The average time course of the responses of one slice of the brain to oddball stimuli. Each image (left to right) represents the average time course of the response separated by 1.5 seconds, starting at the time of an auditory (top) or a visual (bottom) oddball stimulus. Various regions activate, and some of these activations are independent of the modality of the stimulus. The yellow arrows indicate activation in the middle frontal and supramarginal gyri. Adapted from ref. 18.