Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
Hiroshi Yamamoto, … , Daniel J. Drucker, Joel K. Elmquist
Hiroshi Yamamoto, … , Daniel J. Drucker, Joel K. Elmquist
Published July 1, 2002
Citation Information: J Clin Invest. 2002;110(1):43-52. https://doi.org/10.1172/JCI15595.
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Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

Abstract

Research Article

Authors

Hiroshi Yamamoto, Charlotte E. Lee, Jacob N. Marcus, Todd D. Williams, J. Michael Overton, Marisol E. Lopez, Anthony N. Hollenberg, Laurie Baggio, Clifford B. Saper, Daniel J. Drucker, Joel K. Elmquist

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Figure 1

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Effects of i.c.v. or i.v. administration of EXN-4 on MAP and HR. Both i....
Effects of i.c.v. or i.v. administration of EXN-4 on MAP and HR. Both i.v. EXN-4 (a and b) and i.c.v. EXN-4 (c and d) dose-dependently increase MAP (a and c) and HR (b and d). EXN-4 was injected at “0.” *P < 0.05, **P < 0.01.