Big mitogen-activated protein kinase 1 (BMK1), also known as ERK5, is a member of the MAPK family. Genetic ablation of BMK1 in mice leads to embryonic lethality, precluding the exploration of pathophysiological roles of BMK1 in adult mice. We generated a BMK1 conditional mutation in mice in which disruption of the BMK1 gene is under the control of the inducible Mx1-Cre transgene. Ablation of BMK1 in adult mice led to lethality within 2–4 weeks after the induction of Cre recombinase. Physiological analysis showed that the blood vessels became abnormally leaky after deletion of the BMK1 gene. Histological analysis revealed that, after BMK1 ablation, hemorrhages occurred in multiple organs in which endothelial cells lining the blood vessels became round, irregularly aligned, and, eventually, apoptotic. In vitro removal of BMK1 protein also led to the death of endothelial cells partially due to the deregulation of transcriptional factor MEF2C, which is a direct substrate of BMK1. Additionally, endothelial-specific BMK1-KO leads to cardiovascular defects identical to that of global BMK1-KO mutants, whereas, surprisingly, mice lacking BMK1 in cardiomyocytes developed to term without any apparent defects. Taken together, the data provide direct genetic evidence that the BMK1 pathway is critical for endothelial function and for maintaining blood vessel integrity.
Masaaki Hayashi, Sung-Woo Kim, Kyoko Imanaka-Yoshida, Toshimichi Yoshida, E. Dale Abel, Brian Eliceiri, Young Yang, Richard J. Ulevitch, Jiing-Dwan Lee
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LRG1 loss effectively restrains glomerular TGF-β signaling to attenuate DKD in diabetic mice
Xuan Wang, Zeguo Sun, Jia Fu, Zhengying Fang, Weijia Zhang, John He, Kyung Lee |
Molecular Therapy | 2024 |
Role of Mitogen-Activated Protein (MAP) Kinase Pathways in Metabolic Diseases
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Genome integrity | 2024 |
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Biomolecules | 2024 |
Comparative analysis of two independent Myh6-Cre transgenic mouse lines
Davenport A, Kessinger CW, Pfeiffer RD, Shah N, Xu R, Abel ED, Tucker NR, Lin Z |
Journal of molecular and cellular cardiology plus | 2024 |
VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells.
Mondru AK, Aljasir MA, Alrumayh A, Nithianandarajah GN, Ahmed K, Muller J, Goldring CEP, Wilm B, Cross MJ |
Cells | 2023 |
Gene Structure, Expression and Function Analysis of MEF2 in the Pacific White Shrimp Litopenaeus vannamei.
Xia Y, Zhong X, Zhang X, Zhang X, Yuan J, Liu C, Sha Z, Li F |
International journal of molecular sciences | 2023 |
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Cells | 2023 |
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Experimental & molecular medicine | 2023 |
TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development
Tsitsikov EN, Phan KP, Liu Y, Tsytsykova AV, Kinter M, Selland L, Garman L, Griffin C, Dunn IF |
iScience | 2023 |
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Frontiers in Cell and Developmental Biology | 2023 |
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International journal of molecular sciences | 2023 |
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Cancers | 2022 |
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Cells | 2022 |
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Cell Chemical Biology | 2022 |
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R Paudel, L Fusi, M Schmidt |
International journal of molecular sciences | 2021 |
Retinal Inflammation, Oxidative Stress, and Vascular Impairment Is Ablated in Diabetic Mice Receiving XMD8-92 Treatment
SJ Howell, CA Lee, JC Batoki, TE Zapadka, SI Lindstrom, BE Taylor, PR Taylor |
Frontiers in pharmacology | 2021 |
MEKK3–TGFβ crosstalk regulates inward arterial remodeling
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Proceedings of the National Academy of Sciences | 2021 |
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AA Zarrin, K Bao, P Lupardus, D Vucic |
