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Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome
Colleen E. Clancy, … , Michihiro Tateyama, Robert S. Kass
Colleen E. Clancy, … , Michihiro Tateyama, Robert S. Kass
Published November 1, 2002
Citation Information: J Clin Invest. 2002;110(9):1251-1262. https://doi.org/10.1172/JCI15928.
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Article Cardiology

Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome

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Abstract

Research Article

Authors

Colleen E. Clancy, Michihiro Tateyama, Robert S. Kass

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Figure 3

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Influence of stimulation rate on Y1795C Isus. Experimental recordings of...
Influence of stimulation rate on Y1795C Isus. Experimental recordings of TTX-sensitive current (see Methods) are shown at high gain in cells expressing Y1795C mutant channels. Currents shown are in response to voltage pulses (500 milliseconds, –10 mV) applied from a holding potential of –100 mV. Y1795C Isus during the initial depolarizing pulse is shown in the top panel. Below are steady-state traces recorded after a train of depolarizing pulses with different interpulse intervals (t) to mimic bradycardia (left, t = 1 second) and tachycardia (right, t = 20 milliseconds).

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