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Citations to this article

Orchestrating the unfolded protein response in health and disease
Randal J. Kaufman
Randal J. Kaufman
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1389-1398. https://doi.org/10.1172/JCI16886.
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Orchestrating the unfolded protein response in health and disease

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Randal J. Kaufman

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Biochemistry and Biophysics Reports 2020
Nutraceuticals: An integrative approach to starve Parkinson's disease.
Lama A, Pirozzi C, Avagliano C, Annunziata C, Mollica MP, Calignano A, Meli R, Mattace Raso G
2020
Pancastatin A and B Have Selective Cytotoxicity on Glucose-Deprived PANC-1 Human Pancreatic Cancer Cells.
Park HR
Journal of Microbiology and Biotechnology 2020
BACE1 Translation: At the Crossroads Between Alzheimer’s Disease Neurodegeneration and Memory Consolidation
FX Guix, CL Sartório, G ILL-Raga
Journal of Alzheimer's Disease Reports 2019
Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes
R Ghosh, K Colon-Negron, FR Papa
Molecular Metabolism 2019
Sleep, Aging, and Cellular Health: Aged-Related Changes in Sleep and Protein Homeostasis Converge in Neurodegenerative Diseases
JM Hafycz, NN Naidoo
Frontiers in aging neuroscience 2019
Ursolic Acid Protected Lung of Rats From Damage Induced by Cigarette Smoke Extract
L Lin, G Hou, D Han, J Kang, Q Wang
Frontiers in pharmacology 2019
Ghrelin alleviates endoplasmic reticulum stress and inflammation-mediated reproductive dysfunction induced by stress
Y Wang, L Cao, X Liu
Journal of Assisted Reproduction and Genetics 2019
A Novel Animal Model for Studying Depression Featuring the Induction of the Unfolded Protein Response in Hippocampus
M Timberlake, B Roy, Y Dwivedi
Molecular Neurobiology 2019
An integrated review on new targets in the treatment of neuropathic pain
RK Khangura, J Sharma, A Bali, N Singh, AS Jaggi
The Korean Journal of Physiology & Pharmacology 2019
Activation of the PERK-ATF4 pathway promotes chemo-resistance in colon cancer cells
Z Shi, X Yu, M Yuan, W Lv, T Feng, R Bai, H Zhong
Scientific Reports 2019
Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma
PS OBrien, , JR Miller, AL Brownell, Q Zeng, GH Yoo, DM Garshott, MB OBrien, AE Galinato, P Cai, N Narula, MU Callaghan, RJ Kaufman, AM Fribley
Journal of Clinical Medicine 2019
Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications for Parkinson's Disease
A Sanyal, S Dutta, A Camara, A Chandran, A Koller, BG Watson, R Sengupta, D Ysselstein, P Montenegro, J Cannon, JC Rochet, S Mattoo
Journal of Molecular Biology 2019
XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease
KA Piróg, EP Dennis, CL Hartley, RM Jackson, J Soul, JM Schwartz, JF Bateman, RP Boot-Handford, MD Briggs, T van Agtmael
PLoS genetics 2019
Exosomes from Microglia Attenuate Photoreceptor Injury and Neovascularization in an Animal Model of Retinopathy of Prematurity
W Xu, Y Wu, Z Hu, L Sun, G Dou, Z Zhang, H Wang, C Guo, Y Wang
Molecular Therapy — Nucleic Acids 2019
Discovery of N ‐(2‐(Benzylamino)‐2‐oxoethyl)benzamide analogs as a novel scaffold of pancreatic β‐cell protective agents against endoplasmic reticulum stress
V Eeda, O HerleaPana, HY Lim, W Wang
Chemical Biology & Drug Design 2019
Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1.
Cheng FY, Lee YH, Hsu YH, Chiu IJ, Chiu YJ, Lin YF, Chiu HW
Aging 2019
Elevated expression of unfolded protein response genes in the prefrontal cortex of depressed subjects: Effect of suicide.
Yoshino Y, Dwivedi Y
Journal of Affective Disorders 2019
Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β.
Talty A, Deegan S, Ljujic M, Mnich K, Naicker SD, Quandt D, Zeng Q, Patterson JB, Gorman AM, Griffin MD, Samali A, Logue SE
Cell Death and Disease 2019
Korean Red Ginseng Extract Increases Apoptosis by Activation of the Noxa Pathway in Colorectal Cancer.
Jeong YA, Kim BR, Kim DY, Jeong S, Na YJ, Kim JL, Yun HK, Kim BG, Park SH, Jo MJ, Lee SI, Han BC, Lee DH, Oh SC
Nutrients 2019
Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity.
Li CF, Pan YK, Gao Y, Shi F, Wang YC, Sun XQ
Apoptosis : an international journal on programmed cell death 2019
Endoplasmic reticulum stress-induced cellular dysfunction and cell death in insulin-producing cells results in diabetes-like phenotypes in Drosophila.
Katsube H, Hinami Y, Yamazoe T, Inoue YH
Biology Open 2019
Restoration of skeletal muscle homeostasis by hydrogen sulfide during hyperhomocysteinemia-mediated oxidative/ER stress condition
A Majumder, M Singh, AK George, SC Tyagi
Canadian Journal of Physiology and Pharmacology 2018
IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases
RP Junjappa, P Patil, KR Bhattarai, HR Kim, HJ Chae
Frontiers in immunology 2018
Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II
Y Osaki, A Saito, S Kanemoto, M Kaneko, K Matsuhisa, R Asada, T Masaki, K Orii, T Fukao, S Tomatsu, K Imaizumi
Cell Death and Disease 2018
Linking unfolded protein response to inflammation and depression: potential pathologic and therapeutic implications
, Y Dwivedi
Molecular Psychiatry 2018
Unfolded protein response and associated alterations in toll-like receptor expression and interaction in the hippocampus of restraint rats
M Timberlake, K Prall, B Roy, Y Dwivedi
Psychoneuroendocrinology 2018
Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria, and Plasma Membrane
A Saito, K Imaizumi
International journal of molecular sciences 2018
New insights into the cellular temporal response to proteostatic stress
J Rendleman, Z Cheng, S Maity, N Kastelic, M Munschauer, K Allgoewer, G Teo, YB Zhang, A Lei, B Parker, M Landthaler, L Freeberg, S Kuersten, H Choi, C Vogel
eLife 2018
Gene Therapy Strategies to Restore ER Proteostasis in Disease
V Valenzuela, KL Jackson, SP Sardi, C Hetz
Molecular Therapy 2018
Understanding the Unfolded Protein Response in the Pathogenesis of Asthma
PS Pathinayake, AC Hsu, DW Waters, PM Hansbro, LG Wood, PA Wark
Frontiers in immunology 2018
Tauroursodeoxycholic Acid Alleviates H 2 O 2 -Induced Oxidative Stress and Apoptosis via Suppressing Endoplasmic Reticulum Stress in Neonatal Rat Cardiomyocytes
L Zhang, Y Wang
Dose-Response 2018
Decreased contraction induced by endothelium-derived contracting factor in prolonged treatment of rat renal artery with endoplasmic reticulum stress inducer
M Ando, T Matsumoto, K Taguchi, T Kobayashi
Naunyn-Schmiedeberg's Archives of Pharmacology 2018
Proteostasis in epicardial versus subcutaneous adipose tissue in heart failure subjects with and without diabetes
A Burgeiro, AC Fonseca, D Espinoza, L Carvalho, N Lourenço, M Antunes, E Carvalho
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2018
Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease
XS Zeng, WS Geng, JJ Jia, L Chen, PP Zhang
Frontiers in aging neuroscience 2018
Loss-of-function of Nav1.8/D1639N linked to human pain can be rescued by lidocaine
L Kaluza, JE Meents, M Hampl, C Rösseler, PA Hautvast, S Detro-Dassen, R Hausmann, G Schmalzing, A Lampert
Pflügers Archiv - European Journal of Physiology 2018
STF-083010, an inhibitor of XBP1 splicing, attenuates acute renal failure in rats by suppressing endoplasmic reticulum stress-induced apoptosis and inflammation
L Liu, L Xu, S Zhang, D Wang, G Dong, H Chen, X Li, C Shu, R Wang
Experimental Animals 2018
Cellular stress and apoptosis contribute to the pathogenesis of autism spectrum disorder: The role of cellular stress and apoptosis in autism
D Dong, HR Zielke, D Yeh, P Yang
Autism research : official journal of the International Society for Autism Research 2018
Genetic Variability in eIF2 α Gene Is Associated with Islet β -Cell Function in the Development of Diabetes in a Chinese Han Population
N Gu, X Ma, J Zhang, M Jin, N Feng, R Deng, G Bai, H Zhang, X Guo
International Journal of Endocrinology 2018
Ixeris dentata Extract Increases Salivary Secretion through the Regulation of Endoplasmic Reticulum Stress in a Diabetes-Induced Xerostomia Rat Model
K Bhattarai, HY Lee, SH Kim, HR Kim, HJ Chae
International journal of molecular sciences 2018
Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review
C Kim, B Kim
Nutrients 2018
Blocking variant surface glycoprotein synthesis alters endoplasmic reticulum exit sites/Golgi homeostasis in Trypanosoma brucei
CP Ooi, TK Smith, E Gluenz, NV Wand, S Vaughan, G Rudenko
Traffic (Copenhagen, Denmark) 2018
Diazoxide inhibits of ER stress‑mediated apoptosis during oxygen‑glucose deprivation in�vitro and cerebral ischemia‑reperfusion in�vivo
X Lei, L Lei, Z Zhang, Y Cheng
Molecular medicine reports 2018
GDC-0879, a BRAF V600E Inhibitor, Protects Kidney Podocytes from Death
J Sieber, N Wieder, A Clark, M Reitberger, S Matan, J Schoenfelder, J Zhang, A Mandinova, JA Bittker, J Gutierrez, O Aygün, N Udeshi, S Carr, P Mundel, AW Jehle, A Greka
Cell Chemical Biology 2018
Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells
S Kamei, H Fujikawa, H Nohara, K Ueno-Shuto, K Maruta, R Nakashima, T Kawakami, C Matsumoto, Y Sakaguchi, T Ono, MA Suico, RC Boucher, DC Gruenert, T Takeo, N Nakagata, JD Li, H Kai, T Shuto
EBioMedicine 2018
Endoplasmic reticulum chaperone glucose-regulated protein�78 in gastric cancer: An emerging biomarker (Review)
Y Wang, JH Wang, XL Zhang, XL Wang, L Yang
Oncology Letters 2018
Tail Vein Infusion of Adipose-Derived Mesenchymal Stem Cell Alleviated Inflammatory Response and Improved Blood Brain Barrier Condition by Suppressing Endoplasmic Reticulum Stress in a Middle Cerebral Artery Occlusion Rat Model
L Chi, Y Huang, Y Mao, K Wu, L Zhang, G Nan
Medical science monitor : international medical journal of experimental and clinical research 2018
Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury
A Majumder, M Singh, J Behera, NT Theilen, AK George, N Tyagi, N Metreveli, SC Tyagi
American journal of physiology. Cell physiology 2018
The endoplasmic reticulum stress transducer old astrocyte specifically induced substance positively regulates glial scar formation in spinal cord injury:
Y Sumida, N Kamei, N Suga, M Ochi, N Adachi
NeuroReport 2018
Different Forms of ER Stress in Chondrocytes Result in Short Stature Disorders and Degenerative Cartilage Diseases: New Insights by Cartilage-Specific ERp57 Knockout Mice
Y Rellmann, R Dreier
Oxidative medicine and cellular longevity 2018
ER Stress, CREB, and Memory: A Tangled Emerging Link in Disease
N Sen
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2018
How to design an optimal sensor network for the unfolded protein response
W Stroberg, H Aktin, Y Savir, S Schnell, L Edelstein-Keshet
Molecular biology of the cell 2018
Intravenous human endothelial progenitor cell administration into aged mice enhances embryo development and oocyte quality by reducing inflammation, endoplasmic reticulum stress and apoptosis
GA KIM, Y LEE, HJ KIM, HJ OH, SK KANG, JC RA, BC LEE
Journal of Veterinary Medical Science 2018
Adaptive responses to low doses of radiation or chemicals: their cellular and molecular mechanisms
Y Guéguen, A Bontemps, TG Ebrahimian
Cellular and Molecular Life Sciences 2018
Systemic signalling and local effectors in developmental stability, body symmetry, and size.
