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Opposing roles of STAT1 and STAT3 in T cell–mediated hepatitis: regulation by SOCS
Feng Hong, … , Van-Anh Nguyen, Bin Gao
Feng Hong, … , Van-Anh Nguyen, Bin Gao
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1503-1513. https://doi.org/10.1172/JCI15841.
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Article Hepatology Article has an altmetric score of 3

Opposing roles of STAT1 and STAT3 in T cell–mediated hepatitis: regulation by SOCS

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Abstract

Research Article

Authors

Feng Hong, Barbara Jaruga, Won Ho Kim, Svetlana Radaeva, Osama N. El-Assal, Zhigang Tian, Van-Anh Nguyen, Bin Gao

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Figure 2

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Liver injury and STAT1 and SOCS1 activation are attenuated, but STAT3 an...
Liver injury and STAT1 and SOCS1 activation are attenuated, but STAT3 and SOCS3 activation are enhanced and prolonged in Con A–induced hepatitis in STAT1–/– mice. (a) Mice were injected with 22 μg/g of Con A. At various time points, serum ALT levels were measured. Values are shown as means ± SEM from four mice at each time point. (b) Photomicrographs of representative mouse livers from 9-hour Con A–treated wild-type and STAT1–/– mice with H&E staining are shown (original magnification ×200 and ×400). White arrows indicate massive necrosis observed in the liver. (c) Wild-type control and STAT1–/– mice were injected with Con A (22 μg/g). At various time points after injection, serum was collected, and circulating IFN-γ levels were measured by ELISA. Values are shown as means ± SEM from three mice at each time point. (d) Total liver protein extracts and RNA from Con A–treated STAT1+/+ and STAT1–/– mice were analyzed by Western blotting and RT-PCR (indicated by asterisks), respectively, using Ab’s and primers as indicated. Induction of pSTAT1, pSTAT3, IRF-1, Bcl-XL, SOCS1, and SOCS3 was quantified by PhosphorImager analysis (left panel), as described in Methods. The values are shown as means ± SEM from four independent experiments at each time point. *P < 0.001, #P < 0.01 vs. corresponding Con A–treated wild-type control groups at the same time points.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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