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Clinical Research and Public HealthIn-Press PreviewOncology
Open Access | 
10.1172/JCI186816
A multicenter prospective clinical trial reveals cell free DNA methylation markers for early esophageal cancer
Ruixiang Zhang,1 Yongzhan Nie,2 Xiaobing Chen,3 Tao Jiang,4 Jinhai Wang,5 Yuhui Peng,6 Guangpeng Zhou,7 Yong Li,1 Lina Zhao,8 Beibei Chen,3 Yunfeng Ni,4 Yan Cheng,5 Yiwei Xu,6 Zhenyu Zhu,7 Xianchun Gao,2 Zhen Wu,7 Tianbao Li,7 Jie Zhao,7 Cantong Liu,6 Gang Zhao,5 Jiakuan Chen,4 Jing Zhao,3 Gang Ji,2 Xiaoliang Han,7 Jie He,1 and Yin Li1
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Chen, X. in: JCI | PubMed | Google Scholar
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Jiang, T. in: JCI | PubMed | Google Scholar
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Wang, J. in: JCI | PubMed | Google Scholar
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Peng, Y. in: JCI | PubMed | Google Scholar
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Zhou, G. in: JCI | PubMed | Google Scholar
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Li, Y. in: JCI | PubMed | Google Scholar
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Zhao, G. in: JCI | PubMed | Google Scholar
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Chen, J. in: JCI | PubMed | Google Scholar
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Zhao, J. in: JCI | PubMed | Google Scholar
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Han, X. in: JCI | PubMed | Google Scholar
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by He, J. in: JCI | PubMed | Google Scholar
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2State Key Laboratory of Holistic Integrative Management of Gastrointestinal, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an, China
5Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi’an, China
6Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, China
7BioChain (Beijing) Science & Technology Inc., Beijing, China
8Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Li, Y. in: JCI | PubMed | Google Scholar
Published February 25, 2025 - More info
Copyright © 2025, Zhang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)