Juarez-Carreño S, Morante J, Dominguez M
2018
Regulation of IRE1α by the small molecule inhibitor 4μ8c in hepatoma cells
C Stewart, A Estrada, P Kim, D Wang, Y Wei, C Gentile, M Pagliassotti
Endoplasmic Reticulum Stress in Diseases 2017
Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma
A Saito, L Cai, K Matsuhisa, Y Ohtake, M Kaneko, S Kanemoto, R Asada, K Imaizumi
Journal of Neurochemistry 2017
Physiological/pathological ramifications of transcription factors in the unfolded protein response
J Han, RJ Kaufman
Genes & development 2017
Reactive oxygen species-mediated unfolded protein response pathways in preimplantation embryos
I Ali, SZ Shah, Y Jin, ZS Li, O Ullah, NZ Fang
Journal of Veterinary Science 2017
Positioning of proteasome inhibitors in therapy of solid malignancies
MS Roeten, J Cloos, G Jansen
Cancer Chemotherapy and Pharmacology 2017
Role of IRE1α/XBP-1 in Cystic Fibrosis Airway Inflammation
C Ribeiro, B Lubamba
International journal of molecular sciences 2017
IRE1α nucleotide sequence cleavage specificity in the unfolded protein response
J Poothong, P Sopha, RJ Kaufman, W Tirasophon
FEBS Letters 2017
Role of endoplasmic reticulum stress signalling in diabetic endothelial dysfunction and atherosclerosis
Y Dong, C Fernandes, Y Liu, Y Wu, H Wu, ML Brophy, L Deng, K Song, A Wen, S Wong, D Yan, R Towner, H Chen
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2017
HMGB1 induces endothelial progenitor cells apoptosis via RAGE-dependent PERK/eIF2α pathway
Q Huang, Z Yang, JP Zhou, Y Luo
Molecular and Cellular Biochemistry 2017
Nck2, an unexpected regulator of adipogenesis
N Haider, J Dusseault, A Rudich, L Larose
Adipocyte 2017
Effects of the Activin A–Follistatin System on Myocardial Cell Apoptosis through the Endoplasmic Reticulum Stress Pathway in Heart Failure
M Liu, C Mao, J Li, F Han, P Yang
International journal of molecular sciences 2017
The Role of Endoplasmic Reticulum Stress in Diabetic Nephropathy
Y Fan, K Lee, N Wang, JC He
Current Diabetes Reports 2017
Japanese encephalitis virus induces human neural stem/progenitor cell death by elevating GRP78, PHB and hnRNPC through ER stress
S Mukherjee, N Singh, N Sengupta, M Fatima, P Seth, A Mahadevan, SK Shankar, A Bhattacharyya, A Basu
Cell Death and Disease 2017
DR5 and caspase-8 are dispensable in ER stress-induced apoptosis
JA Glab, M Doerflinger, C Nedeva, I Jose, GW Mbogo, JC Paton, AW Paton, AJ Kueh, MJ Herold, DC Huang, D Segal, G Brumatti, H Puthalakath
Cell Death and Differentiation 2017
Endoplasmic Reticulum Stress, NRF2 Signalling and Cardiovascular Diseases in a Nutshell
C Mozzini, L Cominacini, U Garbin, AM Pasini
Current Atherosclerosis Reports 2017
Melatonin Modulates Neuronal Cell Death Induced by Endoplasmic Reticulum Stress under Insulin Resistance Condition
J Song, O Kim
Nutrients 2017
Reduced Sleep During Social Isolation Leads to Cellular Stress and Induction of the Unfolded Protein Response
MK Brown, E Strus, N Naidoo
Sleep 2017
A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure
Y Yao, Q Lu, Z Hu, Y Yu, Q Chen, QK Wang
Nature Communications 2017
Transmembrane thioredoxin-related protein TMX1 is reversibly oxidized in response to protein accumulation in the endoplasmic reticulum
Y Matsuo, K Hirota
FEBS Open Bio 2017
Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes
S Alam, CS Abdullah, R Aishwarya, AW Orr, J Traylor, S Miriyala, M Panchatcharam, CB Pattillo, MS Bhuiyan
Bioscience Reports 2017
Suppression of PKC causes oncogenic stress for triggering apoptosis in cancer cells
S Ganapathy, B Peng, L Shen, T Yu, J Lafontant, P Li, R Xiong, A Makriyannis, C Chen
Oncotarget 2017
XBP1-Mediated BiP/GRP78 Upregulation Copes with Oxidative Stress in Mosquito Cells during Dengue 2 Virus Infection
TH Chen, YH Chiang, JN Hou, CC Cheng, E Sofiyatun, CH Chiu, WJ Chen
BioMed Research International 2017
Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress
J Sieber, N Wieder, M Ostrosky-Frid, M Dvela-Levitt, O Aygün, ND Udeshi, SA Carr, A Greka
The Journal of biological chemistry 2017
HIV-1-associated inflammation and antiretroviral therapy regulate astrocyte endoplasmic reticulum stress responses
S Nooka, A Ghorpade
Cell Death Discovery 2017
l-Serine-Mediated Neuroprotection Includes the Upregulation of the ER Stress Chaperone Protein Disulfide Isomerase (PDI)
RA Dunlop, JT Powell, JS Metcalf, GJ Guillemin, PA Cox
Neurotoxicity Research 2017
Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress
C Maillo, J Martín, D Sebastián, M Hernández-Alvarez, M García-Rocha, O Reina, A Zorzano, M Fernandez, R Méndez
Nature Cell Biology 2017
Poxviruses Utilize Multiple Strategies to Inhibit Apoptosis.
Nichols DB, De Martini W, Cottrell J
Viruses 2017
Non-Exertional Heatstroke: A Case Report and Review of the Literature.
Mozzini C, Xotta G, Garbin U, Fratta Pasini AM, Cominacini L
2017
Hepatic BSCL2 (Seipin) Deficiency Disrupts Lipid Droplet Homeostasis and Increases Lipid Metabolism via SCD1 Activity
MA Lounis, S Lalonde, SA Rial, KF Bergeron, JC Ralston, DM Mutch, C Mounier
Lipids 2016
Overexpression of CHOP in Myelinating Cells Does Not Confer a Significant Phenotype under Normal or Metabolic Stress Conditions
CM Southwood, B Fykkolodziej, KJ Maheras, DM Garshott, M Estill, AM Fribley, A Gow
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Altered Expression of Endoplasmic Reticulum Stress Associated Genes in Hippocampus of Learned Helpless Rats: Relevance to Depression Pathophysiology
MA Timberlake, Y Dwivedi
Frontiers in pharmacology 2016
Endoplasmic reticulum stress-induced apoptosis accompanies enhanced expression of multiple inositol polyphosphate phosphatase 1 (Minpp1): a possible role for Minpp1 in cellular stress response
SP Kilaparty, R Agarwal, P Singh, K Kannan, N Ali
Cell Stress and Chaperones 2016
Pancreatic β Cell Mass Death
HI Marrif, SI Al-Sunousi
Frontiers in pharmacology 2016
Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders
Y Cai, J Arikkath, L Yang, ML Guo, P Periyasamy, S Buch
Autophagy 2016
The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury:
H Zhou, J Zhu, S Yue, L Lu, RW Busuttil, JW Kupiec-Weglinski, X Wang, Y Zhai
Transplantation 2016
Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view
MJ Pagliassotti, PY Kim, AL Estrada, CM Stewart, CL Gentile
Metabolism 2016
Pressure Combined with Ischemia/Reperfusion Injury Induces Deep Tissue Injury via Endoplasmic Reticulum Stress in a Rat Pressure Ulcer Model
FF Cui, YY Pan, HH Xie, XH Wang, HX Shi, J Xiao, HY Zhang, HT Chang, LP Jiang
International journal of molecular sciences 2016
Modulating protein quality control
L Plate, RJ Paxman, RL Wiseman, JW Kelly
eLife 2016
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila
T Niccoli, M Cabecinha, A Tillmann, F Kerr, CT Wong, D Cardenes, AJ Vincent, L Bettedi, L Li, S Grönke, J Dols, L Partridge
Current Biology 2016
Drivers: A Biologically Contextualized, Cross-Inferential View of the Epidemiology of Neurodegenerative Disorders
J Pedro-Cuesta, P Martínez-Martín, A Rábano, E Alcalde-Cabero, FJ López, J Almazán-Isla, M Ruiz-Tovar, MJ Medrano, F Avellanal, O Calero, M Calero
Journal of Alzheimer's disease : JAD 2016
Endoplasmic reticulum (ER) stress triggers Hax1-dependent mitochondrial apoptotic events in cardiac cells
E Abdelwahid, H Li, J Wu, AC Irioda, KA de Carvalho, X Luo
Apoptosis 2016
Etiologic Framework for the Study of Neurodegenerative Disorders as Well as Vascular and Metabolic Comorbidities on the Grounds of Shared Epidemiologic and Biologic Features
J Pedro-Cuesta, P Martínez-Martín, A Rábano, M Ruiz-Tovar, E Alcalde-Cabero, M Calero
Frontiers in aging neuroscience 2016
The Natural Occurring Compounds Targeting Endoplasmic Reticulum Stress
H Liu, J Yang, L Li, W Shi, X Yuan, L Wu
Evidence-Based Complementary and Alternative Medicine 2016
Nrf2 expression is increased in peripheral blood mononuclear cells derived from mild–moderate ex-smoker COPD patients with persistent oxidative stress
AM Pasini, M Ferrari, C Stranieri, P Vallerio, C Mozzini, U Garbin, G Zambon, L Cominacini
International journal of chronic obstructive pulmonary disease 2016
Paclitaxel inhibits selenoprotein S expression and attenuates endoplasmic reticulum stress
HS Qin, PP Yu, Y Sun, DF Wang, XF Deng, YL Bao, J Song, LG Sun, ZB Song, YX Li
Molecular medicine reports 2016
NF-Y (CBF) regulation in specific cell types and mouse models
SN Maity
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2016
Exendin-4 protects HUVECs from tunicamycin-induced apoptosis via inhibiting the IRE1a/JNK/caspase-3 pathway
L Wu, XY Liu, LX Wang, YP Wang, LJ Wang, BB Guan, Z Chen, LB Liu
Endocrine 2016
Novel Role of ER Stress and Autophagy in Microcystin-LR Induced Apoptosis in Chinese Hamster Ovary Cells
S Zhang, C Liu, Y Li, MU Imam, H Huang, H Liu, Y Xin, H Zhang
Frontiers in physiology 2016
Tunicamycin-induced Endoplasmic Reticulum Stress Upregulates the Expression of Pentraxin 3 in Human Retinal Pigment Epithelial Cells
N Hwang, MY Kwon, JB Cha, SW Chung, JM Woo
Korean journal of ophthalmology : KJO 2016
Genetic ablation or pharmacologic inhibition of autophagy mitigated NSAID-associated gastric damages
CY Ock, JM Park, YM Han, M Jeong, MY Kim, HJ Lee, KB Hahm
Journal of Molecular Medicine 2016
Endoplasmic Reticulum Stress Induces the Early Appearance of Pro-apoptotic and Anti-apoptotic Proteins in Neurons of Five Familial Alzheimer′s Disease Mice
H Shen, XD Pan, J Zhang, YQ Zeng, M Zhou, LM Yang, B Ye, XM Dai, YG Zhu, XC Chen
Chinese Medical Journal 2016
Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability
TT Yen, A Yang, WT Chiu, TN Li, LH Wang, YH Wu, HC Wang, L Chen, WC Wang, W Huang, CW Chang, MD Chang, MR Shen, IJ Su, LH Wang
Oncotarget 2016
Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway
GR Sareddy, S Viswanadhapalli, P Surapaneni, T Suzuki, A Brenner, RK Vadlamudi
Oncogene 2016
New insights into the unfolded protein response in stem cells
Y Yang, HH Cheung, JJ Tu, KK Miu, WY Chan
Oncotarget 2016
Herpes Simplex Virus 1 UL41 Protein Suppresses the IRE1/XBP1 Signal Pathway of the Unfolded Protein Response via Its RNase Activity
P Zhang, C Su, Z Jiang, C Zheng, RM Sandri-Goldin
Journal of virology 2016
PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration.
