The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression
Enrique Lara-Pezzi, … , Alicia G. Arroyo, Manuel López-Cabrera
Enrique Lara-Pezzi, … , Alicia G. Arroyo, Manuel López-Cabrera
Published December 15, 2002
Citation Information: J Clin Invest. 2002;110(12):1831-1838. https://doi.org/10.1172/JCI15887.
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Article Infectious disease

The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression

Abstract

Research Article

Authors

Enrique Lara-Pezzi, Maria Victoria Gómez-Gaviro, Beatriz G. Gálvez, Emilia Mira, Miguel A. Iñiguez, Manuel Fresno, Carlos Martínez-A., Alicia G. Arroyo, Manuel López-Cabrera

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Figure 6

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HBx induces COX-2 expression. (a) The expression of COX-2 and COX-1 was ...
HBx induces COX-2 expression. (a) The expression of COX-2 and COX-1 was evaluated by Western blot in CMO, CMX, HepG2, 2.2.15, and 4pX cells (treated or not treated with tetracycline). (b) The presence of COX-2 mRNA was analyzed by quantitative RT-PCR in CMO and CMX cells, and in Chang liver cells transiently transfected with pSV-X or the control vector pSV-hygro.