Effect of r-metHuLeptin on T cell proliferation and cytokine production in child C. (a) Proliferative responses of peripheral lymphocytes to T cell–specific stimuli at three different time points before (–) and after (+) recombinant leptin treatment. All data are from triplicate cultures and expressed as mean ± SD. Proliferative responses from normal age-matched controls were measured in parallel experiments (mean shown as single point ± SD). (b) Cytokine profiles in child C at three different time points before (–) and after (+) recombinant leptin treatment. Cytokine measurements from normal age-matched controls were measured in parallel experiments (mean shown as single point ± SEM).