Bell MC, Meier SE, Ingram AL, Abisambra JF
Current Alzheimer research 2016
The unfolded protein response and its potential role in Huntington's disease elucidated by a systems biology approach
Kalathur RK, Giner-Lamia J, Machado S, Barata T, Ayasolla KR, Futschik ME
F1000Research 2016
Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease
S Mulugeta, SI Nureki, MF Beers
American journal of physiology. Lung cellular and molecular physiology 2015
Cellular Signature of SIL1 Depletion: Disease Pathogenesis due to Alterations in Protein Composition Beyond the ER Machinery
A Roos, L Kollipara, S Buchkremer, T Labisch, E Brauers, C Gatz, C Lentz, J Gerardo-Nava, J Weis, RP Zahedi
Molecular Neurobiology 2015
Epigallocatechin-3-gallate protects against cisplatin-induced nephrotoxicity by inhibiting endoplasmic reticulum stress-induced apoptosis
B Chen, G Liu, P Zou, X Li, Q Hao, B Jiang, X Yang, Z Hu
Experimental biology and medicine (Maywood, N.J.) 2015
Promotion of Cancer Cell Proliferation by Cleaved and Secreted Luminal Domains of ER Stress Transducer BBF2H7
H Iwamoto, K Matsuhisa, A Saito, S Kanemoto, R Asada, K Hino, T Takai, M Cui, X Cui, M Kaneko, K Arihiro, K Sugiyama, K Kurisu, A Matsubara, K Imaizumi, MC Vinci
PloS one 2015
Endoplasmic Reticulum Stress in Heat- and Shake-Induced Injury in the Rat Small Intestine
P Yin, J Xu, S He, F Liu, J Yin, C Wan, C mei, Y Yin, X Xu, Z Xia, M Muders
PloS one 2015
Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation
P Gurung, TD Kanneganti
The American Journal of Pathology 2015
Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes☆
J Sun, J Cui, Q He, Z Chen, P Arvan, M Liu
Molecular Aspects of Medicine 2015
Endoplasmic Reticulum Stress May Not Be Involved in Intestinal Epithelial Cell Apoptosis in Experimental Acute Pancreatitis
HX Zhao, XS Fu, XY Zhou, X Chen
Digestive Diseases and Sciences 2015
HIV infection and antiretroviral therapy lead to unfolded protein response activation
M Borsa, PL Ferreira, A Petry, LG Ferreira, MM Camargo, DC Bou-Habib, AR Pinto
Virology Journal 2015
Avarol Induces Apoptosis in Pancreatic Ductal Adenocarcinoma Cells by Activating PERK–eIF2α–CHOP Signaling
T Namba, R Kodama
Marine drugs 2015
The utility of mouse models to provide information regarding the pathomolecular mechanisms in human genetic skeletal diseases: The emerging role of endoplasmic reticulum stress (Review)
M Briggs, P Bell, K Pirog
International journal of molecular medicine 2015
AMPK: energy sensor and survival mechanism in the ischemic heart
D Qi, LH Young
Trends in Endocrinology & Metabolism 2015
NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma
C Fionda, A Soriani, A Zingoni, A Santoni, M Cippitelli
BioMed Research International 2015
Endoplasmic reticulum stress impairment in the spinal dorsal horn of a neuropathic pain model
E Zhang, MH Yi, N Shin, H Baek, S Kim, E Kim, K Kwon, S Lee, HW Kim, YC Bae, Y Kim, OY Kwon, WH Lee, DW Kim
Scientific Reports 2015
Activation of the endoplasmic reticulum stress response in skeletal muscle of G93A*SOD1 amyotrophic lateral sclerosis mice
D Chen, Y Wang, ER Chin
Frontiers in cellular neuroscience 2015
Transmission of ER stress response by ATF6 promotes endochondral bone growth
Z Xiong, R Jiang, P Zhang, X Han, FJ Guo
Journal of orthopaedic surgery and research 2015
Endoplasmic Reticulum Stress in Sepsis:
MM Khan, WL Yang, P Wang
Shock 2015
Protein Folding and Mechanisms of Proteostasis
J Díaz-Villanueva, R Díaz-Molina, V García-González
International journal of molecular sciences 2015
Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress
R Nakato, Y Ohkubo, A Konishi, M Shibata, Y Kaneko, T Iwawaki, T Nakamura, SA Lipton, T Uehara
Scientific Reports 2015
Different Roles of GRP78 on Cell Proliferation and Apoptosis in Cartilage Development
Z Xiong, R Jiang, X Li, Y Liu, F Guo
International journal of molecular sciences 2015
The Role of Lectin-Carbohydrate Interactions in the Regulation of ER-Associated Protein Degradation
M Słomińska-Wojewódzka, K Sandvig
Molecules (Basel, Switzerland) 2015
Endoplasmic reticulum stress induced by tunicamycin increases resistin messenger ribonucleic acid through the pancreatic endoplasmic reticulum eukaryotic initiation factor 2α kinase-activating transcription factor 4-CAAT/enhancer binding protein-α homolog
J Hamada, H Onuma, F Ochi, H Hirai, K Takemoto, A Miyoshi, M Matsushita, Y Kadota, J Ohashi, R Kawamura, Y Takata, W Nishida, S Hashida, E Ishii, H Osawa
Journal of Diabetes Investigation 2015
IRE1α-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes
R Asada, S Kanemoto, K Matsuhisa, K Hino, M Cui, X Cui, M Kaneko, K Imaizumi
Scientific Reports 2015
Traditional Chinese medicine targeting apoptotic mechanisms for esophageal cancer therapy
Y Zhang, Q Shen, J Li
Acta Pharmacologica Sinica 2015
Selenoprotein S-dependent Selenoprotein K Binding to p97(VCP) Protein Is Essential for Endoplasmic Reticulum-associated Degradation
JH Lee, KJ Park, JK Jang, YH Jeon, KY Ko, JH Kwon, SR Lee, IY Kim
The Journal of biological chemistry 2015
Early Life Exposure to Undernutrition Induces ER Stress, Apoptosis, and Reduced Vascularization in Ovaries of Adult Rat Offspring
KA Chan, AB Bernal, MH Vickers, W Gohir, JJ Petrik, DM Sloboda
Biology of reproduction 2015
The Non-Coding RNA Journal Club: Highlights on Recent Papers
Ferracin M, Gautheret D, Hubé F, Mani SA, Mattick JS, Ørom UA, Santulli G, Slotkin RK, Szweykowska-Kulinska Z, Taube JH, Vazquez F, Yang JH
Non-Coding RNA 2015
Kazutoshi Mori and Peter Walter receive the 2014 Albert Lasker Basic Medical Research Award
Corinne Williams
Journal of Clinical Investigation 2014
Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death
S Sharma, R Mishra, BL Walker, S Deshmukh, M Zampino, J Patel, M Anamalai, D Simpson, IS Singh, S Kaushal, S Kaushal
Cell Stress and Chaperones 2014
Glucocerebrosidase is shaking up the synucleinopathies
M Siebert, E Sidransky, W Westbroek
Brain 2014
Master regulator for chondrogenesis, Sox9, Regulates Transcriptional Activation of the ER Stress Transducer BBF2H7/CREB3L2 in Chondrocytes
K Hino, A Saito, M Kido, S Kanemoto, R Asada, T Takai, M Cui, X Cui, K Imaizumi
The Journal of biological chemistry 2014
Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice
K Hino, A Saito, R Asada, S Kanemoto, K Imaizumi, LM Hendershot
PloS one 2014
Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries
VP Nakka, P Prakash-babu, R Vemuganti
Molecular Neurobiology 2014
Reduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor
SM Son, J Byun, SE Roh, SJ Kim, I Mook-Jung
Cell Death and Disease 2014
Phorbol myristate acetate, but not CD40L, induces the differentiation of CLL B cells into Ab-secreting cells
H Ghamlouch, H Ouled-Haddou, A Guyart, A Regnier, S Trudel, JF Claisse, V Fuentes, B Royer, JP Marolleau, B Gubler
Immunology and Cell Biology 2014
Inhibition of transient receptor potential melastatin 7 (TRPM7) channel induces RA FLSs apoptosis through endoplasmic reticulum (ER) stress
X Li, X Wang, Y Wang, X Li, C Huang, J Li
Clinical Rheumatology 2014
Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes
R Stienstra, Y Haim, Y Riahi, M Netea, A Rudich, G Leibowitz
Diabetologia 2014
Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction
M Galán, M Kassan, PJ Kadowitz, M Trebak, S Belmadani, K Matrougui
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2014
ER stress response mechanisms in the pathogenic yeast Candida glabrata and their roles in virulence
T Miyazaki, S Kohno
Virulence 2014
Metabolic Syndrome: An Important Risk Factor for Parkinson's Disease
P Zhang, B Tian
Oxidative Medicine & Cellular Longevity 2014
Glucose-Regulated Protein 78 (Grp78) Confers Chemoresistance to Tumor Endothelial Cells under Acidic Stress
F Visioli, Y Wang, GN Alam, Y Ning, PV Rados, JE Nör, PJ Polverini
PloS one 2014
Proteomic Investigation into Betulinic Acid-Induced Apoptosis of Human Cervical Cancer HeLa Cells
T Xu, Q Pang, D Zhou, A Zhang, S Luo, Y Wang, X Yan
PloS one 2014
Anti-Cancer Effects of REIC/Dkk-3-encoding Adenoviral Vector for the Treatment of Non-small Cell Lung Cancer
K Shien, N Tanaka, M Watanabe, J Soh, M Sakaguchi, K Matsuo, H Yamamoto, M Furukawa, H Asano, K Tsukuda, Y Nasu, NH Huh, S Miyoshi, H Kumon, S Toyooka, S Deb
PloS one 2014
Free Fatty Acids and Their Metabolism Affect Function and Survival of Podocytes
J Sieber, AW Jehle
Frontiers in Endocrinology 2014
TBL2 Is a Novel PERK-Binding Protein that Modulates Stress-Signaling and Cell Survival during Endoplasmic Reticulum Stress
Y Tsukumo, S Tsukahara, A Furuno, S Iemura, T Natsume, A Tomida, DY Jin
PloS one 2014
Single Prolonged Stress induces ATF6 alpha-dependent Endoplasmic reticulum stress and the apoptotic process in medial Frontal Cortex neurons
B Yu, L Wen, B Xiao, F Han, Y Shi
BMC neuroscience 2014
A huntingtin-mediated fast stress response halting endosomal trafficking is defective in Huntington's disease
S Nath, LN Munsie, R Truant
Human Molecular Genetics 2014
The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model
Y Demay, J Perochon, S Szuplewski, B Mignotte, S Gaumer
Cell Death and Disease 2014
Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells
M Thon, T Hosoi, M Yoshii, K Ozawa
Scientific Reports 2014
Single-prolonged stress activates the transcription factor ATF6α branch of the unfolded protein response in rat neurons of dorsal raphe nucleus
J Xie, F Han, Y Shi
Molecular and Cellular Biochemistry 2014
Involvement of Endoplasmic Reticulum Stress Response in Orofacial Inflammatory Pain
ES Yang, JY Bae, TH Kim, YS Kim, K Suk, YC Bae
Experimental Neurobiology 2014
Obesity Has an Interactive Effect with Genetic Variation in the Activating Transcription Factor 6 Gene on the Risk of Pre-Diabetes in Individuals of Chinese Han Descent
N Gu, X Ma, J Zhang, A Dong, M Jin, N Feng, H Zhang, X Guo, V Sanchez-Margalet
PloS one 2014
Proteomic analysis of fibroblastema formation in regenerating hind limbs of Xenopus laevis froglets and comparison to axolotl
N Rao, F Song, D Jhamb, M Wang, DJ Milner, NM Price, TL Belecky-Adams, MJ Palakal, J Cameron, B Li, X Chen, DL Stocum
BMC Developmental Biology 2014
Pro178 and Pro183 of Selenoprotein S Are Essential Residues for Interaction with p97(VCP) during Endoplasmic Reticulum-associated Degradation
JH Lee, JH Kwon, YH Jeon, KY Ko, SR Lee, IY Kim
The Journal of biological chemistry 2014
RETRACTED ARTICLE: Explore on the effect of ATF6 on cell growth and apoptosis in cartilage development
X Han, P Zhang, R Jiang, F Xia, M Li, FJ Guo
Histochemistry and Cell Biology 2014
Asymmetric dimethylarginine triggers macrophage apoptosis via the endoplasmic reticulum stress pathway.
Hong D, Gao HC, Wang X, Li LF, Li CC, Luo Y, Wang KK, Bai YP, Zhang GG
Molecular and Cellular Biochemistry 2014
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins
I Das, CW Png, I Oancea, SZ Hasnain, R Lourie, M Proctor, RD Eri, Y Sheng, DI Crane, TH Florin, MA McGuckin
Journal of Experimental Medicine 2013
Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases
CL Hartley, S Edwards, L Mullan, PA Bell, M Fresquet, RP Boot-Handford, MD Briggs
Human Molecular Genetics 2013
Physiological functions of endoplasmic reticulum stress transducer OASIS in central nervous system
A Saito
Anatomical Science International 2013
Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model
YC Chang, JD Wang, KK Svoboda, RP Casillas, JD Laskin, MK Gordon, DR Gerecke
Toxicology and Applied Pharmacology 2013
Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells
H Miyagi, S Kanemoto, A Saito, R Asada, H Iwamoto, S Izumi, M Kido, F Gomi, K Nishida, Y Kiuchi, K Imaizumi, R Mohanraj
PloS one 2013
Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha 1 -antitrypsin deficiency
A Ordóñez, EL Snapp, L Tan, E Miranda, SJ Marciniak, DA Lomas
Hepatology 2013
Fatty acid-mediated endoplasmic reticulum stress in vivo: Differential response to the infusion of Soybean and Lard Oil in rats
AM Nivala, L Reese, M Frye, CL Gentile, MJ Pagliassotti
Metabolism 2013
The unfolded protein response triggered by environmental factors
M Kitamura
Seminars in Immunopathology 2013
Activation of AMP-Activated Protein Kinase Alleviates Homocysteine-Mediated Neurotoxicity in SH-SY5Y Cells
YJ Park, JW Ko, Y Jang, YH Kwon
Neurochemical Research 2013
A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis
K Erguler, M Pieri, C Deltas
BMC Systems Biology 2013
Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis
M Hamano, H Ezaki, S Kiso, K Furuta, M Egawa, T Kizu, N Chatani, Y Kamada, Y Yoshida, T Takehara
Journal of Gastroenterology 2013
An aryl hydrocarbon receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2
J Terashima, C Tachikawa, K Kudo, W Habano, S Ozawa
BMC Molecular Biology 2013
Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival
T Mori, T Hayashi, E Hayashi, TP Su
PloS one 2013
CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure
X Wang, L Ni, L Yang, Q Duan, C Chen, ML Edin, DC Zeldin, DW Wang
Molecular pharmacology 2013
Inositol-requiring enzyme 1α is required for gut development in Xenopus lavies embryos
J Guo, XX Li, JJ Feng, CY Yin, XJ Wang, N Wang, L Yuan
World journal of gastroenterology : WJG 2013
Single-Prolonged Stress Induces Endoplasmic Reticulum - Dependent Apoptosis in the Hippocampus in a Rat Model of Post-Traumatic Stress Disorder
F Han, S Yan, YX Shi, MG Tansey
PloS one 2013
Activation of the unfolded protein response in vascular endothelial cells of nondiabetic obese adults
RE Kaplon, E Chung, L Reese, K Cox-York, DR Seals, CL Gentile
The Journal of clinical endocrinology and metabolism 2013
Dual Regulation of Cadmium-Induced Apoptosis by mTORC1 through Selective Induction of IRE1 Branches in Unfolded Protein Response
H Kato, R Katoh, M Kitamura, R Sugiura
PloS one 2013
The secretory pathway in control of endoplasmic reticulum homeostasis
NG Tsvetanova
Small GTPases 2013
Chronic inhibition of cGMP-specific phosphodiesterase 5 suppresses endoplasmic reticulum stress in heart failure: PDE5 inhibitor and ER stress in failing heart
W Gong, Q Duan, Z Cai, C Chen, L Ni, M Yan, X Wang, K Cianflone, DW Wang
British Journal of Pharmacology 2013
Exposure to inhaled particulate matter activates early markers of oxidative stress, inflammation and unfolded protein response in rat striatum
R Guerra, E Vera-Aguilar, M Uribe-Ramirez, G Gookin, J Camacho, AR Osornio-Vargas, V Mugica-Alvarez, R Angulo-Olais, A Campbell, J Froines, TM Kleinman, AD Vizcaya-Ruiz
Toxicology Letters 2013
S-adenosyl methionine prevents endothelial dysfunction by inducing heme oxygenase-1 in vascular endothelial cells
SY Kim, SW Hong, MO Kim, HS Kim, JE Jang, J Leem, IS Park, KU Lee, EH Koh
Molecules and Cells 2013
The wobbler mouse, an ALS animal model
JM Moser, P Bigini, T Schmitt-John
Molecular Genetics and Genomics 2013
Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease
AK Leamy, RA Egnatchik, JD Young
Progress in Lipid Research 2013
Dissection of Ire1 Functions Reveals Stress Response Mechanisms Uniquely Evolved in Candida glabrata
T Miyazaki, H Nakayama, Y Nagayoshi, H Kakeya, S Kohno, SG Filler
PLoS pathogens 2013
Depletion of Molecular Chaperones from the Endoplasmic Reticulum and Fragmentation of the Golgi Apparatus Associated with Pathogenesis in Pelizaeus-Merzbacher Disease
Y Numata, T Morimura, S Nakamura, E Hirano, S Kure, Y Goto, K Inoue
The Journal of biological chemistry 2013
A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis
SA Yoo, S You, HJ Yoon, DH Kim, HS Kim, K Lee, JH Ahn, D Hwang, AS Lee, KJ Kim, YJ Park, CS Cho, WU Kim
Journal of Experimental Medicine 2012
Endoplasmic Reticulum Stress Is Involved in Cardiac Damage and Vascular Endothelial Dysfunction in Hypertensive Mice
M Kassan, M Galan, M Partyka, Z Saifudeen, D Henrion, M Trebak, K Matrougui
Arteriosclerosis, thrombosis, and vascular biology 2012
Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation
A Saito, S Kanemoto, N Kawasaki, R Asada, H Iwamoto, M Oki, H Miyagi, S Izumi, T Sanosaka, K Nakashima, K Imaizumi
Nature Communications 2012
The endoplasmic reticulum stress transducer OASIS is involved in the terminal differentiation of goblet cells in the large intestine
R Asada, A Saito, N Kawasaki, S Kanemoto, H Iwamoto, M Oki, H Miyagi, S Izumi, K Imaizumi
The Journal of biological chemistry 2012
The endoplasmic reticulum stress response in aging and age-related diseases
MK Brown, N Naidoo
Frontiers in physiology 2012
Autoantibodies against glucose-regulated protein 78 as serological diagnostic biomarkers in hepatocellular carcinoma
Q Shao, P Ren, Y Li, B Peng, L Dai, N Lei, W Yao, G Zhao, L Li, J Zhang
International journal of oncology 2012
Interaction between Mitochondria and the Endoplasmic Reticulum: Implications for the Pathogenesis of Type 2 Diabetes Mellitus
J Leem, EH Koh
Experimental Diabetes Research 2012
The impact of the unfolded protein response on human disease
S Wang, RJ Kaufman
The Journal of Cell Biology 2012
Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes
FR Papa
Cold Spring Harbor Perspectives in Medicine 2012
The Role of Endoplasmic Reticulum Stress in Autoimmune-Mediated Beta-Cell Destruction in Type 1 Diabetes
J Zhong, X Rao, JF Xu, P Yang, CY Wang
Experimental Diabetes Research 2012
Roles of Endoplasmic Reticulum and Energetic Stress in Disturbed Sleep
N Naidoo
NeuroMolecular Medicine 2012
Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue
N Kawasaki, R Asada, A Saito, S Kanemoto, K Imaizumi
Scientific Reports 2012
The Endoplasmic Reticulum Stress Transducer BBF2H7 Suppresses Apoptosis by Activating the ATF5-MCL1 Pathway in Growth Plate Cartilage*
S Izumi, A Saito, S Kanemoto, N Kawasaki, R Asada, H Iwamoto, M Oki, H Miyagi, M Ochi, K Imaizumi
The Journal of biological chemistry 2012
Hormetic Effects of Acute Methylmercury Exposure on GRP78 Expression in Rat Brain Cortex
Y Zhang, R Lu, W Liu, Y Wu, H Qian, X Zhao, S Wang, G Xing, F Yu, M Aschner
Dose-Response 2012
Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes
X Zhang, K Zhang
Biochemistry Research International 2012
Mechanisms and Biomarkers of Apoptosis in Liver Disease and Fibrosis
JB Chakraborty, F Oakley, MJ Walsh
International Journal of Hepatology 2012
Obesity and endoplasmic reticulum (ER) stresses
YB Tripathi, V Pandey
Frontiers in immunology 2012
Endoplasmic Reticulum Stress Stimulates p53 Expression through NF-κB Activation
WC Lin, YC Chuang, YS Chang, MD Lai, YN Teng, IJ Su, CC Wang, KH Lee, JH Hung
PloS one 2012
Vaccinia and influenza A viruses select rather than adjust tRNAs to optimize translation
M Pavon-Eternod, A David, K Dittmar, P Berglund, T Pan, JR Bennink, JW Yewdell
Nucleic Acids Research 2012
Hsp70 promotes epithelial sodium channel functional expression by increasing its association with coat complex II and its exit from endoplasmic reticulum
RA Chanoux, A Robay, CB Shubin, C Kebler, L Suaud, RC Rubenstein
The Journal of biological chemistry 2012
Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response
CM Sayers, I Papandreou, DM Guttmann, NL Maas, JA Diehl, ES Witze, AC Koong, C Koumenis
Molecular pharmacology 2012
A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death
D Maddalo, A Neeb, K Jehle, K Schmitz, C Muhle-Goll, L Shatkina, TV Walther, A Bruchmann, SM Gopal, W Wenzel, AS Ulrich, AC Cato
PloS one 2012
Clarifying the cardiac proteasome paradox: protein quality control
CC Glembotski
Circulation research 2012
RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis
N Yagishita, S Aratani, C Leach, T Amano, Y Yamano, K Nakatani, K Nishioka, T Nakajima
International journal of molecular medicine 2012
ER Stress Activates NF-κB by Integrating Functions of Basal IKK Activity, IRE1 and PERK
AB Tam, EL Mercado, A Hoffmann, M Niwa, M Koritzinsky
PloS one 2012
Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenuating Endoplasmic Reticulum Stress and Modulating SERCA Activity: The Differential Role for PI3K/Akt and JAK2/STAT3 Signaling Pathways
Y Li, W Zhu, J Tao, P Xin, M Liu, J Li, M Wei, F Gallyas
PloS one 2012
Expression and distribution of grp-78/bip in mineralizing tissues and mesenchymal cells
S Ravindran, Q Gao, A Ramachandran, P Sundivakkam, C Tiruppathi, A George
Histochemistry and Cell Biology 2012
Low levels of Bax inhibitor-1 gene expression increase tunicamycin-induced apoptosis in human neuroblastoma SY5Y cells
Dan Wu, Peirong Wang, Shiyao Wang
NEURAL REGEN RES 2012
Induction of ER Stress-Mediated Apoptosis by α-Lipoic Acid in A549 Cell Lines
JI Kim, SR Cho, CM Lee, ES Park, KN Kim, HC Kim, HY Lee
The Korean Journal of Thoracic and Cardiovascular Surgery 2012
Activation status of integrated stress response pathways in neurones and astrocytes of HIV-associated neurocognitive disorders (HAND) cortex: Activation of integrated stress response in HAND
C Akay, KA Lindl, N Shyam, B Nabet, Y Goenaga-Vazquez, J Ruzbarsky, Y Wang, DL Kolson, KL Jordan-Sciutto
Neuropathology and Applied Neurobiology 2012
The Anaphase-Promoting Complex or Cyclosome Supports Cell Survival in Response to Endoplasmic Reticulum Stress
M Chen, GJ Gutierrez, ZA Ronai, MT Ling
PloS one 2012
Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology
KR Monk, MG Voas, C Franzini-Armstrong, IS Hakkinen, WS Talbot
Disease models & mechanisms 2012
ER stress increases StarD5 expression by stabilizing its mRNA and leads to relocalization of its protein from the nucleus to the membranes
D Rodriguez-Agudo, M Calderon-Dominguez, MA Medina, S Ren, G Gil, WM Pandak
Journal of lipid research 2012
Exploitation of a mitochondrial unfolded protein response for cancer therapy in humans
Markus Siegelin, Takehiko Dohi, Christopher Raskett, Gregory Orlowski, Christine Powers, Candace Gilbert, Alonzo Ross, Janet Plescia, Dario Altieri
Journal of Clinical Investigation 2011
Compromising the Unfolded Protein Response Induces Autophagy-Mediated Cell Death in Multiple Myeloma Cells
AS Michallet, P Mondiere, M Taillardet, Y Leverrier, L Genestier, T Defrance
PloS one 2011
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
I Tabas, D Ron
Nature Cell Biology 2011
Endoplasmic Reticulum Stress and the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease
CL Gentile, M Frye, MJ Pagliassotti
Antioxidants & Redox Signaling 2011
ER stress and its functional link to mitochondria: role in cell survival and death
JD Malhotra, RJ Kaufman
Cold Spring Harbor perspectives in biology 2011
Role of Endoplasmic Reticulum Stress in Epithelial–Mesenchymal Transition of Alveolar Epithelial Cells: Effects of Misfolded Surfactant Protein
Q Zhong, B Zhou, DK Ann, P Minoo, Y Liu, A Banfalvi, MS Krishnaveni, M Dubourd, L Demaio, BC Willis, KJ Kim, RM duBois, ED Crandall, MF Beers, Z Borok
American journal of respiratory cell and molecular biology 2011
Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
M Donadelli, I Dando, T Zaniboni, C Costanzo, ED Pozza, MT Scupoli, A Scarpa, S Zappavigna, M Marra, A Abbruzzese, M Bifulco, M Caraglia, M Palmieri
Cell Death and Disease 2011
β-AR Blockers Suppresses ER Stress in Cardiac Hypertrophy and Heart Failure
L Ni, C Zhou, Q Duan, J Lv, X Fu, Y Xia, DW Wang
PloS one 2011
Endoplasmic Reticulum Stress-induced Apoptosis in Leishmania through Ca2+-dependent and Caspase-independent Mechanism*
S Dolai, S Pal, RK Yadav, S Adak
The Journal of biological chemistry 2011
Oxidative stress and redox modulation potential in type 1 diabetes
MM Delmastro, JD Piganelli
Clinical & developmental immunology 2011
HIV-1 modulates the tRNA pool to improve translation efficiency
A Weringh, M Ragonnet-Cronin, E Pranckeviciene, M Pavon-Eternod, L Kleiman, X Xia
Molecular Biology and Evolution 2011
The Small Chaperone Protein p23 and Its Cleaved Product p19 in Cellular Stress
KS Poksay, S Banwait, D Crippen, X Mao, DE Bredesen, RV Rao
Journal of Molecular Neuroscience 2011
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders
KM Doyle, D Kennedy, AM Gorman, S Gupta, SJ Healy, A Samali
Journal of Cellular and Molecular Medicine 2011
Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
L Ferraiuolo, J Kirby, AJ Grierson, M Sendtner, PJ Shaw
Nature Reviews Neurology 2011
Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease
HS Park, BH Jeon, SH Woo, J Leem, JE Jang, MS Cho, IS Park, KU Lee, EH Koh
Molecules and Cells 2011
Mechanisms of Lipotoxicity in NAFLD and Clinical Implications
SH Ibrahim, R Kohli, GJ Gores
Journal of Pediatric Gastroenterology and Nutrition 2011
Hepatitis E Virus ORF2 Protein Activates the Pro-Apoptotic Gene CHOP and Anti-Apoptotic Heat Shock Proteins
L John, S Thomas, O Herchenröder, BM Pützer, S Schaefer
PloS one 2011
Endoplasmic Reticulum Stress Pathway-Mediated Apoptosis in Macrophages Contributes to the Survival of Mycobacterium tuberculosis
YJ Lim, JA Choi, HH Choi, SN Cho, HJ Kim, EK Jo, JK Park, CH Song
PloS one 2011
Glycogen Synthase Kinase-3 (GSK-3) Inhibition Attenuates Hepatocyte Lipoapoptosis
SH Ibrahim, Y Akazawa, SC Cazanave, SF Bronk, NA Elmi, NW Werneburg, DD Billadeau, GJ Gores
Journal of Hepatology 2011
ERp29 Regulates ΔF508 and Wild-type Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Trafficking to the Plasma Membrane in Cystic Fibrosis (CF) and Non-CF Epithelial Cells*
L Suaud, K Miller, L Alvey, W Yan, A Robay, C Kebler, JL Kreindler, S Guttentag, MJ Hubbard, RC Rubenstein
The Journal of biological chemistry 2011
Cellular senescence and tumor suppressor gene p16
H Rayess, MB Wang, ES Srivatsan
International Journal of Cancer 2011
Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease
CL Gentile, AM Nivala, JC Gonzales, KT Pfaffenbach, D Wang, Y Wei, H Jiang, DJ Orlicky, DR Petersen, MJ Pagliassotti, KN Maclean
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2011
Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-β release in lung epithelial cells
EC Roberson, JE Tully, AS Guala, JN Reiss, KE Godburn, DA Pociask, JF Alcorn, DW Riches, O Dienz, YM Janssen-Heininger, V Anathy
American journal of respiratory cell and molecular biology 2011
A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo
CN Hancock, LH Stockwin, B Han, RD Divelbiss, JH Jun, SV Malhotra, MG Hollingshead, DL Newton
Free radical biology & medicine 2011
Involvement of Noxa in mediating cellular ER stress responses to lytic virus infection
S Rosebeck, K Sudini, T Chen, DW Leaman
Virology 2011
Endoplasmic Reticulum Stress and Microvascular Endothelial Dysfunction in Diabetes
M Kassan, M Galán, SK Choi
Journal of Diabetes & Metabolism 2011
Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping
S Kim, S You, D Hwang
Nature Reviews Cancer 2011
Sulfur dioxide inhibits excessively activated endoplasmic reticulum stress in rats with myocardial injury
S Chen, J Du, Y Liang, T Ochs, D Liu, L Zhu, X Tang, C Tang, H Jin
Heart and Vessels 2011
Inhibition of endoplasmic reticulum stress by intermedin1–53 protects against myocardial injury through a PI3 kinase–Akt signaling pathway
X Teng, J Song, G Zhang, Y Cai, F Yuan, J Du, C Tang, Y Qi
Journal of Molecular Medicine 2011
Unfolded Protein Response Regulation in Keloid Cells
PD Butler, Z Wang, DP Ly, MT Longaker, AC Koong, GP Yang
Journal of Surgical Research 2011
The anticancer flavonoid chrysin induces the unfolded protein response in hepatoma cells
X Sun, X Huo, T Luo, M Li, Y Yin, Y Jiang
Journal of Cellular and Molecular Medicine 2011
In vitro mannose trimming property of human ER α-1,2 mannosidase I
J Aikawa, I Matsuo, Y Ito
Glycoconjugate Journal 2011
HCV Causes Chronic Endoplasmic Reticulum Stress Leading to Adaptation and Interference with the Unfolded Protein Response
E Merquiol, D Uzi, T Mueller, D Goldenberg, Y Nahmias, RJ Xavier, B Tirosh, O Shibolet, JH Niess
PloS one 2011
Post-conditioning protecting rat cardiomyocytes from apoptosis via attenuating calcium-sensing receptor-induced endo(sarco)plasmic reticulum stress.
