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IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells
Robin Parihar, … , Yan Hu, William E. Carson
Robin Parihar, … , Yan Hu, William E. Carson
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):983-992. https://doi.org/10.1172/JCI15950.
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Article Oncology Article has an altmetric score of 12

IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells

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Abstract

Research Article

Authors

Robin Parihar, Julie Dierksheide, Yan Hu, William E. Carson

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Figure 5

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PBMCs secrete higher levels of immunostimulatory cytokines than do pure ...
PBMCs secrete higher levels of immunostimulatory cytokines than do pure NK cells in response to Herceptin-coated human breast cancer cells and IL-12. The SKBR3 cell line was cultured with purified NK cells or a whole PBMC population in our in vitro coculture assay. Standard controls were also included. Culture supernatants were harvested after 72 hours and analyzed for (a) IFN-γ (b) TNF-α (c) GM-CSF, and (d) MIP-1α.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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Referenced in 10 patents
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