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Usage Information

The TRAIL to arthritis
George C. Tsokos, Maria Tsokos
George C. Tsokos, Maria Tsokos
Published November 1, 2003
Citation Information: J Clin Invest. 2003;112(9):1315-1317. https://doi.org/10.1172/JCI20297.
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Commentary

The TRAIL to arthritis

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Abstract

Antigen-specific lymphocytes are involved in synovial proliferation within inflamed joints. Activated lymphocytes and synoviocytes from patients with rheumatoid arthritis express receptors that can bind TNF-related apoptosis-inducing ligand (TRAIL). A new study demonstrates that DCs pulsed with collagen and transduced with an adenovirus-based vector able to express TRAIL limit the incidence of arthritis in a model of collagen-induced arthritis and joint inflammation. These results suggest that gene-modified cell therapy represents a therapeutic option for systemic rheumatic diseases.

Authors

George C. Tsokos, Maria Tsokos

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Usage data is cumulative from May 2024 through May 2025.

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PDF 49 9
Figure 44 2
Citation downloads 70 0
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