Gan R, Hu G, Zhao Y, Li H, Jin Z, Ren H, Dong S, Zhong X, Li H, Yang B, Xu C, Lu F, Zhang W
Molecular and Cellular Biochemistry 2011
Protection of taurine and granulocyte colony-stimulating factor against excitotoxicity induced by glutamate in primary cortical neurons
C Pan, A Gupta, H Prentice, JY Wu
Journal of Biomedical Science 2010
Suppression of Expression of Endoplasmic Reticulum Chaperones by Helicobacter pylori and Its Role in Exacerbation of Non-steroidal Anti-inflammatory Drug-induced Gastric Lesions*
T Namba, T Hoshino, S Suemasu, M Takarada-Iemata, O Hori, N Nakagata, A Yanaka, T Mizushima
The Journal of biological chemistry 2010
Attenuation of endoplasmic reticulum stress-related myocardial apoptosis by SERCA2a gene delivery in ischemic heart disease
W Xin, X Lu, X Li, K Niu, J Cai
Molecular Medicine 2010
The unfolded protein response is required to maintain the integrity of the ER, prevent oxidative stress, and preserve differentiation in β-cells
RJ Kaufman, SH Back, B Song, J Han, J Hassler
Diabetes, obesity & metabolism 2010
Roles for Endoplasmic Reticulum–Associated Degradation and the Novel Endoplasmic Reticulum Stress Response Gene Derlin-3 in the Ischemic Heart
PJ Belmont, WJ Chen, MN Pedro, DJ Thuerauf, NG Lowe, N Gude, B Hilton, R Wolkowicz, MA Sussman, CC Glembotski
Circulation research 2010
Endoplasmic reticulum overcrowding as a mechanism of beta-cell dysfunction in diabetes
F Despa
Biophysical Journal 2010
The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis
I Tabas, M Kitakaze
Circulation research 2010
Molecular Mechanism for Various Pharmacological Activities of NSAIDS
T Mizushima
Pharmaceuticals (Basel, Switzerland) 2010
Endoplasmic reticulum stress (ER-stress) by 2-deoxy-D-glucose (2DG) reduces cyclooxygenase-2 (COX-2) expression and N-glycosylation and induces a loss of COX-2 activity via a Src kinase-dependent pathway in rabbit articular chondrocytes
SM Yu, SJ Kim
Experimental & molecular medicine 2010
Cutting Edge Issues in Polymyositis
A Ghirardello, S Zampieri, E Tarricone, L Iaccarino, L Gorza, A Doria
Clinical Reviews in Allergy & Immunology 2010
Capsaicinoids, chloropicrin and sulfur mustard: possibilities for exposure biomarkers
M Pesonen, K Vähäkangas, M Halme, P Vanninen, H Seulanto, M Hemmilä, M Pasanen, T Kuitunen
Frontiers in pharmacology 2010
AMP-activated protein kinase activation during cardioplegia-induced hypoxia/reoxygenation injury attenuates cardiomyocytic apoptosis via reduction of endoplasmic reticulum stress
CH Yeh, TP Chen, YC Wang, YM Lin, SW Fang
Mediators of Inflammation 2010
Taurine protection of PC12 cells against endoplasmic reticulum stress induced by oxidative stress
C Pan, GS Giraldo, H Prentice, JY Wu
Journal of Biomedical Science 2010
Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response
Y Yan, YY Gao, BQ Liu, XF Niu, Y Zhuang, HQ Wang
BMC Cancer 2010
Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
S Gupta, L Cuffe, E Szegezdi, SE Logue, C Neary, S Healy, A Samali
International Journal of Cell Biology 2010
Gene expression profiles in Atlantic salmon adipose-derived stromo-vascular fraction during differentiation into adipocytes
M Todorcević, S Skugor, A Krasnov, B Ruyter
BMC Genomics 2010
Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids
J Sieber, MT Lindenmeyer, K Kampe, KN Campbell, CD Cohen, H Hopfer, P Mundel, AW Jehle
AJP Renal Physiology 2010
Neuroligin Trafficking Deficiencies Arising from Mutations in the α/β-Hydrolase Fold Protein Family*
AD Jaco, MZ Lin, N Dubi, D Comoletti, MT Miller, S Camp, M Ellisman, MT Butko, RY Tsien, P Taylor
The Journal of biological chemistry 2010
Gene expression in primary cultured astrocytes affected by aluminum: alteration of chaperons involved in protein folding
DA Aremu, OF Ezomo, S Meshitsuka
Environmental Health and Preventive Medicine 2010
BiP, an endoplasmic reticulum chaperone, modulates the development of morphine antinociceptive tolerance
T Dobashi, S Tanabe, H Jin, N Mimura, T Yamamoto, T Nishino, T Aoe
Journal of Cellular and Molecular Medicine 2010
Dysferlin overexpression in skeletal muscle produces a progressive myopathy
LE Glover, K Newton, G Krishnan, R Bronson, A Boyle, LS Krivickas, RH Brown
Annals of Neurology 2010
Gene Expression and Genetic Variation in Response to Endoplasmic Reticulum Stress in Human Cells
BA Dombroski, RR Nayak, KG Ewens, W Ankener, VG Cheung, RS Spielman
The American Journal of Human Genetics 2010
The UPR and the Anti-oxidant Response: Relevance to Sleep and Sleep Loss
MK Brown, N Naidoo
Molecular Neurobiology 2010
Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1
RL Wiseman, Y Zhang, KP Lee, HP Harding, CM Haynes, J Price, F Sicheri, D Ron
Molecular Cell 2010
The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans
CM Haynes, Y Yang, SP Blais, TA Neubert, D Ron
Molecular Cell 2010
An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia
S Nundlall, MH Rajpar, PA Bell, C Clowes, LA Zeeff, B Gardner, DJ Thornton, RP Boot-Handford, MD Briggs
Cell Stress and Chaperones 2010
Antiangiogenic Activity of 2-Deoxy-D-Glucose
JR Merchan, K Kovács, JW Railsback, M Kurtoglu, Y Jing, Y Piña, N Gao, TG Murray, MA Lehrman, TJ Lampidis, R Chammas
PloS one 2010
Cell Type-Specific Neuroprotective Activity of Untranslocated Prion Protein
E Restelli, L Fioriti, S Mantovani, S Airaghi, G Forloni, R Chiesa, MR Cookson
PloS one 2010
Rapamycin Inhibits Postprandial-Mediated X-Box-Binding Protein-1 Splicing in Rat Liver
KT Pfaffenbach, AM Nivala, L Reese, F Ellis, D Wang, Y Wei, MJ Pagliassotti
The Journal of nutrition 2010
Examination of Association with Candidate Genes for Diabetic Nephropathy in a Mexican American Population
S Kim, HE Abboud, MV Pahl, J Tayek, S Snyder, J Tamkin, H Alcorn, E Ipp, CC Nast, RC Elston, SK Iyengar, SG Adler
Clinical journal of the American Society of Nephrology : CJASN 2010
Valosin-containing Protein (VCP) in Novel Feedback Machinery between Abnormal Protein Accumulation and Transcriptional Suppression
M Koike, J Fukushi, Y Ichinohe, N Higashimae, M Fujishiro, C Sasaki, M Yamaguchi, T Uchihara, S Yagishita, H Ohizumi, S Hori, A Kakizuka
The Journal of biological chemistry 2010
β-Cell dysfunction under hyperglycemic stress: a molecular model.
Despa F, Berry RS
Journal of diabetes science and technology 2010
Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract
Z Firtina, BP Danysh, X Bai, DB Gould, T Kobayashi, MK Duncan
The Journal of biological chemistry 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis
WK Syn, V Teaberry, SS Choi, AM Diehl
Seminars in liver disease 2009
Macrophage Apoptosis in Atherosclerosis: Consequences on Plaque Progression and the Role of Endoplasmic Reticulum Stress
I Tabas
Antioxidants & Redox Signaling 2009
Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells
Y Wei, D Wang, CL Gentile, MJ Pagliassotti
Molecular and Cellular Biochemistry 2009
IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates
D Han, AG Lerner, LV Walle, JP Upton, W Xu, A Hagen, BJ Backes, SA Oakes, FR Papa
Cell 2009
Essential Role of PACT-Mediated PKR Activation in Tunicamycin-Induced Apoptosis
M Singh, V Fowlkes, I Handy, CV Patel, RC Patel
Journal of Molecular Biology 2009
Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress
RL Hull, S Zraika, J Udayasankar, K Aston-Mourney, SL Subramanian, SE Kahn
Diabetologia 2009
CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells
SC Pino, B O'Sullivan-Murphy, EA Lidstone, C Yang, KL Lipson, A Jurczyk, P diIorio, MA Brehm, JP Mordes, DL Greiner, AA Rossini, R Bortell
PloS one 2009
Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP
E Thorp, G Li, TA Seimon, G Kuriakose, D Ron, I Tabas
Cell Metabolism 2009
A transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells
R Calligaris, C Bellarosa, R Foti, P Roncaglia, P Giraudi, H Krmac, C Tiribelli, S Gustincich
BMC Genomics 2009
Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure
M Zivná, H Hůlková, M Matignon, K Hodanová, P Vylet'al, M Kalbácová, V Baresová, J Sikora, H Blazková, J Zivný, R Ivánek, V Stránecký, J Sovová, K Claes, E Lerut, JP Fryns, PS Hart, TC Hart, JN Adams, A Pawtowski, M Clemessy, JM Gasc, MC Gübler, C Antignac, M Elleder, K Kapp, P Grimbert, AJ Bleyer, S Kmoch
The American Journal of Human Genetics 2009
Proteomic analysis of blastema formation in regenerating axolotl limbs
N Rao, D Jhamb, DJ Milner, B Li, F Song, M Wang, SR Voss, M Palakal, MW King, B Saranjami, HL Nye, JA Cameron, DL Stocum
BMC Biology 2009
Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner
AD Nardo, I Kramvis, N Cho, A Sadowski, L Meikle, DJ Kwiatkowski, M Sahin
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Changes in proteasome structure and function caused by HAMLET in tumor cells
L Gustafsson, S Aits, P Onnerfjord, M Trulsson, P Storm, C Svanborg
PloS one 2009
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development
HP Harding, Y Zhang, D Scheuner, JJ Chen, RJ Kaufman, D Ron
Proceedings of the National Academy of Sciences 2009
NADPH Oxidases: Molecular Understanding Finally Reaching the Clinical Level?
TJ Guzik, KK Griendling
Antioxidants & Redox Signaling 2009
PI3K Acts in synergy with loss of PKC to elicit apoptosis via the UPR
J Guo, T Zhu, LY Luo, Y Huang, RG Sunkavalli, CY Chen
Journal of Cellular Biochemistry 2009
Successful Versus Failed Adaptation to High-Fat Diet-Induced Insulin Resistance: The Role of IAPP-Induced  -Cell Endoplasmic Reticulum Stress
AV Matveyenko, T Gurlo, M Daval, AE Butler, PC Butler
Diabetes 2009
Structural and functional link between the mitochondrial network and the endoplasmic reticulum
C Giorgi, DD Stefani, A Bononi, R Rizzuto, P Pinton
The International Journal of Biochemistry & Cell Biology 2009
A unique modulator of endoplasmic reticulum stress-signalling pathways: the novel pharmacological properties of amiloride in glial cells: Modulation of ER stress by amiloride
T Hosoi, A Kume, K Otani, T Oba, K Ozawa
British Journal of Pharmacology 2009
What are microarrays teaching us about sleep?
M Mackiewicz, JE Zimmerman, KR Shockley, GA Churchill, AI Pack
Trends in Molecular Medicine 2009
Association of X-box binding protein 1 ( XBP1) genotype with morning cortisol and 1-year clinical course after a major depressive episode
MF Grunebaum, HC Galfalvy, Y Huang, TB Cooper, AK Burke, M Agnello, MA Oquendo, JJ Mann
The International Journal of Neuropsychopharmacology 2009
Physical and Functional Interaction of Transmembrane Thioredoxin-related Protein with Major Histocompatibility Complex Class I Heavy Chain: Redox-based Protein Quality Control and Its Potential Relevance to Immune Responses
Y Matsuo, H Masutani, A Son, S Kizaka-Kondoh, J Yodoi, RS Hegde
Molecular biology of the cell 2009
Apoptosis
P Erhardt, A Toth
Apoptosis 2009
Bcl-2 Regulates the Onset of Shiga Toxin 1-Induced Apoptosis in THP-1 Cells
MS Lee, RP Cherla, D Leyva-Illades, VL Tesh
Infection and immunity 2009
Sep15, a Thioredoxin-like Selenoprotein, Is Involved in the Unfolded Protein Response and Differentially Regulated by Adaptive and Acute ER Stresses
VM Labunskyy, MH Yoo, DL Hatfield, VN Gladyshev
Biochemistry 2009
Neural relay from the liver induces proliferation of pancreatic beta cells: a path to regenerative medicine using the self-renewal capabilities.
Katagiri H, Imai J, Oka Y
Communicative & integrative biology 2009
The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis
A Delaunay, KD Bromberg, Y Hayashi, M Mirabella, D Burch, B Kirkwood, C Serra, MC Malicdan, AP Mizisin, R Morosetti, A Broccolini, LT Guo, SN Jones, SA Lira, PL Puri, GD Shelton, Z Ronai
PloS one 2008
Intracellular iron transport and storage: from molecular mechanisms to health implications
EL MacKenzie, K Iwasaki, Y Tsuji
Antioxidants & Redox Signaling 2008
The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
CL Gentile, MJ Pagliassotti
The Journal of Nutritional Biochemistry 2008
Altered Quality Control in the Endoplasmic Reticulum Causes Cortical Dysplasia in Knock-In Mice Expressing a Mutant BiP
N Mimura, S Yuasa, M Soma, H Jin, K Kimura, S Goto, H Koseki, T Aoe
Molecular and cellular biology 2008
From endoplasmic-reticulum stress to the inflammatory response
K Zhang, RJ Kaufman
Nature 2008
Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis
L Haataja, T Gurlo, CJ Huang, PC Butler
Endocrine reviews 2008
Adoptive passive transfer of rabbit beta1-adrenoceptor peptide immune cardiomyopathy into the Rag2-/- mouse: participation of the ER stress
J Liu, W Mao, C Iwai, S Fukuoka, R Vulapalli, H Huang, T Wang, VK Sharma, SS Sheu, M Fu, CS Liang
Journal of Molecular and Cellular Cardiology 2008
Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response
SC Pino, B O'Sullivan-Murphy, EA Lidstone, TB Thornley, A Jurczyk, F Urano, DL Greiner, JP Mordes, AA Rossini, R Bortell
Cell stress & chaperones 2008
High levels of hyaluronan in idiopathic pulmonary arterial hypertension
M Aytekin, SA Comhair, C la Motte, SK Bandyopadhyay, CF Farver, VC Hascall, SC Erzurum, RA Dweik
American journal of physiology. Lung cellular and molecular physiology 2008
Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity
KA Haskins, JF Russell, N Gaddis, HK Dressman, A Aballay
Developmental Cell 2008
SEPS1 Gene is Activated during Astrocyte Ischemia and Shows Prominent Antiapoptotic Effects
N Fradejas, MD Pastor, S Mora-Lee, P Tranque, S Calvo
Journal of Molecular Neuroscience 2008
Chemical and biological approaches synergize to ameliorate protein-folding diseases
TW Mu, DS Ong, YJ Wang, WE Balch, JR 3rd, L Segatori, JW Kelly
Cell 2008
Unfolding the Therapeutic Potential of Chemical Chaperones for Age-related Macular Degeneration
T Sauer, M Patel, CC Chan, J Tuo
Expert Review of Ophthalmology 2008
Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons
MW Halterman, CD Jesus, DA Rempe, NF Schor, HJ Federoff
Molecular and cellular neurosciences 2008
Structural Requirements for Sorting Pro-Vasopressin to the Regulated Secretory Pathway in a Neuronal Cell Line
DR Cool, SB Jackson, KS Waddell
Open neuroendocrinology journal (Online) 2008
Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells
E Jorgensen, A Stinson, L Shan, J Yang, D Gietl, AP Albino
BMC Cancer 2008
Chemical induction of the unfolded protein response in the liver increases glucose production and is activated during insulin-induced hypoglycaemia in rats
JC Gonzales, CL Gentile, KT Pfaffenbach, Y Wei, D Wang, MJ Pagliassotti
Diabetologia 2008
Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling
N Naidoo, M Ferber, M Master, Y Zhu, AI Pack
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response
OV Oskolkova, T Afonyushkin, A Leitner, E Schlieffen, PS Gargalovic, AJ Lusis, BR Binder, VN Bochkov
Blood 2008
Heat shock response relieves ER stress
Y Liu, A Chang
The EMBO Journal 2008
Time series proteome profiling to study endoplasmic reticulum stress response
M Mintz, A Vanderver, KJ Brown, J Lin, Z Wang, C Kaneski, R Schiffmann, K Nagaraju, EP Hoffman, Y Hathout
Journal of Proteome Research 2008
Endoplasmic reticulum stress in the kidney
M Kitamura
Clinical and Experimental Nephrology 2008
Caspase-3 activation as a key factor for HBx-transformed cell death
A Kim, OS Kwon, SO Kim, L He, EY Bae, MS Lee, SJ Jeong, JH Shim, DY Yoon, CH Kim, A Moon, KE Kim, JS Ahn, BY Kim
Cell Proliferation 2008
The energy hypothesis of sleep revisited
MT Scharf, N Naidoo, JE Zimmerman, AI Pack
Progress in Neurobiology 2008
Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways
W Mao, C Iwai, J Liu, SS Sheu, M Fu, C Liang
Journal of Molecular and Cellular Cardiology 2008
Activation of endoplasmic reticulum stress response following trauma-hemorrhage
B Jian, CH Hsieh, J Chen, M Choudhry, K Bland, I Chaudry, R Raju
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2008
Methods in Enzymology
K Zhang, RJ Kaufman
Methods in enzymology 2008
The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells
KL Lipson, R Ghosh, F Urano, K Maedler
PloS one 2008
Novel Oxidative Stress-responsive Gene ERS25 Functions as a Regulator of the Heat-shock and Cell Death Response
SO Hwang, SA Boswell, JS Seo, SW Lee
The Journal of biological chemistry 2008
Involvement of Endoplasmic Reticulum Stress in Palmitate-induced Apoptosis in HepG2 Cells.
Cho HK, Lee JY, Jang YM, Kwon YH
Toxicological Research 2008
Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation
MP Leighton, S Nundlall, T Starborg, RS Meadows, F Suleman, L Knowles, R Wagener, DJ Thornton, KE Kadler, RP Boot-Handford, MD Briggs
Human Molecular Genetics 2007
Activating Transcription Factor 6 (ATF6) Sequence Polymorphisms in Type 2 Diabetes and Pre-Diabetic Traits
WS Chu, SK Das, H Wang, JC Chan, P Deloukas, P Froguel, LJ Baier, W Jia, MI McCarthy, MC Ng, C Damcott, AR Shuldiner, E Zeggini, SC Elbein
Diabetes 2007
The endoplasmic reticulum and the unfolded protein response
JD Malhotra, RJ Kaufman
Seminars in Cell & Developmental Biology 2007
SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis
KH Kim, Y Gao, K Walder, GR Collier, J Skelton, AH Kissebah
Biochemical and Biophysical Research Communications 2007
BBF2H7, a Novel Transmembrane bZIP Transcription Factor, Is a New Type of Endoplasmic Reticulum Stress Transducer
S Kondo, A Saito, S Hino, T Murakami, M Ogata, S Kanemoto, S Nara, A Yamashita, K Yoshinaga, H Hara, K Imaizumi
Molecular and cellular biology 2007
Endoplasmic reticulum chaperones inhibit the production of amyloid-β peptides
T Hoshino, T Nakaya, W Araki, K Suzuki, T Suzuki, T Mizushima
Biochemical Journal 2007
Aggregated myocilin induces russell bodies and causes apoptosis: implications for the pathogenesis of myocilin-caused primary open-angle glaucoma
GH Yam, K Gaplovska-Kysela, C Zuber, J Roth
The American Journal of Pathology 2007
Fold up or perish: unfolded protein response and chemotherapy
A Strasser, H Puthalakath
Cell Death and Differentiation 2007
Dengue virus serotype infection specifies the activation of the unfolded protein response
I Umareddy, O Pluquet, QY Wang, SG Vasudevan, E Chevet, F Gu
Virology Journal 2007
A novel role in cytokinesis reveals a housekeeping function for the unfolded protein response
AA Bicknell, A Babour, CM Federovitch, M Niwa
The Journal of Cell Biology 2007
Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells
Y Wei, D Wang, MJ Pagliassotti
Molecular and Cellular Biochemistry 2007
Molecular Targeting of Proteins by L-Homocysteine: Mechanistic Implications for Vascular Disease
AV Glushchenko, DW Jacobsen
Antioxidants & Redox Signaling 2007
An In Vitro Model for Lewy Body-Like Hyaline Inclusion/Astrocytic Hyaline Inclusion: Induction by ER Stress with an ALS-Linked SOD1 Mutation
S Yamagishi, Y Koyama, T Katayama, M Taniguchi, J Hitomi, M Kato, M Aoki, Y Itoyama, S Kato, M Tohyama, XJ Li
PloS one 2007
Maintenance of Endoplasmic Reticulum (ER) Homeostasis in Herpes Simplex Virus Type 1-Infected Cells through the Association of a Viral Glycoprotein with PERK, a Cellular ER Stress Sensor
M Mulvey, C Arias, I Mohr
Journal of virology 2007
Mining literature for a comprehensive pathway analysis: a case study for retrieval of homocysteine related genes for genetic and epigenetic studies
P Sharma, RD Senthilkumar, V Brahmachari, E Sundaramoorthy, A Mahajan, A Sharma, S Sengupta
Lipids in Health and Disease 2006
Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK
SJ Marciniak, L Garcia-Bonilla, J Hu, HP Harding, D Ron
The Journal of Cell Biology 2006
Regulating apoptosis in mammalian cell cultures
N Arden, MJ Betenbaugh
Cytotechnology 2006
The Unfolded Protein Response Transducer Ire1p Contains a Nuclear Localization Sequence Recognized by Multiple β Importins
L Goffin, S Vodala, C Fraser, J Ryan, M Timms, S Meusburger, B Catimel, EC Nice, PA Silver, CY Xiao, DA Jans, MJ Gething, R Gilmore
Molecular biology of the cell 2006
Phosphorylation of the α subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus
LS Carnevalli, CM Pereira, CB Jaqueta, VS Alves, VN Paiva, KM Vattem, RC Wek, LE Mello, BA Castilho
Biochemical Journal 2006
Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress
M Ogata, S Hino, A Saito, K Morikawa, S Kondo, S Kanemoto, T Murakami, M Taniguchi, I Tanii, K Yoshinaga, S Shiosaka, JA Hammarback, F Urano, K Imaizumi
Molecular and cellular biology 2006
Functional Coupling of p38-Induced Up-regulation of BiP and Activation of RNA-Dependent Protein Kinase–Like Endoplasmic Reticulum Kinase to Drug Resistance of Dormant Carcinoma Cells
AC Ranganathan, L Zhang, AP Adam, JA Aguirre-Ghiso
Cancer research 2006
Translational Control of Cytochrome c by RNA-Binding Proteins TIA-1 and HuR
T Kawai, A Lal, X Yang, S Galban, K Mazan-Mamczarz, M Gorospe
Molecular and cellular biology 2006
Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels
SB Goldfarb, OB Kashlan, JN Watkins, L Suaud, W Yan, TR Kleyman, RC Rubenstein
Proceedings of the National Academy of Sciences 2006
Elevated levels of homocysteine compromise blood-brain barrier integrity in mice
AF Kamath, AK Chauhan, J Kisucka, VS Dole, J Loscalzo, DE Handy, DD Wagner
Blood 2006
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
DT Rutkowski, SM Arnold, CN Miller, J Wu, J Li, KM Gunnison, K Mori, AA Akha, D Raden, RJ Kaufman
PLoS Biology 2006
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
J Zhou, CY Liu, SH Back, RL Clark, D Peisach, Z Xu, RJ Kaufman
Proceedings of the National Academy of Sciences 2006
Mediators of endoplasmic reticulum stress-induced apoptosis
E Szegezdi, SE Logue, AM Gorman, A Samali
EMBO reports 2006
GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development
S Luo, C Mao, B Lee, AS Lee
Molecular and cellular biology 2006
Resistance of mRNA translation to acute endoplasmic reticulum stress-inducing agents in herpes simplex virus type 1-infected cells requires multiple virus-encoded functions
M Mulvey, C Arias, I Mohr
Journal of virology 2006
Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae
M Arvas, T Pakula, K Lanthaler, M Saloheimo, M Valkonen, T Suortti, G Robson, M Penttilä
BMC Genomics 2006
Endoplasmic Reticulum-Associated Degradation Is Required for Cold Adaptation and Regulation of Sterol Biosynthesis in the Yeast Saccharomyces cerevisiae
J Loertscher, LL Larson, CK Matson, ML Parrish, A Felthauser, A Sturm, C Tachibana, M Bard, R Wright
Eukaryotic cell 2006
Cis-hydroxyproline-induced inhibition of pancreatic cancer cell growth is mediated by endoplasmic reticulum stress.
Mueller C, Emmrich J, Jaster R, Braun D, Liebe S, Sparmann G
World Journal of Gastroenterology 2006
Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy.
Ranganathan AC, Adam AP, Aguirre-Ghiso JA
Cell cycle (Georgetown, Tex.) 2006
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
M Bi, C Naczki, M Koritzinsky, D Fels, J Blais, N Hu, H Harding, I Novoa, M Varia, J Raleigh, D Scheuner, RJ Kaufman, J Bell, D Ron, BG Wouters, C Koumenis
The EMBO Journal 2005
AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress
K Terai, Y Hiramoto, M Masaki, S Sugiyama, T Kuroda, M Hori, I Kawase, H Hirota
Molecular and cellular biology 2005
Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha
A Lal, T Kawai, X Yang, K Mazan-Mamczarz, M Gorospe
The EMBO Journal 2005
Rheumatoid arthritis as a hyper-endoplasmic-reticulum-associated degradation disease
S Yamasaki, N Yagishita, K Tsuchimochi, K Nishioka, T Nakajima
Arthritis Research & Therapy 2005
PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes
C Zhou, F Arslan, S Wee, S Krishnan, AR Ivanov, A Oliva, J Leatherwood, DA Wolf
BMC Biology 2005
Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response
J Shen, EL Snapp, J Lippincott-Schwartz, R Prywes
Molecular and cellular biology 2005
Endoplasmic Reticulum Stress Accelerates p53 Degradation by the Cooperative Actions of Hdm2 and Glycogen Synthase Kinase 3β
O Pluquet, LK Qu, D Baltzis, AE Koromilas
Molecular and cellular biology 2005
Identification of a Crucial Site for Synoviolin Expression
K Tsuchimochi, N Yagishita, S Yamasaki, T Amano, Y Kato, K Kawahara, S Aratani, H Fujita, F Ji, A Sugiura, T Izumi, A Sugamiya, I Maruyama, A Fukamizu, S Komiya, K Nishioka, T Nakajima
Molecular and cellular biology 2005
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression
HP Harding, Y Zhang, S Khersonsky, S Marciniak, D Scheuner, RJ Kaufman, N Javitt, YT Chang, D Ron
Cell Metabolism 2005
Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers
P Baumeister, S Luo, WC Skarnes, G Sui, E Seto, Y Shi, AS Lee
Molecular and cellular biology 2005
The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma
KT Chin, HJ Zhou, CM Wong, JM Lee, CP Chan, BQ Qiang, JG Yuan, IO Ng, DY Jin
Nucleic Acids Research 2005
Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients
L Kantor, HP Harding, D Ron, R Schiffmann, CR Kaneski, SR Kimball, O Elroy-Stein
Human Genetics 2005
Birth pangs: the stressful origins of lymphocytes
S Pillai
Journal of Clinical Investigation 2005
Dilated cardiomyopathy caused by aberrant endoplasmic reticulum quality control in mutant KDEL receptor transgenic mice
H Hamada, M Suzuki, S Yuasa, N Mimura, N Shinozuka, Y Takada, M Suzuki, T Nishino, H Nakaya, H Koseki, T Aoe
Molecular and cellular biology 2004
Diverse and specific gene expression responses to stresses in cultured human cells
JI Murray, ML Whitfield, ND Trinklein, RM Myers, PO Brown, D Botstein
Molecular biology of the cell 2004
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
SJ Marciniak, CY Yun, S Oyadomari, I Novoa, Y Zhang, R Jungreis, K Nagata, HP Harding, D Ron
Genes & development 2004
Apoptosis-inducing signal sequence mutation in carbonic anhydrase IV identified in patients with the RP17 form of retinitis pigmentosa
G Rebello, R Ramesar, A Vorster, L Roberts, L Ehrenreich, E Oppon, D Gama, S Bardien, J Greenberg, G Bonapace, A Waheed, GN Shah, WS Sly
Proceedings of the National Academy of Sciences 2004
IRE1-independent gain control of the unfolded protein response
JH Leber, S Bernales, P Walter
PLoS Biology 2004
Plasticity of the β cell insulin secretory competence: preparing the pancreatic β cell for the next meal: Plasticity of β cell insulin secretory competence
SA Hinke, K Hellemans, FC Schuit
The Journal of Physiology 2004
Proteasome Inhibitor PS-341 Induces Apoptosis through Induction of Endoplasmic Reticulum Stress-Reactive Oxygen Species in Head and Neck Squamous Cell Carcinoma Cells
A Fribley, Q Zeng, CY Wang
Molecular and cellular biology 2004
Regulation of multimers via truncated isoforms: a novel mechanism to control nitric-oxide signaling
Y Stasiv, B Kuzin, M Regulski, T Tully, G Enikolopov
Genes & development 2004
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death
J Hitomi, T Katayama, Y Eguchi, T Kudo, M Taniguchi, Y Koyama, T Manabe, S Yamagishi, Y Bando, K Imaizumi, Y Tsujimoto, M Tohyama
The Journal of Cell Biology 2004
Portability and fidelity of RNA-repair systems
B Schwer, R Sawaya, CK Ho, S Shuman
Proceedings of the National Academy of Sciences 2004
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2
PD Lu, C Jousse, SJ Marciniak, Y Zhang, I Novoa, D Scheuner, RJ Kaufman, D Ron, HP Harding
The EMBO Journal 2004
Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy
T Amano, S Yamasaki, N Yagishita, K Tsuchimochi, H Shin, K Kawahara, S Aratani, H Fujita, L Zhang, R Ikeda, R Fujii, N Miura, S Komiya, K Nishioka, I Maruyama, A Fukamizu, T Nakajima
Genes & development 2003
Site-1 protease is required for cartilage development in zebrafish
K Schlombs, T Wagner, J Scheel
Proceedings of the National Academy of Sciences 2003
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
AH Lee, NN Iwakoshi, LH Glimcher
Molecular and cellular biology 2003
The cellular response to aggregated proteins associated with human disease
David Perlmutter
Journal of Clinical Investigation 2002
Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions
Arthur Horwich
Journal of Clinical Investigation 2002
Translational control in the endoplasmic reticulum stress response
David Ron
Journal of Clinical Investigation 2002
Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis
Marina Gelman, Ron Kopiko
Journal of Clinical Investigation 2002
Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease
Giovanni Corsetti, Evasio Pasini, Tiziano M Scarabelli, Claudia Romano, Pratik R Agrawal, Carol Chen-Scarabelli, Richard Knight, Louis Saravolatz, Jagat Narula, Mario Ferrari-Vivaldi, Vincenzo Flati, Deodato Assanelli, Francesco S Dioguardi
Journal of Geriatric Cardiology
Circadian variation of the pancreatic islet transcriptome
K Rakshit, J Qian, J Ernst, AV Matveyenko
Physiological genomics 2016
SEL1L affects human pancreatic cancer cell cycle and invasiveness through modulation of PTEN and genes related to cell-matrix interactions.
Cattaneo M, Fontanella E, Canton C, Delia D, Biunno I
Neoplasia (New York, N.Y.) 2005
Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle.
Vattemi G, Engel WK, McFerrin J, Askanas V
The American Journal of Pathology 2004
Openers of ATP-dependent K+-channels protect against a signal-transduction-linked and not freely reversible defect of insulin secretion in a rat islet transplantation model of Type 2 diabetes.
Björklund A, Bondo Hansen J, Falkmer S, Grill V
Diabetologia 2004
Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury.
Ji C, Kaplowitz N
World Journal of Gastroenterology 2004
The unfolded protein response in protein aggregating diseases.
Gow A, Sharma R
NeuroMolecular Medicine 2003

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