Usage Information

Critical roles of TRAIL in hepatic cell death and hepatic inflammation
Shi-Jun Zheng, … , Galit Tsabary, Youhai H. Chen
Shi-Jun Zheng, … , Galit Tsabary, Youhai H. Chen
Published January 1, 2004
Citation Information: J Clin Invest. 2004;113(1):58-64. https://doi.org/10.1172/JCI19255.
View: Text | PDF
Article Immunology

Critical roles of TRAIL in hepatic cell death and hepatic inflammation

Abstract

The TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis of tumor cells but not most normal cells. Its role in hepatic cell death and hepatic diseases is not clear. In vitro studies suggest that murine hepatocytes are not sensitive to TRAIL-induced apoptosis, indicating that TRAIL may not mediate hepatic cell death. Using two experimental models of hepatitis, we found that hepatic cell death in vivo was dramatically reduced in TRAIL-deficient mice and mice treated with a blocking TRAIL receptor. Although both TRAIL and its death receptor 5 were constitutively expressed in the liver, TRAIL expression by immune cells alone was sufficient to restore the sensitivity of TRAIL-deficient mice to hepatitis. Thus, TRAIL plays a crucial role in hepatic cell death and hepatic inflammation.

Authors

Shi-Jun Zheng, Pu Wang, Galit Tsabary, Youhai H. Chen

×

Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 747 0
PDF 74 0
Figure 307 0
Citation downloads 61 0
Totals 1,189 0
Total Views 1,189
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement