Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice
Hong Xiao, … , Ronald J. Falk, J. Charles Jennette
Hong Xiao, … , Ronald J. Falk, J. Charles Jennette
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):955-963. https://doi.org/10.1172/JCI15918.
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Article Immunology

Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice

Abstract

Research Article

Authors

Hong Xiao, Peter Heeringa, Peiqi Hu, Zhi Liu, Minglang Zhao, Yasuaki Aratani, Nobuyo Maeda, Ronald J. Falk, J. Charles Jennette

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Vasculitic lesions in WT B6 mice 6 days after they received anti-MPO IgG...
Vasculitic lesions in WT B6 mice 6 days after they received anti-MPO IgG. (a) Glomerulus with segmental fibrinoid neurosis (periodic acid Schiff stain). (b) Glomerulus with segmental fibrinoid necrosis and crescent formation (periodic acid Schiff stain). (c) Glomerulus with segmental fibrinoid necrosis and crescent formation (H&E stain). (d) Immunofluorescence microscopy for fibrin showing prominent staining corresponding to segmental necrosis and crescent formation. (e) Necrotizing arteritis with leukocytoclasia in the dermis of the ear (H&E stain). (f) Pulmonary alveolar capillaritis on the left and more normal lung on the right.