Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy
Junwei Yang, … , Kari Nejak, Youhua Liu
Junwei Yang, … , Kari Nejak, Youhua Liu
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1525-1538. https://doi.org/10.1172/JCI16219.
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Article Nephrology

Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy

Abstract

Research Article

Authors

Junwei Yang, Ryan W. Shultz, Wendy M. Mars, Rodney E. Wegner, Yingjian Li, Chunsun Dai, Kari Nejak, Youhua Liu

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Disruption of tPA gene reduces total collagen accumulated in the obstruc...
Disruption of tPA gene reduces total collagen accumulated in the obstructed kidney. Total kidney collagen content in the obstructed kidneys in sham-operated mice and at day 3 and day 7 after UUO in tPA+/+ and tPA–/– mice was determined by biochemical assay. Results in various groups are expressed as μg per mg kidney and presented as mean ± SEM (n = 5). **P < 0.01 vs. all other groups. *P < 0.01 vs. tPA+/+ mice.