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Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice
Wouter J. de Jonge, … , Marinus C. Lamers, Wouter H. Lamers
Wouter J. de Jonge, … , Marinus C. Lamers, Wouter H. Lamers
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1539-1548. https://doi.org/10.1172/JCI16143.
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Article Aging

Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice

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Abstract

Research Article

Authors

Wouter J. de Jonge, Karin L. Kwikkers, Anje A. te Velde, Sander J.H. van Deventer, Martijn A. Nolte, Reina E. Mebius, Jan M. Ruijter, Marinus C. Lamers, Wouter H. Lamers

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Figure 3

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Prevalence of T and B lymphocytes in the small intestine of wild-type an...
Prevalence of T and B lymphocytes in the small intestine of wild-type and F/A-2+/+ mice. The relative percentage of intestinal lymphocytes, including those from PPs, that express the T cell markers CD3 (a), CD8 (b),CD4 (c), integrin αIEL (d), the B cell markers CD19 (e), and MHC-II (f), was determined in wild-type (squares) and F/A-2+/+ small intestine (diamonds) by flow cytometry. The percentage of cells that expresses T cell markers is similar in both groups, but the percentage that expresses B cell markers is significantly reduced in F/A-2+/+ small intestine. Data shown are mean ± SEM of six mice of each genotype. Significant differences (P < 0.05), determined by one-way ANOVA followed by Dunnett’s multiple comparison test, are indicated by asterisks.

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