Effect of TNF-α inhibitors on cisplatin nephrotoxicity. Mice were injected with saline (squares), 20 mg/kg cisplatin (circles), cisplatin and GM6001 (triangles), or neutralizing TNF-α Ab (inverted triangles), as described in Methods. Blood urea nitrogen was measured at the indicated times. *P < 0.01 vs. cisplatin, n = 4–7.