Diabetic retinopathy, the most frequent complication of diabetes and leading cause of vision loss, involves vascular and neural damage in the retina. Insulin and IGF-1 signaling are now shown to contribute to retinal neovascularization, in part, by modulating the expression of various vascular mediators.
Sarah K. Bronson, Chad E.N. Reiter, Thomas W. Gardner
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Ocular manifestations of central insulin resistance
Faiq MA, Sengupta T, Nath M, Velpandian T, Saluja D, Dada R, Dada T, Chan KC |
Neural Regeneration Research | 2022 |
The Safety of Pharmacological and Surgical Treatment of Diabetes in Patients with Diabetic Retinopathy—A Review
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Journal of Clinical Medicine | 2021 |
TNFα and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis
Y Jiang, Q Zhang, C Soderland, JJ Steinle |
Cellular Signalling | 2012 |
What can we learn about stroke from retinal ischemia models?
PM D'Onofrio, PD Koeberle |
Acta Pharmacologica Sinica | 2012 |
High calorie diet triggers hypothalamic angiopathy
CX Yi, M Gericke, M Krüger, A Alkemade, DG Kabra, S Hanske, J Filosa, P Pfluger, N Bingham, SC Woods, J Herman, A Kalsbeek, M Baumann, R Lang, JE Stern, I Bechmann, MH Tschöp |
Molecular Metabolism | 2012 |
Role of β-Adrenergic Receptor Regulation of TNF-α and Insulin Signaling in Retinal Müller Cells
RJ Walker, NM Anderson, Y Jiang, S Bahouth, JJ Steinle |
Investigative ophthalmology & visual science | 2011 |
Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway
P Geraldes, K Yagi, Y Ohshiro, Z He, Y Maeno, J Yamamoto-Hiraoka, C Rask-Madsen, SW Chung, MA Perrella, GL King |
The Journal of biological chemistry | 2008 |
Insulin Receptor Substrate 2 Is Essential for Maturation and Survival of Photoreceptor Cells
X Yi |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2005 |