JCI - Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis

Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis

Khemissa Bejaoui, … , Walter M. Holleran, Kentaro Hanada

Published November 1, 2002
Citation Information: J Clin Invest. 2002;110(9):1301-1308. https://doi.org/10.1172/JCI16450.

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Western immunoblot analysis of LCB1 and LCB2 proteins present in lymphoblastoid cells from HSN1 patients and healthy controls. Each lane contains an equal amount (5 μg) of microsomal proteins isolated from lymphoblastoid cells of healthy controls (Cont) and from HSN1 patients (HSN1). LCB1 and LCB2 proteins were detected by Western immunoblot analysis as described in Methods. The ID numbers of cell lines used are in parentheses.

Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis

Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis

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