling pathway requirements for induction of senescence by telomere homolog oligonucleotides
GZ Li, MS Eller, K Hanna, BA Gilchrest |
Experimental Cell Research | 2004 |
|
Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention
Z Hou, JD Lambert, KV Chin, CS Yang |
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2004 |
|
Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence
JJ Jacobs, T Lange |
Current Biology | 2004 |
|
Using DNA Damage Responses to Prevent and Treat Skin Cancers
BA Gilchrest |
The Journal of Dermatology | 2004 |
|
Nanoscale Technology in Biological Systems
RL Smith |
Nanoscale Technology in Biological Systems | 2004 |
|
Dioxin-induced Immortalization of Normal Human Keratinocytes and Silencing of p53 and p16 INK4a
SS Ray, HI Swanson |
The Journal of biological chemistry | 2004 |
|
Decreased Longevity and Enhancement of Age-Dependent Lesions in Mice Lacking the Nuclear Receptor Peroxisome Proliferator-Activated Receptor α (PPARα)
P Howroyd, C Swanson, C Dunn, RC Cattley, JC Corton |
Toxicologic pathology | 2004 |
|
Replicative senescence: a critical review
VJ Cristofalo, A Lorenzini, RG Allen, C Torres, M Tresini |
Mechanisms of Ageing and Development | 2004 |
|
Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?
Pelicci PG |
Journal of Clinical Investigation | 2004 |
|
Expression of IAP family proteins in colon cancers from patients with different age groups
Endo T, Abe S, Seidlar HB, Nagaoka S, Takemura T, Utsuyama M, Kitagawa M, Hirokawa K |
Cancer Immunology, Immunotherapy | 2004 |
|
Do Sunscreens Increase or Decrease Melanoma Risk: An Epidemiologic Evaluation
MA Weinstock |
Journal of Investigative Dermatology Symposium Proceedings | 1999 |
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