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ResearchIn-Press PreviewNephrology Open Access | 10.1172/JCI176402
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Yamaguchi, J. in: JCI | PubMed | Google Scholar
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
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1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Robil, N. in: JCI | PubMed | Google Scholar
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by de la Grange, P. in: JCI | PubMed | Google Scholar |
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Hoguin, C. in: JCI | PubMed | Google Scholar
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Schmitt, A. in: JCI | PubMed | Google Scholar
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Hummel, A. in: JCI | PubMed | Google Scholar
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Mégret, J. in: JCI | PubMed | Google Scholar
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
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1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Luka, M. in: JCI | PubMed | Google Scholar
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Ménager, M. in: JCI | PubMed | Google Scholar
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Masson, C. in: JCI | PubMed | Google Scholar
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Zarhrate, M. in: JCI | PubMed | Google Scholar
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Bôle-Feysot, C. in: JCI | PubMed | Google Scholar |
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Janiszewska, M. in: JCI | PubMed | Google Scholar
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Polyak, K. in: JCI | PubMed | Google Scholar |
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Dairou, J. in: JCI | PubMed | Google Scholar
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Baldassari, S. in: JCI | PubMed | Google Scholar
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Baulac, S. in: JCI | PubMed | Google Scholar |
1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
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1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
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1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
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1Université Paris Cité, Paris, France
2Genosplice Technology, Paris Biotech Santé, Paris, France
3Institut Cochin, Paris, France
4Service de Néphrologie, Transplantation Adults, Hôpital Necker-Enfants Malades, Paris, France
5Structure Fédérative de Recherche Necker, INSERM US 24, CNRS UMS 3633, Institut Necker-Enfants Malades, Paris, France
6Inflammatory Responses and Transcriptomic Networks in Diseases, Institut Imagine, Paris, France
7Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Paris, France
8Plateforme Génomique, INSERM U1163, Institut Imagine, Paris, France
9Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technologies, Jupiter, United States of America
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
11Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpital de, Sorbonne Université, Paris, France
12Pharmacie, Hôpital Necker-Enfants Malades, Paris, France
13Institut Necker-Enfants Malades, INSERM U1151, Paris, France
Find articles by Canaud, G. in: JCI | PubMed | Google Scholar
Published June 6, 2024 - More info
Proliferative glomerulonephritis is a severe condition often leading to kidney failure. There is a significant lack of effective treatment for these disorders. Here, following the identification of a somatic PIK3CA gain-of-function mutation in podocytes of a patient, we demonstrate using multiple genetically engineered mouse models, single-cell RNA sequencing and spatial transcriptomics the crucial role played by this pathway for proliferative glomerulonephritis development by promoting podocyte proliferation, dedifferentiation and inflammation. Additionally, we show that alpelisib, a PI3Kα inhibitor, improves glomerular lesions and kidney function in different mouse models of proliferative glomerulonephritis and lupus nephritis by targeting podocytes. Surprisingly, we determined that pharmacological inhibition of PI3Kα affects B and T lymphocyte population in lupus nephritis mouse models with decrease in the production of proinflammatory cytokines, autoantibodies and glomerular complement deposition, which are all characteristic features of PI3K delta (PI3Kδ) inhibition, the primary PI3K isoform expressed in lymphocytes. Importantly, PI3Kα inhibition does not impact lymphocyte function under normal conditions. These findings were then confirmed in human lymphocytes isolated from patients with active lupus nephritis. In conclusion, we demonstrate the major role played by PI3Kα in proliferative glomerulonephritis and show that in this condition, alpelisib acts on both podocytes and the immune system.