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Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype
Kazuhiko Takahashi, … , Tomoo Ishikawa, Hidehito Kotani
Kazuhiko Takahashi, … , Tomoo Ishikawa, Hidehito Kotani
Published December 15, 2002
Citation Information: J Clin Invest. 2002;110(12):1791-1799. https://doi.org/10.1172/JCI15784.
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Article Metabolism

Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype

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Abstract

Research Article

Authors

Kazuhiko Takahashi, Hiroaki Suwa, Tomoo Ishikawa, Hidehito Kotani

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Figure 3

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Caloric efficiency and locomotor activity of H3+/+ and H3–/– mice. (a) B...
Caloric efficiency and locomotor activity of H3+/+ and H3–/– mice. (a) Body weight and 3-hour food intake were measured after 21 hours of food restriction in 20- to 27-week-old male mice. H3+/+ mice are indicated by filled squares (food intake) and open squares (body weight) and H3–/– mice by filled triangles (food intake) and open triangles (body weight) (n = 10, *P < 0.05). (b) Basal and total oxygen consumption rate in 16- to 17-week-old female mice. Data are normalized to lean body mass. H3+/+ mice are indicated by white bars and H3–/– mice by black bars (n = 3 or 4, *P < 0.05; **P < 0.01). (c) Light-phase and dark-phase locomotor activity in 16- to 21-week-old female mice. H3+/+ mice are indicated by squares and H3–/– mice by triangles (n = 9–11). Measurements were taken for 4 consecutive days, and data from the last 3 days are shown. (d) Light-phase and dark-phase total locomotor activity in 16- to 21-week-old female mice. H3+/+ mice are indicated by white bars and H3–/– mice by black bars (n = 9–11, *P < 0.05). Measurements are averages for the last 3 days.

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