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ResearchIn-Press PreviewVascular biology
Open Access | 10.1172/JCI173690
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Song, T. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Zhao, S. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Luo, S. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Chen, C. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Liu, X. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Wu, X. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Sun, Z. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Cao, J. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Wang, Z. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Wang, Y. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Yu, B. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Zhang, Z. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Du, X. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Li, X. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Han, Z. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Chen, H. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Chen, F. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Wang, L. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Wang, H. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Sun, K. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Han, Y. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Xie, L. in: JCI | PubMed | Google Scholar
1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Gusu School, Nanjing Medical University, Nanjing, China
2State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China
3Department of Vascular Surgery, Nanjing University Medical School, Nanjing, China
4Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Forensic Medicine, Nanjing Medical University, Nanjing, China
6Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
7Center for Metabolic Disease Research, Department of Microbiology and Immun, Temple University Lewis Katz School of Medicine, Philadelphia, United States of America
8Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical, Gusu School, Nanjing Medical University, Suzhou, China
9Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Find articles by Ji, Y. in: JCI | PubMed | Google Scholar
Published June 25, 2024 - More info
Aortic aneurysm is a life-threatening disease with limited interventions, closely related to vascular smooth muscle cells (VSMCs) phenotypic switching. SLC44A2, a member of solute carrier series 44 (SLC44) family, remains under-characterized in the context of cardiovascular diseases. Venn diagram analysis based on microarray and single-cell RNA sequencing identified SLC44A2 as a major regulator of VSMCs phenotypic switching in aortic aneurysm. Screening for Slc44a2 amongst aortic cell lineages demonstrated its predominant location in VSMCs. Elevated levels of SLC44A2 were evidenced in the aorta of both abdominal aortic aneurysm patients and angiotensin II (Ang II)-infused Apoe–/– mice. In vitro, SLC44A2 silencing promoted VSMCs towards a synthetic phenotype, while SLC44A2 overexpression attenuated VSMCs phenotypic switching. VSMCs-specific SLC44A2 knockout mice were more susceptible to aortic aneurysm under Ang II infusion, while SLC44A2 overexpression showed protective effects. Mechanistically, SLC44A2 interaction with NRP1 and ITGB3 activates TGF-β/SMAD signaling, thereby promoting contractile genes expression. Elevated SLC44A2 in aortic aneurysm is associated with upregulated runt-related transcription factor 1 (RUNX1). Furthermore, low dose of lenalidomide (LEN) suppressed aortic aneurysm progression by enhancing SLC44A2 expression. These findings reveal SLC44A2/NRP1/ITGB3 complex is a major regulator of VSMCs phenotypic switching and provide potential therapeutic approach (LEN) for aortic aneurysm treatment.