Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
The functional CD8 T cell response to HIV becomes type-specific in progressive disease
Sang Kyung Lee, … , Judy Lieberman, Premlata Shankar
Sang Kyung Lee, … , Judy Lieberman, Premlata Shankar
Published November 1, 2002
Citation Information: J Clin Invest. 2002;110(9):1339-1347. https://doi.org/10.1172/JCI16028.
View: Text | PDF
Article Aging

The functional CD8 T cell response to HIV becomes type-specific in progressive disease

  • Text
  • PDF
Abstract

Research Article

Authors

Sang Kyung Lee, Zhan Xu, Judy Lieberman, Premlata Shankar

×

Figure 2

Options: View larger image (or click on image) Download as PowerPoint
Frequency of IFN-γ–producing cells responding to HIV-infected targets de...
Frequency of IFN-γ–producing cells responding to HIV-infected targets declines in more advanced disease stages. (a) Representative flow cytometric analysis of surface IFN-γ and CD8 staining on gated CD8 T cells in PBMCs from subject 307 after overnight stimulation with uninfected CD4 T cells (left) or HIVIIIB (middle) and autologous (right) virus–infected CD4 T cell targets and capture of secreted IFN-γ on the cell surface. The numbers shown are the percentages of CD8 T cells producing IFN-γ. (b) The percentage of CD8 T cells producing IFN-γ in response to IIIB (black bars) and autologous (white bars) virus–infected targets are shown for subjects at various disease stages after subtracting background values for uninfected targets. In subjects 606 and CW15, the response was measured only against IIIB virus because no autologous virus could be generated.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts