The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth
Tadahiro Kitamura, … , Karen C. Arden, Domenico Accili
Tadahiro Kitamura, … , Karen C. Arden, Domenico Accili
Published December 15, 2002
Citation Information: J Clin Invest. 2002;110(12):1839-1847. https://doi.org/10.1172/JCI16857.
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Article Metabolism

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

Abstract

Research Article

Authors

Tadahiro Kitamura, Jun Nakae, Yukari Kitamura, Yoshiaki Kido, William H. Biggs III, Christopher V.E. Wright, Morris F. White, Karen C. Arden, Domenico Accili

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Figure 3

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Foxo1 haploinsufficiency restores Pdx1 expression in β cells of Irs2–/– ...
Foxo1 haploinsufficiency restores Pdx1 expression in β cells of Irs2–/– mice. Real time RT-PCR analysis of gene expression. We isolated mRNA from islets and amplified it with primers encoding the genes indicated above each graph. An asterisk indicates a statistically significant difference (P < 0.05 by ANOVA) between genotypes.