Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
The organization and consequences of eicosanoid signaling
Roy J. Soberman, Peter Christmas
Roy J. Soberman, Peter Christmas
Published April 15, 2003
Citation Information: J Clin Invest. 2003;111(8):1107-1113. https://doi.org/10.1172/JCI18338.
View: Text | PDF
Perspective

The organization and consequences of eicosanoid signaling

  • Text
  • PDF
Abstract

Authors

Roy J. Soberman, Peter Christmas

×

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
LT biosynthesis and assembly. Upon cellular activation of a mast cell or...
LT biosynthesis and assembly. Upon cellular activation of a mast cell or macrophage by IgE-antigen complexes or other stimuli, a cascade of cell activation events results in LT biosynthesis. A concomitant rise in free calcium induces translocation of cPLA2 to intracellular membranes, where it releases arachidonic acid. In parallel, 5-LO is phosphorylated by MAP kinase kinase and traffics through the nuclear pore to the nucleus (possibly in association with NF-κB) or directly to the outer nuclear envelope. 5-LO then associates with the nuclear membrane, and possibly with FLAP. FLAP facilitates arachidonic acid presentation to 5-LO and subsequent conversion of arachidonic acid to LTA4. LTA4 interacts with LTA4 hydrolase to form LTB4, or with LTC4 synthase to form LTC4. The synthesis of LTs A4, B4, and C4probably takes place within the lumen of, or in close proximity to, the nuclear membranes. However, for clarity they are shown here throughout the cytosol. FLAP is present on both the inner and the outer nuclear envelope, but LTC4 synthase is exclusively expressed on the outer nuclear membrane and ER.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts