Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
Liqing Yu, … , Jonathan C. Cohen, Helen H. Hobbs
Liqing Yu, … , Jonathan C. Cohen, Helen H. Hobbs
Published September 1, 2002
Citation Information: J Clin Invest. 2002;110(5):671-680. https://doi.org/10.1172/JCI16001.
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Article Cardiology

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

Abstract

Research Article

Authors

Liqing Yu, Jia Li-Hawkins, Robert E. Hammer, Knut E. Berge, Jay D. Horton, Jonathan C. Cohen, Helen H. Hobbs

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The fecal lipid content and composition of ABCG5 and ABCG8 transgenic mi...
The fecal lipid content and composition of ABCG5 and ABCG8 transgenic mice. Feces were collected from 9- to 10-week-old transgenic mice and their littermate controls (n = 10 in each group) for 3 days while they consumed a chow diet. The daily total fecal weight, neutral sterols, bile acids, and total fat were measured and expressed per 100 g body weight (BW). *P < 0.01, **P < 0.001.