A monoclonal thyroid-stimulating antibody
Takao Ando, … , Yuji Nagayama, Terry F. Davies
Takao Ando, … , Yuji Nagayama, Terry F. Davies
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1667-1674. https://doi.org/10.1172/JCI16991.
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Article Autoimmunity

A monoclonal thyroid-stimulating antibody

Abstract

Research Article

Authors

Takao Ando, Rauf Latif, Alla Pritsker, Thomas Moran, Yuji Nagayama, Terry F. Davies

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Recognition of a TSHR conformational epitope by MS-1. MS-1 recognized th...
Recognition of a TSHR conformational epitope by MS-1. MS-1 recognized the native conformation of hTSHR antigen on unfixed CHO-hTSHR cells (a), but not on fixed CHO-hTSHR cells (b). In contrast to MS-1, mouse monoclonal TSHR-Ab RSR-1 (29) recognized both the native (c) and fixed (d) conformations of the hTSHR. Thin and thick lines indicate staining on CHO and CHO-hTSHR cells, respectively. Fluorescence intensity was measured in FL-1.