Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
Burkhard Becher, … , Brigit G. Durell, Randolph J. Noelle
Burkhard Becher, … , Brigit G. Durell, Randolph J. Noelle
Published August 15, 2002
Citation Information: J Clin Invest. 2002;110(4):493-497. https://doi.org/10.1172/JCI15751.
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Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

Abstract

Research Article

Authors

Burkhard Becher, Brigit G. Durell, Randolph J. Noelle

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Cellular makeup of infiltrates. Animals were sacrificed at day 24 after ...
Cellular makeup of infiltrates. Animals were sacrificed at day 24 after immunization, and spinal cord inflammation was assessed by flow cytometry. Infiltrates were stained with antibodies against CD45, CD11b, CD4, CD8, and GR-1 as described in Methods. Gate statistics are expressed as percentages as follows (WT:p35–/–): R1 (lymphocyte gate CD45hi/CD11b–) = 28%:39%; R2 (macrophage/granulocyte gate CD45hi/CD11b+) = 8%:10%; R3 (microglia gate CD45lo/CD11b+) = 30%:25%.