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Cell Death Discovery | 2020 |
Beyond Kinase Activity: ERK5 Nucleo-Cytoplasmic Shuttling as a Novel Target for Anticancer Therapy
A Tubita, Z Lombardi, I Tusa, PD Sbarba, E Rovida |
International journal of molecular sciences | 2020 |
The MEK5–ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer
S Cristea, GL Coles, D Hornburg, M Gershkovitz, J Arand, S Cao, T Sen, SC Williamson, JW Kim, AP Drainas, A He, LL Cam, LA Byers, MP Snyder, K Contrepois, J Sage |
Cancer research | 2020 |
CRISPR-Cas deployment in non-small cell lung cancer for target screening, validations, and discoveries
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Cancer Gene Therapy | 2020 |
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B Stecca, E Rovida |
International journal of molecular sciences | 2019 |
MEF2 and the Right Ventricle: From Development to Disease
KR Clapham, I Singh, IS Capuano, S Rajagopal, HJ Chun |
Frontiers in Cardiovascular Medicine | 2019 |
A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis
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Nature Communications | 2019 |
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Journal of Atherosclerosis and Thrombosis | 2018 |
Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity
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Oncogene | 2018 |
Fluvastatin inhibits AGE-induced cell proliferation and migration via an ERK5-dependent Nrf2 pathway in vascular smooth muscle cells
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PloS one | 2017 |
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Journal of Molecular Neuroscience | 2017 |
Inhibition of Mef2a Enhances Neovascularization via Post-transcriptional Regulation of 14q32 MicroRNAs miR-329 and miR-494
SM Welten, MR de Vries, EA Peters, S Agrawal, PH Quax, AY Nossent |
Molecular Therapy - Nucleic Acids | 2017 |
Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase
LQ Zhang, LV Haandel, M Xiong, P Huang, DP Heruth, C Bi, R Gaedigk, X Jiang, DY Li, G Wyckoff, DN Grigoryev, L Gao, L Li, M Wu, JS Leeder, SQ Ye |
Cell Death and Disease | 2017 |
Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ
H Mao, P Lockyer, L Li, CM Ballantyne, C Patterson, L Xie, X Pi |
Nature Communications | 2017 |
Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells
EL Wilkinson, JE Sidaway, MJ Cross |
Journal of Cellular Physiology | 2017 |
Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity
CJ Loveridge, RJ van Hof, G Charlesworth, A King, EH Tan, L Rose, A Daroszewska, A Prior, I Ahmad, M Welsh, EJ Mui, C Ford, M Salji, O Sansom, K Blyth, HY Leung |
Scientific Reports | 2017 |
Shear Stress Induces Change in Extracellular Signal-Regulated Kinase 5 Levels with Sustained Activation under Disturbed and Continuous Laminar Flow
S Shalaby, G Chitragari, B Sumpio, B Sumpio |
International Journal of Angiology | 2017 |
DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma
H Wang, YY Dai, WQ Zhang, PC Hsu, YL Yang, YC Wang, G Chan, A Au, ZD Xu, SJ Jiang, W Wang, D Jablons, L You |
International journal of oncology | 2017 |
Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten -Deficient Mouse Model of Prostate Carcinogenesis
CJ Loveridge, EJ Mui, R Patel, EH Tan, I Ahmad, M Welsh, J Galbraith, A Hedley, C Nixon, K Blyth, O Sansom, HY Leung |
Cancer research | 2017 |
Extracellular Signal-Regulated Kinase 5 is Required for Low-Concentration H 2 O 2 -Induced Angiogenesis of Human Umbilical Vein Endothelial Cells
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BioMed Research International | 2017 |
Kinase-SUMO networks in diabetes-mediated cardiovascular disease
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Metabolism | 2016 |
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Cellular and Molecular Life Sciences | 2016 |
Overexpression of HDAC9 promotes oral squamous cell carcinoma growth, regulates cell cycle progression, and inhibits apoptosis
B Rastogi, SK Raut, NK Panda, V Rattan, BD Radotra, M Khullar |
Molecular and Cellular Biochemistry | 2016 |
ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells
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Proceedings of the National Academy of Sciences | 2016 |
Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site
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Acta Crystallographica Section D-Structural Biology | 2016 |
Targeting MAPK Signaling in Age-Related Macular Degeneration
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Ophthalmology and Eye Diseases | 2016 |
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Genes & development | 2016 |
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Molecular and cellular biology | 2015 |
Endothelial protective genes induced by statin is mimicked by FTI-277 and GGTI-298 drug combination-mediated ERK5 activation
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Biochimica et Biophysica Acta (BBA) - General Subjects | 2015 |
The case for inhibiting p38 mitogen-activated protein kinase in heart failure
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Frontiers in pharmacology | 2015 |
ERK5 Is a Critical Mediator of Inflammation-Driven Cancer
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Cancer research | 2015 |
Platelet ERK5 is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion
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Circulation | 2015 |
Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma
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BMC Cancer | 2015 |
Myocyte enhancer factor 2D promotes tumorigenicity in malignant glioma cells
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Tumor Biology | 2015 |
Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation
K Wilhelmsen, F Xu, K Farrar, A Tran, S Khakpour, S Sundar, A Prakash, J Wang, NS Gray, J Hellman |
Science signaling | 2015 |
MEF2 transcription factors: developmental regulators and emerging cancer genes
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Oncotarget | 2015 |
Inhibition of BMK1 pathway suppresses cancer stem cells through BNIP3 and BNIP3L.
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Oncotarget | 2015 |
Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells
T Maejima, T Inoue, Y Kanki, T Kohro, G Li, Y Ohta, H Kimura, M Kobayashi, A Taguchi, S Tsutsumi, H Iwanari, S Yamamoto, H Aruga, S Dong, JF Stevens, HM Poh, K Yamamoto, T Kawamura, I Mimura, J Suehiro, A Sugiyama, K Kaneki, H Shibata, Y Yoshinaka, T Doi, A Asanuma, S Tanabe, T Tanaka, T Minami, T Hamakubo, J Sakai, N Nozaki, H Aburatani, M Nangaku, X Ruan, H Tanabe, Y Ruan, S Ihara, A Endo, T Kodama, Y Wada, M Aikawa |
PloS one | 2014 |
Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes
II Badshah, DL Baines, ME Dockrell |
Frontiers in pharmacology | 2014 |
Forkhead BoxO transcription factors restrain exercise-induced angiogenesis: FoxO proteins delay exercise-driven angiogenesis
D Slopack, E Roudier, ST Liu, E Nwadozi, O Birot, TL Haas |
The Journal of Physiology | 2014 |
Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectives
S Javadov, S Jang, B Agostini |
Pharmacology & Therapeutics | 2014 |
Role of Extracellular Signal-regulated Kinase 5 in Adipocyte Signaling
H Zhu, S Guariglia, W Li, D Brancho, ZV Wang, PE Scherer, CW Chow |
The Journal of biological chemistry | 2014 |
The transcription factor MEF2C negatively controls angiogenic sprouting of endothelial cells depending on oxygen
C Sturtzel, J Testori, B Schweighofer, M Bilban, E Hofer |
PloS one | 2014 |
Identification of Activators of ERK5 Transcriptional Activity by High-Throughput Screening and the Role of Endothelial ERK5 in Vasoprotective Effects Induced by Statins and Antimalarial Agents
NT Le, Y Takei, Y Izawa-Ishizawa, KS Heo, H Lee, AV Smrcka, BL Miller, KA Ko, S Ture, C Morrell, K Fujiwara, M Akaike, J Abe |
2014 | |
Novel Mechanisms of Endothelial Mechanotransduction
J Abe, BC Berk |
Arteriosclerosis, thrombosis, and vascular biology | 2014 |
Characterization of Extracellular Signal-Regulated Kinase 5 Levels in Human Umbilical Vein Endothelial Cells Exposed to Disturbed and Uniform Flow
S Shalaby, G Chitragari, B Sumpio, B Sumpio |
International Journal of Angiology | 2014 |
Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle
E Roudier, M Milkiewicz, O Birot, D Slopack, A Montelius, T Gustafsson, JH Paik, RA DePinho, GP Casale, II Pipinos, TL Haas |
Angiogenesis | 2013 |
X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor
JM Elkins, J Wang, X Deng, MJ Pattison, JS Arthur, T Erazo, N Gomez, JM Lizcano, NS Gray, S Knapp |
Journal of Medicinal Chemistry | 2013 |
Role of adult neurogenesis in hippocampus-dependent memory, contextual fear extinction and remote contextual memory: New insights from ERK5 MAP kinase
YW Pan, DR Storm, Z Xia |
Neurobiology of Learning and Memory | 2013 |
The wooly mutation (wly) on mouse chromosome 11 is associated with a genetic defect in Fam83g
LA Radden, KM Child, EB Adkins, DV Spacek, AM Feliciano, TR King |
BMC Research Notes | 2013 |
Extracellular Signal-Regulated Kinase 5: A Potential Therapeutic Target for Malignant Mesotheliomas
A Shukla, JM Miller, C Cason, M Sayan, MB MacPherson, SL Beuschel, J Hillegass, PM Vacek, HI Pass, BT Mossman |
Clinical cancer research | 2013 |
Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module
G Glatz, G Gogl, A Alexa, A Remenyi |
The Journal of biological chemistry | 2013 |
ERK5/BMK1 is a novel target of the tumor suppressor VHL: implication in clear cell renal carcinoma.
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Neoplasia (New York, N.Y.) | 2013 |
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis
NT Le, KS Heo, Y Takei, H Lee, CH Woo, E Chang, C McClain, C Hurley, X Wang, F Li, H Xu, C Morrell, MA Sullivan, MS Cohen, IM Serafimova, J Taunton, K Fujiwara, JI Abe |
Circulation | 2012 |
BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction
Q Yang, L Liao, X Deng, R Chen, NS Gray, JR 3rd, JD Lee |
Oncogene | 2012 |
Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer
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BMC Cancer | 2012 |
Transient Ureteral Obstruction Prevents against Kidney Ischemia/Reperfusion Injury via Hypoxia-Inducible Factor (HIF)-2α Activation
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PloS one | 2012 |
Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation
M Kim, S Kim, JH Lim, CH Lee, HC Choi, CH Woo |
The Journal of biological chemistry | 2012 |
MEK5/ERK5 pathway: The first fifteen years
BA Drew, ME Burow, BS Beckman |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2012 |
Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations
K Cunningham, Y Uchida, E O'Donnell, E Claudio, W Li, K Soneji, H Wang, Y Mukouyama, U Siebenlist |
Human Molecular Genetics | 2011 |
Targeting the BMK1 MAP Kinase Pathway in Cancer Therapy
Q Yang, JD Lee |
Clinical cancer research | 2011 |
Disturbed-flow-mediated vascular reactive oxygen species induce endothelial dysfunction.
Heo KS, Fujiwara K, Abe J |
Circulation journal : official journal of the Japanese Circulation Society | 2011 |
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale
BA Rose, T Force, Y Wang |
Physiological reviews | 2010 |
Targeted Deletion of the Extracellular Signal-Regulated Protein Kinase 5 Attenuates Hypertrophic Response and Promotes Pressure Overload–Induced Apoptosis in the Heart
TE Kimura, J Jin, M Zi, S Prehar, W Liu, D Oceandy, J Abe, L Neyses, AH Weston, EJ Cartwright, X Wang |
Circulation research | 2010 |
ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy
Y Wu, Y Zuo, R Chakrabarti, B Feng, S Chen, S Chakrabarti |
Journal of Ophthalmology | 2010 |
Systematic discovery of nonobvious human disease models through orthologous phenotypes
KL McGary, TJ Park, JO Woods, HJ Cha, JB Wallingford, EM Marcotte |
Proceedings of the National Academy of Sciences | 2010 |
SUMO--a post-translational modification with therapeutic potential?
CH Woo, JI Abe |
Current Opinion in Pharmacology | 2010 |
RSK in tumorigenesis: connections to steroid signaling
TS Eisinger-Mathason, J Andrade, DA Lannigan |
Steroids | 2010 |
Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein
Q Yang, X Deng, B Lu, M Cameron, C Fearns, MP Patricelli, JR Yates, NS Gray, JD Lee |
Cancer Cell | 2010 |
Postselection Thymocyte Maturation and Emigration Are Independent of IL-7 and ERK5
MA Weinreich, SC Jameson, KA Hogquist |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Regulation of vascular integrity
M Murakami, M Simons |
Journal of Molecular Medicine | 2009 |
Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development
J Whyte, O Bergin, A Bianchi, S McNally, F Martin |
Breast Cancer Research | 2009 |
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis
RC Doebele, FT Schulze-Hoepfner, J Hong, A Chlenski, BD Zeitlin, K Goel, S Gomes, Y Liu, MK Abe, JE Nor, MW Lingen, MR Rosner |
Blood | 2009 |
MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover
D Spiering, M Schmolke, N Ohnesorge, M Schmidt, M Goebeler, J Wegener, V Wixler, S Ludwig |
The Journal of biological chemistry | 2009 |
Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target
JC Montero, A Ocaña, M Abad, MJ Ortiz-Ruiz, A Pandiella, A Esparís-Ogando |
PloS one | 2009 |
Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells
L Li, RJ Tatake, K Natarajan, Y Taba, G Garin, C Tai, E Leung, J Surapisitchat, M Yoshizumi, C Yan, JI Abe, BC Berk |
Biochemical and Biophysical Research Communications | 2008 |
The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
S Wang, AB Aurora, BA Johnson, X Qi, J McAnally, JA Hill, JA Richardson, R Bassel-Duby, EN Olson |
Developmental Cell | 2008 |
Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7
S Wang, X Li, M Parra, E Verdin, R Bassel-Duby, EN Olson |
Proceedings of the National Academy of Sciences | 2008 |
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis
G Liu, J Han, J Profirovic, E Strekalova, TA Voyno-Yasenetskaya |
Angiogenesis | 2008 |
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
J Rius, M Guma, C Schachtrup, K Akassoglou, AS Zinkernagel, V Nizet, RS Johnson, GG Haddad, M Karin |
Nature | 2008 |
Activation of ERK5 in angiotensin II-induced hypertrophy of human aortic smooth muscle cells
Z Zhao, J Geng, Z Ge, W Wang, Y Zhang, W Kang |
Molecular and Cellular Biochemistry | 2008 |
Non-redundant function of the MEK5–ERK5 pathway in thymocyte apoptosis
SJ Sohn, GM Lewis, A Winoto |
The EMBO Journal | 2008 |
Vascular Endothelial Growth Factor Induces MEF2C and MEF2-Dependent Activity in Endothelial Cells
D Maiti, Z Xu, EJ Duh |
Investigative ophthalmology & visual science | 2008 |
Thymic emigration: when and how T cells leave home.
Weinreich MA, Hogquist KA |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Mitogen-activated protein kinases in heart development and diseases
Y Wang |
Circulation | 2007 |
Recombinant adenovirus as a methodology for exploration of physiologic functions of growth factor pathways
K Wei, F Kuhnert, CJ Kuo |
Journal of Molecular Medicine | 2007 |
Cellular Signaling and Potential New Treatment Targets in Diabetic Retinopathy
ZA Khan, S Chakrabarti |
Experimental Diabetes Research | 2007 |
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
JH Paik, R Kollipara, G Chu, H Ji, Y Xiao, Z Ding, L Miao, Z Tothova, JW Horner, DR Carrasco, S Jiang, DG Gilliland, L Chin, WH Wong, DH Castrillon, RA DePinho |
Cell | 2007 |
Defective Metabolic Signaling in Adenylate Kinase AK1 Gene Knock-out Hearts Compromises Post-ischemic Coronary Reflow*
PP Dzeja, P Bast, D Pucar, B Wieringa, A Terzic |
The Journal of biological chemistry | 2007 |
Integration of Flow-Dependent Endothelial Phenotypes by KLF2
Kush M. Parmar, H. Benjamin Larman, Guohao Dai, Yuzhi Zhang, Eric T. Wang, Sripriya N. Moorthi, Johannes R. Kratz, Zhiyong Lin, Mukesh Jain, Michael A. Gimbrone, Jr., and Guillermo García-Cardeña |
Journal of Clinical Investigation | 2006 |
Transcription factor and kinase-mediated signaling in atherosclerosis and vascular injury
N Adhikari, N Charles, U Lehmann, JL Hall |
Current Atherosclerosis Reports | 2006 |
MAPK signalling: ERK5 versus ERK1/2
S Nishimoto, E Nishida |
EMBO reports | 2006 |
Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms
K Kondoh, K Terasawa, H Morimoto, E Nishida |
Molecular and cellular biology | 2006 |
Genetics and heritability of coronary artery disease and myocardial infarction
B Mayer, J Erdmann, H Schunkert |
Clinical Research in Cardiology | 2006 |
Expressed in the Yeast Saccharomyces cerevisiae , Human ERK5 Is a Client of the Hsp90 Chaperone That Complements Loss of the Slt2p (Mpk1p) Cell Integrity Stress-Activated Protein Kinase
AW Truman, SH Millson, JM Nuttall, V King, M Mollapour, C Prodromou, LH Pearl, PW Piper |
Eukaryotic cell | 2006 |
PB1 Domain-Dependent Signaling Complex Is Required for Extracellular Signal-Regulated Kinase 5 Activation
K Nakamura, MT Uhlik, NL Johnson, KM Hahn, GL Johnson |
Molecular and cellular biology | 2006 |
Dynamic purine signaling and metabolism during neutrophil-endothelial interactions
T Weissmuller, HK Eltzschig, SP Colgan |
Purinergic Signalling | 2005 |
Requirement of the MEK5-ERK5 pathway for neural differentiation in Xenopus embryonic development
S Nishimoto, M Kusakabe, E Nishida |
EMBO reports | 2005 |
Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase
SJ Sohn, D Li, LK Lee, A Winoto |
Molecular and cellular biology | 2005 |
Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation
K Ma, JK Chan, G Zhu, Z Wu |
Molecular and cellular biology | 2005 |
Targeted Deletion of mek5 Causes Early Embryonic Death and Defects in the Extracellular Signal-Regulated Kinase 5/Myocyte Enhancer Factor 2 Cell Survival Pathway
X Wang, AJ Merritt, J Seyfried, C Guo, ES Papadakis, KG Finegan, M Kayahara, J Dixon, RP Boot-Handford, EJ Cartwright, U Mayer, C Tournier |
Molecular and cellular biology | 2005 |
Tumor Necrosis Factor Alpha-Mediated Reduction of KLF2 Is Due to Inhibition of MEF2 by NF-κB and Histone Deacetylases
A Kumar, Z Lin, S SenBanerjee, MK Jain |
Molecular and cellular biology | 2005 |
A Novel Mitogen-Activated Protein Kinase Docking Site in the N Terminus of MEK5α Organizes the Components of the Extracellular Signal-Regulated Kinase 5 Signaling Pathway
J Seyfried, X Wang, G Kharebava, C Tournier |
Molecular and cellular biology | 2005 |
Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice
M Hayashi, JD Lee |
Journal of Molecular Medicine | 2004 |
Undermining the endothelium by ablation of MAPK-MEF2 signaling
EN Olson |
Journal of Clinical Investigation | 2004 |