Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins
Alberto Auricchio, … , Roberto Calcedo, James M. Wilson
Alberto Auricchio, … , Roberto Calcedo, James M. Wilson
Published August 15, 2002
Citation Information: J Clin Invest. 2002;110(4):499-504. https://doi.org/10.1172/JCI15780.
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Article Genetics

Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins

Abstract

Research Article

Authors

Alberto Auricchio, Erin O’Connor, Daniel Weiner, Guang-Ping Gao, Markus Hildinger, Lili Wang, Roberto Calcedo, James M. Wilson

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FIX secretion from FIX–/– murine lung transduced with AAV2/5. (a) Circul...
FIX secretion from FIX–/– murine lung transduced with AAV2/5. (a) Circulating FIX levels over time following viral delivery. White bars correspond to animals that received AAV2/5-CC10-lacZ, black bars to animals that were given AAV2/5-CC10-cFIX. (b) aPTT levels following intranasal delivery of AAV2/5-CC10-lacZ (white bars) or AAV2/5-CC10-FIX (black bars). Values shown are mean ± SD.