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Anxiolytic drug targets: beyond the usual suspects
Joshua A. Gordon
Joshua A. Gordon
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):915-917. https://doi.org/10.1172/JCI16846.
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Anxiolytic drug targets: beyond the usual suspects

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Abstract

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Authors

Joshua A. Gordon

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Figure 1

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In PKCε knockouts, the GABAA receptor has enhanced sensitivity to neuros...
In PKCε knockouts, the GABAA receptor has enhanced sensitivity to neurosteroids, resulting in increased Cl– conductance when activated by both GABA and endogenous neurosteroids. PKCε knockouts also have reduced anxiety-like behavior, suggesting that PKCε deficiency leads to decreased anxiety by making the GABAA receptor more sensitive to the anxiolytic action of endogenous compounds such as neurosteroids.

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